Cited by 642Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis MechanismsMyeloproliferative Neoplasms: Diagnosis and Treatment

The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.

Thrombopoietin: the primary regulator of platelet production [see comments]

Open access

Kaushansky, K·1995·Blood

DOI 10.1182/blood.v86.2.419.bloodjournal862419

Open this paper in CoChat — free account Open PDF

Abstract

CONCEPT was advanced some 37 years ago, evidence for the existence of a humoral regulator of platelet production, first termed thrombopoietin (Tpo) by Kelemen et al,' accumulated very slowly.Initial studies in the 1960s and 1970s indicated that thrombocytopenia evokes characteristic marrow changes including increases in the number, size, ploidy, and maturation rate of megakaryocyte^.^"Platelet transfusion-induced thrombocytosis was associated with the opposite effects.*These findings were later confirmed with the availability of improved methods of assessing cellular DNA content and megakaryocyte maturation.'"'Ode11 et allz are generally acknowledged as providing the first description of a humoral substance in the sera of thrombocytopenic rats which induced thrombocytosis in recipient animals.Subsequent investigators have reported that thrombocytopenic serum also induces many of the marrow effects associated with thromb~cytopenia.'~"~However, significant progress in the field awaited the development of reliable, albeit cumbersome, assays of Tpo activity.I7-*' Attempts to biochemically purify Tpo from plasma, serum, urine, and conditioned culture medium from various cell lines occupied much effort during the 1 9 8 0 ~.~" ~~ Unfortunately, because of the complex nature of the starting material and difficulties associated with the use of an in vivo assay, these attempts failed to yield homogeneous protein adequate for protein sequencing and cDNA cloning, the official rite of passage for a hematopoietic growth factor.Furthermore, a number of cytokines were described in the late 1980s and early 1990s that possessed activity in various assays of megakaryocyte development.2943During the past several years, many investigators suggested that a distinct, lineage-specific thrombopoietin may not exist. THE SEARCH FOR TPOFour groups have published extensively on the purification of substances that either augment platelet production or stimulate megakaryocyte development.Levin's group has reported on the biologic effects of Tpo partially purified from thrombocytopenic rabbit plasma.24b27"*45These workers used ammonium sulfate fractionation, two types of lectin affinity chromatography, and gel filtration on high-pressure liquid chromatography (HPLC) columns to obtain material that reproducibly increased platelet production in recipient animals.Its reported molecular weight (M,) was 40 to 47 kD."Additional biologic activities ascribed to partially purified Tpo include augmentation of megakaryocyte ploidy, both in vitro Blood, Voi 86, No 2 (July 15).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood.v86.2.419.bloodjournal862419

Cites

103 of 103 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cytokine signal transduction
Kishimoto, T., Taga, T., & Akira, S. (1994) · Cell · doi:10.1016/0092-8674(94)90333-6 · Cited by 1,318
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
de Sauvage, F. J., Hass, P. E., Spencer, S. D., Malloy, B., Gurney, A. L., Spencer, S. A., Darbonne, W. C., Henzel, W. J., Wong, S. C., Kuang, W.-J., et al. (1994) · Nature · doi:10.1038/369533a0 · Cited by 1,270
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
Lok, S., Kaushansky, K., Holly, R. D., Kuijper, J. L., Lofton–Day, C., Oort, P. J., Grant, F. J., Heipel, M., Burkhead, S. K., Kramer, J. M., et al. (1994) · Nature · doi:10.1038/369565a0 · Cited by 1,068
Self-citation
Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
Kaushansky, K., Lok, S., Holly, R. D., Broudy, V. C., Lin, N. L., Bailey, M. C., Forstrom, J. W., Buddle, M. M., Oort, P. J., Hagen, F. S., et al. (1994) · Nature · doi:10.1038/369568a0 · Cited by 1,024
Self-citation
Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.
Ikebuchi, K., Wong, G. G., Clark, S., Ihle, J. N., Hirai, Y., & Ogawa, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9035 · Cited by 800
Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.
Paul, S. R., Bennett, F., Calvetti, J., Kelleher, K. S., Wood, C. R., O'Hara, R. M., Leary, A. C., Sibley, B. S., Clark, S., & Williams, D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7512 · Cited by 651
Thrombocytopenia in c-mpl-deficient mice
Gurney, A. L., Carver-Moore, K., de Sauvage, F., & Moore, M. W. (1994) · Science · doi:10.1126/science.8073287 · Cited by 648
c-Mpl ligand is a humoral regulator of megakaryocytopoiesis
Wendling, F., Maraskovsky, E., Debili, N., Florindo, C., Teepe, M., Titeux, M., Methia, N., BRETON-GORIUS, J., Cosman, D. J., & Vainchenker, W. (1994) · Nature · doi:10.1038/369571a0 · Cited by 640
HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression
Martin, P. J., & Papayannopoulou, T. (1982) · Science · doi:10.1126/science.6177045 · Cited by 608
Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.
Vigon, I., Mornon, J., Petit, L., Mitjavila, M. T., Tambourin, P. E., Gisselbrecht, S., & Souyri, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5640 · Cited by 504

