The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Lung microbiome dynamics in COPD exacerbations
Open accessAbstract
Increasing evidence suggests that the lung microbiome plays an important role in chronic obstructive pulmonary disease (COPD) severity. However, the dynamics of the lung microbiome during COPD exacerbations and its potential role in disease aetiology remain poorly understood. We completed a longitudinal 16S ribosomal RNA survey of the lung microbiome on 476 sputum samples collected from 87 subjects with COPD at four visits defined as stable state, exacerbation, 2 weeks post-therapy and 6 weeks recovery. Our analysis revealed a dynamic lung microbiota where changes appeared to be associated with exacerbation events and indicative of specific exacerbation phenotypes. Antibiotic and steroid treatments appear to have differential effects on the lung microbiome. We depict a microbial interaction network for the lung microbiome and suggest that perturbation of a few bacterial operational taxonomic units, in particular Haemophilus spp., could greatly impact the overall microbial community structure. Furthermore, several serum and sputum biomarkers, in particular sputum interleukin-8, appear to be highly correlated with the structure and diversity of the microbiome. Our study furthers the understanding of lung microbiome dynamics in COPD patients and highlights its potential as a biomarker, and possibly a target, for future respiratory therapeutics.
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Cites
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Cited by
Microbiome effects on immunity, health and disease in the lung
Shukla, S. D., Budden, K. F., Neal, R., & Hansbro, P. M. (2017) · Clinical & Translational Immunology · doi:10.1038/cti.2017.6 · Cited by 287
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The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases
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Metadata
- Authors
- Wang, Z., Bafadhel, M., Haldar, K., Spivak, A., Mayhew, D., Miller, B. E., Tal-Singer, R., Johnston, S. L., Ramsheh, M. Y., Barer, M. R., Brightling, C. E., & Brown, J. R.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2016-02-25
- Volume
- 47
- Issue
- 4
- Pages
- 1082-1092
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2333373066
- Cited by
- 459
- References
- 11
- FWCI
- 29.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, Z., Bafadhel, M., Haldar, K., Spivak, A., Mayhew, D., Miller, B. E., Tal-Singer, R., Johnston, S. L., Ramsheh, M. Y., Barer, M. R., Brightling, C. E., & Brown, J. R. (2016). Lung microbiome dynamics in COPD exacerbations. European Respiratory Journal. https://doi.org/10.1183/13993003.01406-2015
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