Cell Therapy Strategies to Combat Immunosenescence
Open accessAbstract
Declining function of the immune system, termed "immunosenescence," leads to a higher incidence of infection, cancer, and autoimmune disease related mortalities in the elderly population. (1) Increasing interest in the field of immunosenescence is well-timed, as 20% of the United States population is expected to surpass the age of 65 by the year 2030. (2) Our current understanding of immunosenescence involves a shift in function of both adaptive and innate immune cells, leading to a reduced capacity to recognize new antigens and widespread chronic inflammation. The present review focuses on changes that occur in haematopoietic stem cells, macrophages, and T-cells using knowledge gained from both rodent and human studies. The review will discuss emerging strategies to combat immunosenescence, focusing on cellular and genetic therapies, including bone marrow transplantation and genetic reprogramming. A better understanding of the mechanisms and implications of immunosenescence will be necessary to combat age-related mortalities in the future.
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Genetically reprogramming cells into induced pluripotent stem cells can rejuvenate any cell type through telomere elongation, overcoming hurdles of replicative senescence.
“In particular, genetically reprogramming cells into induced pluripotent stem cells can rejuvenate any cell type through telomere elongation, overcoming hurdles of replicative senescence (224).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [224]
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- Authors
- Stahl, E. C., & Brown, B. N.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Stahl, Elizabeth C
- Venue
- Organogenesis
- Publisher
- Informa UK Limited
- Published
- 2015-10-02
- Volume
- 11
- Issue
- 4
- Pages
- 159-172
- ISSN
- 1547-6278 (ISSN-L)
- 1555-8592
- PMC
- PMC4879890
- OpenAlex
- W2172755251
- Cited by
- 73
- References
- 77
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 7 · 2023: 8 · 2022: 14 · 2021: 14 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 6
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Organogenesis (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R03AG043606)
- National Institute of Biomedical Imaging and Bioengineering (T32EB001026)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD043441)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- immunosenescence, cell therapy, hematopoietic stem cells, macrophages, T cells, bone marrow transplantation, genetic reprogramming, chronic inflammation, age-related diseases
- MeSH terms
- Immunosenescence, Aging, Humans, Immune System, Bone Marrow Transplantation, Cell- and Tissue-Based Therapy
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