The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Interferon- Activates Multiple STAT Proteins and Upregulates Proliferation-Associated IL-2R, c-myc, and pim-1 Genes in Human T Cells
Abstract
Interferon- (IFN-) is a pleiotropic cytokine that has antiviral, antiproliferative, and immunoregulatory functions. There is increasing evidence that IFN- has an important role in T-cell biology. We have analyzed the expression ofIL-2R, c-myc, and pim-1 genes in anti-CD3–activated human T lymphocytes. The induction of these genes is associated with interleukin-2 (IL-2)–induced T-cell proliferation. Treatment of T lymphocytes with IFN-, IL-2, IL-12, and IL-15 upregulated IL-2R, c-myc, andpim-1 gene expression. IFN- also sensitized T cells to IL-2–induced proliferation, further suggesting that IFN- may be involved in the regulation of T-cell mitogenesis. When we analyzed the nature of STAT proteins capable of binding to IL-2R,pim-1, and IRF-1 GAS elements after cytokine stimulation, we observed IFN-–induced binding of STAT1, STAT3, and STAT4, but not STAT5 to all of these elements. Yet, IFN- was able to activate binding of STAT5 to the high-affinity IFP53 GAS site. IFN- enhanced tyrosine phosphorylation of STAT1, STAT3, STAT4, STAT5a, and STAT5b. IL-12 induced STAT4 and IL-2 and IL-15 induced STAT5 binding to the GAS elements. Taken together, our results suggest that IFN-, IL-2, IL-12, and IL-15 have overlapping activities on human T cells. These findings thus emphasize the importance of IFN- as a T-cell regulatory cytokine.
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“two prominent rCap markers Pim3 and Bcl3 are direct transcriptional targets of the JAK-STAT pathway38,39”
From Endothelial Pim3 kinase protects the vascular barrier during lung metastasis (2024) · cites this paper as [39]
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Self-citationMolecular pathogenesis of acute promyelocytic leukaemia and APL variants
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Santio, N. M., Ganesh, K., Kaipainen, P. P., Halme, A., Seyednasrollah, F., Arbash, E., Hänninen, S., Kivelä, R., Carpen, O., & Saharinen, P. (2024) · Nature Communications · doi:10.1038/s41467-024-54445-1 · Cited by 9
Metadata
- Authors
- Matikainen, S., Sareneva, T., Ronni, T., Lehtonen, A., Koskinen, P. J., & Julkunen, I.
- Affiliations
- Åbo Akademi University (FI)
- From the Department of Virology, National Public Health Institute, Helsinki, Finland; and Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1999-03-15
- Volume
- 93
- Issue
- 6
- Pages
- 1980-1991
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1551136390
- Cited by
- 278
- References
- 57
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 9 · 2015: 10 · 2014: 11 · 2013: 15 · 2012: 16
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- interferon-alpha, STAT proteins, T cell proliferation, IL-2 receptor alpha, c-Myc, PIM-1, STAT1, STAT3, STAT4, STAT5, gene expression regulation, tyrosine phosphorylation, IL-12, IL-15, interleukin-2, interferon-stimulated genes, T cell regulation
- MeSH terms
- DNA, DNA-Binding Proteins, Gene Expression Regulation, Humans, Lymphocyte Activation, Milk Proteins, Proto-Oncogene Proteins, Recombinant Proteins, RNA, Messenger, T-Lymphocytes, Receptors, Interleukin-2, Trans-Activators, Genes, myc, Interferon-alpha, CD3 Complex, Protein Serine-Threonine Kinases, Interleukin-12, Phosphotyrosine, Interleukin-15, Tumor Suppressor Proteins, STAT1 Transcription Factor, STAT3 Transcription Factor, STAT4 Transcription Factor, STAT5 Transcription Factor, Proto-Oncogene Proteins c-pim-1
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