The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma
Abstract
This study was designed to determine if macrophage inhibitory protein-1 (MIP-1), a recently described osteoclast (OCL) stimulatory factor,1 was present in marrow from patients with multiple myeloma (MM) and possibly involved in the bone destructive process. MIP-1, but not interleukin-1β (IL-1β), tumor necrosis factor-β (TNF-β), or interleukin-6 (IL-6), messenger RNA was elevated in freshly isolated bone marrow from 3 of 4 patients with MM compared to normal controls. Furthermore, enzyme-linked immunosorbent assays of freshly isolated bone marrow plasma detected increased concentrations of hMIP-1 (range, 75-7784 pg/mL) in 8 of 13 patients (62%) with active myeloma, in 3 of 18 patients (17%) with stable myeloma (range, 75-190.3), as well as in conditioned media from 4 of 5 lymphoblastoid cell lines (LCLs) derived from patients with MM. Mildly elevated levels of MIP-1 were detected in 3 of 14 patients (21%) with other hematologic diagnoses (range, 80.2-118.3, median value of 96 pg/mL) but not in normal controls (0 of 7). MIP-1 was not detected in the peripheral blood of any patients with MM. In addition, recombinant hMIP-1 induced OCL formation in human bone marrow cultures. Importantly, addition of a neutralizing antibody to MIP-1 to human bone marrow cultures treated with freshly isolated marrow plasma from patients with MM blocked the increased OCL formation induced by these marrow samples but had no effect on control levels of OCL formation. Thus, high levels of MIP-1 are expressed in marrow samples from patients with MM, but not in marrow from patients with other hematologic disorders or controls, and support an important role for MIP-1 as one of the major factors responsible for the increased OCL stimulatory activity in patients with active MM.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kurihara, N., Bertolini, D., Suda, T., Akiyama, Y., & Roodman, G. D. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.11.4226 · Cited by 486
Self-citationBataille, R., Jourdan, M., Zhang, X. G., & Klein, B. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114392 · Cited by 479
Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.
Olsson, L., & Kaplan, H. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5429 · Cited by 379
Production of Lymphotoxin, a Bone-Resorbing Cytokine, by Cultured Human Myeloma Cells
Garrett, I. R., Durie, B. G. M., Nedwin, G. E., Gillespie, A., Bringman, T., Sabatini, M., Bertolini, D. R., & Mundy, G. R. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708273170902 · Cited by 373
Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone.
Roodman, G. D., Kurihara, N., Ohsaki, Y., Kukita, A., Hosking, D., Demulder, A., Smith, J. F., & Singer, F. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115584 · Cited by 366
Self-citationMatsuoka, Y., Moore, G. E., Yagi, Y., & Pressman, D. (1967) · Experimental Biology and Medicine · doi:10.3181/00379727-125-32327 · Cited by 287
Horton, M. A., Lewis, D., McNulty, K., Pringle, J. A. S., & Chambers, T. J. (1985) · PubMed · Cited by 275
Bataille, R., Chappard, D., Marcelli, C., Dessauw, P., Sany, J., Baldet, P., & Alexandre, C. (1989) · Journal of Clinical Oncology · doi:10.1200/jco.1989.7.12.1909 · Cited by 241
The role of MIP-1α in Inflammation and hematopoiesis
Cook, D. N. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.1.61 · Cited by 214
Production of interleukin-1 by bone marrow myeloma cells
Cozzolino, F., Torcia, M., Aldinucci, D., Rubartelli, A., Miliani, A., Shaw, A., Lansdorp, P., & Di Guglielmo, R. (1989) · Blood · doi:10.1182/blood.v74.1.380.380 · Cited by 185
Cited by
Roodman, G. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030831 · Cited by 2,755
Self-citationOsteonecrosis of the Jaw in Multiple Myeloma Patients: Clinical Features and Risk Factors
Badros, A., Weikel, D., Salama, A., Goloubeva, O., Schneider, A., Rapoport, A., Fenton, R., Gahres, N., Sausville, E., Ord, R., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.2465 · Cited by 593
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
Hideshima, T., & Anderson, K. C. (2002) · Nature Reviews Cancer · doi:10.1038/nrc952 · Cited by 425
Biology of Osteoclast Activation in Cancer
Roodman, G. D. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.15.3562 · Cited by 306
Self-citationYaccoby, S., Pearse, R. N., Johnson, C. L., Barlogie, B., Choi, Y., & Epstein, J. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03257.x · Cited by 305
Metadata
- Authors
- Choi, S. J., Cruz, J. C., Craig, F., Chung, H., Devlin, R. D., Roodman, G. D., & Alsina, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-07-15
- Volume
- 96
- Issue
- 2
- Pages
- 671-675
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W30364595
- Cited by
- 408
- References
- 27
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. https://app.cochat.ai/papers/10.1182/blood.v96.2.671
- The paper
- Choi, S. J., Cruz, J. C., Craig, F., Chung, H., Devlin, R. D., Roodman, G. D., & Alsina, M. (2000). Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood. https://doi.org/10.1182/blood.v96.2.671
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
