Cited by 1,012Cytokine Signaling Pathways and InteractionsImmune Response and InflammationT-cell and B-cell Immunology

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

Schindler, R, Mancilla, J, Endres, S, Ghorbani, R, Clark, SC, Dinarello, CA·1990·Blood

Open this paper in CoChat — free account

Abstract

Interleukin-6 (IL-6) shares several biologic properties with IL-1, including hematopoietin-1 activity and stimulation of T cells. Because many of their biologic activities overlap, we developed and used a specific radioimmunoassay (RIA) for IL-6 to compare production of this cytokine on a molar basis with that of IL-1 alpha, IL-1 beta, and tumor necrosis factor (TNF)alpha. The RIA correlated well with the hybridoma bioassay for IL-6 (r = .87, P less than .001). Freshly isolated human peripheral blood mononuclear cells (PBMC) cultured in the absence of stimuli did not produce IL-6 in most cases. Kinetics of secretion and cell-association of IL-6 were studied. In contrast to IL-1 alpha but similar to TNF, IL-6 was almost entirely secreted into the extracellular fluid. Incubation with different stimuli (lipopolysaccharide [LPS], phytohemagglutinin [PHA], Staphylococcus epidermidis, or IL-1 alpha) resulted in production of IL-6. However, on a molar basis PBMC produced approximately two to three times less IL-6 than IL-1 alpha, IL-1 beta, or TNF, regardless of the stimulus. The amount of IL-6 produced from PBMC was consistent when measured in the same subjects six time during a 12-week period. In a cohort of 38 donors, the coefficient of variation for IL-6 production was .32, compared with .92 for IL-1 beta and .96 for TNF. Comparing cytokine production by PBMC, there was a significant correlation between IL-6 and IL-1 beta (r = .72) and between IL-6 and TNF (r = .66). IL-6 did not stimulate IL-1 beta or TNF production, but suppressed IL-1 beta and TNF production induced by LPS or PHA by 30% (P less than .01). This suppression of IL-1 beta and TNF by IL-6 appears to be on the level of transcription.

Integrity signals

Registry

Crossref · 10.1182/blood.v75.1.40.40

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.
Gauldie, J., Richards, C. D., Harnish, D. C., Lansdorp, P. M., & Baumann, H. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7251 · Cited by 1,635
Production of hybridoma growth factor by human monocytes
Aarden, L. A., de Groot, E. R., Schaap, O. L., & Lansdorp, P. M. (1987) · European Journal of Immunology · doi:10.1002/eji.1830171004 · Cited by 1,091
The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells
Muraguchi, A., Hirano, T., Tang, B., Matsuda, T., Horii, Y., Nakajima, K., & Kishimoto, T. (1988) · The Journal of experimental medicine · doi:10.1084/jem.167.2.332 · Cited by 783
Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.
Damme, J. V., Opdenakker, G., Simpson, R. J., Rubira, M. R., Cayphas, S., Vink, A., Billiau, A., & Snick, J. V. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.3.914 · Cited by 669
Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
Perlmutter, D. H., Dinarello, C. A., Punsal, P. I., & Colten, H. R. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112721 · Cited by 566
Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.
Dinarello, C. A., Ikejima, T., Warner, S. J. C., Orencole, S. F., Lonnemann, G., Cannon, J. G., & Libby, P. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.6.1902 · Cited by 537
Structure and expression of cDNA and genes for human interferon‐beta‐2, a distinct species inducible by growth‐stimulatory cytokines.
Zilberstein, A., Ruggieri, R., Korn, J. H., & Revel, M. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04531.x · Cited by 486
SERUM LEVELS OF INTERLEUKIN-6 AND ACUTE PHASE RESPONSES
Nijsten, M. W., de Groot, E. R., ten Duis, H. J., Klasen, H. J., Hack, C. E., & Aarden, L. A. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91413-9 · Cited by 457
Interleukin 6 is involved in interleukin 1‐induced activities
Helle, M., Brakenhoff, J. P. J., de Groot, E. R., & Aarden, L. A. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180619 · Cited by 409
Induction of rat acute‐phase proteins by interleukin 6 in vivo
Geiger, T. M., Andus, T., Klapproth, J., Hirano, T., Kishimoto, T., & Heinrich, P. C. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180510 · Cited by 401

Show all 34 references

Sorted by citations

Items 701–800 of 998

Dibutyltin alters immune cell production of the pro-inflammatory cytokines interleukin (IL) 1β and IL-6: role of mitogen-activated protein kinases and changes in mRNA
Sushak, L. B., Gabure, S., Maise, J., Arnett, J., & Whalen, M. (2020) · Journal of Applied Toxicology · doi:10.1002/jat.3964 · Cited by 11
Effects of dietary protein content and crystalline amino acid supplementation patterns on growth performance, intestinal histomorphology, and immune response in weaned pigs raised under different sanitary conditions
Lee, J., González-Vega, J. C., Htoo, J. K., Yang, C., & Nyachoti, C. M. (2022) · Journal of Animal Science · doi:10.1093/jas/skac285 · Cited by 11
Cysteamine suppresses human peripheral blood mononuclear cells--human corneal endothelial cell reaction via reactive oxygen species reduction.
