Increased blood angiotensin converting enzyme 2 activity in critically ill COVID-19 patients
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Critically ill #COVID19 patients display markedly increased alternative angiotensin pathway activity compared to healthy controls, reflected by increased blood ACE2 levels as well as decreased angiotensin-II and enhanced angiotensin-1–7 formationhttps://bit.ly/2MU1z4z
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Abnormal plasma levels of angiotensin-II and angiotensin-(1-7) have been reported in COVID-19 patients.
“Accordingly, abnormal plasma levels of Ang-II and angiotensin-(1–7) have been reported in COVID-19 patients.15, 16, 17”
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Cites
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., et al. (2005) · Nature Medicine · doi:10.1038/nm1267 · Cited by 3,445 · see citing works
Angiotensin-converting enzyme 2 protects from severe acute lung failure
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Renin-angiotensin-aldosterone system inhibitors in patients with Covid-19
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Angiotensin II revisited: new roles in inflammation, immunology and aging
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Paz Ocaranza, M., Riquelme, J. A., García, L., Jalil, J. E., Chiong, M., Santos, R. A. S., & Lavandero, S. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0244-8 · Cited by 561 · see citing works
Human recombinant soluble ACE2 in severe COVID-19
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Increased circulating levels of angiotensin-(1-7) in severely ill COVID-19 patients
Valle Martins, A. L., da Silva, F. A., Bolais-Ramos, L., de Oliveira, G. C., Ribeiro, R. C., Pereira, D. A. A., Annoni, F., Diniz, M. M. L., Silva, T. G. F., Zivianni, B., et al. (2021) · ERJ Open Research · doi:10.1183/23120541.00114-2021 · Cited by 58 · see citing works
Lobo, S. M., Plantefève, G., Nair, G., Joaquim Cavalcante, A., Franzin de Moraes, N., Nunes, E., Barnum, O., Berdun Stadnik, C. M., Lima, M. P., Lins, M., et al. (2024) · eClinicalMedicine · doi:10.1016/j.eclinm.2023.102383 · Cited by 27 · see citing works
- Authors
- van Lier, D., Kox, M., Santos, K., van der Hoeven, H., Pillay, J., & Pickkers, P.
- Affiliations
- Radboud University Nijmegen (NL)
- University Medical Center Groningen (NL)
- Corresponding author
- Kox, Matthijs
- Venue
- ERJ Open Research
- Publisher
- European Respiratory Society (ERS)
- Published
- 2021-01
- Volume
- 7
- Issue
- 1
- Pages
- 00848-2020
- ISSN
- 2312-0541 (ISSN-L)
- PMC
- PMC7848790
- OpenAlex
- W3128439668
- Cited by
- 73
- References
- 13
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 11 · 2023: 12 · 2022: 29 · 2021: 19
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- ERJ Open Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- COVID-19 pandemic, critically ill patients, angiotensin-converting enzyme 2, ACE2, angiotensin II, angiotensin-(1-7), blood biomarkers
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