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pain DETECT : a new screening questionnaire to identify neuropathic components in patients with back pain
Open accessAbstract
OBJECTIVE: Nociceptive and neuropathic components both contribute to pain. Since these components require different pain management strategies, correct pain diagnosis before and during treatment is highly desirable. As low back pain (LBP) patients constitute an important subgroup of chronic pain patients, we addressed the following issues: (i) to establish a simple, validated screening tool to detect neuropathic pain (NeP) components in chronic LBP patients, (ii) to determine the prevalence of neuropathic pain components in LBP in a large-scale survey, and (iii) to determine whether LBP patients with an NeP component suffer from worse, or different, co-morbidities. METHODS: In co-operation with the German Research Network on Neuropathic Pain we developed and validated the painDETECT questionnaire (PD-Q) in a prospective, multicentre study and subsequently applied it to approximately 8000 LBP patients. RESULTS: The PD-Q is a reliable screening tool with high sensitivity, specificity and positive predictive accuracy; these were 84% in a palm-top computerised version and 85%, 80% and 83%, respectively, in a corresponding pencil-and-paper questionnaire. In an unselected cohort of chronic LBP patients, 37% were found to have predominantly neuropathic pain. Patients with NeP showed higher ratings of pain intensity, with more (and more severe) co-morbidities such as depression, panic/anxiety and sleep disorders. This also affected functionality and use of health-care resources. On the basis of given prevalence of LBP in the general population, we calculated that 14.5% of all female and 11.4% of all male Germans suffer from LBP with a predominant neuropathic pain component. CONCLUSION: Simple, patient-based, easy-to-use screening questionnaires can determine the prevalence of neuropathic pain components both in individual LBP patients and in heterogeneous cohorts of such patients. Since NeP correlates with more intense pain, more severe co-morbidity and poorer quality of life, accurate diagnosis is a milestone in choosing appropriate therapy.
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“Participants will be randomized to stratified blocks based on sex/gender and pain type (neuropathic, non-neuropathic, mixed or undetermined), assessed via the Pain DETECT[50] measure and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS)[51] to ensure uniform distribution of these factors across the three conditions.”
From The chronic pain skills study: Protocol for a randomized controlled trial comparing hypnosis, mindfulness meditation and pain education in Veterans (2020) · cites this paper as [51]
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“This is a popular well-validated measure of pain severity used in research and clinical settings.”
From Risk Factors for Self-Harm Ideation among Persons Treated with Opioids for Chronic Low Back Pain (2023) · cites this paper as [33]
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Citations
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“An English language version of the PD-Q can be retrieved from the original publication (37).”
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Self-citationKim, M. S., Kim, J. J., Kang, K. H., Lee, J. H., & In, Y. (2023) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.23.00399 · Cited by 22
“The painDETECT Questionnaire (PDQ) was developed and validated as a self-administered psychometric questionnaire to differentiate between neuropathic and non-neuropathic pain 32 .”
InfluentialVas, L. C., & Pai, R. (2015) · Pain Practice · doi:10.1111/papr.12338 · Cited by 20
“Patients were considered to have NeuP if their painDETECT scores were more than 12.(12) All of them had chronic pain after surgery or trauma.”
BackgroundSadosky, A., Igarashi, A., Akazawa, M., Murata, T., Taguchi, T., Ebata, N., Willke, R. J., Fujii, K., Doherty, J. P., & Kobayashi, M. (2015) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s89833 · Cited by 20
“3 months, often has a neuropathic pain (NeP) component; up to 37% of patients with CLBP have characteristics indicative of NeP.”
InfluentialPain Intensity as Prognostic Factor in Cancer Pain Management
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“Patients with shorter duration of symptoms were more likely to achieve better effect than those with longer duration.(71,72) Therefore, Cohen believed that the study by Iversen et al(67) was probably underpowered.”
Bilić, E., Delimar, V., Desnica, L., Pulanić, D., Bilić, E., Bakovic, M., Curtis, L. M., Seiwerth, R. S., Mravak‐Stipetić, M., Čeović, R., et al. (2016) · Bone Marrow Transplantation · doi:10.1038/bmt.2016.158 · Cited by 20
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“Therefore, CNP diagnosis is inherently complex and remains subjective, with the primary methods for diagnosis being the painDETECT [5], Neuropathic Pain Questionnaire (NPQ) [6] and the Leeds Assessment of Neuropathic Symptoms and Electronic supplementary material The online version of this article (doi:10.”
