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Cited by 423

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

The mononuclear phagocyte system revisited

Hume, David A, Ross, Ian L, Himes, S Roy, Sasmono, R Tedjo, Wells, Christine A, Ravasi, Timothy·2002·Journal of Leukocyte Biology

Abstract

The mononuclear phagocyte system (MPS) was defined as a family of cells comprising bone marrow progenitors, blood monocytes, and tissue macrophages. In this review, we briefly consider markers for cells of this lineage in the mouse, especially the F4/80 surface antigen and the receptor for macrophage colony-stimulating factor. The concept of the MPS is challenged by evidence that there is a separate embryonic phagocyte lineage, the blurring of the boundaries between macrophages and other cells types arising from phenotypic plasticity and transdifferentiation, and evidence of local renewal of tissue macrophage populations as opposed to monocyte recruitment. Nevertheless, there is a unity to cells of the MPS suggested by their location, morphology, and shared markers. We discuss the origins of macrophage heterogeneity and argue that macrophages and antigen-representing dendritic cells are closely related and part of the MPS.

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Metadata

Authors
Hume, D. A., Ross, I. L., Himes, S. R., Sasmono, R. T., Wells, C. A., & Ravasi, T.
Venue
Journal of Leukocyte Biology
Published
2002-10-01
Volume
72
Issue
4
Pages
621-627
ISSN
  • 0741-5400 (ISSN-L)
  • 1938-3673
OpenAlex
W2136930121
Cited by
423
References
64
FWCI
6.66
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The mononuclear phagocyte system revisited. https://app.cochat.ai/papers/10.1189/jlb.72.4.621
The paper
Hume, D. A., Ross, I. L., Himes, S. R., Sasmono, R. T., Wells, C. A., & Ravasi, T. (2002). The mononuclear phagocyte system revisited. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.72.4.621

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.