The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Iron-Chelating Therapy and the Treatment of Thalassemia
Abstract
Iron-chelating therapy with deferoxamine in patients with thalassemia major has dramatically altered the prognosis of this previously fatal disease. The successes achieved with deferoxamine, as well as the limitations of this treatment, have stimulated the design of alternative strategies of iron-chelating therapy, including orally active iron chelators. The development of the most promising of these, deferiprone, has progressed rapidly over the last 5 years; data from several trials have provided direct and supportive evidence for its short-term efficacy. At the same time, the toxicity of this agent mandates a careful evaluation of the balance between risk and benefit of deferiprone in patients with thalassemia, in most of whom long-term deferoxamine is safe and efficacious therapy.
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Cites
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664
Regulators of iron balance in humans [see comments]
Finch, C. (1994) · Blood · doi:10.1182/blood.v84.6.1697.1697 · Cited by 455
IRON ABSORPTION AND LOADING IN β-THALASSÆMIA INTERMEDIA
Pippard, M. J., Warner, G. T., Callender, S. T., & Weatherall, D. J. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92175-5 · Cited by 419
Magnetic-Susceptibility Measurement of Human Iron Stores
Brittenham, G. M., Farrell, D. E., Harris, J. W., Feldman, E. S., Danish, E. H., Muir, W. A., Tripp, J. H., & Bellon, E. M. (1982) · New England Journal of Medicine · doi:10.1056/nejm198212303072703 · Cited by 367
Self-citationHershko, C., Weatherall, D. J., & Finch, C. (1988) · CRC Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408368809105894 · Cited by 141
Cited by
Taher, A. T., Weatherall, D. J., & Cappellini, M. D. (2018) · The Lancet · doi:10.1016/s0140-6736(17)31822-6 · Cited by 807
The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer
Kalinowski, D. S., & Richardson, D. R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.2 · Cited by 721
Body iron metabolism and pathophysiology of iron overload
Kohgo, Y., Ikuta, K., Ohtake, T., Torimoto, Y., & Kato, J. (2008) · International Journal of Hematology · doi:10.1007/s12185-008-0120-5 · Cited by 616
Vlachos, A., Ball, S., Dahl, N., Alter, B. P., Sheth, S., Ramenghi, U., Meerpohl, J., Karlsson, S., Liu, J. M., Leblanc, T., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07269.x · Cited by 478
An update on iron chelation therapy.
(2012) · Europe PMC (PubMed Central) · doi:10.2450/2012.0008-12 · Cited by 233
Metadata
- Authors
- Olivieri, N. F., & Brittenham, G. M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1997-02-01
- Volume
- 89
- Issue
- 3
- Pages
- 739-761
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1514932744
- Cited by
- 1,089
- References
- 5
- FWCI
- 23.46
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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