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Thrombopoietin: the primary regulator of platelet production [see comments]
Open accessAbstract
CONCEPT was advanced some 37 years ago, evidence for the existence of a humoral regulator of platelet production, first termed thrombopoietin (Tpo) by Kelemen et al,' accumulated very slowly.Initial studies in the 1960s and 1970s indicated that thrombocytopenia evokes characteristic marrow changes including increases in the number, size, ploidy, and maturation rate of megakaryocyte^.^"Platelet transfusion-induced thrombocytosis was associated with the opposite effects.*These findings were later confirmed with the availability of improved methods of assessing cellular DNA content and megakaryocyte maturation.'"'Ode11 et allz are generally acknowledged as providing the first description of a humoral substance in the sera of thrombocytopenic rats which induced thrombocytosis in recipient animals.Subsequent investigators have reported that thrombocytopenic serum also induces many of the marrow effects associated with thromb~cytopenia.'~"~However, significant progress in the field awaited the development of reliable, albeit cumbersome, assays of Tpo activity.I7-*' Attempts to biochemically purify Tpo from plasma, serum, urine, and conditioned culture medium from various cell lines occupied much effort during the 1 9 8 0 ~.~" ~~ Unfortunately, because of the complex nature of the starting material and difficulties associated with the use of an in vivo assay, these attempts failed to yield homogeneous protein adequate for protein sequencing and cDNA cloning, the official rite of passage for a hematopoietic growth factor.Furthermore, a number of cytokines were described in the late 1980s and early 1990s that possessed activity in various assays of megakaryocyte development.2943During the past several years, many investigators suggested that a distinct, lineage-specific thrombopoietin may not exist. THE SEARCH FOR TPOFour groups have published extensively on the purification of substances that either augment platelet production or stimulate megakaryocyte development.Levin's group has reported on the biologic effects of Tpo partially purified from thrombocytopenic rabbit plasma.24b27"*45These workers used ammonium sulfate fractionation, two types of lectin affinity chromatography, and gel filtration on high-pressure liquid chromatography (HPLC) columns to obtain material that reproducibly increased platelet production in recipient animals.Its reported molecular weight (M,) was 40 to 47 kD."Additional biologic activities ascribed to partially purified Tpo include augmentation of megakaryocyte ploidy, both in vitro Blood, Voi 86, No 2 (July 15).
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“Thrombopoietin activates the JAK/STAT3 pathway in megakaryocytes”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Kaushansky, 1995
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Cites
Kishimoto, T., Taga, T., & Akira, S. (1994) · Cell · doi:10.1016/0092-8674(94)90333-6 · Cited by 1,318
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
de Sauvage, F. J., Hass, P. E., Spencer, S. D., Malloy, B., Gurney, A. L., Spencer, S. A., Darbonne, W. C., Henzel, W. J., Wong, S. C., Kuang, W.-J., et al. (1994) · Nature · doi:10.1038/369533a0 · Cited by 1,270
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
Lok, S., Kaushansky, K., Holly, R. D., Kuijper, J. L., Lofton–Day, C., Oort, P. J., Grant, F. J., Heipel, M., Burkhead, S. K., Kramer, J. M., et al. (1994) · Nature · doi:10.1038/369565a0 · Cited by 1,068
Self-citationKaushansky, K., Lok, S., Holly, R. D., Broudy, V. C., Lin, N. L., Bailey, M. C., Forstrom, J. W., Buddle, M. M., Oort, P. J., Hagen, F. S., et al. (1994) · Nature · doi:10.1038/369568a0 · Cited by 1,024
Self-citationIkebuchi, K., Wong, G. G., Clark, S., Ihle, J. N., Hirai, Y., & Ogawa, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9035 · Cited by 800
Paul, S. R., Bennett, F., Calvetti, J., Kelleher, K. S., Wood, C. R., O'Hara, R. M., Leary, A. C., Sibley, B. S., Clark, S., & Williams, D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7512 · Cited by 651
Thrombocytopenia in c-mpl-deficient mice
Gurney, A. L., Carver-Moore, K., de Sauvage, F., & Moore, M. W. (1994) · Science · doi:10.1126/science.8073287 · Cited by 648
c-Mpl ligand is a humoral regulator of megakaryocytopoiesis
Wendling, F., Maraskovsky, E., Debili, N., Florindo, C., Teepe, M., Titeux, M., Methia, N., BRETON-GORIUS, J., Cosman, D. J., & Vainchenker, W. (1994) · Nature · doi:10.1038/369571a0 · Cited by 640
HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression
Martin, P. J., & Papayannopoulou, T. (1982) · Science · doi:10.1126/science.6177045 · Cited by 608
Vigon, I., Mornon, J., Petit, L., Mitjavila, M. T., Tambourin, P. E., Gisselbrecht, S., & Souyri, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5640 · Cited by 504
Research works printed but not linked: 2
- Shivdasani RA, Rosenblatt M F , Vignali K, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJM, Orkin SH: Transcription factor NF-E2 is required for platelet formation independent of the actions SUPPl 1) of thrombopoietin/MGDF in megakaryocyte development. Cell (in press) 106.
