The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age
Open accessAbstract
Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene–environment interactions using longitudinal data from an established cohort study. Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathioneS-transferase gene variants. Living <200 m from a major road was associated with increased prevalence of current asthma and wheeze, and lower lung function. The association between living <200 m from a major road and current asthma and wheeze was more marked for carriers of theGSTT1null andGSTP1 val/valorile/valgenotypes. Over the 5-year period, higher NO2exposures were associated with increased current asthma prevalence. Higher NO2exposure was associated with lower forced vital capacity for carriers of theGSTT1null genotype. TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with theGSTT1genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.
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“Residential markers of traffic-related air pollution, including nitrogen dioxide (NO2) exposure and distance to major roads, have been associated with increased risk for new-onset asthma, persistence of asthma and current asthma in a middle-aged, asthma-enriched, population-based cohort (125).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [125]
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Miller, M. R., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R., Coates, A., Crapo, R., Enright, P., van der Grinten, C. P. M., Gustafsson, P., et al. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00034805 · Cited by 15,627
Quanjer, P. H., Stanojevic, S., Cole, T. J., Baur, X., Hall, G. L., Culver, B. H., Enright, P., Hankinson, J., Ip, M., Zheng, J., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00080312 · Cited by 5,944
Oxidative Stress and Antioxidant Defense
Birben, E., Şahiner, Ü. M., Saçkesen, C., ERZURUM, S. C., & Kalaycı, Ö. (2012) · World Allergy Organization Journal · doi:10.1097/wox.0b013e3182439613 · Cited by 5,190
Asthma phenotypes: the evolution from clinical to molecular approaches
Wenzel, S. E. (2012) · Nature Medicine · doi:10.1038/nm.2678 · Cited by 2,498
Outdoor air pollution and asthma.
Guarnieri, M., & Balmes, J. R. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60617-6 · Cited by 1,889
Eder, W., Ege, M. J., & von Mutius, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054308 · Cited by 1,621
Textor, J. C., Hardt, J., & Knüppel, S. (2011) · Epidemiology · doi:10.1097/ede.0b013e318225c2be · Cited by 1,227
Concentration and Size Distribution of Ultrafine Particles Near a Major Highway
Zhu, Y., Hinds, W. C., Kim, S., & Sioutas, C. (2002) · Journal of the Air & Waste Management Association · doi:10.1080/10473289.2002.10470842 · Cited by 1,002
Near-Roadway Air Quality: Synthesizing the Findings from Real-World Data
Karner, A. A., Eisinger, D. S., & Niemeier, D. (2010) · Environmental Science & Technology · doi:10.1021/es100008x · Cited by 773
Brugge, D., Durant, J. L., & Rioux, C. L. (2007) · Environmental Health · doi:10.1186/1476-069x-6-23 · Cited by 540
Janssen, N., Brunekreef, B., van Vliet, P., Aarts, F., Meliefste, K., Harssema, H., & Fischer, P. H. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6243 · Cited by 422
Long-term air pollution exposure and living close to busy roads are associated with COPD in women
Schikowski, T., Sugiri, D., Ranft, U., Gehring, U., Heinrich, J., Wichmann, H. ‐., & Krämer, U. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-152 · Cited by 418
Ackermann-Liebrich, U. A., Leuenberger, P., Schwartz, J. D., Schindler, C., Monn, C., BOLOGNINI, G., Bongard, J. P., Brändli, O., Domenighetti, G. M., Elsässer, S., et al. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001300 · Cited by 386
Adam, M., Schikowski, T., Carsin, A., Cai, Y. S., Jacquemin, B., Sanchez, M., Vierkötter, A., Marcon, A., Keidel, D., Sugiri, D., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00130014 · Cited by 383
Rice, M. B., Ljungman, P. L. S., Wilker, E. H., DORANS, K. S., Gold, D. R., Schwartz, J. D., Koutrakis, P., Washko, G. R., O’Connor, G. T., & Mittleman, M. A. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201410-1875oc · Cited by 291
Long-Term Ambient Air Pollution and Respiratory Symptoms in Adults (SAPALDIA Study)
Zemp, E., Elsässer, S., Schindler, C., Künzli, N., Perruchoud, A. P., Domenighetti, G. M., Medici, T., Ackermann-Liebrich, U. A., Leuenberger, P., Monn, C., et al. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.4.9807052 · Cited by 282
Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE)
Jacquemin, B., Siroux, V., Sanchez, M., Carsin, A., Schikowski, T., Adam, M., Bellisario, V., Buschka, A., Bono, R., Brunekreef, B., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408206 · Cited by 248
Knibbs, L. D., Hewson, M. G., Bechle, M. J., Marshall, J. D., & Barnett, A. G. (2014) · Environmental Research · doi:10.1016/j.envres.2014.09.011 · Cited by 186
Self-citationAmbient Air Pollution Exposure and Incident Adult Asthma in a Nationwide Cohort of U.S. Women
Young, M. T., Sandler, D. P., DeRoo, L. A., Vedal, S., Kaufman, J. D., & London, S. J. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201403-0525oc · Cited by 169
Bowatte, G., Lodge, C., Knibbs, L. D., Lowe, A. J., Erbas, B., Dennekamp, M., Marks, G. B., Giles, G. G., Morrison, S. C., Thompson, B., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.008 · Cited by 166
Self-citationResidential Proximity to Major Roads and Term Low Birth Weight
Dadvand, P., Ostro, B. D., Figueras, F., Foraster, M., Basagaña, X., Valentín, A., Martinez, D. R., Beelen, R. M. J., Cirach, M., Hoek, G., et al. (2014) · Epidemiology · doi:10.1097/ede.0000000000000107 · Cited by 158
Mechanistic impact of outdoor air pollution on asthma and allergic diseases.
