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Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms

Lewis, Natasha E., Petrova-Drus, Kseniya, Huet, Sarah, Epstein-Peterson, Zachary D., Gao, Qi, Sigler, Allison E., Baik, Jeeyeon, Ozkaya, Neval, Moskowitz, Alison J., Kumar, Anita, Horwitz, Steven M., Zhang, Yanming, Arcila, Maria E., Levine, Ross L., Roshal, Mikhail, Dogan, Ahmet, Xiao, Wenbin·2020·Blood Advances
DOI 10.1182/bloodadvances.2020001636
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Abstract

TET2 and DNMT3A mutations are frequently identified in T-cell lymphomas of T follicular helper cell origin (TCL-TFH), clonal hematopoiesis (CH), and myeloid neoplasms (MNs). The relationships among these 3 entities, however, are not well understood. We performed comprehensive genomic studies on paired bone marrow and tissue samples as well as on flow cytometry–sorted bone marrow and peripheral blood subpopulations from a cohort of 22 patients with TCL-TFH to identify shared CH-type mutations in various hematopoietic cell compartments. Identical mutations were detected in the neoplastic T-cell and myeloid compartments of 15 out of 22 patients (68%), including TET2 (14/15) and DNMT3A (10/15). Four patients developed MNs, all of which shared CH-type mutations with their TCL-TFH; additional unique genetic alterations were also detected in each patient’s TCL-TFH and MN. These data demonstrate that CH is prevalent in patients with TCL-TFH and that divergent evolution of a CH clone may give rise to both TCL-TFH and MNs.

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Research works printed but not linked: 25

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Metadata

Authors
Lewis, N. E., Petrova-Drus, K., Huet, S., Epstein-Peterson, Z. D., Gao, Q., Sigler, A. E., Baik, J., Ozkaya, N., Moskowitz, A. J., Kumar, A., Horwitz, S. M., Zhang, Y., Arcila, M. E., Levine, R. L., Roshal, M., Dogan, A., & Xiao, W.
Affiliations
  • Hematopathology Service, Department of Pathology,
  • Lymphoma Service, Department of Medicine,
  • Cytogenetic Laboratory, Department of Pathology,
  • Molecular Diagnostic Laboratory, Department of Pathology,
  • Molecular Cancer Medicine Service, Human Oncology and Pathogenesis Program,
ORCID
Venue
Blood Advances
Publisher
American Society of Hematology
Published
2020-05-22
Volume
4
Issue
10
Pages
2261-2271
ISSN
  • 2473-9529
  • 2473-9537
DOI
10.1182/bloodadvances.2020001636
Cited by
114
References
5
Language
en

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CoChat. (2026). Citation check: Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms. https://app.cochat.ai/papers/10.1182/bloodadvances.2020001636
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Lewis, N. E., Petrova-Drus, K., Huet, S., Epstein-Peterson, Z. D., Gao, Q., Sigler, A. E., Baik, J., Ozkaya, N., Moskowitz, A. J., Kumar, A., Horwitz, S. M., Zhang, Y., Arcila, M. E., Levine, R. L., Roshal, M., Dogan, A., & Xiao, W. (2020). Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms. Blood Advances. https://doi.org/10.1182/bloodadvances.2020001636