Shin, Y. J., Hyon, J. Y., Kim, S., Koh, J. W., Kwon, S. I., & Wee, W. R. (2011) · Europe PMC (PubMed Central) · Cited by 11
Rabbit Pigmented Ciliary Epithelium Produces Interleukin-6 in Response to Inflammatory Cytokines
Fleisher, L. N., McGahan, M. C., & Ferrell, J. (2000) · Experimental Eye Research · doi:10.1006/exer.1999.0787 · Cited by 11
Serum levels of interleukin-6 in contacts of active pulmonary tuberculosis
Lopes, F. H. A., de Assis, L. C., Neto, R. D. J. P., Botelho, K. P., Sá, K. M., Frota, C. C., Correia, J. W., & Freitas, M. V. C. (2013) · Jornal Brasileiro de Patologia e Medicina Laboratorial · doi:10.1590/s1676-24442013000600005 · Cited by 11
Leishmania major: Interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1β and interleukin-12 in rats
Haber, M., Daher, C. F., Karam, M., & Baroody, G. M. (2008) · Experimental Parasitology · doi:10.1016/j.exppara.2008.11.004 · Cited by 11
Cytokine measurements in gingival crevicular fluid and periodontal ligament: Are they correlated?
Madureira, D. F., da Silva, J. M., Teixeira, A. L., de Abreu, M. H. N. G., Pretti, H., Lages, E. M. B., & Silva, T. A. (2015) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2015.03.030 · Cited by 11
Interleukin-1 regulates cytokine gene expression in human mesangial cells through the interleukin-1 receptor type 1.
Zoja, C., Bettoni, S., Morigi, M., Remuzzi, G., & Rambaldi, A. (1992) · Journal of the American Society of Nephrology · doi:10.1681/asn.v2121709 · Cited by 11
Tumor necrosis factor-α expression induced by anti-YopB antibodies coincides with protection against Yersinia enterocolitica infection in mice
Burdack, S., Schmidt, A., Knieschies, E., Röllinghoff, M., & Beuscher, H. U. (1997) · Medical Microbiology and Immunology · doi:10.1007/s004300050034 · Cited by 11
Transient endotoxemia during burn wound revision causes leukocyte ?2 integrin up-regulation and cytokine release
Ljunghusen, O., Berg, S., HED, J., Lundahl, J., Nettelblad, H., Sj�gren, F., & Stendahl, O. I. (1995) · Inflammation · doi:10.1007/bf01534579 · Cited by 11
THE DIMINISHED POSTOPERATIVE CAPACITY OF BLOOD LEUKOCYTES TO PRODUCE IL-6 IS ASSOCIATED WITH HIGH CONCENTRATIONS OF IL-6 IN THE CIRCULATION
Riese, J., Denzel, C., Mehler, C., Zowe, M., Hohenberger, W., & Haupt, W. (2000) · Cytokine · doi:10.1006/cyto.1999.0579 · Cited by 11
INCREASED PROINFLAMMATORY CYTOKINES PRODUCTION BY ERGOTAMINE IN MALE BALB/c MICE
Filipov, N. M. (1999) · Journal of Toxicology and Environmental Health · doi:10.1080/009841099157359 · Cited by 11
Supernatants derived from CD8+ lymphocytes activated by mycobacterial fractions inhibit cytokine production. The role of interleukin-6
Sussman, G., & Wadee, A. A. (1992) · Biotherapy · doi:10.1007/bf02171753 · Cited by 11
Analysis of the immune response of calves to various saponin-based adjuvants for an experimental Mycoplasma bovis vaccine
Dudek, K., Bednarek, D., Ayling, R. D., Szczotka, M., Iwan, E., & Kocki, J. (2018) · Acta Veterinaria Hungarica · doi:10.1556/004.2018.021 · Cited by 10
Anti-infammatory and antioxidant activities of acteoside isolated from Acanthus ilicifolius var. xiamenensis
Zhang, Y., Shen, J., Ma, X., Yao, M., Zhang, Y., & Cao, D. (2022) · Applied Biological Chemistry · doi:10.1186/s13765-022-00695-w · Cited by 10
Interleukin-6: Still crazy after all these years*
O’Malley, K. A., & Moldawer, L. L. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000239424.59338.2f · Cited by 10
TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads
Low, H. Z., Ahrenstorf, G., Pommerenke, C., Habermann, N., Schughart, K., Ordóñez, D., Stripecke, R., Wilk, E., & Witte, T. (2016) · Retrovirology · doi:10.1186/s12977-016-0248-y · Cited by 10
