The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells
Abstract
Pentraxins are acute-phase proteins produced in vivo during inflammatory reactions. Classical short pentraxins, C-reactive protein, and serum amyloid P component are generated in the liver in response to interleukin (IL)–6. The long pentraxin PTX3 is produced in tissues under the control of primary proinflammatory signals, such as lipopolysaccharide, IL-1β, and tumor necrosis factor-α, which also promote maturation of dendritic cells (DCs). Cell death commonly occurs during inflammatory reactions. In this study, it is shown that PTX3 specifically binds to dying cells. The binding was dose dependent and saturable. Recognition was restricted to extranuclear membrane domains and to a chronological window after UV irradiation or after CD95 cross-linking–induced or spontaneous cell death in vitro. PTX3 bound to necrotic cells to a lesser extent. Human DCs failed to internalize dying cells in the presence of PTX3, while they took up normally soluble or inert particulate substrates. These results suggest that PTX3 sequesters cell remnants from antigen-presenting cells, possibly contributing to preventing the onset of autoimmune reactions in inflamed tissues.
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Citations
Cites
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Cited by
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Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
Garlanda, C., Hirsch, E., Bozza, S., Salustri, A., De Acetis, M., Nota, R., Maccagno, A., Riva, F., Bottazzi, B., Peri, G., et al. (2002) · Nature · doi:10.1038/nature01195 · Cited by 669
Self-citationThe role of defective clearance of apoptotic cells in systemic autoimmunity
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Self-citationPathogenetic mechanisms in radiation fibrosis
Yarnold, J., & Vozenin Brotons, M.-C. (2010) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2010.09.002 · Cited by 622
Metadata
- Authors
- Rovere, P., Peri, G., Fazzini, F., Bottazzi, B., Doni, A., Bondanza, A., Zimmermann, V. S., Garlanda, C., Fascio, U., Sabbadini, M. G., Rugarli, C., Mantovani, A., & Manfredi, A. A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-12-15
- Volume
- 96
- Issue
- 13
- Pages
- 4300-4306
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1541423869
- Cited by
- 327
- References
- 53
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Rovere, P., Peri, G., Fazzini, F., Bottazzi, B., Doni, A., Bondanza, A., Zimmermann, V. S., Garlanda, C., Fascio, U., Sabbadini, M. G., Rugarli, C., Mantovani, A., & Manfredi, A. A. (2000). The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells. Blood. https://doi.org/10.1182/blood.v96.13.4300
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