The intriguing role of polymorphonuclear neutrophils in antitumor reactions
Abstract
Polymorphonuclear neutrophils (PMNs) are the most abundant circulating blood leukocytes. They provide the first-line defense against infection and are potent effectors of inflammation. In addition, their release of soluble chemotactic factors guides the recruitment of both nonspecific and specific
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Neutrophils, mast cells, eosinophils and activated T lymphocytes also contribute to malignancies by releasing extracellular proteases, pro-angiogenic factors and chemokines.
“Genetic and functional experiments indicate that neutrophils, mast cells, eosinophils and activated T lymphocytes also contribute to malignancies by releasing extracellular proteases, pro-angiogenic factors and chemokines11,23–26.”
From Inflammation and cancer (2002) · cites this paper as [23]
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- Authors
- Di Carlo, E., Forni, G., Lollini, P., Colombo, M. P., Modesti, A., & Musiani, P.
- Affiliations
- From the Department of Oncology and Neurosciences, G. d'Annunzio University of Chieti, Chieti, Italy; Department of Clinical and Biological Sciences, University of Torino, Orbassano, Italy; Institute for Cancer Research, University of Bologna, Bologna, Italy; Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy; and Department of Experimental Medicine and Biochemistry, University of Tor Vergata, Rome, Italy.
- University of Rome Tor Vergata (IT)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2001-01-15
- Volume
- 97
- Issue
- 2
- Pages
- 339-345
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1518549789
- Cited by
- 419
- References
- 100
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 16 · 2020: 12 · 2019: 12 · 2018: 12 · 2017: 20 · 2016: 22 · 2015: 16 · 2014: 19 · 2013: 27 · 2012: 23
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- neutrophils, antitumor immunity, inflammation, chemoattractants, leukocyte recruitment, innate immunity
- MeSH terms
- Genetic Engineering, Humans, Immunity, Innate, Neoplasms, Neutrophils, Cytokines, Lymphocytes, Tumor-Infiltrating
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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