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Cited by 60T-cell and Retrovirus StudiesViral-associated cancers and disordersHepatitis B Virus Studies

The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.

Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo

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Imada, K, Takaori-Kondo, A, Akagi, T, Shimotohno, K, Sugamura, K, Hattori, T, Yamabe, H, Okuma, M, Uchiyama, T·1995·Blood
DOI 10.1182/blood.v86.6.2350.bloodjournal8662350
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Abstract

The mechanism involved in leukemogenesis and neoplastic cell growth of adult T-cell leukemia (ATL) still remains unclear. We examined the tumorigenicity of human T-cell leukemia virus type I (HTLV-I)-infected cell lines in an in vivo cell proliferation model using severe combined immunodeficient (SCID) mice. Eleven HTLV-I-infected cell lines were injected into SCID mice and we found that 4 of them were capable of proliferating in SCID mice. Three of four transplantable cell lines are derived from the leukemic cell clone and 6 of 6 HTLV-I-infected cell lines of nonleukemic cell origin could not engraft in SCID mice. Interestingly, it was shown that some HTLV-I-infected and interleukin-2 (IL-2)-dependent cell lines could successfully engraft in SCID mice. The expression of IL-2 mRNA was not detected in these cell lines growing either in vivo or in vitro. HTLV-I viral products were not detected in 3 of 4 transplantable cell lines proliferating in vivo. Peripheral blood T cells immortalized by introduction of tax gene of HTLV-I were found to have no tumorigenic potential in SCID mice. These data suggest that (1) HTLV-I-infected cell lines of nonleukemic cell origin do not have enough leukemogenic changes to acquire the tumorigenic potential in SCID mice; (2) the IL-2 autocrine mechanism is not directly involved in the tumor cell growth; (3) viral gene expression is not needed for the maintenance of neoplastic cell growth; and (4) the expression of tax gene is not sufficient for the neoplastic cell growth in vivo.

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Crossref · 10.1182/blood.v86.6.2350.bloodjournal8662350

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  • Engraftments with patient ATL cells have been shown to more accurately replicate disease.

    “In particular, engraftments with patient ATL cells have been shown to more accurately replicate disease [130,131].”

    From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [130]

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Metadata

Authors
Imada, K., Takaori-Kondo, A., Akagi, T., Shimotohno, K., Sugamura, K., Hattori, T., Yamabe, H., Okuma, M., & Uchiyama, T.
Affiliations
  • Kyoto University (JP)
  • First Department of Internal Medicine, Kyoto University, Japan.
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
1995-09-15
Volume
86
Issue
6
Pages
2350-2357
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood.v86.6.2350.bloodjournal8662350
OpenAlex
W2342874288
Cited by
60
References
48
Citations by year
2024: 1 · 2022: 2 · 2021: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 2
FWCI
2.12
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
Keywords
human T-cell leukemia virus type I, adult T-cell leukemia/lymphoma, tumorigenicity, SCID mice, tax gene, viral gene expression, leukemogenesis, T-cell immortalization
MeSH terms
Animals, Base Sequence, Cell Division, Cell Line, Graft Survival, Interleukin-2, Lymphoid Tissue, Molecular Sequence Data, Neoplasm Proteins, Neoplasm Transplantation, Recombinant Proteins, Specific Pathogen-Free Organisms, T-Lymphocytes, Tumor Cells, Cultured, Neoplastic Stem Cells, Leukemia-Lymphoma, Adult T-Cell, Gene Expression Regulation, Viral, Gene Expression Regulation, Leukemic, Genes, pX, Lymphoma, Large B-Cell, Diffuse, Severe Combined Immunodeficiency, Mice, SCID, Immunocompromised Host, Mice

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