The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The glucocorticoid receptor is required for stress erythropoiesis
Open accessAbstract
The glucocorticoid receptor (GR) coordinates a multitude of physiological responses in vivo. In vitro, glucocorticoids are required for sustained proliferation of erythroid progenitors (ebls). Here, we analyze the impact of the GR on erythropoiesis in vivo, using GR-deficient mice or mice expressing a GR defective for transactivation. In vitro, sustained proliferation of primary ebls requires an intact GR. In vivo, the GR is required for rapid expansion of ebls under stress situations like erythrolysis or hypoxia. A particular, GR-sensitive progenitor could be identified as being responsible for the stress response. Thus, GR-mediated regulation of ebl proliferation is essential for stress erythropoiesis in vivo.
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Cites
Stress hormones: their interaction and regulation
Axelrod, J., & Reisine, T. D. (1984) · Science · doi:10.1126/science.6143403 · Cited by 1,527
Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308
DNA binding of the glucocorticoid receptor is not essential for survival
Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81183-6 · Cited by 1,068
Self-citation
Cited by
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898
Hattangadi, S. M., Wong, P., Zhang, L., Flygare, J., & Lodish, H. F. (2011) · Blood · doi:10.1182/blood-2011-07-356006 · Cited by 423
The miR-144/451 locus is required for erythroid homeostasis
Rasmussen, K. D., Simmini, S., Abreu-Goodger, C., Bartonicek, N., Di Giacomo, M., Bilbao-Cortes, D., Horos, R., Von Lindern, M., Enright, A. J., & O’Carroll, D. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100458 · Cited by 330
Anaemia in kidney disease: harnessing hypoxia responses for therapy
Koury, M. J., & Haase, V. H. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.82 · Cited by 313
Crosstalk between the glucocorticoid receptor and other transcription factors: Molecular aspects
Kassel, O., & Herrlich, P. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.07.003 · Cited by 277
Metadata
- Authors
- Bauer, A., Tronche, F., Wessely, O., Kellendonk, C., Reichardt, H. M., Steinlein, P., Schutz, G., & Beug, H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-11-15
- Volume
- 13
- Issue
- 22
- Pages
- 2996-3002
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2020693727
- Cited by
- 296
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Bauer, A., Tronche, F., Wessely, O., Kellendonk, C., Reichardt, H. M., Steinlein, P., Schutz, G., & Beug, H. (1999). The glucocorticoid receptor is required for stress erythropoiesis. Genes & Development. https://doi.org/10.1101/gad.13.22.2996
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