Show all 103 references

Research works printed but not linked: 2

Shivdasani RA, Rosenblatt M F , Vignali K, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJM, Orkin SH: Transcription factor NF-E2 is required for platelet formation independent of the actions SUPPl 1) of thrombopoietin/MGDF in megakaryocyte development. Cell (in press) 106.
Geissler K, Stockenhuber F, Hinterberger W, Balcke B, Lechner K Recombinant human erythropoietin: A multipotential hemopoietic growth factor in vivo and in vitro, in Schaefer RM, Heidland A, Horl WH (eds): Erythropoietin in the 90s. Contributions to Nephrology, v01 87. Basel, Switzerland, Karger, 1990, p 1 142. Moore MAS, Warren DJ: Synergy of interleukin-l and gran- ulocyte colony-stimulating factor: In vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc Natl Acad Sci USA 84:7134, 1987 143.

Sorted by citations

Items 201–300 of 640

miRNAs can increase the efficiency of ex vivo platelet generation
Emmrich, S., Henke, K., Hegermann, J., Ochs, M., Reinhardt, D., & Klusmann, J. (2012) · Annals of Hematology · doi:10.1007/s00277-012-1517-z · Cited by 39
Effect of Doxycycline‐Regulated ERp57 Expression on Specific Thrombopoietin Productivity of Recombinant CHO Cells
Hwang, S. O., Chung, J. Y., & Lee, G. M. (2003) · Biotechnology Progress · doi:10.1021/bp025578m · Cited by 41
Autoantibodies neutralizing thrombopoietin in a patient with a megakaryocytic thrombocytopenic purpura
Kuwaki, T., Hagiwara, T., Kato, T., & Miyazaki, H. (2000) · Blood · doi:10.1182/blood.v95.6.2187.2187 · Cited by 39
Three parameters, plasma thrombopoietin levels, plasma glycocalicin levels and megakaryocyte culture, distinguish between different causes of congenital thrombocytopenia
van den Oudenrijn, S., Bruin, M. C. A., Folman, C. C., Bussel, J. B., de Haas, M., & Borne, A. E. G. K. V. D. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03455.x · Cited by 39
Thrombopoietin levels in serum and liver tissue in patients with chronic viral hepatitis and hepatocellular carcinoma
Okubo, M., Shiota, G., & Kawasaki, H. (2000) · Clinical Science · doi:10.1042/cs0990207 · Cited by 38
Clinical applicability of reticulated platelets
Dusse, L. M. S., & Freitas, L. G. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.10.024 · Cited by 38
Role of human interleukin-9 as a megakaryocyte potentiator in culture
Fujiki, H., Kimura, T., Minamiguchi, H., Harada, S., Wang, J., Nakao, M., Yokota, S., Urata, Y., Ueda, Y., Yamagishi, H., et al. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00966-9 · Cited by 38
Genetics of epithelial polarity and pattern in the Drosophila retina
Reifegerste, R., & Moses, K. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199904)21:4 · Cited by 62
Self-citation
Developmental biology of the dendritic cell system
Schibler, K., Georgelas, A., & Rigaa, A. (2002) · Acta Paediatrica · doi:10.1080/080352502320764148 · Cited by 38
Expression of osteoprotegerin mRNA and protein in murine megakaryocytes
Chagraoui, H., Sabri, S., Capron, C., Villeval, J., Vainchenker, W., & Wendling, F. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00233-9 · Cited by 38
Pharmacokinetics, Pharmacodynamics, and Safety of Administering Pegylated Recombinant Megakaryocyte Growth and Development Factor to Newborn Rhesus Monkeys
Sola, M. C., Christensen, R. D., Hutson, A. D., & Tarantal, A. F. (2000) · Pediatric Research · doi:10.1203/00006450-200002000-00010 · Cited by 38
Culture, Expansion, and Differentiation of Murine Megakaryocytes
Shivdasani, R. A., & Schulze, H. (2005) · Current Protocols in Immunology · doi:10.1002/0471142735.im22f06s67 · Cited by 37
Pathophysiological significance of simultaneous measurement of reticulated platelets, large platelets and serum thrombopoietin in non‐neoplastic thrombocytopenic disorders
