Complex modulation of cell type-specific signaling in response to type I interferons

van Boxel-Dezaire, Anette H.H.; Rani, M.R. Sandhya; Stark, George R.

doi:10.1016/j.immuni.2006.08.014

Cited by 530interferon and immune responsesCytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Complex modulation of cell type-specific signaling in response to type I interferons

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van Boxel-Dezaire, Anette H.H., Rani, M.R. Sandhya, Stark, George R.·2006·Immunity

DOI 10.1016/j.immuni.2006.08.014

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Abstract

The type I interferons (IFNs) are pleiotropic cytokines that regulate many different cellular functions. The major signaling pathway activated by type I IFNs involves sequential phosphorylation of the tyrosine residues of the Janus kinase (JAK) and signal transducers and activators of transcription (STAT) proteins, providing the primary mechanism through which gene expression is induced. Recent work has shown that the responses are quite complex, as shown by different responses to specific subtypes of type I IFN, activation of kinases in addition to JAKs, patterns of activation of all seven STATs in different cells, and activation of transcription factors other than STATs. The type I IFNs use this complexity to regulate many different biological functions in different types of cells, by activating different specific signals and patterns of gene expression.

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Although the same JAK/STAT components are used, the gene expression in response to a specific cytokine depends on the cell type.
“Although the same JAK/STAT components are used, the gene expression in response to a specific cytokine, depending on the cell type (van Boxel-Dezaire et al., 2006).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as van Boxel-Dezaire et al., 2006

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Authors: van Boxel-Dezaire, A. H. H., Rani, M. R. S., & Stark, G. R.
Affiliations: Cleveland Clinic (US)
Corresponding author: Stark, George R.
ORCID: Rani, M.R. Sandhya
Stark, George R.
Venue: Immunity
Publisher: Elsevier BV
Published: 2006-09
Volume: 25
Issue: 3
Pages: 361-372
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2006.08.014
OpenAlex: W2040653543
Cited by: 530
References: 125
Citations by year: 2026: 10 · 2025: 14 · 2024: 16 · 2023: 15 · 2022: 23 · 2021: 33 · 2020: 21 · 2019: 26 · 2018: 16 · 2017: 26 · 2016: 30 · 2015: 33 · 2014: 28 · 2013: 29 · 2012: 30
FWCI: 16.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2547 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P01CA062220)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: type I interferon, JAK/STAT signaling, cell type-specific signaling, STAT phosphorylation, interferon subtypes, kinase activation, transcription factors, gene expression regulation, cytokine signaling
MeSH terms: Animals, Blood Cells, Humans, Interferon Type I, Signal Transduction, STAT Transcription Factors

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Complex modulation of cell type-specific signaling in response to type I interferons

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