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The Glucocorticoid Receptor Cooperates With the Erythropoietin Receptor and c-Kit to Enhance and Sustain Proliferation of Erythroid Progenitors In Vitro
Open accessAbstract
Although erythropoietin (Epo) is essential for the production of mature red blood cells, the cooperation with other factors is required for a proper balance between progenitor proliferation and differentiation. In avian erythroid progenitors, steroid hormones cooperate with tyrosine kinase receptors to induce renewal of erythroid progenitors. We examined the role of corticosteroids in the in vitro expansion of primary human erythroid cells in liquid cultures and colony assays. Dexamethasone (Dex), a synthetic glucocorticoid hormone, cooperated with Epo and stem cell factor to induce erythroid progenitors to undergo 15 to 22 cell divisions, corresponding to a 105- to 106-fold amplification of erythroid cells. Dex acted directly on erythroid progenitors and maintained the colony-forming capacity of the progenitor cells expanded in liquid cultures. The hormone delayed terminal differentiation into erythrocytes, which was assayed by morphology, hemoglobin accumulation, and the expression of genes characteristic for immature cells. Sustained proliferation of erythroid progenitors could be induced equally well from purified erythroid burst-forming units (BFU-E), from CD34+ blast cells, and from bone marrow depleted from CD34+ cells.
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Cites
DNA binding of the glucocorticoid receptor is not essential for survival
Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81183-6 · Cited by 1,068
Functional interactions between Stat5 and the glucocorticoid receptor
Stöcklin, E., Wissler, M., Gouilleux, F., & Groner, B. (1996) · Nature · doi:10.1038/383726a0 · Cited by 675
Cited by
Hattangadi, S. M., Wong, P., Zhang, L., Flygare, J., & Lodish, H. F. (2011) · Blood · doi:10.1182/blood-2011-07-356006 · Cited by 423
Proof of principle for transfusion of in vitro–generated red blood cells
Giarratana, M.-C., Rouard, H., Dumont, A., Kiger, L., Safeukui, I., Le Pennec, P.-Y., François, S., Trugnan, G., Peyrard, T., Marie, T., et al. (2011) · Blood · doi:10.1182/blood-2011-06-362038 · Cited by 342
The glucocorticoid receptor is required for stress erythropoiesis
Bauer, A., Tronche, F., Wessely, O., Kellendonk, C., Reichardt, H. M., Steinlein, P., Schutz, G., & Beug, H. (1999) · Genes & Development · doi:10.1101/gad.13.22.2996 · Cited by 296
Self-citationBao, B., Prasad, A. S., Beck, F. W. J., Snell, D., Suneja, A., Sarkar, F. H., Doshi, N., Fitzgerald, J. T., & Swerdlow, P. (2008) · Translational Research · doi:10.1016/j.trsl.2008.06.001 · Cited by 187
Potentiation of Glucocorticoid Activity in Hypoxia through Induction of the Glucocorticoid Receptor
Leonard, M. O., Godson, C., Brady, H. R., & Taylor, C. T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2250 · Cited by 100
Metadata
- Authors
- von Lindern, M., Zauner, W., Mellitzer, G., Steinlein, P., Fritsch, G., Huber, K., Löwenberg, B., & Beug, H.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1999-07-15
- Volume
- 94
- Issue
- 2
- Pages
- 550-559
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2147032364
- Cited by
- 248
- References
- 2
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Glucocorticoid Receptor Cooperates With the Erythropoietin Receptor and c-Kit to Enhance and Sustain Proliferation of Erythroid Progenitors In Vitro. https://app.cochat.ai/papers/10.1182/blood.v94.2.550
- The paper
- von Lindern, M., Zauner, W., Mellitzer, G., Steinlein, P., Fritsch, G., Huber, K., Löwenberg, B., & Beug, H. (1999). The Glucocorticoid Receptor Cooperates With the Erythropoietin Receptor and c-Kit to Enhance and Sustain Proliferation of Erythroid Progenitors In Vitro. Blood. https://doi.org/10.1182/blood.v94.2.550
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