Koh, K., Yamane, T., Ohta, K., Hino, M., Takubo, T., & Tatsumi, N. (1999) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1999.tb01131.x · Cited by 37
High levels of thrombopoietin in sera of patients with essential thrombocythemia: Cause or consequence of abnormal platelet production?
Grießhammer, M., Hornkohl, A. C., Nichol, J. L., Hecht, T., Raghavachar, A., Heimpel, H., & Schrezenmeier, H. (1998) · Annals of Hematology · doi:10.1007/s002770050445 · Cited by 37
Interleukin-1β up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-fos, GATA-1, and nf-E2 in megakaryocytic cells
Chuen, C. K. Y., Li, K., Yang, M., Fok, T. F., Li, C. K., Chui, C. M. Y., & Yuen, P. M. P. (2004) · Journal of Laboratory and Clinical Medicine · doi:10.1016/j.lab.2003.09.006 · Cited by 38
Molecular characterization of β-thalassemia genes in an Argentine population
Roldán, A., Gutiérrez, M., Cygler, A. M., Bonduel, M. M., Sciuccati, G. B., & Torres, A. F. (1997) · American Journal of Hematology · doi:10.1002/(sici)1096-8652(199703)54:3
Self-citation
Implications of Mutations in Hematopoietic Growth Factor Receptor Genes in Congenital Cytopenias
Germeshausen, M., Ballmaier, M., & Welte, K. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03599.x · Cited by 37
WASP is involved in proliferation and differentiation of human haemopoietic progenitors in vitro
Kajiwara, M., Nonoyama, S., Eguchi, M., Morio, T., Imai, K., Okawa, H., Kaneko, M., Sako, M., Ohga, S., Maeda, M., et al. (1999) · British Journal of Haematology · doi:10.1046/j.1365-2141.1999.01694.x · Cited by 37
Simultaneous signalling through c‐mpl, c‐kit and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3‐K, PKC and MAPK pathways
Minamiguchi, H., Kimura, T., Urata, Y., Miyazaki, H., Bamba, T., Abe, T., & Sonoda, Y. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.03068.x · Cited by 37
Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit
Broudy, V., Lin, N., Fox, N., Taga, T., Saito, M., & Kaushansky, K. (1996) · Blood · doi:10.1182/blood.v88.6.2026.bloodjournal8862026 · Cited by 37
Self-citation
Thrombin cleaves recombinant human thrombopoietin: One of the proteolytic events that generates truncated forms of thrombopoietin
Kato, T., Oda, A., Inagaki, Y., Ohashi, H., Matsumoto, A., Ozaki, K., Miyakawa, Y., Watarai, H., Fuju, K., Kokubo, A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4669 · Cited by 36
Thrombopoietin serum concentration in patients with reactive and myeloproliferative thrombocytosis
Uppenkamp, M. J., Макарова, Е. В., Petrasch, S., & Brittinger, G. (1998) · Annals of Hematology · doi:10.1007/s002770050446 · Cited by 36
Serum thrombopoietin and interleukin 6 concentrations in tumour patients and response to chemotherapy‐induced thrombocytopenia
Heits, F., Katschinski, D. M., Wilmsen, U., Wiedemann, G. J., & JELKMANN, W. E. B. (1997) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1997.tb00959.x · Cited by 36
Thrombopoietin
Kaushansky, K. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03230.x · Cited by 36
Self-citation
Normal and pathological dynamics of platelets in humans
Langlois, G. P., Craig, M., Humphries, A. R., Mackey, M. C., Mahaffy, J. M., Bélair, J., Moulin, T., Sinclair, S. R., & Wang, L. (2017) · Journal of Mathematical Biology · doi:10.1007/s00285-017-1125-6 · Cited by 35
Allogeneic stem cell transplantation for patients with congenital amegakaryocytic thrombocytopenia (CAT)
Alahmari, A. D., Ayas, M. F., Al‐Jefri, A., Al-Mahr, M., Rifai, S., & Solh, H. E. (2004) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704445 · Cited by 35
Induction of hyperproliferative fetal megakaryopoiesis by an N‐terminally truncated GATA1 mutant
Shimizu, R., Kobayashi, E. H., Engel, J. D., & Yamamoto, M. P. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01338.x · Cited by 35
