Increased circulating levels of angiotensin-(1-7) in severely ill COVID-19 patients
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Abstract
Abstract The mono-carboxypeptidase Angiotensin-Converting Enzyme 2 (ACE2) is an important “player” of the renin-angiotensin system (RAS). ACE2 is also the receptor for SARS-CoV-2, the new coronavirus that causes COVID-19. It has been hypothesized that following SARS-CoV-2/ACE2 internalization Ang II level would increase in parallel to a decrease of Ang-(1-7) in COVID-19 patients. In this preliminary report, we analyzed the plasma levels of angiotensin peptides in 19 severe COVID-19 patients and 19 non-COVID-19 volunteers, to assess potential outcome associations. Unexpectedly, a significant increase in circulating Ang-(1-7) and lower Ang II plasma level were found in critically ill COVID-19 patients. Accordingly, an increased Ang-(1-7)/ Ang II ratio was observed in COVID-19 suggesting a RAS dysregulation toward an increased formation of Ang-(1-7) in these patients.
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Abnormal plasma levels of angiotensin-II and angiotensin-(1-7) have been reported in COVID-19 patients.
“Accordingly, abnormal plasma levels of Ang-II and angiotensin-(1–7) have been reported in COVID-19 patients.15, 16, 17”
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Cites
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Sustained Dysregulation of the Plasma Renin-angiotensin System in Acute COVID-19Preprint
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- Authors
- Valle Martins, A. L., da Silva, F. A., Bolais-Ramos, L., de Oliveira, G. C., Ribeiro, R. C., Pereira, D. A. A., Annoni, F., Diniz, M. M. L., Silva, T. G. F., Zivianni, B., Cardoso, A. C., Martins, J. C., Motta-Santos, D., Campagnole-Santos, M. J., Taccone, F. S., Verano-Braga, T., & Santos, R. A. S.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Université Libre de Bruxelles (BE)
- Fundação Hospitalar do Estado de Minas Gerais (BR)
- Corresponding author
- Santos, Robson Augusto Souza
- ORCID
- Venue
- ERJ Open Research
- Publisher
- European Respiratory Society (ERS)
- Published
- 2021-06-11
- Volume
- 7
- Issue
- 3
- Pages
- 00114-2021
- ISSN
- 2312-0541 (ISSN-L)
- PMC
- PMC8326714
- OpenAlex
- W3177420748
- Cited by
- 58
- References
- 14
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 14 · 2023: 12 · 2022: 19 · 2021: 5
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- ERJ Open Research (publishedVersion, cc-by-nc)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Universidade Federal de Minas Gerais
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- angiotensin-(1-7), angiotensin II, ACE2, renin-angiotensin system, COVID-19 pandemic, critically ill patients, circulating biomarkers, SARS-CoV-2
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