The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Bifurcation of osteoclasts and dendritic cells from common progenitors
Abstract
Osteoclasts and dendritic cells are derived from monocyte/macrophage precursor cells; however, how their lineage commitment is regulated is unknown. This study investigated the differentiation pathways of osteoclasts and dendritic cells from common precursor cells at the single-cell level. Osteoclastogenesis induced by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor–κB ligand (RANKL) or tumor necrosis factor-α (TNF-α) is completely inhibited by addition of granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-3 at early stages of differentiation. GM-CSF–treated cells express both c-Fms and RANK and also low levels of CD11c and DEC205, which are detected on dendritic cells. Addition of GM-CSF also reduces expression of both c-Fos and Fra-1, which is an important event for inhibition of osteoclastogenesis. Overexpression of c-Fos by retroviral infection or induction in transgenic mice can rescue a failure in osteoclast differentiation even in the presence of GM-CSF. By contrast, differentiation into dendritic cells is inhibited by M-CSF, indicating that M-CSF and GM-CSF reciprocally regulate the differentiation of both lineages. Dendritic cell maturation is also inhibited when c-Fos is expressed at an early stage of differentiation. Taken together, these findings suggest that c-Fos is a key mediator of the lineage commitment between osteoclasts and dendritic cells. The lineage determination of osteoclast progenitors seen following GM-CSF treatment functions through the regulation of c-Fos expression.
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Cites
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Cited by
DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells
Yagi, M., Miyamoto, T., Sawatani, Y., Iwamoto, K., Hosogane, N., Fujita, N., Morita, K., Ninomiya, K., Suzuki, T., Miyamoto, K., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050645 · Cited by 890
Self-citationOSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism
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Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond
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The mononuclear phagocyte system revisited
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Increased Osteoprotegerin Serum Levels in Men with Coronary Artery Disease
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Metadata
- Authors
- Miyamoto, T., Ohneda, O., Arai, F., Iwamoto, K., Okada, S., Takagi, K., Anderson, D. M., & Suda, T.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2001-10-15
- Volume
- 98
- Issue
- 8
- Pages
- 2544-2554
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1987331822
- Cited by
- 281
- References
- 55
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- closed
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