Huang, S.-K., Zhang, Q., Qiu, Z., & Chung, K. F. (2015) · PubMed · doi:10.3978/j.issn.2072-1439.2014.12.13 · Cited by 142
Carlsten, C., Blomberg, A., Pui, M. M., Sandström, T., Wong, S. W., Alexis, N. E., & Hirota, J. A. (2015) · Thorax · doi:10.1136/thoraxjnl-2015-207399 · Cited by 126
Schindler, C., Keidel, D., Gerbase, M. W., Zemp, E., Bettschart, R. W., Brändli, O., Brutsche, M. H., Burdet, L., Karrer, W. L., Knöpfli, B. H., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200803-388oc · Cited by 122
Traffic-Related Air Pollution, Oxidative Stress Genes, and Asthma (ECHRS)
Castro-Giner, F., Künzli, N., Jacquemin, B., Forsberg, B., de Cid, R., Sunyer, J., Jarvis, D., Briggs, D., Vienneau, D., Norbäck, D., et al. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900589 · Cited by 99
Vehicle exhaust outside the home and onset of asthma among adults
Modig, L., Torén, K., Janson, C., Järvholm, B., & Forsberg, B. (2009) · European Respiratory Journal · doi:10.1183/09031936.00101108 · Cited by 97
Home Outdoor NO2 and New Onset of Self-Reported Asthma in Adults
Jacquemin, B., Sunyer, J., Forsberg, B., Aguilera, I., Briggs, D., García‐Esteban, R., Götschi, T., Heinrich, J., Järvholm, B., Jarvis, D., et al. (2008) · Epidemiology · doi:10.1097/ede.0b013e3181886e76 · Cited by 77
GIBSON, H. B., SILVERSTONE, H., Gandevia, B., & Hall, G. J. L. (1969) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1969.tb105698.x · Cited by 71
Ambient Particulate Matter Exhibits Direct Inhibitory Effects on Oxidative Stress Enzymes
Hatzis, C., Godleski, J. J., González‐Flecha, B., Wolfson, J. M., & Koutrakis, P. (2006) · Environmental Science & Technology · doi:10.1021/es0518732 · Cited by 63
Cohort Profile: The Tasmanian Longitudinal Health STUDY (TAHS)
Matheson, M. C., Abramson, M. J., Allen, K. J., Benke, G., Burgess, J. A., Dowty, J. G., Erbas, B., Feather, I. H., Frith, P. A., Giles, G. G., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw028 · Cited by 63
Self-citationAsthma, Genes, and Air Pollution
McCunney, R. J. (2005) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000188561.75578.bf · Cited by 57
Wu, W., Lü, J., Tang, Q., Zhang, S., Yuan, B., Li, J., Wu, D., Sun, H., Lu, C., Xia, Y., et al. (2013) · Scientific Reports · doi:10.1038/srep02258 · Cited by 52
HMOX1 and GST variants modify attenuation of FEF 25–75% decline due to PM 10 reduction
Curjuric, I., Imboden, M., Schindler, C., Downs, S. H., Hersberger, M., Liu, S. L. J., Mátyás, G., Russi, E. W., Schwartz, J. D., Thun, G. A., et al. (2009) · European Respiratory Journal · doi:10.1183/09031936.00044309 · Cited by 36
Tracing 8,600 participants 36 years after recruitment at age seven for the Tasmanian Asthma Study
Wharton, C., Dharmage, S. C., Jenkins, M. A., Dite, G. S., Hopper, J. L., Giles, G. G., Abramson, M. J., & Walters, E. H. (2006) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.2006.tb00100.x · Cited by 36
Self-citationReddy, P., Naidoo, R. N., Robins, T. G., Mentz, G. B., Li, H., London, S. J., & Batterman, S. (2012) · American Journal of Industrial Medicine · doi:10.1002/ajim.22012 · Cited by 33
Lazarevic, N., Dobson, A. J., Barnett, A. G., & Knibbs, L. D. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008714 · Cited by 30
Self-citationGSTP1is a hub gene for gene-air pollution interactions on childhood asthma
Su, M., Tsai, C., Tung, K., Hwang, B., Liang, P., Chiang, B., Yang, Y., & Lee, Y. L. (2013) · Allergy · doi:10.1111/all.12298 · Cited by 28
Do Variants in GSTs Modify the Association between Traffic Air Pollution and Asthma in Adolescence?