Thrombopoietin and the c-Mpl receptor: insights from gene targeting
Alexander, W. S. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00079-5 · Cited by 35
The Membrane-proximal Region of the Thrombopoietin Receptor Confers Its High Surface Expression by JAK2-dependent and -independent Mechanisms
Tong, W., Sulahian, R., Gross, A. W., Hendon, N., Lodish, H. F., & Huang, L. J.-S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607524200 · Cited by 35
Urokinase Receptor (uPAR, CD87) Is a Platelet Receptor Important for Kinetics and TNF-Induced Endothelial Adhesion in Mice
Piguet, P. F., Vesin, C., Donati, Y. R. A., Tacchini‐Cottier, F., Belin, D., & Barazzone‐Argiroffo, C. (1999) · Circulation · doi:10.1161/01.cir.99.25.3315 · Cited by 35
Increased D-type Cyclin Expression Together with Decreased cdc2 Activity Confers Megakaryocytic Differentiation of a Human Thrombopoietin-dependent Hematopoietic Cell Line
Matsumura, I., Tanaka, H., Kawasaki, A., Odajima, J., Daino, H., Hashimoto, K., Wakao, H., Nakajima, K., Kato, T., Miyazaki, H., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5553 · Cited by 35
Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis
Looi, C. Y., Imanishi, M., Τακακι, S., Sato, M., Chiba, N., Sasahara, Y., Futaki, S., Tsuchiya, S., & Kumaki, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023640 · Cited by 34
Cyclical Thrombocytopenia: Characterization by Spectral Analysis and a Review
Swinburne, J. L., & Mackey, M. C. (1999) · Computational and Mathematical Methods in Medicine · doi:10.1080/10273660008833039 · Cited by 34
Malignant hematopoietic cell lines: in vitro models for the study of erythroleukemia
Drexler, H. G., Matsuo, Y., & MacLeod, R. A. F. (2004) · Leukemia Research · doi:10.1016/j.leukres.2004.03.022 · Cited by 34
Thrombopoietin and Hematopoietic Stem Cell Development
Kaushansky, K. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08475.x · Cited by 34
Self-citation
Effects of Recombinant Human Thrombopoietin Alone and in Combination with Erythropoietin and Early‐Acting Cytokines on Human Mobilized Purified CD34 + Progenitor Cells Cultured in Serum‐Depleted Medium
Birkmann, J., Oez, S., Smetak, M., Kaiser, G., Kappauf, H. W., & Gallmeier, W. M. (1997) · Stem Cells · doi:10.1002/stem.150018 · Cited by 34
Upregulation of Cortactin Expression During the Maturation of Megakaryocytes
Zhan, X., Haudenschild, C. C., Ni, Y., Smith, E., & Huang, C. (1997) · Blood · doi:10.1182/blood.v89.2.457 · Cited by 33
Serum levels of thrombopoietin, IL-11, and IL-6 in pediatric thrombocytopenias
Cremer, M., Schulze, H., Linthorst, G. E., Folman, C. C., Wehnert, S., Strauß, G., Borne, A. E. G. K. V. D., Welte, K., & Ballmaier, M. (1999) · Annals of Hematology · doi:10.1007/s002770050538 · Cited by 33
Should medical treatment options be exhausted before splenectomy is performed in adult ITP patients? A debate
Stasi, R., Newland, A. C., Thornton, P., & Pabinger, I. (2010) · Annals of Hematology · doi:10.1007/s00277-010-1066-2 · Cited by 32
In vitroexpansion of human megakaryocytes as a tool for studying megakaryocytic development and function
Baj‐Krzyworzeka, M. (2001) · Platelets · doi:10.1080/09537100120068152 · Cited by 32
Role of Apoptotic Processes in Platelet Biogenesis
Kaluzhny, Y., & Ravid, K. (2003) · Acta Haematologica · doi:10.1159/000074487 · Cited by 32
Plasma thrombopoietin (TPO) levels and expression of TPO receptor on platelets in patients with myelodysplastic syndromes
Tamura, Ogata, Luo, Nakamura, Yokose, Dan, Tohyama, T., Yoshida, Y., Hamaguchi, Sakamaki, et al. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.01054.x · Cited by 32
a:b:c≠a÷b÷c
姜乐 (1994) · 小学教学研究 · Cited by 32
The Induction of Megakaryocyte Differentiation Is Accompanied by Selective Ser133 Phosphorylation of the Transcription Factor CREB in Both HEL Cell Line and Primary CD34+Cells