MethodSCN11A Arg225Cys mutation causes nociceptive pain without detectable peripheral nerve pathology
Castoro, R. J., Simmons, M., Ravi, V., Huang, D., Lee, C., Sergent, J. S., Zhou, L., & Li, J. (2018) · Neurology Genetics · doi:10.1212/nxg.0000000000000255 · Cited by 20
“Evaluation through pain questionnaires is also supportive of a nociceptive or inflammatory pain, not neuropathic pain To systematically characterize pain in patients with the Arg225Cys mutation, we used previously published scales that were designed to detect nociceptive and neuropathic pain.(14,15) ALS primarily affe…”
MethodBruehl, S. P., Burns, J. W., Morgan, A., Koltyn, K. F., Gupta, R. K., Buvanendran, A., Edwards, D. A., Chont, M., Kingsley, P. J., Marnett, L. J., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001447 · Cited by 20
“Participants completed the Pain Detect Questionnaire at baseline to characterize the relative contributions of nociceptive vs neuropathic mechanisms to the chronic back pain.(25) The Pain Detect Questionnaire is a 9-item questionnaire specifically designed to assess for neuropathic back pain characteristics and has be…”
Development and validation of a Taiwan version of the DN4-T questionnaire
Wang, Y.-F., Yang, C., Ro, L., Tsai, Y., Lin, K., Sun, W., Fang, W., & Wang, S. (2019) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000129 · Cited by 20
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Haninec, P., Kaiser, R., Mencl, L., & Waldauf, P. (2014) · BMC Neurology · doi:10.1186/s12883-014-0225-9 · Cited by 20
“Patients from Group I usually complained of residual nociceptive pain according to PD-Q, patients from Group II typically had pain of unclear origin, and all cases those in Group III suffered from neuropathic pain, Cramer’s V = .66, P .001.”
BackgroundMethodInfluentialThe polytrauma clinical triad in patients with chronic pain after motor vehicle collision
Peixoto, C., Thompson-Hyland, L., Buchanan, D. M., Langille, E., & Nahas, R. (2018) · Journal of Pain Research · doi:10.2147/jpr.s165077 · Cited by 21
“According to Freyhagen et al (2006), individuals with neuropathic pain show higher ratings of pain intensity and present with more mood and sleep disorders.(21) Patients with PCT appear to have worse sleep quality, as indicated by higher mean PSQI scores.”
Nociplastic pain: helping to explain disconnect between pain and pathology
Walsh, D. A. (2021) · Pain · doi:10.1097/j.pain.0000000000002323 · Cited by 20
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“Freynhagen R, et al., painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain.”
MethodIdentifying patient subgroups in the heterogeneous chronic pain population using cluster analysis
Rijsdijk, M., Smits, H. M., Azizoglu, H. R., Brugman, S., van de Burgt, Y., van Charldorp, T. C., van Gelder, D. J., de Grauw, J. C., van Lange, E. A., Meye, F. J., et al. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.104792 · Cited by 22
Yoga or Strengthening Exercise for Knee Osteoarthritis
Jemal, B., Singh, A., Aitken, D. A., Ding, C., Moonaz, S. H., Palmer, A. J., Blizzard, C. L., Inglis, A., Drummen, S., Jones, G., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.3698 · Cited by 19
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“PainDETECT is a validated self-reported questionnaire for chronic back pain and other conditions (44).”
painDETECT Questionnaire and Lumbar Epidural Steroid Injection for Chronic Radiculopathy
Radoš, I., Zdravčević, K. Š., & Hrgović, Z. (2012) · European Neurology · doi:10.1159/000338265 · Cited by 19
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Impact of pain sensitisation on the quality of life of patients with knee osteoarthritis
Aw, M. Y. N., Yeo, S.-J., Wylde, V., Wong, S. B.-S., Chan, D. X. H., Thumboo, J., & Leung, Y. Y. (2022) · RMD Open · doi:10.1136/rmdopen-2021-001938 · Cited by 21
“24 Due to its association of pain quality with augmented central pain processing as shown in functional magnetic imaging, 25 PainDETECT has been considered of its utility in the identification of pain sensitisation.”