- Geissler K, Stockenhuber F, Hinterberger W, Balcke B, Lechner K Recombinant human erythropoietin: A multipotential hemopoietic growth factor in vivo and in vitro, in Schaefer RM, Heidland A, Horl WH (eds): Erythropoietin in the 90s. Contributions to Nephrology, v01 87. Basel, Switzerland, Karger, 1990, p 1 142. Moore MAS, Warren DJ: Synergy of interleukin-l and gran- ulocyte colony-stimulating factor: In vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc Natl Acad Sci USA 84:7134, 1987 143.
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Mott, K., & Schulze, H. (2023) · Current Protocols · doi:10.1002/cpz1.783 · Cited by 4
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Saitoh, M., Taguchi, K., Momose, K., Suga, K., Ogawa, Y., Yasuda, S., & Miyata, K. (2001) · Cytokine · doi:10.1006/cyto.2000.0832 · Cited by 4
Suda, M., Okamiya, H., Usuda, S., Nishimori, T., Miyata, K., & Saitoh, M. (2000) · Journal of Interferon & Cytokine Research · doi:10.1089/10799900050044732 · Cited by 4
Balleari, E., Ghirlanda, P., Garrè, S., Casciaro, S., MASSA, G., & Ghio, R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07662.x · Cited by 4
Ito, T., Fujihara, M., Oda, A., Wakamoto, S., Yamaguchi, M., Komatsu, N., Miyazaki, H., Azuma, H., Ikeda, H., & Ikebuchi, K. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024184116764 · Cited by 4
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Sunohara, M., Sato, I., & Morikawa, S. (2017) · Cellular and Molecular Biology · doi:10.14715/cmb/2017.63.11.21 · Cited by 3
Mathur, S. C., Schexneider, K. I., & Hutchison, R. E. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0974-2.00031-2 · Cited by 3
Liang, D.-C., Shih, L., Kuo, M.-C., Chen, S.-H., Liu, H.-Y., & Shimosaka, A. (1999) · Acta Haematologica · doi:10.1159/000040987 · Cited by 3
In Vitro Effects of Mpl Ligand on Human Hemopoietit Progenitor Cells
Debili, N., Cramer, E. M., Wendling, F., & Vainchenker, W. (1997) · Humana Press eBooks · doi:10.1007/978-1-4612-3958-1_14 · Cited by 3
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Taskin, A. H. L., Cohen-Solal, K., Couedic, J. P. L., Abina, A. M., Villeval, J., Debili, N., Casadevall, N., Vainchenker, W., & Wendling, F. C. L. (1998) · Stem Cells · doi:10.1002/stem.5530160718 · Cited by 3
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Hammond, W., Wun, T., Kaplan, A., Kaplan, S., Paglieroni, T., Kaushansky, K., & Foster, D. (1998) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/107602969800400306 · Cited by 3
Self-citationA new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts
Challier, C., Petit, L., Flon, M., Pauchard, M., Porteu, F., Gisselbrecht, S., & Souyri, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203472 · Cited by 3
Blomberg, L. A., Cohn, M. L., Cahill, R. A., & Chan, W. (1998) · Experimental Biology and Medicine · doi:10.3181/00379727-217-44225 · Cited by 3
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Pink, J., & Isbister, J. P. (1996) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1996.tb124814.x · Cited by 3
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Schiffer, C. A. (1997) · Humana Press eBooks · doi:10.1007/978-1-4612-3958-1_4 · Cited by 3
Dame, C. (2006) · Wiley eBooks · doi:10.1002/9780470987001.ch24 · Cited by 3
Wang, R., Cai, J., Chen, Z., Tian, H., Cong, D., Bai, Y., & Zhang, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-89535-7 · Cited by 2
