Cited by 419Neutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancerChemokine receptors and signaling

The intriguing role of polymorphonuclear neutrophils in antitumor reactions

Di Carlo, Emma, Forni, Guido, Lollini, PierLuigi, Colombo, Mario P., Modesti, Andrea, Musiani, Piero·2001·Blood

Abstract

Polymorphonuclear neutrophils (PMNs) are the most abundant circulating blood leukocytes. They provide the first-line defense against infection and are potent effectors of inflammation. In addition, their release of soluble chemotactic factors guides the recruitment of both nonspecific and specific

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Registry

Crossref · 10.1182/blood.v97.2.339

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  • Neutrophils, mast cells, eosinophils and activated T lymphocytes also contribute to malignancies by releasing extracellular proteases, pro-angiogenic factors and chemokines.

    “Genetic and functional experiments indicate that neutrophils, mast cells, eosinophils and activated T lymphocytes also contribute to malignancies by releasing extracellular proteases, pro-angiogenic factors and chemokines11,23–26.”

    From Inflammation and cancer (2002) · cites this paper as [23]

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Authors
Di Carlo, E., Forni, G., Lollini, P., Colombo, M. P., Modesti, A., & Musiani, P.
Affiliations
  • From the Department of Oncology and Neurosciences, G. d'Annunzio University of Chieti, Chieti, Italy; Department of Clinical and Biological Sciences, University of Torino, Orbassano, Italy; Institute for Cancer Research, University of Bologna, Bologna, Italy; Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy; and Department of Experimental Medicine and Biochemistry, University of Tor Vergata, Rome, Italy.
  • University of Rome Tor Vergata (IT)
Venue
Blood
Published
2001-01-15
Volume
97
Issue
2
Pages
339-345
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W1518549789
Cited by
419
References
100
Citations by year
2026: 2 · 2025: 9 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 16 · 2020: 12 · 2019: 12 · 2018: 12 · 2017: 20 · 2016: 22 · 2015: 16 · 2014: 19 · 2013: 27 · 2012: 23
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords
neutrophils, antitumor immunity, inflammation, chemoattractants, leukocyte recruitment, innate immunity
MeSH terms
Genetic Engineering, Humans, Immunity, Innate, Neoplasms, Neutrophils, Cytokines, Lymphocytes, Tumor-Infiltrating

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