Zauli, G., Gibellini, D., Vitale, M., Secchiero, P., Celeghini, C., Bassini, A., Pierpaoli, S., Marchisio, M., Guidotti, L., & Capitani, S. (1998) · Blood · doi:10.1182/blood.v92.2.472 · Cited by 32
Platelets prevent acute hepatitis induced by anti‐fas antibody
Hisakura, K., Murata, S., Takahashi, K., Matsuo, R., Pak, S., Ikeda, N., Kawasaki, T., Kohno, K., Myronovych, A., Nakano, Y., et al. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06334.x · Cited by 31
Measurement of endogenous plasma thrombopoietin in patients with acquired aplastic anaemia by a sensitive enzyme‐linked immunosorbent assay
Kojima, S., Matsuyama, T., Kodera, Y., Tahara, T., & Kato, T. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.992915.x · Cited by 31
A Structure-Function Analysis of Serine/Threonine Phosphorylation of the Thrombopoietin Receptor, c-Mpl
Miyakawa, Y., Drachman, J. G., Gallis, B. M., Kaushansky, A., & Kaushansky, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005080200 · Cited by 31
Self-citation
Thrombopoietin stimulates VEGF release from c‐Mpl‐expressing cell lines and haematopoietic progenitors
Bobik, R., Hong, Y., Breier, G., Martin, J. F., & Erusalimsky, J. D. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00056-8 · Cited by 31
Genes for thrombopoietin and c‐mpl are not responsible for familial thrombocythaemia: a case study
Kunishima, S., Mizuno, S., Naoe, T., Saito, H., & Kamiya, T. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00571.x · Cited by 31
Long-term safety and efficacy of romiplostim for treatment of immune thrombocytopenia
Aboulafia, D. M., & Vishnu, P. (2016) · Journal of Blood Medicine · doi:10.2147/jbm.s80646 · Cited by 30
Remissions after long-term use of romiplostim for immune thrombocytopenia
Marshall, A. L., Scarpone, R., Greef, M. D., Bird, R. J., & Kuter, D. J. (2016) · Haematologica · doi:10.3324/haematol.2016.151886 · Cited by 30
A novel STAT3 inhibitor negatively modulates platelet activation and aggregation
Xu, Z., Xu, Y., Hao, Y., Ren, L., Zhang, Z.-B., Xu, X., Cao, B., Dai, K., Zhu, L., Fang, Q., et al. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.155 · Cited by 30
Recombinant Human Thrombopoietin Promotes Platelet Engraftment and Improves Prognosis of Patients with Myelodysplastic Syndromes and Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation
Wang, H., Huang, M., Zhao, Y., Qi, J., Chen, C., Tang, Y., Qiu, H.-Y., Fu, C., Tang, X., Wu, D., et al. (2017) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2017.06.010 · Cited by 30
Protein Kinase C andc-mycGene Activation Pathways in Thrombopoietin Signal Transduction
Kunitama, M., Shimizu, R., Yamada, M. F., Kato, T., Miyazaki, H., Okada, K., Miura, Y., & Komatsu, N. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.5969 · Cited by 30
Romiplostim in the management of the thrombocytopenic surgical patient
Marshall, A. L., Goodarzi, K., & Kuter, D. J. (2015) · Transfusion · doi:10.1111/trf.13181 · Cited by 29
The prolonged half-lives of new erythropoietin derivatives via peptide addition
Lee, D. E., Son, W., Ha, B.-J., Oh, M. S., & Yoo, O. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.034 · Cited by 29
Plasma thrombopoietin levels in patients with chronic renal failure
Linthorst, G. E., Folman, C. C., van Olden, R. W., & Borne, A. E. G. K. V. D. (2002) · The Hematology Journal · doi:10.1038/sj.thj.6200153 · Cited by 29
Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis
Varricchio, L., Mancini, A., & Migliaccio, A. R. (2009) · Expert Review of Hematology · doi:10.1586/ehm.09.17 · Cited by 29
Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal
Tong, W., Ibarra, Y. M., & Lodish, H. F. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.05.010 · Cited by 29
Serum thrombopoietin levels and anti-thrombopoietin antibodies in systemic lupus erythematosus