Adult Serum Cytokine Concentrations and the Persistence of Asthma
Kandane‐Rathnayake, R., Tang, M. L. K., Simpson, J. A., Burgess, J. A., Mészáros, D., Feather, I. H., Southey, M. C., Schroen, C. J., Hopper, J. L., Morrison, S. C., et al. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000346910 · Cited by 10
Emerging Role of Interleukins in Cancer Treatment
Razavi, G. S. E. (2014) · Immunome Research · doi:10.4172/1745-7580.s2.006 · Cited by 10
Stimulatory effect of fragments from transcribed region of ribosomal repeat on human peripheral blood lymphocytes
Вейко, Н. Н., Kalashnikova, E. A., Kokarovtseva, S. N., Kostyuk, S. V., Ermakov, A. V., Ivanova, S. M., Riazantseva, T. A., Egolina, N. A., Lyapunova, N. A., & Dm, S. (2006) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-006-0384-9 · Cited by 10
Clinical significance of the change of blood monocytic interleukin-1 production in vitro in severely burned patients
Liu, X.-S., Yang, Z.-C., Luo, Z.-H., & Li, A. (1994) · Burns · doi:10.1016/0305-4179(94)90056-6 · Cited by 10
Acute-Phase Hepatocytes Regulate Liver Sinusoidal Cell Mediator Production
Bankey, P. E. (1994) · Archives of Surgery · doi:10.1001/archsurg.1994.01420350064008 · Cited by 10
Decreased IL-6 secretion by fibroblasts following repeated doses of TNFα or IL-1α: Post-transcriptional gene regulation
Carty, S. E., Buresh, C. M., & Norton, J. A. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90065-t · Cited by 10
The effects of calcium pentosan polysulfate on inflammatory mediators in the rat air-pouch model of inflammation
Bansal, M. K., Smith, M. M., Numata, Y., & Ghosh, P. B. (1993) · Current Therapeutic Research · doi:10.1016/s0011-393x(05)80702-7 · Cited by 10
Adaptation to the Microbial Environment
Toth, L. A., & Blatteis, C. M. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp040266 · Cited by 10
Titrating the Translational Relevance of a Low-Level Repetitive Head Impact Model
Boucher, M. L., Conley, G. M., Nowlin, J., Qiu, J., Kawata, K., Bazarian, J. J., Meehan, W. P., III, & Mannix, R. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.857654 · Cited by 9
Macrophage Infection by Mycobacteria
Saleh, M. T., & Longhi, G. (2016) · Mycobacterial Diseases · doi:10.4172/2161-1068.1000197 · Cited by 8
Clostridial collagenase aggravates the systemic inflammatory response in rats with partial-thickness burns
Dökümcü, Z., Ergün, O., Celik, H. A., Aydemir, Ş., Sezak, M., Özok, G., & Çelik, A. (2008) · Burns · doi:10.1016/j.burns.2008.01.001 · Cited by 9
Major liver resection results in early exacerbation of insulin resistance, and may be a risk factor of developing overt diabetes in the future
Durczyński, A., Strzelczyk, J., Wojciechowska-Durczyńska, K., Borkowska, A., Hogendorf, P., Szymański, D., Chałubińska, J., & Czupryniak, L. (2012) · Surgery Today · doi:10.1007/s00595-012-0268-8 · Cited by 9
Dynamics of antagonistic potency of Rhodobacter capsulatus PG lipopolysaccharide against endotoxin-induced effects
Kabanov, D. S., Serov, D. A., Zubova, S. V., Grachev, S. V., & Прохоренко, И. Р. (2016) · Biochemistry (Moscow) · doi:10.1134/s000629791603010x · Cited by 9
Amniotic Fluid Interleukin-6 and the Risk of Early-Onset Sepsis Among Preterm Infants
Figueroa-Damián, R., Arredondo-Garcı́a, J. L., & Mancilla-Ramı́rez, J. (1999) · Archives of Medical Research · doi:10.1016/s0188-0128(99)00015-9 · Cited by 9
Interactions between rnacrophage cytokines and eicosanoids in expression of antitumour activity
Ben‐Efraim, S. (1992) · Mediators of Inflammation · doi:10.1155/s0962935192000449 · Cited by 9
Interference of circulating azathioprine but not methotrexate or sulfasalazine with measurements of interleukin-6 bioactivity.
Barrera, P., Boerbooms, A. M., Sauerwein, R. W., Demacker, P. N. M., van de Putte, L. B., & van der Meer, J. W. (1994) · PubMed · Cited by 9
Soluble urokinase Plasminogen Activator Receptor (suPAR) levels are predictive of COVID-19 severity: an Italian experience
Infantino, M. G., Morena, L., Pietro, M. A. D., Romanin, B., Cimolato, B., Rocca, B. A. L., Tunnera, S., Modi, G., Tilli, M., Grossi, V., et al. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109091 · Cited by 8
Short-term assays for mesenchymal stromal cell immunosuppression of T-lymphocytes
Herzig, M. C. S., Christy, B. A., Montgomery, R. K., Cantu, C., Barrera, G. D., Lee, J. H., Mucha, N., Talackine, J. R., Abaasah, I. E., Bynum, J. A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1225047 · Cited by 8
A Meta-Analysis of the Effects of Interleukin-6 −174 G>C Genetic Polymorphism on Acute Graft-Versus-Host Disease Susceptibility
Choi, B., Lee, D.-E., Park, H. Y., Jeong, S., Lee, S., Ji, E., Park, S., & Oh, J. M. (2012) · Clinical Therapeutics · doi:10.1016/j.clinthera.2012.01.010 · Cited by 8
Exercise-induced cytokine changes in antigen stimulated whole-blood cultures compared to serum
Pilat, C., Krüger, K., Frech, T., & Mooren, F. C. (2016) · Journal of Immunological Methods · doi:10.1016/j.jim.2016.11.007 · Cited by 8
Hyperglycemic condition influence on mineral trioxide aggregate biocompatibility and biomineralization
Queiroz, Í. O. D. A., Gonçalves, L. D. O., Takamiya, A. S., REZENDE, G. C., Machado, T., Siveiri‐Araujo, G., Ervolino, E., Oliveira, S. H. P., & Gomes‐Filho, J. E. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34420 · Cited by 8
Interleukin-1 and its inhibitors: Implications for disease biology and therapy
Estrov, Z. E., Kurzrock, R., & Talpaz, M. (1995) · Cancer treatment and research · doi:10.1007/978-1-4613-1241-3_3 · Cited by 8
Effects of natural human interleukin-6 on thrombopoiesis and tumor progression in tumor-bearing mice
Yoshizawa, K., Okamoto, T., Moriya, K., Izawa, A., Satoh, Y., Naruto, M., & Ida, N. (1994) · Cancer Letters · doi:10.1016/0304-3835(94)90067-1 · Cited by 8
Cytokines involved in monocyte mediated tumor cell death and growth inhibition in serum‐free medium
Bosch, J. V. D., Rüller, E., Ernst, M., Schade, U. F., Mathison, J. C., Rüller, S., & Schlaak, M. S. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041520321 · Cited by 8
Assessing multiple sclerosis activity: is the in vitro production of tumor necrosis factor-α, interleukins 2, 6, 4, and 10, and immunoglobulin G of value?
Schluep, M., van Melle, G., Henry, H., Städler, C., Roth-Wicky, B., & Magistretti, P. J. (1999) · Journal of Neurology · doi:10.1007/s004150050510 · Cited by 8
A simple and rapid radioimmunoassay for human interleukin-6
Peppard, J., Rediske, J. J., Koehler, J. A., & Koehne, C. F. (1992) · Journal of Immunological Methods · doi:10.1016/0022-1759(92)90154-l · Cited by 8
Type 2‐biased expression of cytokine genes in lung granulomatous lesions induced by Nippostrongylus brasiliensis infection
Matsuda, S., Tani, Y., Yamada, M., Yoshimura, K., & Arizono, N. (2001) · Parasite Immunology · doi:10.1046/j.1365-3024.2001.00376.x · Cited by 8
Cytokine concentrations in people with eating disorders: A comprehensive updated systematic review and meta-analysis
Keeler, J. L., Bovenberg, C., Himmerich, H., Treasure, J. L., Carter, B., Schmidt, U. H., & Dalton, B. (2025) · Communications Medicine · doi:10.1038/s43856-025-01122-z · Cited by 8
Membrane interleukin‐18 revisits membrane IL ‐1α in T ‐helper type 1 responses
Dinarello, C. A. (2012) · European Journal of Immunology · doi:10.1002/eji.201242635 · Cited by 7
Early murine immune responses from endotracheal exposures to biotechnology-relatedBacillusstrains
Tayabali, A. F., Nguyen, K. C., & Seligy, V. L. (2010) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772248.2010.526784 · Cited by 7
In silico study of principal sex hormone effects on post-injury synovial inflammatory response
Powell, B., Szleifer, I. G., & Dhaher, Y. Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209582 · Cited by 7
The Essential Role of 17-Octadecynoic Acid in the Pathogenesis of Periapical Abscesses
Altaie, A. M., Mohammad, M. G., Madkour, M. I., Shakartalla, S. B., Jayakumar, M. N., Gopalakrishnan, A. R. K., Halwani, R., Samsudin, A. R., Hamoudi, R., & Soliman, S. S. M. (2022) · Journal of Endodontics · doi:10.1016/j.joen.2022.12.002 · Cited by 7
Effect of knife castration on leukocyte cytokine expression and indicators of stress, pain, and inflammation in Korean cattle bull calves
Yoo, S. P., Beak, S.-H., Kang, H. J., Jung, D. J. S., Fassah, D. M., Jeong, I., Park, S. J., Haque, M. N., Kim, M., & Baik, M. (2023) · Animal Bioscience · doi:10.5713/ab.22.0368 · Cited by 7
The role of TRB3 in mast cells sensitized with monomeric IgE
Kuo, C., Morohoshi, K., Aye, C. C., Garoon, R. B., Collins, A., & Ono, S. J. (2012) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2012.09.008 · Cited by 7
Effects of Euterpe edulis Martius on inflammatory responses to high-intensity intermittent exercise: Crossover randomized trial
Mendes, B. C., Copetti, C. L. K., Panza, V. P., Orssatto, L. B. R., da Rosa, J. S., Diefenthaeler, F., Dalmarco, E. M., Pietro, P. F. D., & Rieger, D. K. (2021) · Nutrition · doi:10.1016/j.nut.2021.111344 · Cited by 7
5-Aza-2′-deoxycytidine enhances the antimicrobial response of vitamin D receptor against Mycobacterium tuberculosis
Yang, Y., Liu, X., Yin, W., Xie, D., He, W., Jiang, G., & Fan, J. (2016) · RSC Advances · doi:10.1039/c6ra10647a · Cited by 7
The Cytokine Network in Sepsis II: IL-1 and IL-6
Waage, A., Redl, H. R., Schlag, G., & Schade, U. F. (1993) · Springer eBooks · doi:10.1007/978-3-642-76736-4_36 · Cited by 7
Changes in serum levels of cytokines in mice injected with an immunostimulator C3bgp isolated from Cuscuta europea
Stanilova, S. A., Dobreva, Z. G., & Zhelev, Z. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00074-1 · Cited by 7
Le rétrocontrôle négatif de l'inflammation: rôle des cytokines antiinflammatoires
Marie, C., & Cavaillon, J. (1997) · Bulletin de l Institut Pasteur · doi:10.1016/s0020-2452(97)82541-9 · Cited by 7
In vitro TNF-α production and in vivo alteration of TNF-α RNA in mouse peritoneal macrophages after treatment with different bacterial derived agents
Novaković, S., & Boldogh, I. R. (1994) · Cancer Letters · doi:10.1016/0304-3835(94)90171-6 · Cited by 7
Suppression of cytokine production by supernatants from CD8+ lymphocytes activated by mycobacterial fractions: The role of interleukins 4 and 6
Wadee, A. A., Sussman, G., Kuschke, R. H., & Reddy, S. (1993) · Biotherapy · doi:10.1007/bf01877736 · Cited by 7
Effects of intravenous immunoglobulins on T‐cell mediated, concanavalin A‐induced hepatitis in mice
Shirin, H., Bruck, R., Aeed, H., Hershkoviz, R., Lider, O., Kenet, G., Avni, Y., & Halpern, Z. (1997) · Liver International · doi:10.1111/j.1600-0676.1997.tb01032.x · Cited by 7
Defects in Host Defense Mechanisms
van der Meer, J. W. M. (1994) · Springer eBooks · doi:10.1007/978-1-4615-2490-8_3 · Cited by 7
Low molecular weight heparin-induced pharmacological modulation of burn wound healing.
Ravikumar, T., Shanmugasundaram, N., Jayaraman, V., Ramakrishnan, K. M., & Babu, M. (2006) · PubMed Central · Cited by 7
Neonatal Pulmonary Host Defense Mechanisms
Metinko, A. (2004) · Elsevier eBooks · doi:10.1016/b978-0-7216-9654-6.50167-3 · Cited by 8
Skeletal Muscle as Endocrine Organ
Ma, M., Zhang, Z., Hai, B., & Zhang, Y. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_22 · Cited by 9
Age-dependent nasal immune responses in non-hospitalized bronchiolitis children
Cortegano, I., Rodríguez, M., Hernangómez, S., Arrabal, A., Garcia-Vao, C., Rodríguez, J. D., Fernández, S., Díaz, J., de la Rosa, B., Solís, B., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1011607 · Cited by 6
Time-Dependent Long-Term Effect of Memantine following Repetitive Mild Traumatic Brain Injury
Boucher, M. L., Conley, G. M., Morriss, N. J., Ospina-Mora, S., Qiu, J., Mannix, R., & Meehan, W. P., III (2024) · Journal of Neurotrauma · doi:10.1089/neu.2023.0423 · Cited by 6
Anti-inflammatory activity of aqueous extract of Mimusops elengi in human whole blood and peripheral blood mononuclear cells
Gupta, A. K., Khamkar, P. R., & Chaphalkar, S. R. (2014) · Cited by 6
EFFECT OF INTERLEUKIN-6 POLYMORPHISM ON FUNCTION OF THE RENAL ALLOGRAFT FUNTION AND EFFICACY OF IMMUNOSUPPRESSIVE THERAPY
Kotowski, M. J. (2018) · FARMACIA · doi:10.31925/farmacia.2018.5.8 · Cited by 6
A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis
Shen, C., Qi, H., Sun, L., Xiao, J., Yin, Q.-Q., Jiao, W., Wu, X., Tian, J., Han, R., & Shen, A. (2014) · BioMed Research International · doi:10.1155/2014/483759 · Cited by 6
The effect of endotoxin administration on cytokine production in obstructive jaundiced rats.
Dawiskiba, J., Zimecki, M., Kwiatkowska, D., & Kuźmiński, A. (2001) · PubMed · Cited by 6
The impact of exercise training on adipose tissue remodelling in cancer cachexia
Ferreira, R. M., Nogueira‐Ferreira, R., Vitorino, R. M. P., Santos, L. L., & Moreira‐Gonçalves, D. (2017) · Porto Biomedical Journal · doi:10.1016/j.pbj.2017.02.006 · Cited by 8
Pathophysiology of Krabbe disease
Davenport, A., Williamson, P., & Taylor, R. M. (2009) · Undergraduate Research Journal · Cited by 6
Effect of soluble interleukin‐6 receptor α and interleukin‐6 secreted by polymorphonuclear leukocytes on tumor necrosis factor‐α expression and its production by peripheral blood mononuclear cells
Jabłońska, E. (2002) · Mediators of Inflammation · doi:10.1080/09629350210000015746 · Cited by 6
Divergent cytokine response following maximum progressive swimming in hot water
Campi‐Azevedo, A. C., Cleto, L. S., da Silva, R. S., Sousa-Franco, J., de Magalhães, J. C., Penaforte, C. L., Pinto, K. M. D. C., & Rocha‐Vieira, E. (2011) · Cell Biochemistry and Function · doi:10.1002/cbf.1795 · Cited by 6
Mutual modulation between interleukin-10 and interleukin-6 induced by Rhodococcus aurantiacus infection in mice
Yimin, Kohanawa, M., Ozaki, M., Haga, S., Fujikawa, K., Zhao, S., Kuge, Y., & Tamaki, N. (2008) · Microbes and Infection · doi:10.1016/j.micinf.2008.08.013 · Cited by 6
Cytokine production in human mixed leukocyte reactions performed in serum-free media
Bishara, A., Malka, R., Brautbar, C., Barak, V., Cohen, I., & Kedar, E. (1998) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00078-7 · Cited by 6
Interleukin-6 in Bacterial Infection and Sepsis: Innocent Bystander or Essential Mediator?
van der Poll, T., & van Deventer, S. J. H. (1999) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-662-13453-5_5 · Cited by 6
Interleukin 1
Colotta, F., Ghezzi, P., & Mantovani, A. (1998) · Elsevier eBooks · doi:10.1016/b978-012498340-3/50002-6 · Cited by 6
Mortality in Humans With Pneumonia and Sepsis Is Related to an Uncompensated Anti-inflammatory Response to Infection
White, M., Mankan, A. K., Lawless, M. W., O’Dwyer, M. J., McManus, R., & Ryan, T. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.13.1468-b · Cited by 6
Transgenic Modeling of Cytokines in the Investigation of Pulmonary Disease
Elias, J. A., Geba, G. P., Tang, W., Schilz, R. J., Zheng, T., DiCosmo, B., & Flavell, R. A. (1996) · CHEST Journal · doi:10.1378/chest.109.3_supplement.69s · Cited by 6
High levels of interleukin 6 and its secondary mediators in spontaneous bacterial peritonitis
Propst, T., Propst, A., Herold, M., Judmaier, G., Braunsteiner, H., & Vogel, W. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90060-p · Cited by 6
Interleukin-6
Richards, C. D. (1998) · Elsevier eBooks · doi:10.1016/b978-012498340-3/50007-5 · Cited by 6
Flame Retardant, Hexabromocyclododecane, Increases Production of Pro-inflammatory Cytokines, Interleukin 1-Beta and Interleukin 6, in Human Immune Cells
Falconer-Turner, A., Brooks, K., Ogaga, E. I., & Whalen, M. (2024) · Journal of Applied Toxicology · doi:10.1002/jat.4700 · Cited by 5
Adjuvant conditioning shapes the adaptive immune response promoting immunotolerance via NLRP3/interleukin-1
Boccia, T., Pan, W., Fattori, V., Cervantes‐Díaz, R., Rogers, M. S., Zanoni, I., & Cuenca, A. G. (2025) · iScience · doi:10.1016/j.isci.2025.112653 · Cited by 5
Characterization of a Broadly Reactive Anti-CD40 Agonistic Monoclonal Antibody for Potential Use as an Adjuvant
Martin, C. L., Waghela, S. D., Lokhandwala, S., Ambrus, A., Bray, J., Vuong, C. N., Vinodkumar, V., Dominowski, P. J., Rai, S., Mwangi, D. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170504 · Cited by 5
Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients
Córdoba, E., Lacunza, E., Abba, M. C., Fernández, E., & Güerci, A. M. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.06.005 · Cited by 5
Identification of a lncRNA/circRNA-miRNA-mRNA network to explore the effects of ricin toxin-induced inflammation in RAW264.7 cells
Yu, K., Yu, H., Wang, Y., Dong, M., Wang, Y., Zhao, N., Zhang, J., Sun, C., Xu, N., & Liu, W. (2021) · Toxicon · doi:10.1016/j.toxicon.2021.10.007 · Cited by 5
Investigation on the Efficacy of Two Food Supplements Containing a Fixed Combination of Selected Probiotics and β-Glucans or Elderberry Extract for the Immune System: Modulation on Cytokines Expression in Human THP-1 and PBMC
Cappellucci, G., Baini, G., Miraldi, E., Pauletto, L., Togni, H. D., Raso, F., & Biagi, M. (2024) · Foods · doi:10.3390/foods13030458 · Cited by 5
Effect of Combined K. pinnata and Metformin Preparation on Inflammatory Cytokines in Normal and Diabetic Skeletal Muscle Cells
Ramon, P., Sparks, J., & Omoruyi, F. O. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2020.0078 · Cited by 5
The inflammatory signalling mediator TAK1 mediates lymphocyte recruitment to lipopolysaccharide-activated murine mesenchymal stem cells through interleukin-6
Oelze, B., Elger, K., Schadzek, P., Burmeister, L., Hamm, A., Laggies, S., Seiffart, V., Groß, G., & Hoffmann, A. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04180-8 · Cited by 5
Inflammatory Mediators as Predictors of Outcome in Perinatal Asphyxia
Bharathi, B., Bhat, B. V., Negi, V., & Adhisivam, B. (2014) · The Indian Journal of Pediatrics · doi:10.1007/s12098-014-1575-4 · Cited by 5
Resistance to Yersinia pestis Infection Decreases with Age in B10.T(6R) Mice
Lambert, N. D., Langfitt, D. M., Nilles, M. L., & Bradley, D. S. (2011) · Infection and Immunity · doi:10.1128/iai.05267-11 · Cited by 5
Cardiotrophin-1 Improves Kidney Preservation, Graft Function, and Survival in Transplanted Rats
Cenador, M. B. G., Blanco-Gozalo, V., López-Montañés, D., Giménez-Rico, J. R. S., López-Novoa, J. M., & López-Hernández, F. J. (2018) · Transplantation · doi:10.1097/tp.0000000000002313 · Cited by 5
Inhibitory Effect of Inflammatory Cytokines Production from Activated Mast Cells by Gamisopoonghwanghyul‐Tang
Shin, H., Song, Y., Kim, H., & Shin, T. (2004) · Immunopharmacology and Immunotoxicology · doi:10.1081/iph-200042351 · Cited by 5
The effects of IgG and immune complexes on the endotoxin-induced cytokine response
Yentis, S. M., Gooding, R. P., & Riches, P. G. (1994) · Cytokine · doi:10.1016/1043-4666(94)90020-5 · Cited by 5
Drugs affecting plasma fibrinogen levels. Implications for new antithrombotic strategies
Margaglione, M., Grandone, E., Mancini, F. P., & Minno, G. D. (1996) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8996-4_4 · Cited by 5
CCK1-Receptor Stimulation Protects Against Gut Mediator-Induced Lung Damage During Endotoxemia
Eisner, F., Martin, E. M., Küper, M. A., Raybould, H. E., & Glatzle, J. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000356644 · Cited by 5
Effects of Mineral Fibers on the Expression of Genes Whose Product May Play a Role in Fiber Pathogenesis
Tsuda, T., Morimoto, Y., Yamato, H., Nakamura, H. K., Hori, H., Nagata, N., Kido, M., Higashi, T., & Tanaka, I. (1997) · Environmental Health Perspectives · doi:10.2307/3433528 · Cited by 5
Protective effect of diclofenac sodium against endotoxic shock in anaesthetized pigs
Mózes, T., Heiligers, J. P. C., Tak, C. J. A. M., Zijlstra, F. J., Ben‐Efraim, S., Saxena, P. R., & Bonta, I. L. (1993) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(93)90109-a · Cited by 5
Time course of circulating acute phase proteins and cytokines in septic patients
Fratelli, M., Zinetti, M., Fantuzzi, G., Spina, C., Napoletano, G., Donatiello, G., Ravagnan, R., Sipe, J. D., Casey, C. A., & Ghezzi, P. (1997) · Amyloid · doi:10.3109/13506129708995266 · Cited by 5
Modulation of hu/mu severe combined immunodeficient (SCID) mouse arthritis by local application of human recombinant IL-1β, IL-2 and IL-6
Kühn, H., Ermann, J., & Sack, U. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.d01-883.x · Cited by 5

Authors: Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S., & Dinarello, C.
Affiliations: Tufts University (US)
Department of Medicine, Tufts University School of Medicine, Boston, MA.
ORCID: Endres, S
Venue: Blood
Publisher: American Society of Hematology
Published: 1990-01-01
Volume: 75
Issue: 1
Pages: 40-47
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v75.1.40.40
OpenAlex: W204546040
Cited by: 1,012
References: 34
Citations by year: 2026: 7 · 2025: 17 · 2024: 16 · 2023: 11 · 2022: 29 · 2021: 19 · 2020: 22 · 2019: 31 · 2018: 33 · 2017: 18 · 2016: 35 · 2015: 17 · 2014: 32 · 2013: 26 · 2012: 38
FWCI: 24.10
Type: journal article
Language: en
Open access: closed
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI‑15614)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: interleukin-6, IL-1β, TNF-α, cytokine production, peripheral blood mononuclear cells, cytokine inhibition, lipopolysaccharide, phytohemagglutinin, Staphylococcus epidermidis, radioimmunoassay, transcriptional regulation, hematopoietic function
MeSH terms: Biological Assay, Gene Expression Regulation, Humans, Interleukin-1, Leukocytes, Mononuclear, Radioimmunoassay, RNA, Messenger, Tumor Necrosis Factor-alpha, Interleukin-6, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks