The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
pain DETECT : a new screening questionnaire to identify neuropathic components in patients with back pain
Open accessAbstract
OBJECTIVE: Nociceptive and neuropathic components both contribute to pain. Since these components require different pain management strategies, correct pain diagnosis before and during treatment is highly desirable. As low back pain (LBP) patients constitute an important subgroup of chronic pain patients, we addressed the following issues: (i) to establish a simple, validated screening tool to detect neuropathic pain (NeP) components in chronic LBP patients, (ii) to determine the prevalence of neuropathic pain components in LBP in a large-scale survey, and (iii) to determine whether LBP patients with an NeP component suffer from worse, or different, co-morbidities. METHODS: In co-operation with the German Research Network on Neuropathic Pain we developed and validated the painDETECT questionnaire (PD-Q) in a prospective, multicentre study and subsequently applied it to approximately 8000 LBP patients. RESULTS: The PD-Q is a reliable screening tool with high sensitivity, specificity and positive predictive accuracy; these were 84% in a palm-top computerised version and 85%, 80% and 83%, respectively, in a corresponding pencil-and-paper questionnaire. In an unselected cohort of chronic LBP patients, 37% were found to have predominantly neuropathic pain. Patients with NeP showed higher ratings of pain intensity, with more (and more severe) co-morbidities such as depression, panic/anxiety and sleep disorders. This also affected functionality and use of health-care resources. On the basis of given prevalence of LBP in the general population, we calculated that 14.5% of all female and 11.4% of all male Germans suffer from LBP with a predominant neuropathic pain component. CONCLUSION: Simple, patient-based, easy-to-use screening questionnaires can determine the prevalence of neuropathic pain components both in individual LBP patients and in heterogeneous cohorts of such patients. Since NeP correlates with more intense pain, more severe co-morbidity and poorer quality of life, accurate diagnosis is a milestone in choosing appropriate therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Participants will be randomized to stratified blocks based on sex/gender and pain type (neuropathic, non-neuropathic, mixed or undetermined), assessed via the Pain DETECT[50] measure and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS)[51] to ensure uniform distribution of these factors across the three conditions.”
From The chronic pain skills study: Protocol for a randomized controlled trial comparing hypnosis, mindfulness meditation and pain education in Veterans (2020) · cites this paper as [51]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“This is a popular well-validated measure of pain severity used in research and clinical settings.”
From Risk Factors for Self-Harm Ideation among Persons Treated with Opioids for Chronic Low Back Pain (2023) · cites this paper as [33]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment
Breivik, H., Collett, B., Ventafridda, V., Cohen, R., & Gallacher, D. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2005.06.009 · Cited by 5,486
Bouhassira, D., Attal, N., Alchaar, H., Boureau, F., Brochet, B., Bruxelle, J., Cunin, G., Fermanian, J., Giniès, P., Grun-Overdyking, A., et al. (2005) · Pain · doi:10.1016/j.pain.2004.12.010 · Cited by 2,834
Chapter 4 European guidelines for the management of chronic nonspecific low back pain
Airaksinen, O., Brox, J. I., Cedraschi, C., Hildebrandt, J., Klaber-Moffett, J., Kovacs, F., Mannion, A. F., Reis, S., Staal, J. B., Ursin, H., et al. (2006) · European Spine Journal · doi:10.1007/s00586-006-1072-1 · Cited by 2,594
Deyo, R. A., & Weinstein, J. N. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102013440508 · Cited by 1,675
Monitoring Depression Treatment Outcomes With the Patient Health Questionnaire-9
L??we, B., Un??tzer, J., Callahan, C. M., Perkins, A. J., & Kroenke, K. (2004) · Medical Care · doi:10.1097/00005650-200412000-00006 · Cited by 1,354
Algorithm for neuropathic pain treatment: An evidence based proposal
Finnerup, N. B., Otto, M., McQuay, H. J., Jensen, T. S., & Sindrup, S. H. (2005) · Pain · doi:10.1016/j.pain.2005.08.013 · Cited by 1,337
Dworkin, R. H., Bačkonja, M., Rowbotham, M. C., Allen, R. R., Argoff, C., Bennett, G. J., Bushnell, M. C., Farrar, J. T., Galer, B. S., Haythornthwaite, J. A., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.11.1524 · Cited by 1,213
The LANSS Pain Scale: the Leeds assessment of neuropathic symptoms and signs
Bennett, M. (2001) · Pain · doi:10.1016/s0304-3959(00)00482-6 · Cited by 1,165
O’Sullivan, P. (2005) · Manual Therapy · doi:10.1016/j.math.2005.07.001 · Cited by 985
Development and preliminary validation of a pain measure specific to neuropathic pain
Galer, B. S., & Jensen, M. (1997) · Neurology · doi:10.1212/wnl.48.2.332 · Cited by 778
Research works printed but not linked: 1
- Kohlmann TRH, 1996, Rehabilitation, 35, 1
Cited by
Sorted by citations
Items 301–400 of 1,002
Tapentadol for neuropathic pain: a review of clinical studies
Freo, U., Romualdi, P., & Kress, H. G. (2019) · Journal of Pain Research · doi:10.2147/jpr.s190162 · Cited by 61
Brummett, C. M., Goesling, J., Tsodikov, A., Meraj, T. S., Wasserman, R. A., Clauw, D. J., & Hassett, A. L. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38178 · Cited by 60
Optimizing the management of chronic pain in sickle cell disease
Osunkwo, I., O’Connor, H. F., & Saah, E. N. (2020) · Hematology · doi:10.1182/hematology.2020000143 · Cited by 61
Sainsbury, B., Bloxham, J., Pour, M. H., Padilla, M., & Enciso, R. (2021) · Journal of Dental Anesthesia and Pain Medicine · doi:10.17245/jdapm.2021.21.6.479 · Cited by 61
“Secondary outcomes for reported pain included percentage improvement in NP intensity [70], responders with a 30% or more reduction in pain intensity, responders with a 50% or more reduction in pain intensity, brief pain inventory [71], pain disability index [72], painDETECT [73], McGill Pain Questionnaire [74], and Do…”
BackgroundDiabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
So, W. Z., Wong, N. S. Q., Tan, H. C., Lin, M. T. Y., Lee, I. X. Y., Mehta, J. S., & Liu, Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.327364 · Cited by 64
“It is fully patient-reported, measuring responses on a dichotomous scale (yes/no) with a maximum score of 35 points (Freynhagen et al., 2006).”
BackgroundIntercostobrachial nerve handling and pain after axillary lymph node dissection for breast cancer
Andersen, K. G., Aasvang, E. K., Kroman, N. T., & Kehlet, H. (2014) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12393 · Cited by 60
“Have you had pins and needles, sleeping or stabbing sensations in or around the area of your surgery? Yes, n (%) 26 (58) 30 (61) 15 (39) 71 (53) No, n (%) 18 (40) 14 (29) 22 (56) 54 (41) Missing, n (%) 1 (2) 5 (10) 2 (5) 8 (6) Have you experienced an electric shock like sensation or jabbing feelings in the skin area i…”
Tapentadol extended-release for treatment of chronic pain: a review
Vadivelu, N., Timchenko, Hyang, & Sinatra (2011) · Journal of Pain Research · doi:10.2147/jpr.s14842 · Cited by 60
“Chronic low back pain A large proportion of patients suffer from low back pain, with many having a predominant neuropathic pain component as well.(29) The safety and effectiveness of tapentadol ER was evaluated in 958 patients presenting with chronic low back pain.”
Characteristics of chronic ischemic pain in patients with peripheral arterial disease
Rüger, L. J., Irnich, D., Abahji, T. N., Crispin, A., Hoffmann, U., & Lang, P. M. (2008) · Pain · doi:10.1016/j.pain.2008.03.027 · Cited by 60
“For the evaluation of neuropathic pain several tools have been developed [4]: the Leeds Assessment of Neuropathic Pain (LANSS) [3], the Neuropathic Pain Symptom Inventory (NPSI) [8], the DN4 [7], the Neuropathic Pain Scale (NPS) [15], the painDetect [14] and the Neuropathic Pain Questionnaire (NPQ) [21].”
MethodRoubille, C., Raynauld, J., Abram, F., Paiement, P., Dorais, M., Delorme, P., Bessette, L., Beaulieu, A. D., Martel‐Pelletier, J., & Pelletier, J. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0507-z · Cited by 60
“The presence of NP was determined based on use of the PainDETECT questionnaire (score 0 to 38) [7-11].”
BackgroundMethodSmall-Fiber Neuropathy Is Associated With Corneal Nerve and Dendritic Cell Alterations
Bucher, F., Schneider, C. A., Blau, T., Cursiefen, C., Fink, G. R., Lehmann, H. C., & Heindl, L. M. (2015) · Cornea · doi:10.1097/ico.0000000000000535 · Cited by 60
Classification and Treatment of Chronic Neck Pain
Liu, R., Kurihara, C., Tsai, H.-T., Silvestri, P. J., Bennett, M., Pasquina, P. F., & Cohen, S. P. (2016) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000505 · Cited by 60
The prevalence of neuropathic pain is high after treatment for breast cancer: a systematic review
İlhan, E., Chee, E., Hush, J. M., & Moloney, N. A. (2017) · Pain · doi:10.1097/j.pain.0000000000001004 · Cited by 59
Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions
Henson, J. D., Vitetta, L., & Hall, S. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01020-z · Cited by 62
“This study used the painDETECT questionnaire (Freynhagen et al. 2006) to identify the presence of the neuropathic pain mechanism; however, the painDETECT questionnaire was devised before recognition of the nociplastic pain mechanism and does not distinguish between neuropathic and nociplastic pain.”
MethodA Systematic Review of Patient-Reported Outcome Measures Used in Adult Burn Research
Griffiths, C., Guest, E., White, P., Gaskin, E., Rumsey, N., Pleat, J., & Harcourt, D. M. (2016) · Journal of Burn Care & Research · doi:10.1097/bcr.0000000000000474 · Cited by 60
Prevalence of neuropathic pain in early multiple sclerosis
Heitmann, H., Biberacher, V., Tiemann, L., Buck, D., Loleit, V., Selter, R., Knier, B., Tölle, T. R., Mühlau, M., Berthele, A., et al. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515613643 · Cited by 59
Self-citationBaron, R., Eberhart, L. H. J., Kern, K., Regner, S., Rolke, R., Simanski, C., & Tölle, T. R. (2016) · Pain Practice · doi:10.1111/papr.12515 · Cited by 59
“This is an interesting finding, because neuropathic pain is often more severe with more severe comorbidities and poorer quality of life.(30) More than half of the patients (59.”
BackgroundSelf-citationArendt‐Nielsen, L., Jiang, G.-L., DeGryse, R. E., & Turkel, C. (2016) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.2016.1203988 · Cited by 59
“The 68 patients classified as having nociceptive pain (PD-Q ≤ 12) demonstrated significant differences favouring onabotA for percentage change from baseline for the spreading sensitization parameter as assessed by PPT in the tibialis anterior at weeks 4 (p = 0.030) and 8 (p = 0.021; Figure 3B) and the extensor carpi r…”
MethodInfluentialHansen, S., Vægter, H. B., & Petersen, K. K. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000771 · Cited by 59
Bohlega, S., Alsaadi, T. M., Amir, A., Hosny, H., Karawagh, A., Moulin, D. E., Riachi, N. J., Salti, A., & Shelbaya, S. (2010) · Journal of International Medical Research · doi:10.1177/147323001003800201 · Cited by 57
Kisler, L. B., Kim, J. A., Hemington, K. S., Rogachov, A., Cheng, J. C., Bosma, R. L., Osborne, N. R., Dunkley, B. T., Inman, R. D., & Davis, K. D. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102241 · Cited by 58
Characterizing chronic pain phenotypes in multiple sclerosis: a nationwide survey study
Kratz, A. L., Whibley, D., Alschuler, K. N., Ehde, D. M., Williams, D. A., Clauw, D. J., & Braley, T. J. (2020) · Pain · doi:10.1097/j.pain.0000000000002136 · Cited by 62
“Neuropathic pain was assessed using the painDETECT questionnaire (PD-Q), a 13-item screening survey to determine the presence/severity of pain of neuropathic origin.(20) The PD-Q assesses current average and worst pain intensity over the past 4 weeks (rated on an 11-point numeric rating scale of 0-10) as well as the p…”
MethodAcute neuropathic pain: diagnosis and treatment
Gray, P. D. (2008) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32830c900c · Cited by 57
Pain in Parkinson's Disease: Current Concepts and a New Diagnostic Algorithm
Mylius, V., de Andrade, D. C., Cury, R. G., Teepker, M., Ehrt, U., Eggert, K. M., Beer, S. M., Kesselring, J., Stamelou, M., Oertel, W. H., et al. (2015) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12217 · Cited by 57
“, PainDETECT or DN-4).(55,56) This facilitates the diagnosis of an underlying pain syndrome not attributable to PD.”
BackgroundYounis, S., Maarbjerg, S., Reimer, M., Wolfram, F., Olesen, J., Baron, R., & Bendtsen, L. (2016) · Pain · doi:10.1097/j.pain.0000000000000528 · Cited by 57
“The Pain DETECT Questionnaire is a validated screening tool developed in cooperation with DFNS.(7) The pain intensities were rated on an 11-point numerical rating scale.”
MethodSelf-citationSpahr, N., Hodkinson, D. J., Jolly, K. B., Williams, S., Howard, M. A., & Thacker, M. A. (2016) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2016.12.006 · Cited by 59
“The PDQ has been shown to have a high sensitivity (85%), specificity, (80%) and positive predictive accuracy (83%) in LBP (Freynhagen et al., 2006).”
BackgroundMethodInfluentialErlenwein, J., Müller, M., Falla, D., Przemeck, M., Pfingsten, M., Budde, S., Quintel, M., & Petzke, F. W. (2017) · Journal of Pain Research · doi:10.2147/jpr.s137892 · Cited by 59
“Neuropathic characteristics of the hip pain were assessed with the painDETECT questionnaire.(25) This questionnaire quantifies typical symptoms of neuropathic pain.”
MethodVersorgungsLeitlinie, N. (2011) · Cited by 58
Meyer‐Frießem, C. H., Malewicz, N. M., Rath, S., Ebel, M., Kaisler, M., Tegenthoff, M., Schildhauer, T. A., Pogatzki-Zahn, E. M., Maier, C., & Zahn, P. K. (2020) · Journal of Intensive Care Medicine · doi:10.1177/0885066620949178 · Cited by 61
“Questions concerning pain, hypesthesia, and paresthesia were inclined toward validated questionnaires screening for minus and plus symptoms of neuropathic pain.(21-23) Mean pain intensity in the past 14d was assessed (Numerical Rating Scale, NRS: 0-10, 0 1⁄4 “no pain,” 10 1⁄4 “worst imaginable pain”).”
MethodDiabetes is associated with persistent pain after hip and knee replacement
Rajamäki, T. J., Jämsen, E., Puolakka, P. A., Nevalainen, P. I., & Moilanen, T. P. S. (2015) · Acta Orthopaedica · doi:10.3109/17453674.2015.1044389 · Cited by 57
“The Finnish version of the PainDetect questionnaire (Freynhagen et al. 2006) was included in the postal questionnaire to determine whether the pain reported was of neuropathic origin.”
MethodKinfe, T. M., Schu, S., Quack, F., Wille, C., & Vesper, J. (2012) · Neuromodulation Technology at the Neural Interface · doi:10.1111/j.1525-1403.2012.00473.x · Cited by 56
“Using a pain questionnaire (painDETECT) program, a visual analog scale (VAS), and neuropsychological evaluation, patients with non-neuropathic causes for pain were excluded (18).”
MethodThe importance of psychological assessment in chronic pain
Williams, D. A. (2013) · Current Opinion in Urology · doi:10.1097/mou.0b013e3283652af1 · Cited by 65
“Examples of assessment instruments by domain for chronic pain Domain Purpose Instrument Pain symptom Pain intensity VAS [10&], NRS, VRS Pain quality MPQ [11] Pain distribution WPI [12] Combination: intensity/distribution/quality PainDetect [13] Comorbid symptoms Fatigue MFI [14] Sleep problems PSQI [15] Perceived cogn…”
Kuhns, B. D., Lubelski, D., Alvin, M. D., Taub, J. S., McGirt, M. J., Benzel, E. C., & Mroz, T. E. (2015) · Journal of Neurosurgery Spine · doi:10.3171/2014.10.spine14228 · Cited by 56
A PROMIS Measure of Neuropathic Pain Quality
Askew, R. L., Cook, K. F., Keefe, F. J., Nowinski, C. J., Cella, D. F., Revicki, D. A., DeWitt, E. M., Michaud, K. D., Trence, D., & Amtmann, D. (2016) · Value in Health · doi:10.1016/j.jval.2016.02.009 · Cited by 56
“[5] Freynhagen R, Baron R, Gockel U, et al.”
Manchikanti, L. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/se97 · Cited by 56
Gardiner, M., Weldon, A. V., Poindexter, S. A., Gibson, N., & Nekaris, K. A. I. (2018) · Europe PMC (PubMed Central) · Cited by 55
Fernández‐de‐las‐Peñas, C., & von Piekartz, H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113686 · Cited by 62
“A positive LANSS (>12 points) or Pain DETECT (>19 points) suggests an NPSH dominance, possibly caused by the sprouting of nerve branches eliciting spontaneous shooting pain and sensory changes such as hypo-hyperesthesia or dysesthesia.”
BackgroundInfluentialReview of Neuropathic Pain Screening and Assessment Tools
Jones, R. C. W., & Bačkonja, M. (2013) · Current Pain and Headache Reports · doi:10.1007/s11916-013-0363-6 · Cited by 55
“The painDETECT is a self-assessment tool consisting of seven items relating to symptoms quality: burning, tingling/prickling, sensitivity to light touch, paroxysmal pattern, sensitivity to temperature, numbness, and sensitivity to slight pressure [18].”
MethodWasserman, R. A., Brummett, C. M., Goesling, J., Tsodikov, A., & Hassett, A. L. (2013) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000024 · Cited by 56
“Studies have demonstrated correlations between high neuropathic pain description on the PainDETECT and widespread pain.(21) Scores”
BackgroundGinckel, A. V., Bennell, K. L., Campbell, P. K., Wrigley, T. V., Hunter, D. J., & Hinman, R. S. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.01.986 · Cited by 55
“Scores 4 ≥13 and ≤18 indicate uncertain results and the possibility o f a neuropathic component.[27] 5 We categorised participants accordingly and also us ed mean scores for analyses.”
Differential expression of P2X7 receptor and IL-1β in nociceptive and neuropathic pain
Luchting, B., Heyn, J., Woehrle, T., Rachinger-Adam, B., Kreth, S., Hinske, L. C., & Azad, S. C. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0565-z · Cited by 54
“This questionnaire consists of several items related to neuropathic pain symptoms (burning sensations, tingling or prickling sensations, shooting/lancinating, hyperalgesia, dysesthesia, allodynia, or paresthesia) with excellent sensitivity (85 %) and specificity (80 %) [17].”
BackgroundChronic Pelvic Pain: Assessment, Evaluation, and Objectivation
Passavanti, M. B., Pota, V., Sansone, P., Aurilio, C., Nardis, L. D., & Pace, M. C. (2017) · Pain Research and Treatment · doi:10.1155/2017/9472925 · Cited by 57
“PainDETECT [77] is a self-report questionnaire which includes a schematic drawing of pain distribution and esteem of pain fluctuations in time.”
BackgroundPathogenesis of pain in peripheral diabetic neuropathy
Calcutt, N. A., & Bačkonja, M. (2007) · Current Diabetes Reports · doi:10.1007/s11892-007-0072-9 · Cited by 55
Neuropathic Pain in Cancer: What Are the Current Guidelines?
Mulvey, M. R., Paley, C. A., Schuberth, A., King, N., Page, A., & Neoh, K. (2024) · Current Treatment Options in Oncology · doi:10.1007/s11864-024-01248-7 · Cited by 55
“The Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) [18], Douleur Neuropathique en 4 (DN4) [19] and painDETECT (PDQ) [20] have all demonstrated acceptable discriminatory performance in patients with neuropathic versus non-neuro-pathic cancer pain [21].”
BackgroundWilkinson, I., & Cohen, S. P. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-011-0236-9 · Cited by 53
“[85] Multicenter study in Germany 7772 pts with chronic LBP painDETECT 37% of patients found to have predominantly neuropathic pain”
Harifi, G., Ouilki, I., Bouchti, I. E., Ouazar, M. A., Belkhou, A., Younsi, R., Amine, M., Tazi, I., Abouqal, R., Niamane, R., et al. (2010) · Pain Practice · doi:10.1111/j.1533-2500.2010.00399.x · Cited by 54
Tumor necrosis factor inhibitor therapy in ankylosing spondylitis
Wu, Q., Inman, R. D., & Davis, K. D. (2015) · Pain · doi:10.1097/01.j.pain.0000460310.71572.16 · Cited by 54
Neville, S. J., Clauw, A. D., Moser, S. E., Urquhart, A. G., Clauw, D. J., Brummett, C. M., & Harte, S. E. (2018) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000619 · Cited by 56
Cheng, J. C., Rogachov, A., Hemington, K. S., Kucyi, A., Bosma, R. L., Lindquist, M. A., Inman, R. D., & Davis, K. D. (2018) · Pain · doi:10.1097/j.pain.0000000000001264 · Cited by 54
Neuropathic pain as part of chronic widespread pain
Momi, S. K., Fabiane, S. M., Lachance, G., Livshits, G., & Williams, F. M. K. (2015) · Pain · doi:10.1097/j.pain.0000000000000277 · Cited by 54
“For clinical purposes, a score#12 indicates that NP is unlikely, whereas a score $19 indicates that NP is likely.(10) Scores of 13 to 18 are ambiguous for the likelihood of NP.”
BackgroundMethodNabiximols in Chronic Neuropathic Pain: A Meta-Analysis of Randomized Placebo-Controlled Trials
Dykukha, I., Malessa, R., Essner, U., & Ueberall, M. A. (2021) · Pain Medicine · doi:10.1093/pm/pnab050 · Cited by 55
High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression
Previtali, D., Capone, G., Marchettini, P., Candrian, C., Zaffagnini, S., & Filardo, G. (2022) · Cartilage · doi:10.1177/19476035221087698 · Cited by 53
Williams, K., González‐Fernández, M., Hamzehzadeh, S., Wilkinson, I., Erdek, M. A., Plunkett, A., Griffith, S. R., Crooks, M. T., Larkin, T. M., & Cohen, S. P. (2011) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01184.x · Cited by 53
Warner, S. C., van Meurs, J. B. J., Schiphof, D., Bierma‐Zeinstra, S., Albert Hofman, D., Uitterlinden, A. G., Richardson, H., Jenkins, W., Doherty, M., & Valdes, A. M. (2017) · European Journal of Human Genetics · doi:10.1038/ejhg.2016.196 · Cited by 55
Hussain, N., Shastri, U., McCartney, C. J. L., Gilron, I., Fillingim, R. B., Clarke, H. A., Katz, J. D., Jüni, P., Laupacis, A., Wijeysundera, D. N., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001292 · Cited by 53
Held, M., Karl, F., Vlčková, E., Rajdová, A., Escolano‐Lozano, F., Stetter, C., Bharti, R., Förstner, K. U., Leinders, M., Dušek, L., et al. (2019) · Pain · doi:10.1097/j.pain.0000000000001623 · Cited by 53
“Median age (y) 53 (18-80) 50 (34-73) 51 (20-78)”
Tampin, B., Briffa, K., Goucke, R. C., & Slater, H. (2013) · Pain · doi:10.1016/j.pain.2013.08.018 · Cited by 52
“Neuropathic pain (NeP), defined as ‘‘pain arising as a direct consequence of a lesion or disease affecting the somatosensory system’’ [42,64], is associated with more severe pain for patients than nociceptive pain [18,30] and with suffering, disability, impaired health-related quality of life [13,25,30], and increased…”
InfluentialHeadache in acute ischaemic stroke: a lesion mapping study
Seifert, C. L., Schönbach, E. M., Magon, S., Gross, E. C., Zimmer, C., Förschler, A., Tölle, T. R., Mühlau, M., Sprenger, T., & Poppert, H. (2015) · Brain · doi:10.1093/brain/awv333 · Cited by 52
Self-citationSalaffi, F., Gerardi, M. C., Atzeni, F., Batticciotto, A., Talotta, R., Draghessi, A., Carlo, M. D., & Sarzi‐Puttini, P. (2017) · Rheumatology International · doi:10.1007/s00296-017-3792-4 · Cited by 52
“The final score ranges from −1 to 38, and indicates the likelihood of a neuropathic component: a score of ≤12 indicates a low likelihood (NoP), and a score of ≥19 suggests a high likelihood (NP); an intermediate score indicates the possibility of a neuropathic component [26].”
