Tumors and inflammatory infiltrates: Friends or foes?
Abstract
The recognition of a role for inflammation in the natural history of a tumor has a long record, stretching from the mid-19th century. From the times of Virkow, who postulated that cancer originates from inflamed tissues, to Metchnikoff and many others, this field has continued to excite (and divide) the scientific community. The question as to whether the inflammatory infiltrate helps or hinders tumors is still open. In a sense, modern molecular biology has, if anything, worsened this dualism, and the literature on this issue shows a plethora of conflicting reports. We would like to provide another contribution to this topic, which was the subject of a recent brilliant review (Balkwill F and Mantovani A. Lancet 2001; 357: 539-45), by focussing more specifically to the relation between inflammation and tumor invasion and how this could drive rational therapeutic approaches.
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TAMs have a dual role in neoplasms: they may kill neoplastic cells following activation by IL-2, interferon and IL-12, but they produce angiogenic and lymphangiogenic growth factors, cytokines and proteases that potentiate neoplastic progression.
“TAMs have a dual role in neoplasms — although they may kill neoplastic cells following activation by IL-2, interferon and IL-12 (refs 15, 16), TAMs produce a number of potent angiogenic and lymphangiogenic growth factors, cytokines and proteases, all of which are mediators that potentiate neoplastic progression17.”
From Inflammation and cancer (2002) · cites this paper as [15]
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- Authors
- Brigati, C., Noonan, D. M., Albini, A., & Benelli, R.
- Corresponding author
- Brigati, Claudio
- Venue
- Clinical & Experimental Metastasis
- Published
- 2002-05
- Volume
- 19
- Issue
- 3
- Pages
- 247-258
- ISSN
- 0262-0898 (ISSN-L)
- 1573-7276
- OpenAlex
- W1550108534
- Cited by
- 230
- References
- 125
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 6 · 2013: 10 · 2012: 19
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Clinical & Experimental Metastasis (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Funders
- Compagnia di San Paolo
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- tumor inflammation, inflammatory cell infiltration, tumor invasion, tumor microenvironment
- MeSH terms
- Humans, Inflammation, Models, Biological, Neoplasms, Prostaglandin-Endoperoxide Synthases, Transcription Factors, Cytokines, Receptors, Cytoplasmic and Nuclear, Chemokines
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