The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor
Abstract
We describe thrombogenic tissue factor (TF) on leukocyte-derived microparticles and their incorporation into spontaneous human thrombi. Polymorphonuclear leukocytes and monocytes transfer TF+particles to platelets, thereby making them capable of triggering and propagating thrombosis. This phenomenon calls into question the original dogma that vessel wall injury and exposure of TF within the vasculature to blood is sufficient for the occurrence of arterial thrombosis. The transfer of TF+ leukocyte-derived particles is dependent on the interaction of CD15 and TF with platelets. Both the inhibition of TF transfer to platelets by antagonizing the interaction CD15 with P-selectin and the direct interaction of TF itself suggest a novel therapeutic approach to prevent thrombosis.
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Metadata
- Authors
- Rauch, U., Bonderman, D., Bohrmann, B., Badimon, J. J., Himber, J., Riederer, M. A., & Nemerson, Y.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-07-01
- Volume
- 96
- Issue
- 1
- Pages
- 170-175
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1489988243
- Cited by
- 419
- References
- 26
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rauch, U., Bonderman, D., Bohrmann, B., Badimon, J. J., Himber, J., Riederer, M. A., & Nemerson, Y. (2000). Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor. Blood. https://doi.org/10.1182/blood.v96.1.170
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