The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development
Open accessAbstract
Tissue factor (TF) is best known as the primary cellular initiator of blood coagulation. After vessel injury, the TF:FVIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets. TF deficiency causes embryonic lethality in the mouse and there have been no reports of TF deficiency in humans. These results indicate that TF is essential for life, most likely because of its central role in hemostasis. In addition, aberrant TF expression within the vasculature initiates life-threatening thrombosis in various diseases, such as sepsis, atherosclerosis, and cancer. Finally, recent studies have revealed a nonhemostatic role of TF in the generation of coagulation proteases and subsequent activation of protease activated receptors (PARs) on vascular cells. This TF-dependent signaling contributes to a variety of biological processes, including inflammation, angiogenesis, metastasis, and cell migration. This review focuses on the roles of TF in hemostasis, thrombosis, and vascular development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Thrombin signalling and protease-activated receptors
Coughlin, S. R. (2000) · Nature · doi:10.1038/35025229 · Cited by 2,482
Placental development: Lessons from mouse mutants
Rossant, J., & Cross, J. C. (2001) · Nature Reviews Genetics · doi:10.1038/35080570 · Cited by 1,273
Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque.
Wilcox, J. N., Smith, K. M., Schwartz, S. M., & Gordon, D. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2839 · Cited by 1,214
Drake, T. A., Morrissey, J. H., & Edgington, T. S. (1989) · Europe PMC (PubMed Central) · Cited by 1,192
Blood-borne tissue factor: Another view of thrombosis
Giesen, P. L. A., Rauch, U., Bohrmann, B., Kling, D., Roqué, M., Fallon, J. T., Badimon, J. J., Himber, J., Riederer, M. A., & Nemerson, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2311 · Cited by 991
A dual thrombin receptor system for platelet activation
Kahn, M. L., Zheng, Y.-W., Huang, W., Bigornia, V., Zeng, D., Moff, S., Farese, R. V., Tam, C., & Coughlin, S. R. (1998) · Nature · doi:10.1038/29325 · Cited by 979
Bolton-Maggs, P. H., & Pasi, K. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13405-8 · Cited by 763
Falati, S., Liu, Q., Gross, P., Merrill-Skoloff, G., Chou, J., Vandendries, E., Celi, A., Croce, K., Furie, B. C., & Furie, B. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021868 · Cited by 752
Combes, V., Simon, A.-C., Grau, G.-E., Arnoux, D., Camoin, L., Sabatier, F., Mutin, M., Sanmarco, M., Sampol, J., & Dignat-George, F. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4985 · Cited by 732
Shivdasani, R. A., Rosenblatt, M. F., Zucker-Franklin, D., Jackson, C. W., Hunt, P., Saris, C. J. M., & Orkin, S. H. (1995) · Cell · doi:10.1016/0092-8674(95)90531-6 · Cited by 693
Cited by
Challis, J. R., Lockwood, C. J., Myatt, L., Norman, J. E., Strauss, J. F., & Petraglia, F. (2009) · Reproductive Sciences · doi:10.1177/1933719108329095 · Cited by 893
Membrane Microparticles: Two Sides of the Coin
Hugel, B., Martínez, M. C., Kunzelmann, C., & Freyssinet, J.-M. (2005) · Physiology · doi:10.1152/physiol.00029.2004 · Cited by 698
Inflammation and Atherosclerosis: Novel Insights Into Plaque Formation and Destabilization
Stoll, G., & Bendszus, M. (2006) · Stroke · doi:10.1161/01.str.0000226901.34927.10 · Cited by 503
The stimulation of thrombosis by hypoxia
Gupta, N., Zhao, Y.-Y., & Evans, C. E. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.07.013 · Cited by 435
Emerging materials for hemostasis
Li, X.-F., Lu, P., Jia, H.-R., Li, G., Zhu, B., Wang, X., & Wu, F.-G. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214823 · Cited by 164
Metadata
- Authors
- Mackman, N.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2004-06
- Volume
- 24
- Issue
- 6
- Pages
- 1015-1022
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2169083127
- Cited by
- 658
- References
- 78
- FWCI
- 18.12
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development. https://app.cochat.ai/papers/10.1161/01.atv.0000130465.23430.74
- The paper
- Mackman, N. (2004). Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.0000130465.23430.74
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
