Interleukin 15: biology and relevance to human disease
Abstract
Since the cloning of interleukin (IL)-15 six years ago, there have been numerous studies examining the molecular and cellular biology of this cytokine. IL-15 and IL-2 have similar biologic properties in vitro, consistent with their shared receptor (R) signaling components (IL-2/15Rβγc). However,
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Deregulation of IL-15 can lead to pathologies linked to autoimmune diseases such as rheumatoid arthritis and leukemia.
“In addition, any deregulation of this cytokine can lead to several pathologies linked to autoimmune diseases such as rheumatoid arthritis and leukemia (Fehniger and Caligiuri, 2001).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Fehniger and Caligiuri, 2001
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“In addition, any deregulation of this cytokine can lead to several pathologies linked to autoimmune diseases such as rheumatoid arthritis and leukemia (Fehniger and Caligiuri, 2001).”
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- Authors
- Fehniger, T. A., & Caligiuri, M. A.
- Affiliations
- The Ohio State University (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2001-01-01
- Volume
- 97
- Issue
- 1
- Pages
- 14-32
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1970563382
- Cited by
- 976
- References
- 0
- Citations by year
- 2026: 19 · 2025: 25 · 2024: 26 · 2023: 29 · 2022: 34 · 2021: 29 · 2020: 34 · 2019: 36 · 2018: 23 · 2017: 33 · 2016: 35 · 2015: 39 · 2014: 42 · 2013: 33 · 2012: 45
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca065670-05)
- National Cancer Institute (P-30-CA-16058, CA-65670, CA 68458, P30CA016058)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- IL-15, cytokine biology, interleukin-2, human disease
- MeSH terms
- Animals, Autoimmune Diseases, Communicable Diseases, Humans, Interleukin-2, Killer Cells, Natural, Neoplasms, Interleukin-15
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