Adewole, K. E., Igunnu, A., & Adebayo, J. O. (2018) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-018-0776-4 · Cited by 2
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Sun, S., Jackson, C. W., & Ravid, K. (2000) · Blood · doi:10.1182/blood.v95.4.1511 · Cited by 2
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Briggs, M., Adams, J. A., Brereton, M. L., Burgess, R., Hyde, K., Lenehan, H., & Yin, J. A. L. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.03162.x · Cited by 2
Nishiyama, U., KUWAKI, T., Akahori, H., Kato, T., Ikeda, Y., & Miyazaki, H. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01113.x · Cited by 2
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Serraj, K. A., Mecili, M., Azzouzi, H., Ghiura, C., & Andrès, E. (2012) · MT. Médecine thérapeutique · doi:10.1684/met.2012.0350 · Cited by 2
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Bergmann, F. (2005) · Springer eBooks · doi:10.1007/3-540-29036-2_32 · Cited by 2
Plateletpheresis does not lead to a lasting increase in serum thrombopoiesis growth factor levels
Schöffski, P., Tacke, F., Ganser, A., Trautwein, C., Martin, M. U., & Petersen, D. (1999) · Transfusion · doi:10.1046/j.1537-2995.1999.39499235679.x · Cited by 2
Zhou, X., & Tan, M. (2007) · Stem Cells and Development · doi:10.1089/scd.2006.0111 · Cited by 2
Liang, D.-C., Shih, L., Kuo, M.-C., Chen, S.-H., Liu, H.-C., & Shimosaka, A. (1998) · Annals of Hematology · doi:10.1007/s002770050408 · Cited by 2
Thrombopoietin Levels in Patients Undergoing Autologous Peripheral Blood Stem Cell Transplantation
Yoshimura, C., Nomura, S., Katsura, K., Yamaguchi, K., & Fukuhara, S. (2000) · Vox Sanguinis · doi:10.1046/j.1423-0410.2000.7820106.x · Cited by 2
Miyazawa, K., Nishimaki, J., Katagiri, T., Yaguchi, M., Iwase, O., Gotoh, A., Tauchi, T., Kawanishi, Y., Toyama, K., Ohyashiki, K., et al. (2000) · Hematology · doi:10.1080/10245332.2000.11746512 · Cited by 2
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Kaushansky, K., & Begley, C. G. (2000) · CRC Press eBooks · doi:10.1201/b14000-4 · Cited by 2
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Saxonhouse, M. A., & Sola-Visner, M. C. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2662-6.00002-x · Cited by 2
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Farese, A. M., & MacVittie, T. J. (1997) · Humana Press eBooks · doi:10.1007/978-1-4612-3958-1_20 · Cited by 2
In Vitro Effects of Mpl Ligands on Platelet Function
Harker, L. A., Marzec, U. M., & Toombs, C. F. (1997) · Humana Press eBooks · doi:10.1007/978-1-4612-3958-1_18 · Cited by 2
Fehér, Á., Istenes, I., Weisinger, J., Király, P. A., Rakonczai, A., Tárkányi, I., Kárpáti, Á., Hanna, E., Megyeri, A., Nagy, Z., et al. (2021) · Orvosi Hetilap · doi:10.1556/650.2021.32149 · Cited by 1
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Roback, J. D., & Hillyer, C. D. (2001) · Elsevier eBooks · doi:10.1016/b978-012348775-9/50058-2 · Cited by 1
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Balint, B. (2003) · Vojnosanitetski pregled · doi:10.2298/vsp0301043b · Cited by 1
Opportunities for the use of thrombopoietic growth factors
Schiffer, C. A. (1998) · Stem Cells · doi:10.1002/stem.5530160728 · Cited by 1
Short review – Management of Immune Thrombocytopenia in adults
Weiss, L., & Greil, R. (2010) · memo - Magazine of European Medical Oncology · doi:10.1007/s12254-010-0189-4 · Cited by 1
The Effect of Iron Bound Transferrin on Megakaryocytopoiesis in Bone Marrow Culture
Kabadere, S. (2000) · Cited by 1
SLE Thrombocytopenia: From Peripheral Platelet Destruction to Central Hemopoietic Defect
Ziakas, P. D. (2008) · The Open Hematology Journal · doi:10.2174/1874276900802010111 · Cited by 1
Lerch-Haner, J. K. (2008) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1
Pixley, F. J., & Stanley, E. R. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50713-0 · Cited by 1
Penchansky, L. (2004) · Springer eBooks · doi:10.1007/978-3-642-18799-5_1 · Cited by 1
Optimal Use of Cytokines/Chemokines in Peripheral Blood Stem Cell Transplantation
Korbling, M. J. (1997) · BioDrugs · doi:10.2165/00063030-199708020-00004 · Cited by 1
Review : Amifostine and other chemoprotective agents in cancer chemotherapy: A brief review
Summerhayes, M. (1995) · Journal of Oncology Pharmacy Practice · doi:10.1177/107815529500100403 · Cited by 1
Gegenwärtige Modelle der Thrombozytopoese
Schulze, H. (2010) · Der Pathologe · doi:10.1007/s00292-010-1370-6 · Cited by 1
Manzoor, S., Musadiq, M. A., Chowdhary, S., Khurshid, W., Chib, R., & Malik, I. (2014) · doi:10.22038/ijp.2014.3559 · Cited by 1
Potent In Vitro Peptide Antagonists of the Thrombopoietin Receptor as Potential Myelofibrosis Drugs
Szabó, M., Kowalczyk, W., Tarasova, A., Andrade, J., Be, C. L., Mulder, R. J., White, J., Meyer, A. G., Schwab, K. E., Cartledge, K., et al. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000241 · Cited by 1
Derigs, G., & Huber, C. H. (2004) · Springer eBooks · doi:10.1007/978-3-662-06670-6_20 · Cited by 1
Haynes, A., & Russell, N. H. (1998) · Humana Press eBooks · doi:10.1007/978-1-59259-726-0_19 · Cited by 1
Quantitative Platelet Disorders
Robertson, J. D., Blanchette, V. S., & Kahr, W. H. A. (2009) · Wiley eBooks · doi:10.1002/9781444306286.ch10 · Cited by 1
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Juutistenaho, S. (2010) · Työväentutkimus Vuosikirja · Cited by 1
The role of the embryonic microenvironment in hematopoietic cell development
Haak, E. (2007) · RePub (Erasmus University Rotterdam) · Cited by 1
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Haznedaroğlu, İ. C., Büyükaşık, Y., Koşar, A., Ozcebe, O. I., Kirazlı, Ş., & Dündar, S. (1999) · Springer eBooks · doi:10.1007/978-1-4615-4797-6_27 · Cited by 1
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Wendling, F., Cohen-Solal, K., Villeval, J., Debili, N., & Vainchenker, W. (1998) · Biotherapy · doi:10.1007/bf02678547 · Cited by 1
Greenberger, J. S. (2000) · Current Opinion in Hematology · doi:10.1097/00062752-200005000-00006 · Cited by 1
Blood centres: The effect of cytokine therapy on transfusion medicine
Pamphilon, D. H. (1997) · Transfusion Science · doi:10.1016/s0955-3886(96)00091-4 · Cited by 1
Effects of mpl ligands on platelet production and function in nonhuman primates
Harker, L. A., Marzec, U. M., & Kelly, A. B. (1998) · Stem Cells · doi:10.1002/stem.5530160714 · Cited by 1
Effect of thrombopoietin on peroxidase activity of cryopreserved peripheral blood stem cells
Date, M., Nomura, S., Katsura, K., Ichiyoshi, H., Kitajima, H., Kishimoto, Y., Kimura, T., & Fukuhara, S. (1997) · Medical Molecular Morphology · doi:10.1007/bf01545770 · Cited by 1
The Thrombopoietin Receptor, Mpl, and Signal Transduction
Kaushansky, K., Broudy, V. C., & Drachman, J. G. (1997) · Humana Press eBooks · doi:10.1007/978-1-4612-3958-1_16 · Cited by 1
Self-citationKawahara, K., Honma, Y., KAWAI, Y., Mizutani, N., Mizunuma, H., & Kubota, E. (1999) · Japanese Journal of Oral & Maxillofacial Surgery · doi:10.5794/jjoms.45.694 · Cited by 1
Erythroid — Megakaryocytic Cell Lines
Drexler, H. G. (2002) · Human cell culture · doi:10.1007/0-306-46877-8_8 · Cited by 1
Thrombopoietin: Biological Effects Beyond Megakaryopoiesis
Kaushansky, K. (1997) · Springer eBooks · doi:10.1007/978-1-4613-1137-9_16
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Veldhuis, G. J. (1997) · University of Groningen research database (University of Groningen / Centre for Information Technology)
Current View of the Coagulation System
Kang, Y., & Audu, P. (2005) · Wiley eBooks · doi:10.1002/9780470994788.ch5
Current view of coagulation system
Kang, Y., & Elia, E. (2014) · Wiley eBooks · doi:10.1002/9781118554685.ch6
Byrne, J., & Russell, N. H. (2005) · Wiley eBooks · doi:10.1002/9780470987056.ch18
Clinical Studies of Thrombopoietin
Basser, R. L. (1999) · Springer eBooks · doi:10.1007/978-1-4615-5013-6_14
Role of platelets during innate immunity to Streptococcus pneumoniae pneumonia
Dreimanis, K. (2008) · Epsilon Archive for Student Projects (University of Southampton)
Barnes, C. L. T. (2006) · Europe PMC (PubMed Central)
Sheridan, W. P., & Foote, M. (1998) · Emerging Drugs · doi:10.1517/14728214.3.1.261
Berdel, W. E., Topp, M. S., Oelmann, E. M., Reufi, B., & Serve, H. L. (1998) · Oncology Research and Treatment · doi:10.1159/000026819
Tsuji, K., Ohnuma, M., Jung, S. M., & Moroi, M. (2009) · The Kurume Medical Journal · doi:10.2739/kurumemedj.56.61
Al-Qtaitat, A., Al-Dalaen, S., Mahgoub, S., Alnawaiseh, N. A., Al-Shuneiqat, J., Al-Sarayreh, S. A., & Saraireh, Y. A. (2014) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2015/9860
Elemental study of gene therapy with thrombopoietin
Lu, C., Jianzeng, Z., Wang, X., & Liu, L. (1997) · Chinese Journal of Cancer Research · doi:10.1007/bf02953886
Growth Factors and Thrombopoietin—Impact on Future Patterns of Platelet Use
Boulton, F. E. (1997) · Transfusion Science · doi:10.1016/s0955-3886(97)00031-3
Tyagi, P., Crawford, J., & Jain, V. K. (2005) · Supportive Cancer Therapy · doi:10.1016/s1543-2912(13)60051-x
TPO/c-mpl and hemopoietic stem cell.
到, 松., & Kanakura, Y. (1999) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.88.2487
Metadata
- Authors
- Kaushansky, K.
- Corresponding author
- Kaushansky, K
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1995-07-15
- Volume
- 86
- Issue
- 2
- Pages
- 419-431
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2230842386
- Cited by
- 642
- References
- 103
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 13 · 2016: 13 · 2015: 8 · 2014: 15 · 2013: 5 · 2012: 10
- FWCI
- 39.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Myeloproliferative Neoplasms: Diagnosis and Treatment
- Keywords
- thrombopoietin, megakaryopoiesis, megakaryocyte development, thrombocytopenia, thrombocytosis, hematopoietic growth factors, thrombopoietin receptor, cDNA cloning, protein purification, cytokines, megakaryocyte maturation, platelet transfusion
- MeSH terms
- Animals, Blood Platelets, Cell Division, Gene Expression Regulation, Genes, Hematopoiesis, Humans, Megakaryocytes, Mice, Inbred BALB C, Radiation Injuries, Experimental, Receptors, Immunologic, Thrombocytopenia, Thrombopoietin, Carboplatin, Mice
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