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Teclistamab is an active T cell–redirecting bispecific antibody against B-cell maturation antigen for multiple myeloma
Open accessAbstract
B-cell maturation antigen (BCMA), a member of the tumor necrosis factor family of receptors, is predominantly expressed on the surface of terminally differentiated B cells. BCMA is highly expressed on plasmablasts and plasma cells from multiple myeloma (MM) patient samples. We developed a BCMAxCD3 bispecific antibody (teclistamab [JNJ-64007957]) to recruit and activate T cells to kill BCMA-expressing MM cells. Teclistamab induced cytotoxicity of BCMA+ MM cell lines in vitro (H929 cells, 50% effective concentration [EC50] = 0.15 nM; MM.1R cells, EC50 = 0.06 nM; RPMI 8226 cells, EC50 = 0.45 nM) with concomitant T-cell activation (H929 cells, EC50 = 0.21 nM; MM.1R cells, EC50 = 0.1 nM; RPMI 8226 cells, EC50 = 0.28 nM) and cytokine release. This activity was further increased in the presence of a γ-secretase inhibitor (LY-411575). Teclistamab also depleted BCMA+ cells in bone marrow samples from MM patients in an ex vivo assay with an average EC50 value of 1.7 nM. Under more physiological conditions using healthy human whole blood, teclistamab mediated dose-dependent lysis of H929 cells and activation of T cells. Antitumor activity of teclistamab was also observed in 2 BCMA+ MM murine xenograft models inoculated with human T cells (tumor inhibition with H929 model and tumor regression with the RPMI 8226 model) compared with vehicle and antibody controls. The specific and potent activity of teclistamab against BCMA-expressing cells from MM cell lines, patient samples, and MM xenograft models warrant further evaluation of this bispecific antibody for the treatment of MM. Phase 1 clinical trials (monotherapy, #NCT03145181; combination therapy, #NCT04108195) are ongoing for patients with relapsed/refractory MM.
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“This effect occurs regardless of T-cell–receptor specificity or major histocompatibility complex class I molecules on the surface of myeloma cells.18”
From Teclistamab in Relapsed or Refractory Multiple Myeloma (2022) · cites this paper as [18]
In the citing paper
“Teclistamab redirects CD3+ T cells to BCMA+ myeloma cells, resulting in T-cell activation and subsequent lysis and death of BCMA+ cells.18”
From Teclistamab in Relapsed or Refractory Multiple Myeloma (2022) · cites this paper as [18]
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BackgroundElotuzumab Therapy for Relapsed or Refractory Multiple Myeloma
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BackgroundTargeting CD38 with Daratumumab Monotherapy in Multiple Myeloma
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“Within the past decade, the introduction of proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies has changed the landscape of myeloma management, leading to improved disease control and prolonged survival.(3-12) Despite these therapeutic advances, nearly all patients will eventually relapse”
Background
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“In preclinical studies, teclistamab promoted efficient cytotoxicity of MM cells in vitro, even in the presence of sBCMA, and tumor regression in vivo [55].”
BackgroundReal-world analysis of teclistamab in 123 RRMM patients from Germany
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“In addition, pretreatment or combination with anti-CD38 MoAb, such as daratumumab, or a g-secretase inhibitor further enhanced MM cell lysis (37).”
BackgroundA pivotal decade for bispecific antibodies?
Surowka, M., & Klein, C. (2024) · mAbs · doi:10.1080/19420862.2024.2321635 · Cited by 64
“…2) the CD20/CD3ε TCEs mosunetuzumab for the treatment of R/R non-Hodgkin’s lymphoma (NHL), 51 and glofitamab 53 and epcoritamab 44 for the treatment of R/R DLBCL, and 3) the BCMA/CD3ε TCEs teclistamab 43 and elranatamab, 47 and GPRC5D/CD3ε talquetamab, 45 for the treatment of R/R multiple myeloma.”
