The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation
Abstract
Key Points: Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis. Children with trisomy 21 who exhibit clonal hematopoiesis display cytokine and gene expression profiles indicative of disrupted immunity.
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“Among individuals with rare Mendelian cancer predisposition syndromes, carriers often show distinct CH mutational profiles reflecting strong selective pressures18–21.”
From Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy (2025) · cites this paper as [21]
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Cites
Clonal hematopoiesis in human aging and disease
Jaiswal, S., & Ebert, B. L. (2019) · Science · doi:10.1126/science.aan4673 · Cited by 1,156 · cited 4×
“This interplay is evident in clonal hematopoiesis (CH), in which human hematopoietic stem and progenitor cells acquire driver mutations that promote their clonal expansion.(1) Although hematopoietic clonality is rare in young people, the incidence dramatically increases after midlife.”
BackgroundInfluentialClonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
Young, A. L., Challen, G. A., Birmann, B. M., & Druley, T. E. (2016) · Nature Communications · doi:10.1038/ncomms12484 · Cited by 692
Trisomy 21 consistently activates the interferon response
Sullivan, K. D., Lewis, H. C., Hill, A. A., Pandey, A., Jackson, L. P., Cabral, J. M., Smith, K. P., Liggett, L. A., Gomez, E. B., Galbraith, M. D., et al. (2016) · eLife · doi:10.7554/elife.16220 · Cited by 362
Self-citationCancer as a disease of old age: changing mutational and microenvironmental landscapes
Laconi, E., Marongiu, F., & DeGregori, J. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0721-1 · Cited by 348
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Research works printed but not linked: 16
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- Van Rhijn, 2014, TCR bias and affinity define two compartments of the CD1b-glycolipid-specific T cell repertoire, J Immunol, 192, 4054, 10.4049/jimmunol.1400158 · DOI
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Cited by
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
Florez, M. A., Tran, B. T., Wathan, T. K., DeGregori, J., Pietras, E. M., & King, K. Y. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.05.006 · Cited by 129
Self-citationClonal hematopoiesis and inflammation – the perpetual cycle
Avagyan, S., & Zon, L. I. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.12.001 · Cited by 79
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy
Liu, J., Tran, D., Xue, L., Wiley, B. J., Vlasschaert, C., Watson, C. J., MacGregor, H. A. J., Zong, X., Chan, I. C. C., Das, I., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02250-x · Cited by 33
Metadata
- Authors
- Liggett, L. A., Galbraith, M. D., Smith, K. P., Sullivan, K. D., Granrath, R. E., Enriquez-Estrada, B., Kinning, K. T., Shaw, J. R., Rachubinski, A. L., Espinosa, J. M., & DeGregori, J.
- Venue
- Blood Advances
- Publisher
- American Society of Hematology
- Published
- 2021-03-31
- Volume
- 5
- Issue
- 7
- Pages
- 1791-1796
- ISSN
- 2473-9529
- 2473-9537
- Cited by
- 17
- References
- 4
- Language
- en
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