Füreder, W., Firbas, U., Nichol, J. L., Pistillo, J., Winkler, S., Hiesberger, H., Sperr, W. R., Smolen, J. S., & Schett, G. A. (2002) · Lupus · doi:10.1191/0961203302lu177oa · Cited by 29
Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets.
Ozaki, K., Oda, A., Wakao, H., Rhodes, J., Druker, B. J., Ishida, A., Wakui, M., Okamoto, S., Morita, K., Handa, M., et al. (1998) · PubMed · doi:10.1182/blood.v92.12.4652 · Cited by 29
Plasma thrombopoietin levels in liver cirrhosis and kidney failure
Stockelberg, D., Andersson, P., Bjornsson, E. S., Björk, S., & Wadenvik, H. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00529.x · Cited by 29
Regulation of Hepatic Thrombopoietin Production by Portal Hemodynamics in Liver Cirrhosis
Sezai, S., KAMISAKA, K., Ikegami, F., Usuki, K., Urabe, A., Tahara, T., Kato, T., & Miyazaki, H. (1998) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(97)00027-0 · Cited by 29
Developmental biology of thrombopoietin in the human fetus and neonate
Dame, C. (2002) · Acta Paediatrica · doi:10.1111/j.1651-2227.2002.tb02906.x · Cited by 29
Comparison between anagrelide and hydroxycarbamide in their activities against haematopoietic progenitor cell growth and differentiation: selectivity of anagrelide for the megakaryocytic lineage
Hong, Y., Wang, G., del Arroyo, A. G., Hernandez, J., Skene, C., & Erusalimsky, J. D. (2006) · Leukemia · doi:10.1038/sj.leu.2404180 · Cited by 28
Changes in Serum Thrombopoietin Levels after Splenectomy
Ichikawa, N., Kitano, K., Shimodaira, S., Ishida, F., Ito, T., Kajikawa, S., Tahara, T., Kato, T., & Kiyosawa, K. (1998) · Acta Haematologica · doi:10.1159/000040888 · Cited by 28
Signaling by the Mpl receptor involves IKK and NF‐κB*
Zhang, Y., Sun, S., Wang, Z., Thompson, A., Kaluzhny, Y., Zimmet, J. M., & Ravid, K. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10141 · Cited by 28
Thrombopoietin as a Drug: Biologic Expectations, Clinical Realities, and Future Directions
Haznedaroğlu, İ. C., Göker, H., Turgut, M., Büyükaşık, Y., & Beneklı, M. (2002) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/107602960200800301 · Cited by 28
Thrombopoietin: More than a lineage‐specific megakaryocyte growth factor
Kaushansky, K. (1997) · Stem Cells · doi:10.1002/stem.5530150813 · Cited by 28
Self-citation
Functional analysis of single amino‐acid mutations in the thrombopoietin‐receptor Mpl underlying congenital amegakaryocytic thrombocytopenia
Tijssen, M. R., di Summa, F. M., van den Oudenrijn, S., Zwaginga, J. J., van der Schoot, C. E., Voermans, C., & de Haas, M. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07139.x · Cited by 27
Effects of Flt-3 Ligand in Combination with TPO on the Expansion of Megakaryocytic Progenitors
Li, K., Yang, M., Lam, A. C., Yau, F. W., & Yuen, P. M. P. (2000) · Cell Transplantation · doi:10.1177/096368970000900115 · Cited by 27
CD34+ cells from mobilized peripheral blood retain fetal bone marrow repopulating capacity within the Thy-1+ subset following cell division ex vivo
Young, J. C., Lin, K., Hansteen, G., Travis, M. A., Murray, L. J., Jaing, L., Scollay, R. G., & Hill, B. L. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(99)00030-2 · Cited by 27
Differential Effects of Human Granulocyte Colony-Stimulating Factor (hG-CSF) and Thrombopoietin on Megakaryopoiesis and Platelet Function in hG-CSF Receptor-Transgenic Mice
Yang, F., Tsuji, K., Oda, A., Ebihara, Y., Xu, M., Kaneko, A., Hanada, S., Mitsui, T., Kikuchi, A., Manabe, A., et al. (1999) · Blood · doi:10.1182/blood.v94.3.950.415a18_950_958 · Cited by 27
Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs
Xie, X., Chan, R. J., Johnson, S. A., Starr, M. D., McCarthy, J., Kapur, R., & Yöder, M. C. (2003) · Blood · doi:10.1182/blood-2002-05-1468 · Cited by 26