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“The first BCMA-specific Ab drug conjugate (ADC) belantamab mafodotin was approved by FDA to treat heavily pretreated RRMM in 2020 [7], quickly followed by the approval of the anti-BCMA chimeric antigen receptor (CAR)-T therapies idecabtagene vicleucel (ide-cel) [8, 9] and ciltacabtagene autoleucel [10], as well as the…”
BackgroundGirgis, S., Lin, S. X. W., Pillarisetti, K., Verona, R. I., Vieyra, D. S., Casneuf, T., Fink, D., Miao, X., Chen, Y., Stephenson, T., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022007625 · Cited by 55
“Preclinical studies have also indicated that incubation with sBCMA (up to 166 nM) had minimal effect on the cytotoxicity potential of teclistamab.(13)”
BackgroundSelf-citationMarkouli, M., Ullah, F., Unlu, S., Omar, N., Lopetegui-Lia, N., Duco, M. R., Anwer, F., Raza, S., & Dima, D. (2023) · Current Oncology · doi:10.3390/curroncol30070467 · Cited by 51
“TEC is the only approved bsAb for clinical use in RRMM [41].”
BackgroundEpidemiology, genetics and treatment of multiple myeloma and precursor diseases
Hemminki, K., Försti, A., Houlston, R. S., & Sud, A. (2021) · International Journal of Cancer · doi:10.1002/ijc.33762 · Cited by 61
Zhou, X., Rasche, L., Kortüm, K. M., Mersi, J., & Einsele, H. (2022) · Haematologica · doi:10.3324/haematol.2020.266841 · Cited by 59
“LY-411575 and nirogacestat, is currently under clinical investigation in phase 1 trials (80, 81).”
BackgroundCD8 effector T cells enhance teclistamab response in BCMA-exposed and -naïve multiple myeloma
Firestone, R., McAvoy, D. P., Shekarkhand, T., Serrano, E., Hamadeh, I. S., Wang, A., Zhu, M., Qin, W. G., Patel, D., Tan, C. R. C., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023011225 · Cited by 53
Carretero-Iglesia, L., Hall, O. J., Berret, J., Pais, D., Estoppey, C., Chimen, M., Monney, T., Loyau, J., Dreyfus, C., Macoin, J., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00821-1 · Cited by 56
“APRIL, sBCMA and sCD38 are found at higher levels in the serum of patients with MM compared to healthy donors (HDs) (up to 50-, 10-and fourfold, respectively) 2,22,23 .”
Ramasamy, K., Gay, F., Weisel, K. C., Zweegman, S., Mateos, M., & Richardson, P. G. G. (2021) · Blood Reviews · doi:10.1016/j.blre.2021.100808 · Cited by 55
Miao, X., Wu, L. S., Lin, S. X. W., Xu, Y. C., Chen, Y., Iwaki, Y., Kobos, R., Stephenson, T., Kemmerer, K., Uhlar, C., et al. (2023) · Targeted Oncology · doi:10.1007/s11523-023-00989-z · Cited by 48
“…therapies for heavily pretreated patients with RRMM. Teclistamab is the first BCMA × CD3 bispecific antibody approved for the treatment of triple-class–exposed RRMM. Teclistamab redirects CD3+ T cells to mediate T-cell activation and subsequent lysis of BCMA-expressing multiple myeloma cells [14].”
BackgroundConnolly, K., Brungs, D., Szeto, E., & Epstein, R. J. (2013) · Current Oncology · doi:10.3747/co.21.1661 · Cited by 42
Díez-Alonso, L., Falgàs, A., Arroyo-Ródenas, J., Romencín, P. A., Martínez, A., Gómez-Rosel, M., Blanco, B., Jiménez-Reinoso, A., Mayado, A., Pérez-Pons, A., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adg7962 · Cited by 31
“BCMA shedding is an obstacle to BCMA-targeted therapies both by reducing cell surface BCMA density and by acting as a decoy that neutralizes the activity of redirected T cells, as reported for BCMA-specific CAR-T cells ( 20 ); however, the impact on TCE-based therapies is considerably lower ( 21 ).”
BackgroundT-Cell Engagers—The Structure and Functional Principle and Application in Hematological Malignancies
Cech, P., Skórka, K., Dziki, L., & Giannopoulos, K. (2024) · Cancers · doi:10.3390/cancers16081580 · Cited by 42
“Teclistamab (JNJ-7957) is a humanized BsAb developed by Janssen on the Duobody platform, targeting BCMA and CD3 [96].”
