The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding
Open accessAbstract
All available evidence today indicates that chronic thromboembolic pulmonary hypertension (CTEPH) is primarily caused by venous thromboembolism, as opposed to primary pulmonary vascular in situ thrombosis. Both the initial magnitude of clot and pulmonary embolism (PE) recurrence may contribute to the development of CTEPH. Only few specific thrombophilic factors, such as phospholipid antibodies, lupus anticoagulant and elevated factor VIII, are statistically associated with CTEPH. A mechanistic view of CTEPH as a disease caused by obliteration of central pulmonary arteries by pulmonary emboli is too simplistic. Based on available data one may speculate that PE may be followed by a pulmonary vascular remodelling process modified by infection, immune phenomena, inflammation, circulating and vascular-resident progenitor cells, thyroid hormone replacement or malignancy. Both plasmatic factors (hypercoagulation, “sticky” red blood cells, high platelet counts and uncleavable fibrinogens) and a misguided vascular remodelling process contribute to major vessel and small vessel obliteration. Endothelial dysfunction and endothelial–mesenchymal transition may be important, but their precise roles remain obscure. There exists no animal model for CTEPH; therefore, experimentation in the future must include human tissues and clinical data in parallel.
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Citations
Cites
Incidence of Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Embolism
Pengo, V., Lensing, A. W. A., Prins, M. H., Marchiori, A., Davidson, B. L., Tiozzo, F., Albanese, P., Biasiolo, A., Pegoraro, C., Iliceto, S., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032274 · Cited by 1,828
Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome
PENGO, V., RUFFATTI, A., LEGNANI, C., GRESELE, P., BARCELLONA, D., ERBA, N., TESTA, S., MARONGIU, F., BISON, E., DENAS, G., et al. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03674.x · Cited by 632
Pengo, V., Ruffatti, A., Legnani, C., Testa, S., Fierro, T., Marongiu, F., De Micheli, V., Gresele, P., Tonello, M., Ghirarduzzi, A., et al. (2011) · Blood · doi:10.1182/blood-2011-03-340232 · Cited by 468
Prandoni, P., Prins, M. H., Lensing, A. W. A., Ghirarduzzi, A., Ageno, W., Imberti, D., Scannapieco, G., Ambrosio, G. B., Pesavento, R., Cuppini, S., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-9-200905050-00003 · Cited by 232
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Cited by
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N., Humbert, M., Vachiery, J.-L., Gibbs, S., Lang, I., Torbicki, A., Simonneau, G., Peacock, A., Vonk Noordegraaf, A., Beghetti, M., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv317 · Cited by 6,931
Self-citationGaliè, N., Humbert, M., Vachiery, J.-L., Gibbs, S., Lang, I., Torbicki, A., Simonneau, G., Peacock, A., Vonk Noordegraaf, A., Beghetti, M., et al. (2015) · European Respiratory Journal · doi:10.1183/13993003.01032-2015 · Cited by 3,172
Self-citation2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism
Authors/Task Force Members, Konstantinides, S. V., Torbicki, A., Agnelli, G., Danchin, N., Fitzmaurice, D., Galiè, N., Gibbs, J. S. R., Huisman, M. V., Humbert, M., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu283 · Cited by 3,128
Self-citationEnde-Verhaar, Y. M., Cannegieter, S. C., Vonk Noordegraaf, A., Delcroix, M., Pruszczyk, P., Mairuhu, A. T. A., Huisman, M. V., & Klok, F. A. (2017) · European Respiratory Journal · doi:10.1183/13993003.01792-2016 · Cited by 521
The post-PE syndrome: a new concept for chronic complications of pulmonary embolism
Klok, F. A., van der Hulle, T., den Exter, P. L., Lankeit, M., Huisman, M. V., & Konstantinides, S. (2014) · Blood Reviews · doi:10.1016/j.blre.2014.07.003 · Cited by 441
Metadata
- Authors
- Lang, I. M., Pesavento, R., Bonderman, D., & Yuan, J. X.-J.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2012-06-14
- Volume
- 41
- Issue
- 2
- Pages
- 462-468
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2113319085
- Cited by
- 456
- References
- 4
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Lang, I. M., Pesavento, R., Bonderman, D., & Yuan, J. X.-J. (2013). Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding. European Respiratory Journal. https://doi.org/10.1183/09031936.00049312
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