Serum thrombopoietin levels in relation to disease status in patients with immune thrombocytopenic purpura
Kappers‐Klunne, M. C., Haan, M. D., Struijk, P. C., & van Vliet, H. H. D. M. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.03184.x · Cited by 26
Pharmacokinetics and Hematological Effects of the PEGylated Thrombopoietin Peptide Mimetic GW395058 in Rats and Monkeys After Intravenous or Subcutaneous Administration
de Serres, M., Yeager, R. L., Dillberger, J. E., Lalonde, G., Gardner, G. H., Rubens, C. A., Simkins, A. H., Sailstad, J. M., McNulty, M. J., & Woolley, J. L. (1999) · Stem Cells · doi:10.1002/stem.170316 · Cited by 26
Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells
Gotoh, A., Ritchie, A., Takahira, H., & Broxmeyer, H. E. (1997) · Annals of Hematology · doi:10.1007/s002770050344 · Cited by 26
Ex vivo expansion of hematopoietic cells and their clinical use.
Aglietta, M., Bertolini, F., Carlo‐Stella, C., Vincentiis, A. D., Lanata, L., Lemoli, R. M., Olivieri, A., Siena, S., Zanon, P., & Tura, S. (1998) · PubMed · Cited by 26
The Glycoprotein Ib/IX Complex Regulates Cell Proliferation
Feng, S., Christodoulides, N. J., & Kroll, M. H. (1999) · Blood · doi:10.1182/blood.v93.12.4256.412k33_4256_4263 · Cited by 26
Seeing old friends from a different angle: Novel properties of hematopoietic growth factors in the healthy and diseased brain
Diederich, K., Schäbitz, W., & Minnerup, J. (2010) · Hippocampus · doi:10.1002/hipo.20904 · Cited by 25
Role of GATA‐1 in Normal and Neoplastic Hemopoiesis
Migliaccio, A. R., Rana, R. A., Vannucchi, A. M., & Manzoli, F. A. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1349.019 · Cited by 25
Chronic Thrombocytopenia Is Induced in Dogs by Development of Cross-Reacting Antibodies to the MpL Ligand
Dale, D. C., Nichol, J. L., Rich, D. A., Best, D. M., Slichter, S. J., Sheridan, W. P., & Hunt, P. (1997) · Blood · doi:10.1182/blood.v90.9.3456 · Cited by 25
Monocyte/Macrophage Dysfunctions Do Not Impair the Promotion of Myelofibrosis by High Levels of Thrombopoietin
Wagner‐Ballon, O., Chagraoui, H., Prina, E., Tulliez, M., Milon, G., Raslová, H., Villeval, J., Vainchenker, W., & Giraudier, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6425 · Cited by 25
Differential Amplification of Murine Bipotent Megakaryocytic/Erythroid Progenitor and Precursor Cells During Recovery from Acute and Chronic Erythroid Stress
Sanchez, M., Weissman, I. L., Pallavicini, M. G., Valeri, M., Guglielmelli, P., Vannucchi, A. M., Migliaccio, G., & Migliaccio, A. R. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0023 · Cited by 25
Fulminant Meningococcal Septicemia: Dissociation between Plasma Thrombopoietin Levels and Platelet Counts
Bjerre, A. K., Øvstebø, R., Kierulf, P., Halvorsen, S., & Brandtzaeg, P. (2000) · Clinical Infectious Diseases · doi:10.1086/313754 · Cited by 25
Regulation of Megakaryocytopoiesis
Caen, J., Han, Z., Bellucci, S., & Alemany, M. (1999) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000022458 · Cited by 25
Marked heterogeneity in protein levels and functional integrity of the thrombopoietin receptor c‐mpl in polycythaemia vera
Blanc, L., Andersson, A., & Samuelsson (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.01794.x · Cited by 25
Thrombopoietin Enhances Proliferation and Differentiation of Murine Yolk Sac Erythroid Progenitors
Era, T., Takahashi, T., Sakai, K., Kawamura, K., & Nakano, T. (1997) · Blood · doi:10.1182/blood.v89.4.1207 · Cited by 25
Recombinant Human Ligand for MPL, Megakaryocyte Growth and Development Factor (MGDF), Stimulates Thrombopoiesis in Vivo in Normal and Myelosuppressed Baboons
Andrews, R. G., Winkler, A. R., Myerson, D., Briddell, R. A., Knitter, G. H., McNiece, I., & Hunt, P. (1996) · Stem Cells · doi:10.1002/stem.140661 · Cited by 25
Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction
