Cited by 208Hematopoietic Stem Cell TransplantationGenetics, Aging, and Longevity in Model OrganismsMesenchymal stem cell research

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Dynamic Changes in Mouse Hematopoietic Stem Cell Numbers During Aging

de Haan, Gerald, Van Zant, Gary·1999·Blood

DOI 10.1182/blood.v93.10.3294.410k07_3294_3301

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Abstract

To address the fundamental question of whether or not stem cell populations age, we performed quantitative measurements of the cycling status and frequency of hematopoietic stem cells in long-lived C57BL/6 (B6) and short-lived DBA/2 (DBA) mice at different developmental and aging stages. The frequency of cobblestone area-forming cells (CAFC) day-35 in DBA fetal liver was twofold to threefold higher than in B6 mice, and by late gestation, the total stem cell number was nearly as large as that of young DBA adults. Following a further ≈50% increase in stem cells between 6 weeks and 1 year of age, numbers in old DBA mice dropped precipitously between 12 and 20 months of age. In marked contrast, this stem cell population in B6 mice increased at a constant rate from late gestation to 20 months of age with no signs of abatement. Throughout development an inverse correlation was observed between stem cell numbers and the percentage of cells in S-phase. Because a strong genetic component contributed to the changes in stem cell numbers during aging, we quantified stem cells of 20-month old BXD recombinant inbred (RI) mice, derived from B6 and DBA progenitor strains, thus permitting detailed interstrain genetic analysis. For each BXD strain we calculated the stem cell increase or decrease as mice aged from 2 to 20 months. Net changes in CAFC-day 35 numbers among BXD strains ranged from an ≈10-fold decrease to an ≈10-fold increase. A genome-wide search for loci associated with this quantitative trait was performed. Several loci contribute to the trait—putative loci map to chromosomes X, 2, and 14. We conclude that stem cell numbers fluctuate widely during aging and that this has a strong genetic basis.

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Authors: de Haan, G., & Van Zant, G.
Affiliations: From the Blood and Marrow Transplant Program, Division of Hematology/Oncology, University of Kentucky, Markey Cancer Center, Lexington, KY; and the Department of Physiological Chemistry, University of Groningen, Groningen, the Netherlands.
Venue: Blood
Publisher: American Society of Hematology
Published: 1999-05-15
Volume: 93
Issue: 10
Pages: 3294-3301
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v93.10.3294.410k07_3294_3301
OpenAlex: W2291689896
Cited by: 208
References: 56
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 3 · 2016: 9 · 2015: 5 · 2014: 8 · 2013: 6 · 2012: 10
FWCI: 5.43
Type: journal article
Language: en
Open access: closed
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: hematopoietic stem cells, aging, cobblestone area-forming cells, cell cycle, S phase, fetal liver, developmental stages, BXD recombinant inbred mice, genetic loci, quantitative trait loci, C57BL/6 mice, DBA/2 mice, strain differences
MeSH terms: Aging, Animals, Cell Cycle, Chromosome Mapping, Female, Embryonic and Fetal Development, Hematopoietic Stem Cells, Genetic Linkage, Liver, Mice, Inbred CBA, Mice, Inbred C57BL, Mice, Inbred Strains, Recombination, Genetic, Species Specificity, S Phase, Mice

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Dynamic Changes in Mouse Hematopoietic Stem Cell Numbers During Aging

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