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“Multiple other T-cell engagers targeting BCMA are now in clinical trials (70, 71).”
BackgroundTeclistamab: Mechanism of action, clinical, and translational science
Guo, Y., Cardé, N. A. Q., Kang, L., Verona, R. I., Banerjee, A., Kobos, R., Chastain, K. M., Uhlar, C., Pillarisetti, K., Doyle, M., et al. (2024) · Clinical and Translational Science · doi:10.1111/cts.13717 · Cited by 33
“Nonetheless, patients who responded to teclistamab had higher induction of interferon-γ (IFN-γ ), interleukin-6 (IL-6), IL-10, and IL-2 receptor α , as well as surface levels of CD38 or TIM-3 on CD8 + T cells after teclistamab administration.”
BackgroundSelf-citationNovellis, D. D., Fontana, R., Giudice, V., Serio, B., & Selleri, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010645 · Cited by 34
Shin, H. G., Yang, H. R., Yoon, A., & Lee, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105686 · Cited by 35
“Teclistamab (JNJ-64007957) is a CD3- and BCMA-specific bsAb-based T-cell engager based on the DuoBody platform [282].”
BackgroundAnti-BCMA novel therapies for multiple myeloma
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“Teclistamab is an off-the-shelf, T-cell-redirecting, B-cell maturation antigen (BCMA) 9 CD3 bispecific antibody that mediates T-cell activation and subsequent lysis of BCMA-expressing myeloma cells [13, 14].”
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“Teclistamab is an IgG4 engineered antibody targeting CD3 and BCMA that showed cytotoxic activity in vitro by T cell activation and cytokine release [97].”
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“0003 mg/kg administered intravenously once every two weeks [8], was determined from the mean 20% of maximum effect (EC20) from an in vitro cytotoxicity assay using isolated T cells [4].”
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“This effect occurs regardless of the specificity of the T-cell receptor or class I major histocompatibility complex molecules on the surface of myeloma cells [81].”
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Martino, E. A., Bruzzese, A., Labanca, C., Mendicino, F., Lucia, E., Olivito, V., Neri, A., Morabito, F., Vigna, E., & Gentile, M. (2023) · European Journal Of Haematology · doi:10.1111/ejh.14121 · Cited by 22
“24 The antibody, in particular, was found to be capable of inducing cytotoxicity of MM cell lines expressing BCMA, as well as concomitant T-cell activation and consequent cytokines release.”
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Martin, T. G., Moreau, P., Usmani, S. Z., Garfall, A. L., Mateos, M., Miguel, J. F. S., Oriol, A., Nooka, A. K., Rosiñol, L., Chari, A., et al. (2023) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2023.11.001 · Cited by 17
Differential Diagnosis and Therapeutic Advances in Multiple Myeloma: A Review Article
Hussain, M., Yellapragada, S. V., & Hadidi, S. A. (2023) · Blood and Lymphatic Cancer Targets and Therapy · doi:10.2147/blctt.s272703 · Cited by 18
Structure and function of therapeutic antibodies approved by the US FDA in 2024
Strohl, W. R. (2025) · Antibody Therapeutics · doi:10.1093/abt/tbaf014 · Cited by 16
Advances in the clinical application of bispecific antibodies in cancer therapy
Zhou, S., Feng, L., Niu, M., Wu, K., Li, T., & Yi, M. (2025) · iScience · doi:10.1016/j.isci.2025.114203 · Cited by 17
Murtadha, M., Park, M., Zhu, Y., Caserta, E., Napolitano, O., Tandoh, T., Moloudizargari, M., Pozhitkov, A. E., Singer, M., Donà, A., et al. (2024) · Blood · doi:10.1182/blood.2023021570 · Cited by 15
Liao, X., Qi, T., Zhou, J., Liu, C., & Cao, Y. (2024) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3302 · Cited by 15
Lang, Y., Lyu, Y., Tan, Y., & Hu, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1195194 · Cited by 15
Greenberg, R. S., Ruddy, J. A., Boyarsky, B. J., Werbel, W. A., Garonzik‐Wang, J., Segev, D. L., & Imus, P. H. (2021) · BMC Cancer · doi:10.1186/s12885-021-09097-5 · Cited by 14
“Teclistamab induces T cell-mediated destruction of B-cell maturation antigen (BCMA) positive B-cells [16].”
BackgroundPan, D., & Richter, J. R. (2023) · Cancer Management and Research · doi:10.2147/cmar.s372237 · Cited by 15
“Activated T cells also release cytokines such as IL-2, IL-6, IL-10, and IFNγ which contribute to their efficacy.(1,11) Preclinical studies have found no association between degree of BCMA expression on myeloma samples and teclistamab efficacy.”
BackgroundTargeting BCMA in Multiple Myeloma
Tan, C. R. C., & Shah, U. A. (2021) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-021-00639-z · Cited by 12
Targeting CD276 for T cell-based immunotherapy of breast cancer
Hagelstein, I., Wessling, L., Rochwarger, A., Zekri, L., Klimovich, B., Tegeler, C. M., Jung, G., Schürch, C. M., Salih, H. R., & Lutz, M. S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05689-4 · Cited by 12
“…of impressive clinical results with bsAbs include the CD20 and CD3 targeting bsAbs mosunetuzumab as well as glofitamab for the treatment of relapsed or refractory lymphoma [23–25] and the BCMA-directed constructs teclistamab as well as elranatamab for treatment of multiple myeloma [26, 27].”
BackgroundVolta, L. G., Myburgh, R., Hofstetter, M., Koch, C., Kiefer, J. D., Gobbi, C., Manfredi, F., Zimmermann, K., Kaufmann, P. A., Fazio, S., et al. (2024) · HemaSphere · doi:10.1002/hem3.70055 · Cited by 12
Pharmacological Profile of Novel Anti-cancer Drugs Approved by USFDA in 2022: A Review
Sangwan, K., Sharma, V., & Goyal, P. K. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230622151034 · Cited by 12
When and How to Treat Relapsed Multiple Myeloma
Nathwani, N., Bertamini, L., Banerjee, R. K., Gay, F., Shah, N. D., & Krishnan, A. Y. (2021) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_320129 · Cited by 14
Multi-targeted immunotherapeutics to treat B cell malignancies
Gambles, M. T., Yang, J., & Kopec̆ek, J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.04.048 · Cited by 12
Why Immunotherapy Fails in Multiple Myeloma
Rodríguez‐Lobato, L. G., Oliver‐Caldés, A., Moreno, D. F., de Larrea, C. F., & Bladé, J. (2020) · Hemato · doi:10.3390/hemato2010001 · Cited by 11
“In preclinical studies, the drug proved capable of recruiting and activating T cells to direct their cytotoxicity against BCMA+ MM cells from an MM cell line (H929) and in BM samples obtained from patients with MM as well [113].”
BackgroundBarilà, G., Rizzi, R., Zambello, R., & Musto, P. (2021) · Pharmaceuticals · doi:10.3390/ph14010040 · Cited by 11
“Teclistamab (formerly JNJ-64007957) is a humanized IgG-4 bases BCMA × CD3 bispecific antibody that induces T cell-mediated cytotoxicity against BCMA-expressing MM cells [63].”
BackgroundTaking a BiTE out of the CAR T space race
Patel, A., Oluwole, O. O., Savani, B. N., & Dholaria, B. (2021) · British Journal of Haematology · doi:10.1111/bjh.17622 · Cited by 10
Straßl, I., Schreder, M., Steiner, N., Rudzki, J. D., Agis, H., Kunz, T., Müser, N., Willenbacher, W., Petzer, A. L., Neumeister, P., et al. (2021) · Cancers · doi:10.3390/cancers13184701 · Cited by 10
Applications of pharmacometrics in drug development
Xiong, Y., Samtani, M. N., & Ouellet, D. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115503 · Cited by 9
Guo, Y., Niu, J., Cardé, N. A. Q., Wu, L. S., Miao, X., Hanson, S., Su, Y., Pérez‐Ruixo, C., Vishwamitra, D., Chastain, K. M., et al. (2025) · Targeted Oncology · doi:10.1007/s11523-025-01149-1 · Cited by 9
“The pharmacokinetics (PK) and pharmacodynamics (PD) of teclistamab have previously been characterized in detail, supporting the selection of the recommended phase II dose (RP2D) of subcutaneous (SC) teclistamab 1.5 mg/ kg QW following step-up dosing [17–20].”
InfluentialGrahnert, A., Seiffert, S., Wenk, K., Schmiedel, D., Boldt, A., Vučinić, V., Merz, M., Platzbecker, U., Klemann, C., Koehl, U., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12081641 · Cited by 8
Update on B‐cell maturation antigen‐directed therapies in AL amyloidosis
Jamroziak, K., Zielonka, K., Khwaja, J., & Wechalekar, A. D. (2025) · British Journal of Haematology · doi:10.1111/bjh.19960 · Cited by 11
Charkviani, M., Vargas-Brochero, M. J., Mohan, A., Vaughan, L. E., Sandahl, T. B., Corraes, A. D. M. S., Lin, Y., Leung, N., & Herrmann, S. M. (2025) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaf004 · Cited by 8
Li, W., Zhao, D., Yu, J., Dong, W., Wang, Z., & Yan, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1565407 · Cited by 8
Teclistamab impairs detection of BCMA CAR-T cells
Glatte, B., Wenk, K., Grahnert, A., Friedrich, M., Merz, M., Vučinić, V., Fischer, L., Reiche, K., Alb, M., Hudecek, M., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023009714 · Cited by 8
Wijnands, C., Karel, P. G. A., Gloerich, J., Armony, G., Tzasta, A., Angelino, C. M. D. K., Stéfano, L. D., Bonifay, V., Luider, T. M., VanDuijn, M. M., et al. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17010135 · Cited by 7
“…advancements in the field of MM therapeutics have led to the development of new agents including T-cell-redirecting bispecific antibodies (bsAbs) which bind simultaneously to CD3 on the T-cell and to an epitope present on MM cells (e.g., BCMA for teclistamab or GPRC5D for talquetamab) [7,8].”
Mechanism-Driven Design of Multispecific Antibodies for Targeted Disease Treatment
Fine, J., Meksiriporn, B., Tan, J., & Spangler, J. B. (2024) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-100522-102155 · Cited by 7
Haustrate, A., Cordier, C., Shapovalov, G., Mihalache, A., Desruelles, E., Soret, B., Essonghé, N. C., Spriet, C., Yassine, M., Barras, A., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06809-0 · Cited by 7
Xie, Z., & Protzer, U. (2024) · Antiviral Research · doi:10.1016/j.antiviral.2024.105972 · Cited by 10
Melflufen for the treatment of multiple myeloma
Ocio, E. M., Nadeem, O., Schjesvold, F. H., Gay, F., Touzeau, C., Dimopoulos, M. A., Richardson, P. G. G., & Mateos, M. (2022) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2022.2075847 · Cited by 8
“CC93269, teclistamab) [13,14], antibody-drug conjugates (e.”
Lapietra, G., Fazio, F., & Petrucci, M. T. (2022) · Biomolecules · doi:10.3390/biom12081146 · Cited by 8
“In vitro assays showed that this drug induces cytotoxicity of BCMA+ cells through multiple mechanisms, including dose-dependent lysis, T-cell activation, and cytokine release, especially if in the presence of a γ-secretase inhibitor [71].”
BackgroundWang, M., Wang, C., Deng, J., Wang, H., Sun, C., Luo, S., & Hu, Y. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2906216 · Cited by 9
“Teclistamab is a humanized IgG bsAb that targets BCMA and CD3 [40].”
BackgroundBispecific Antibodies for the Treatment of Multiple Myeloma
Goldsmith, S. R., Streeter, S., & Covut, F. (2022) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-022-00675-3 · Cited by 6
Update on bi-specific monoclonal antibodies for blood cancers
Shouse, G. (2023) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000966 · Cited by 4
Large scale controlled Fab exchange GMP process to prepare bispecific antibodies
Yao, X., Xie, M., Ben, Y., Zhu, Y., Yang, G., Kwong, S. C. W., Zhang, Z., & Chiu, M. L. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1298890 · Cited by 6
Willemin, M., Lin, S. X. W., Zwart, L. D., Wu, L. S., Miao, X., Verona, R. I., Banerjee, A., Liu, B., Kobos, R., Qi, M., et al. (2024) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.13144 · Cited by 6
“17,18 The accelerated approval of te-clistamab was based on the pivotal portion of the phase I/ II MajesTEC-1 trial (NCT03145181/NCT04557098), which assessed the efficacy and safety of teclistamab at the recommended phase II dose (RP2D; once weekly 1.5 mg/kg subcutaneous) in patients with TCE RRMM.…”
MethodInfluentialBispecific Antibodies in the Treatment of Multiple Myeloma
Zhou, X., Xiao, X., Kortuem, K. M., & Einsele, H. (2024) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2023.12.003 · Cited by 5
Segers, F., & Delforge, M. (2026) · Targeted Oncology · doi:10.1007/s11523-025-01189-7 · Cited by 4
“In co-culture experiments, low concentrations of sBCMA, APRIL or BAFF did not interfere with the cytotoxic effect [33].”
Kim, H., & Kim, Y. K. (2025) · Han-guk hyeonmigyeong hakoeji/Applied microscopy · doi:10.1186/s42649-024-00106-y · Cited by 4
“For example, researchers can utilize CLEM to observe how a BsAb engages with tumor cells and the resultant formation of immune synapses in real-time (Chan et al. 2018; Pillarisetti et al. 2020).”
Wang, Z., Song, Y., Guo, H., Yan, Y., Ma, L., & Liu, B. (2025) · Current Treatment Options in Oncology · doi:10.1007/s11864-025-01290-z · Cited by 3
“Teclistamab, a bispecific antibody targeting BCMA and CD3 from the surface of T cells, mediates T cell activation and lysis of BCMA-expressing myeloma cells [33].”
BCMA CAR-T: From Multiple Myeloma to Light-Chain Amyloidosis
Lewis, E., & Jimenez-Zepeda, V. H. (2025) · Current Oncology · doi:10.3390/curroncol32080418 · Cited by 4
Menon, V. C. A., Matsuura, T., Holkova, B., Gudi, G. S., Drake, A. C. B., Pihlgren, M., van der Graaf, P. H., Gn, S., Garton, A., Perro, M., et al. (2026) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.70319 · Cited by 3
Kikuchi, J., Osada, N., Matsuoka, S., Yasui, H., Furukawa, Y., & Nakasone, H. (2025) · Leukemia · doi:10.1038/s41375-025-02792-3 · Cited by 3
Metadata
- Authors
- Pillarisetti, K., Powers, G., Luistro, L., Babich, A., Baldwin, E., Li, Y., Zhang, X., Mendonça, M., Majewski, N., Nanjunda, R., Chin, D., Packman, K., Elsayed, Y., Attar, R., & Gaudet, F.
- Affiliations
- Oncology and
- Janssen Research & Development (United States) (US)
- IBM (United States) (US)
- Legend Biotech (United States) (US)
- Century Therapeutics (United States) (US)
- Venue
- Blood Advances
- Publisher
- American Society of Hematology
- Published
- 2020-09-21
- Volume
- 4
- Issue
- 18
- Pages
- 4538-4549
- ISSN
- 2473-9529 (ISSN-L)
- 2473-9537
- PMC
- PMC7509877
- OpenAlex
- W3087111554
- Cited by
- 144
- References
- 40
- Citations by year
- 2026: 23 · 2025: 21 · 2024: 31 · 2023: 27 · 2022: 19 · 2021: 20 · 2020: 1
- FWCI
- 10.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Blood Advances (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Keywords
- teclistamab, BCMA, multiple myeloma, bispecific antibodies, T cell redirection, T cell activation, gamma-secretase inhibitors, tumor cell lysis, xenograft models, relapsed/refractory multiple myeloma
- MeSH terms
- Animals, Humans, Lymphocyte Activation, Multiple Myeloma, T-Lymphocytes, Antibodies, Bispecific, Mice, B-Cell Maturation Antigen
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