Blikman, T., Rienstra, W., van Raay, J. J. A. M., Dijkstra, B., Bulstra, S. K., Stevens, M. J., & van den Akker‐Scheek, I. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199165 · Cited by 52
Treatment of Neuropathic Pain Directly Due to Cancer: An Update
Shkodra, M., & Caraceni, A. T. (2022) · Cancers · doi:10.3390/cancers14081992 · Cited by 51
Painful Diabetic Peripheral Neuropathy: Practical Guidance and Challenges for Clinical Management
Preston, F., Riley, D. R. J., Azmi, S., & Alam, U. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s370050 · Cited by 63
“presence of neuropathic pain and has demonstrated a sensitivity of 85%, specificity of 80% and positive predictive value of 83%.(28) The McGill Pain Questionnaire allows quantification of a patient’s subjective pain experience through a pain”
BackgroundThe role of tramadol in current treatment strategies for musculoskeletal pain.
Schug, S. A. (2007) · Europe PMC (PubMed Central) · Cited by 51
Smith, B. H., Torrance, N., Ferguson, J. A., Bennett, M., Serpell, M. G., & Dunn, K. M. (2012) · BMC Neurology · doi:10.1186/1471-2377-12-29 · Cited by 53
“If three items are rated at least 3 (strongly) and one item 4 (very strongly), a positive score is reached [8].”
BackgroundMethodInfluentialMake a CHANGE: optimising communication and pain management decisions
Müller-Schwefe, G. H. H., Jaksch, W., Morlion, B. J., Kalso, E. A., Schäfer, M., Coluzzi, F., Huygen, F. J. P. M., Kocot-Kępska, M., Mangas, A. C., Margarit, C., et al. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.545377 · Cited by 54
Aşkın, A., Özkan, A., Tosun, A., Demirdal, Ü. S., & İsnaç, F. (2017) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2016.12.007 · Cited by 51
“It was first used to detect neuropathic pain caused by back pain, and its specificity and sensitivity were reported as 80% and 85%, respectively [23].”
BackgroundHøjgaard, P., Ellegaard, K., Nielsen, S. M., Christensen, R., Guldberg–Møller, J., Ballegaard, C., Dreyer, L., Mease, P. J., de Wit, M. P. T., Skov, L., et al. (2018) · Arthritis Care & Research · doi:10.1002/acr.23693 · Cited by 50
“nociceptive pain features (21,23), a TPC ≥8, i.”
BackgroundMethodWylde, V., Bertram, W., Sanderson, E., Noble, S., Howells, N., Peters, T. J., Beswick, A. D., Blom, A. W., Moore, A. J., Bruce, J., et al. (2022) · The Lancet Rheumatology · doi:10.1016/s2665-9913(21)00371-4 · Cited by 51
Pérez, C., Sanchez-Martinez, N., Ballesteros, A. I., Blanco, T., Collazo, A., González, F., & Villoria, J. (2014) · European Journal of Pain · doi:10.1002/ejp.598 · Cited by 52
“The low sensitivity of the painDETECT may relate to the fact that this tool was specifically developed for patients with low back pain (Freynhagen et al., 2006), that it does not include items for negative sensory phenomena, which predominate in neuropathic cancer pain (Mulvey et al.”
BackgroundMethodMay, E. S., Ávila, C. G., Dinh, S. T., Heitmann, H., Hohn, V. D., Nickel, M. M., Tiemann, L., Tölle, T. R., & Ploner, M. (2021) · Pain · doi:10.1097/j.pain.0000000000002281 · Cited by 50
Self-citationThe International Spinal Cord Injury Pain Extended Data Set (Version 1.0)
Widerström-Noga, E. G., Biering‐Sørensen, F., Bryce, T. N., Cardenas, D. D., Finnerup, N. B., Jensen, M. P., Richards, J. S., Richardson, E. J., & Siddall, P. J. (2016) · Spinal Cord · doi:10.1038/sc.2016.51 · Cited by 50
Castillo, R. C., Raja, S. N., Frey, K. P., Vallier, H. A., Tornetta, P., Jaeblon, T., Goff, B. J., Gottschalk, A., Scharfstein, D. O., O’Toole, R. V., et al. (2017) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000000793 · Cited by 50
Zhang, S., Li, T., Kobinata, H., Ikeda, E., Ota, T., & Kurata, J. (2018) · Molecular Pain · doi:10.1177/1744806918767512 · Cited by 52
“A high PDQ score is considered to imply high intensity of pain, more severe comorbidity, and lower quality of life.(16) ACC belongs to the medial nociceptive system that mediates an affective component of pain(39) and is also among cortical centers to drive descending pain modulatory system.”
BackgroundDavis, A. M., King, L. K., Stanaitis, I., & HAWKER, G. A. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.07.016 · Cited by 50
Alshuft, H., Condon, L. A., Dineen, R. A., & Auer, D. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161687 · Cited by 48
Voepel‐Lewis, T., Caird, M. S., Tait, A. R., Malviya, S. V., Farley, F. A., Li, Y., Abbott, M. D., van Veen, T., Hassett, A. L., & Clauw, D. J. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001963 · Cited by 49
Fernandes, G., Valdes, A. M., Walsh, D. A., Zhang, W., & Doherty, M. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1717-6 · Cited by 51
Gaynor, S. M., Bortsov, A. V., Bair, E., Fillingim, R. B., Greenspan, J. D., Ohrbach, R. K., Diatchenko, L. B., Nackley, A. G., Tchivileva, I. E., Whitehead, W. E., et al. (2020) · Pain · doi:10.1097/j.pain.0000000000002153 · Cited by 47
Assessment of Pain in Osteoarthritis of the Knee
Thirumaran, A. J., Deveza, L. A., Atukorala, I. G., & Hunter, D. J. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13071139 · Cited by 52
“Though painDETECT was initially developed to characterise the neuropathic elements of lower back pain [37,38], it has since been validated for the diagnosis of neuropathic pain in chronic pain conditions [32].”
BackgroundEffectiveness of Pilates exercise on low back pain: a systematic review with meta-analysis
Patti, A., Thornton, J. S., Giustino, V., Drid, P., Paoli, A., Schulz, J. M., Palma, A., & Bianco, A. (2023) · Disability and Rehabilitation · doi:10.1080/09638288.2023.2251404 · Cited by 49
“In the collection of the patient’s history, various elements allow to distinguish mechanical LBP from neuropathic LBP [5].”
the CSAW Study Group, Beard, D. J., Rees, J. L., Rombach, I., Cooper, C., Cook, J. A., Merritt, N., Gray, A. M., Gwilym, S., Judge, A., et al. (2015) · Trials · doi:10.1186/s13063-015-0725-y · Cited by 48
“Constant-Murley shoulder score: assesses shoulder function and range of motion and is commonly used by health care practitioners [40] PainDETECT: a patient-based screening questionnaire used to predict the prevalence of neuropathic pain components that has been widely used in many areas of musculoskeletal care [41]”
MethodSzczudlik, A., Dobrogowski, J., Wordliczek, J., Stępień, A., Krajnik, M., Leppert, W., Woroń, J., Przeklasa-Muszyńska, A., Kocot-Kępska, M., Zajączkowska, R., et al. (2014) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2014.11.002 · Cited by 50
Slater, H., Davies, S., Parsons, R. W., Quintner, J. L., & Schug, S. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038037 · Cited by 48
“These tools included the Orebro Musculoskeletal Pain Screening Questionnaire [45] measuring pain and disability (although the 9 item STarT Back Screening Tool [70] may be more appropriate in primary care), the Depression, Anxiety and Stress Scale (DASS21) measuring emotional functioning [46] and the painDETECT [47] sc…”
MethodCharacterizing Pain Flares From the Perspective of Individuals With Symptomatic Knee Osteoarthritis
Murphy, S. L., Lyden, A. K., Kratz, A. L., Fritz, H., Williams, D. A., Clauw, D. J., Gammaitoni, A. R., & Phillips, K. (2015) · Arthritis Care & Research · doi:10.1002/acr.22545 · Cited by 48
“Pain was measured at baseline with 1) the Brief Pain Inventory (BPI), which has severity and interference subscales measured on 0–10 scales (31); 2) the PainDETECT questionnaire, which examines neuropathic pain (32), ranging from 21 to 38, with a higher score indicating more neuropathic pain; and 3) the Pain Quality A…”
MethodChetty, S., Baalbergen, E., Bhigjee, A. I., Kamerman, P. R., Ouma, J., Raath, R., Raff, M., & Salduker, S. (2012) · South African Medical Journal · doi:10.7196/samj.5472 · Cited by 48
Negrão, L., Almeida, P., Alcino, S., Duro, H., Libório, T., Silva, U. M., Figueira, R., Gonçalves, S., & Parra, L. N. (2014) · Pain Management · doi:10.2217/pmt.14.10 · Cited by 48
Christensen, A., Rifbjerg-Madsen, S., Christensen, R., Dreyer, L., Tillingsøe, H., Seven, S., Boesen, M., Ellegaard, K., Bliddal, H., Danneskiold‐Samsøe, B., et al. (2016) · Scandinavian Journal of Rheumatology · doi:10.3109/03009742.2016.1139174 · Cited by 48
Entrapment of middle cluneal nerves as an unknown cause of low back pain
Aota, Y. (2016) · World Journal of Orthopedics · doi:10.5312/wjo.v7.i3.167 · Cited by 48
Reckziegel, D., Raschke, F., Cottam, W. J., & Auer, D. P. (2016) · Molecular Pain · doi:10.1177/1744806916650690 · Cited by 51
“OA pain is largely considered nociceptive, but in order to exclude putative neuropathic pain phenotypes, patients with likely neuropathic-like syndromes were excluded using the PainDETECT screening tool (score 19 or higher).(34) All participants provided written informed consent and underwent MRI, pain and affect ques…”
MethodWhen to consider “mixed pain”? The right questions can make a difference!
Freynhagen, R., Rey, R., & Argoff, C. E. (2020) · Current Medical Research and Opinion · doi:10.1080/03007995.2020.1832058 · Cited by 53
Self-citationJUNKER, U., Freynhagen, R., Längler, K., Gockel, U., Schmidt, U., Tölle, T. R., Baron, R., & Kohlmann, T. (2008) · Current Medical Research and Opinion · doi:10.1185/03007990802121059 · Cited by 48
Self-citationMeadow, D., Lindner, G., & Needleman, H. L. (1984) · PubMed · Cited by 48
Alter, B. J., Anderson, N. P., Gillman, A. G., Yin, Q., Jeong, J., & Wasan, A. D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254862 · Cited by 45
“PainDetect is a validated instrument rating the neuropathic quality of multiple pain complaints [40] that has been used in the study of several chronic pain syndromes [41, 42].”
BackgroundRigoard, P., Ounajim, A., Goudman, L., Louis, P., Slaoui, Y., Manuel Roulaud, B., Naïditch, N., Bouche, B., Page, P., Lorgeoux, B., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10214910 · Cited by 43
“PainDetect [35,36] and DN4 [37] questionnaires have been used in routine practice to bridge this gap.”
Central Neuropathic Pain Syndromes: Current and Emerging Pharmacological Strategies
Gurba, K. N., Chaudhry, R., & Haroutounian, S. (2022) · CNS Drugs · doi:10.1007/s40263-022-00914-4 · Cited by 47
Wylde, V., Lenguerrand, E., Gooberman‐Hill, R., Beswick, A. D., Marques, E. M. R., Noble, S., Horwood, J. P., Pyke, M., Dieppe, P. A., & Blom, A. W. (2015) · Pain · doi:10.1097/j.pain.0000000000000114 · Cited by 48
“Noninterpretable 12 (7) 12 (8) 1 (1) 5 (3)”
Baron, R., Allegri, M., Correa‐Illanes, G., Hans, G. H., Serpell, M. G., Mick, G., & Mayoral, V. (2016) · Pain and Therapy · doi:10.1007/s40122-016-0060-3 · Cited by 47
“Studies have demonstrated that neuropathic pain is more severe than non-neuropathic pain [50], it is associated with an excessive psychosocial burden compared with nociceptive pain, and it can induce more intense psychological comorbidity than other types of chronic pain [48, 50, 51].”
BackgroundSelf-citationTackley, G., Vecchio, D., Hamid, S. H. M., Juryńczyk, M., Kong, Y., Gore, R., Mutch, K., Woodhall, M. R., Waters, P. J., Vincent, A. C., et al. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314991 · Cited by 47
Raicher, I., Stump, P., Baccarelli, R., Marciano, L. H. S. C., Ura, S., Virmond, M., Teixeira, M. J., & de Andrade, D. C. (2015) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2015.10.012 · Cited by 46
Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations
Edwards, R. R., Dworkin, R. H., Turk, D. C., Angst, M. S., Dionne, R. A., Freeman, R. L., Hansson, P. T., Haroutounian, S., Arendt‐Nielsen, L., Attal, N., et al. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000896 · Cited by 48
“It has good sensitivity, specificity, and positive predictive value in identifying neuropathic pain.(98) NPSI 12-item measure that queries respondents about the degree of neuropathic pain symptoms (eg, “Does your pain feel like electric shocks?”) over the past 24 hours.”
BackgroundSelf-citationDainese, P., Mahieu, H., Mits, S. D., Wittoek, R., Stautemas, J., & Calders, P. (2023) · RMD Open · doi:10.1136/rmdopen-2022-002945 · Cited by 48
“45 46 48 The three studies assessing presence of neuropathic-like pain applied the painDETECT Questionnaire, 45 48 neuropathic pain-related DN4 48 and NPQ. 46 Quality assessment of included studies Agreement was reached on 117 of 126 (93”
Metadata
- Authors
- Freynhagen, R., Baron, R., Gockel, U., & Tölle, T. R.
- Affiliations
- Düsseldorf University Hospital (DE)
- University Hospital Schleswig-Holstein (DE)
- Pfizer (Germany) (DE)
- Technical University of Munich (DE)
- Corresponding author
- Freynhagen, Rainer
- Venue
- Current Medical Research and Opinion
- Publisher
- Informa UK Limited
- Published
- 2006-08-29
- Volume
- 22
- Issue
- 10
- Pages
- 1911-1920
- ISSN
- 0300-7995 (ISSN-L)
- 1473-4877
- OpenAlex
- W2154693681
- Cited by
- 2,280
- References
- 25
- Citations by year
- 2026: 158 · 2025: 182 · 2024: 187 · 2023: 177 · 2022: 172 · 2021: 179 · 2020: 149 · 2019: 121 · 2018: 161 · 2017: 128 · 2016: 130 · 2015: 99 · 2014: 99 · 2013: 102 · 2012: 68
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Medical Research and Opinion (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- neuropathic pain, low back pain, chronic pain, painDETECT questionnaire, screening questionnaire, prevalence, comorbidities, depression, anxiety, sleep disorders, pain intensity, quality of life, health care utilization, pain diagnosis
- MeSH terms
- Adult, Aged, Chronic Disease, Female, Humans, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Sensitivity and Specificity, Comorbidity, Low Back Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