Amraotkar, A. R., Song, D. D., Otero, D., Trainor, P. J., Ismail, I., Kothari, V., Singh, A., Moore, J. B., Rai, S. N., & DeFilippis, A. P. (2016) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029616683804 · Cited by 24
Myelodysplastic Syndromes (MDS)
Pleyer, L., Neureiter, D., Faber, V., & Greil, R. (2010) · Springer eBooks · doi:10.1007/978-3-211-79892-8_6 · Cited by 24
Cyclotides: a patent review
Smith, A. B., Daly, N. L., & Craik, D. J. (2011) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2011.620606 · Cited by 24
Markedly High Plasma Thrombopoietin (TPO) Level is a Predictor of Poor Response to Immunosuppressive Therapy in Children With Acquired Severe Aplastic Anemia
Elmahdi, S., Muramatsu, H., Narita, A., Ismael, O., Hama, A., Nishio, N., Okuno, Y., Xu, Y., Wang, X., Takahashi, Y., et al. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25820 · Cited by 24
Antiplatelet effect of aspirin in patients with coronary artery disease.
Grove, E. L. (2012) · PubMed · Cited by 24
Defective c‐Mpl signaling in the syndrome of thrombocytopenia with absent radii
Ballmaier, M., Schulze, H., Cremer, M., Strauß, G., Welte, K., & Folman, C. C. (1998) · Stem Cells · doi:10.1002/stem.5530160720 · Cited by 24
Platelet‐associated IgM elevated in patients with chronic hepatitis C contains no anti‐platelet autoantibodies
Kosugi, S., Imai, Y., Kurata, Y., Tomiyama, Y., Shiraga, M., Honda, S., Nishikawa, M., Yonezawa, T., Kanakura, Y., & Matsuzawa, Y. (1997) · Liver International · doi:10.1111/j.1600-0676.1997.tb01023.x · Cited by 24
Tissue Uptake of Circulating Thrombopoietin Is Increased in Immune-Mediated Compared With Irradiated Thrombocytopenic Mice
Chang, M., Qian, J. X., Lee, S. M., Joubran, J., Fernandez, G., Nichols, J., Knoppel, A., & Buzby, J. S. (1999) · Blood · doi:10.1182/blood.v93.8.2515 · Cited by 24
Anesthesia for Organ Transplantation
Scott, V. L., Wahl, K. M., Soltys, K. A., Belani, K. G., Beebe, D. S., & Davis, P. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-06612-9.00028-6 · Cited by 25
Thrombopoietin and Mean Platelet Volume in Patients With Ischemic Stroke
Balçık, Ö. Ş., Bilen, Ş., Ulusoy, E. K., Akdeniz, D., Uysal, S., İkizek, M., Ak, F., & Koşar, A. (2012) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029611434528 · Cited by 24
Characterization of defective megakaryocytic development in patients with myelodysplastic syndromes
Hofmann, W., Kalina, U., Wagner, S., Seipelt, G., Ries, C., Hoelzer, D. F., & Ottmann, O. G. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(98)00077-0 · Cited by 24

Authors: Kaushansky, K.
Corresponding author: Kaushansky, K
Venue: Blood
Publisher: American Society of Hematology
Published: 1995-07-15
Volume: 86
Issue: 2
Pages: 419-431
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v86.2.419.bloodjournal862419
OpenAlex: W2230842386
Cited by: 642
References: 103
Citations by year: 2026: 6 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 13 · 2016: 13 · 2015: 8 · 2014: 15 · 2013: 5 · 2012: 10
FWCI: 39.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Hematology › Myeloproliferative Neoplasms: Diagnosis and Treatment
Keywords: thrombopoietin, megakaryopoiesis, megakaryocyte development, thrombocytopenia, thrombocytosis, hematopoietic growth factors, thrombopoietin receptor, cDNA cloning, protein purification, cytokines, megakaryocyte maturation, platelet transfusion
MeSH terms: Animals, Blood Platelets, Cell Division, Gene Expression Regulation, Genes, Hematopoiesis, Humans, Megakaryocytes, Mice, Inbred BALB C, Radiation Injuries, Experimental, Receptors, Immunologic, Thrombocytopenia, Thrombopoietin, Carboplatin, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Thrombopoietin: the primary regulator of platelet production [see comments]

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks