The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes
Abstract
The JE gene was first described as a platelet-derived growth factor (PDGF)-inducible gene in mouse 3T3 cells. The human homologue of JE encodes a protein whose predicted amino acid sequence is identical to that of the monocyte chemoattractant MCP-1 (also called MCAF and SMC- CF), which belongs to a recently identified family of small secretory proteins with cytokine properties. We purified recombinant human MCP- 1/JE (hMCP-1/JE) produced in COS cells and demonstrated that it is chemotactic for human monocytes with a specific activity similar to natural MCP-1. In addition, pure recombinant hMCP-1/JE stimulates monocytes, inducing an increase in cytosolic free calcium and the respiratory burst, but is completely inactive on human neutrophils. These results help to define functionally a well-known growth factor- inducible gene and a member of a new family of cytokines.
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Metadata
- Authors
- Rollins, B., Walz, A., & Baggiolini, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1991-08-15
- Volume
- 78
- Issue
- 4
- Pages
- 1112-1116
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2342908712
- Cited by
- 369
- References
- 30
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. https://app.cochat.ai/papers/10.1182/blood.v78.4.1112.1112
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- Rollins, B., Walz, A., & Baggiolini, M. (1991). Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. Blood. https://doi.org/10.1182/blood.v78.4.1112.1112
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