Bowatte, G., Lodge, C., Lowe, A. J., Erbas, B., Dennekamp, M., Marks, G. B., Perret, J. L., Hui, J., Wjst, M., Gurrin, L. C., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040485 · Cited by 28
Self-citationJm, W., Th, U., & Jk, L. (1992) · PubMed · Cited by 11
Flagged first, then by citations
1 of the 40 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Curjuric, 2009, HMOX1 and GST variants modify attenuation of FEF25–75% decline due to PM10 reduction, Eur Respir J, 35, 505
- HEI Panel on the Health Effects of Traffic-Related Air Pollution . Traffic-Related Air Pollution: A Critical Review of the Literature on Emissions, Exposure, and Health Effects. Special Report. Boston, Health Effects Institute, 2010.
Cited by
Sorted by citations
Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200
Self-citationAssessing nitrogen dioxide (NO2) levels as a contributing factor to coronavirus (COVID-19) fatality
Ogen, Y. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138605 · Cited by 817
Nitrogen Losses and Potential Mitigation Strategies for a Sustainable Agroecosystem
Mahmud, K., Panday, D., Mergoum, A. M., & Missaoui, A. (2021) · Sustainability · doi:10.3390/su13042400 · Cited by 241
Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD
Aghapour, M., Ubags, N. D. J., Bruder, D., Hiemstra, P. S., Sidhaye, V. K., Rezaee, F., & Heijink, I. H. (2022) · European Respiratory Review · doi:10.1183/16000617.0112-2021 · Cited by 232
Impact of Outdoor Air Pollution on Indoor Air Quality in Low-Income Homes during Wildfire Seasons
Shrestha, P. M., Humphrey, J. L., Carlton, E. J., Adgate, J. L., Barton, K. E., Root, E. D., & Miller, S. L. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16193535 · Cited by 155
Metadata
- Authors
- Bowatte, G., Erbas, B., Lodge, C. J., Knibbs, L. D., Gurrin, L. C., Marks, G. B., Thomas, P. S., Johns, D. P., Giles, G. G., Hui, J., Dennekamp, M., Perret, J. L., Abramson, M. J., Walters, E. H., Matheson, M. C., & Dharmage, S. C.
- Affiliations
- The University of Melbourne (AU)
- La Trobe University (AU)
- The University of Queensland (AU)
- The University of Sydney (AU)
- UNSW Sydney (AU)
- University of Tasmania (AU)
- The University of Western Australia (AU)
- University of Limerick (IE)
- Monash University (AU)
- ORCID
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2017-10
- Volume
- 50
- Issue
- 4
- Pages
- 1602357
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2765204948
- Cited by
- 111
- References
- 40
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 15 · 2023: 11 · 2022: 17 · 2021: 13 · 2020: 20 · 2019: 15 · 2018: 9
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UTAS Research Repository (submittedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- traffic-related air pollution, asthma, wheezing, lung function, nitrogen dioxide, gene-environment interaction, glutathione S-transferase, GSTT1, GSTP1, antioxidant defense, middle-aged adults, Tasmanian Longitudinal Health Study
- MeSH terms
- Air Pollution, Asthma, Australia, Cross-Sectional Studies, Environmental Exposure, Female, Glutathione Transferase, Heterozygote, Humans, Longitudinal Studies, Lung, Male, Middle Aged, Nitrogen Dioxide, Respiratory Sounds, Severity of Illness Index, Vital Capacity, Multivariate Analysis, Logistic Models, Risk Assessment, Gene-Environment Interaction
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