Cited by 230Immune cells in cancerInflammatory mediators and NSAID effectsInflammatory Biomarkers in Disease Prognosis

Tumors and inflammatory infiltrates: Friends or foes?

Brigati, Claudio, Noonan, Douglas M., Albini, Adriana, Benelli, Roberto·2002·Clinical & Experimental Metastasis

Abstract

The recognition of a role for inflammation in the natural history of a tumor has a long record, stretching from the mid-19th century. From the times of Virkow, who postulated that cancer originates from inflamed tissues, to Metchnikoff and many others, this field has continued to excite (and divide) the scientific community. The question as to whether the inflammatory infiltrate helps or hinders tumors is still open. In a sense, modern molecular biology has, if anything, worsened this dualism, and the literature on this issue shows a plethora of conflicting reports. We would like to provide another contribution to this topic, which was the subject of a recent brilliant review (Balkwill F and Mantovani A. Lancet 2001; 357: 539-45), by focussing more specifically to the relation between inflammation and tumor invasion and how this could drive rational therapeutic approaches.

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Crossref · 10.1023/a:1015587423262

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125 of 125 references verified0 citation errors · 0 not checkable

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  • TAMs have a dual role in neoplasms: they may kill neoplastic cells following activation by IL-2, interferon and IL-12, but they produce angiogenic and lymphangiogenic growth factors, cytokines and proteases that potentiate neoplastic progression.

    “TAMs have a dual role in neoplasms — although they may kill neoplastic cells following activation by IL-2, interferon and IL-12 (refs 15, 16), TAMs produce a number of potent angiogenic and lymphangiogenic growth factors, cytokines and proteases, all of which are mediators that potentiate neoplastic progression17.”

    From Inflammation and cancer (2002) · cites this paper as [15]

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Authors
Brigati, C., Noonan, D. M., Albini, A., & Benelli, R.
Corresponding author
Brigati, Claudio
Venue
Clinical & Experimental Metastasis
Published
2002-05
Volume
19
Issue
3
Pages
247-258
ISSN
  • 0262-0898 (ISSN-L)
  • 1573-7276
OpenAlex
W1550108534
Cited by
230
References
125
Citations by year
2025: 2 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 6 · 2013: 10 · 2012: 19
FWCI
0.97
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical & Experimental Metastasis (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
  • IrInSubria (University of Insubria) (submittedVersion)
Funders
Compagnia di San Paolo
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
tumor inflammation, inflammatory cell infiltration, tumor invasion, tumor microenvironment
MeSH terms
Humans, Inflammation, Models, Biological, Neoplasms, Prostaglandin-Endoperoxide Synthases, Transcription Factors, Cytokines, Receptors, Cytoplasmic and Nuclear, Chemokines

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