Hasvik, E., Haugen, A. J., & Grøvle, L. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-065500 · Cited by 24
Which Comprehensive Geriatric Assessment (CGA) instruments are currently used in Germany: a survey
Kudelka, J., Ollenschläger, M., Dodel, R. C., Eskofier, B. M., Hobert, M. A., Jahn, K., Klucken, J., Labeit, B., Polidori, M. C., Prell, T., et al. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-04913-6 · Cited by 20
“…e.g. the Beobach-tungsinstrument für das Schmerzassessment bei alten Menschen mit Demenz (BISAD; [33]) ( n = 21, 27.6%), the Pain Assessment in Advanced Dementia Scale (PAINAD; [34]) ( n = 14, 18.4%), the Faces Pain Scale (FPS; e.g. [35]) ( n = 6, 7.9%), or the painDETECT [36] ( n = 4, 5.3%).”
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Hush, J. M., Stanton, T. R., Siddall, P. J., Marcuzzi, A., & Attal, N. (2013) · Pain Management · doi:10.2217/pmt.13.11 · Cited by 20
Chronic pain: the burden of disease and treatment innovations
Monti, S. M., & Caporali, R. F. (2015) · Reumatismo · doi:10.4081/reumatismo.2015.840 · Cited by 19
Emerging targets in treating pain
Chang, D. S., Raghavan, R. S., Christiansen, S., & Cohen, S. P. (2015) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000216 · Cited by 19
“arthritis), neuropathic (neuropathy), or mixed (failed back surgery syndrome), with two of the most common being painDETECT and self-completed Leeds Assessment of Neuropathic Symptoms and Signs pain scale (s-LANSS) [6,7]; however, physician designation based on clinical presentation remains the reference standard.”
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Seifert, C. L., Schönbach, E. M., Zimmer, C., Förschler, A., Tölle, T. R., Feurer, R., Gempt, J., Papadopoulou, A., Magon, S., Sprenger, T., et al. (2016) · Cephalalgia · doi:10.1177/0333102416686342 · Cited by 19
“To investigate a potential neuropathic component of the stroke-related headache, we used the Pain DETECT questionnaire (5).”
MethodSelf-citationWelte‐Jzyk, C., Pfau, D. B., Hartmann, A., & Daubländer, M. (2018) · BMC Oral Health · doi:10.1186/s12903-018-0601-8 · Cited by 19
Effects of tapentadol on pain, motor symptoms and cognitive functions in Parkinson’s disease
Freo, U., Furnari, M., & Ori, C. (2018) · Journal of Pain Research · doi:10.2147/jpr.s164939 · Cited by 19
“The painDETECT score ranges from −1 to 38, with scores ≥19 suggesting a high likelihood of neuropathic pain.(23) At each treatment visit, the patients were also asked to rate their pain relief on a 0%–100% rating scale.”
Neuropathic pain in ankylosing spondylitis: a meta-analysis
Kim, T. W., Son, S. M., & Lee, J. S. (2019) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-019-0654-3 · Cited by 19
Pain thresholds and intensities of CRPS type I and neuropathic pain in respect to sex
Meyer‐Frießem, C. H., Attal, N., Baron, R., Bouhassira, D., Finnerup, N. B., Freynhagen, R., Gierthmühlen, J., Haanpää, M., Hansson, P. T., Jensen, T. S., et al. (2020) · European Journal of Pain · doi:10.1002/ejp.1550 · Cited by 19
“Q) (Freynhagen et al., 2006), which collects information about average pain intensity.”
BackgroundMethodSelf-citationC-Fiber Loss as a Possible Cause of Neuropathic Pain in Schwannomatosis
Farschtschi, S. C., Mainka, T., Glatzel, M., Hannekum, A.-L., Hauck, M., Gelderblom, M., Hagel, C., Friedrich, R. E., Schuhmann, M. U., Schulz, A., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103569 · Cited by 19
“Pain perception was assessed by the PainDETECT questionnaire, which provides high sensitivity, specificity, and positive predictive value to detect neuropathic pain [15].”
MethodMorf, H., Pinheiro, G. D. R. C., Vargas‐Santos, A. B., Baerwald, C., & Seifert, O. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05470-0 · Cited by 19
Pain Assessment–Can it be Done with a Computerised System? A Systematic Review and Meta-Analysis
Pombo, N. G. C. C., García, N. M., Bousson, K., Spinsante, S., & Chorbev, I. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13040415 · Cited by 18
“ABC: Addiction Behaviours Checklist [117]; AMS: Analysys of Musculoskeletal Symptoms [118]; ARCS: Adult Responses to Children’s Symptoms Questionnaire [119]; ASEX: Arizona Sexual Experience [120]; ASI: Anxiety Sensitivity Index [121]; BASC: Behaviour Assessment System for Children [122]; BDI: Beck Depression Inventory…”
Gálvez, R., Pardo, A., Cerón, J. M. D., Villasante, F., Aranguren, J. L., Saldaña, M. T., Navarro, A. M., Ruiz, M. Á., Díaz‐Cerezo, S., & Rejas, J. (2008) · Medicina Clínica · doi:10.1157/13128018 · Cited by 19
Epidural steroid injections for low back pain
Cohen, S. P. (2011) · BMJ · doi:10.1136/bmj.d5310 · Cited by 19
A Review of the Literature on Multiple Factors Involved in Postoperative Pain Course and Duration
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Blikman, T., Rienstra, W., van Raaij, T. M., ten Hagen, A. J., Dijkstra, B., Zijlstra, W. P., Bulstra, S. K., van den Akker‐Scheek, I., & Stevens, M. J. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010343 · Cited by 18
“score result is an aggregated score ranging from −1 to 38 points.(49) Patients who are experiencing a possible or likely NP phenotype (mPD-Q score >12 points) and who are willing to consider participation will receive written”
BackgroundCheng, J., Kahn, R. L., YaDeau, J. T., Tsodikov, A. D., Goytizolo, E. A., Guheen, C. R., Haskins, S. C., Oxendine, J. A., Allen, A. A., Gulotta, L. V., et al. (2015) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000316 · Cited by 18
Impact of Fibromyalgia Phenotype in Temporomandibular Disorders
Harper, D., Sayre, K. S., Schrepf, A., Clauw, D. J., & Aronovich, S. (2021) · Pain Medicine · doi:10.1093/pm/pnab077 · Cited by 19
Mucalo, L., Field, J. J., Highland, J., Khan, H., Hankins, J. S., Singh, A., & Brandow, A. M. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023009707 · Cited by 18
“Scores from −1 to 12 indicate a neuropathic pain component does not exist, 13 to 18 indicate a probable neuropathic pain component, and 19 to 38 indicate a definite neuropathic pain component.(16)”
BackgroundMethodA pilot study to improve pain phenotyping in head and neck cancer patients
Ye, Y., Cardoso, D. D. M., Kayahara, G. M., & Bernabé, D. G. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1146667 · Cited by 18
Li, W., Pucka, A. Q., Debats, C., Reyes, B., Syed, F., O’Brien, A. R., Mehta, R. P., Manchanda, N., Jacob, S. A., Hardesty, B. M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1288187 · Cited by 18
Bertram, W., Howells, N., White, S. P., Sanderson, E., Wylde, V., Lenguerrand, E., Gooberman‐Hill, R., & Bruce, J. (2024) · The Bone & Joint Journal · doi:10.1302/0301-620x.106b6.bjj-2023-0889.r1 · Cited by 19
Pușcașu, C., Chiriță, C., Negreș, S., & Blebea, N. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011111 · Cited by 20
“Patients suffering from chronic NeP typically experience poorer physical and mental health in comparison to those with other forms of chronic pain, even after adjusting the pain intensity [8–10].”
BackgroundAberrant Analgesic Response to Medial Branch Blocks in Patients With Characteristics of Fibromyalgia
Brummett, C. M., Lohse, A. G., Tsodikov, A., Moser, S. E., Meraj, T. S., Goesling, J., Hooten, M. W., & Hassett, A. L. (2015) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000235 · Cited by 18
“Copyright © 2015 American Society of Regional Anesthesia and Pain Missing data for the validated instrumentswere handled as described by instrument authors.(30,31) Missing data rates are described in Table, Supplemental Digital Content 1, http://links.”
MethodImaging in mechanical back pain: Anything new?
Hansen, B. B., Hansen, P., Carrino, J. A., Fournier, G. L., Rasti, Z., & Boesen, M. (2016) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2016.08.008 · Cited by 18
Tapentadol Extended Release in the Treatment of Severe Chronic Low Back Pain and Osteoarthritis Pain
Pergolizzi, J. V., Taylor, R., LeQuang, J. A., Raffa, R. B., & Bisney, J. (2018) · Pain and Therapy · doi:10.1007/s40122-018-0095-8 · Cited by 18
“Neuropathic pain occurs in the setting of cLBP at a rate of 65–77% [49], but not all clinical trials of tapentadol for cLBP evaluated its specific effectiveness in treating the neuropathic component of cLBP.”
BackgroundAntunes, F. D., Silva, C. L., Cerqueira, K. S., Faro, M. D. L., & Cipolotti, R. (2019) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-019-1082-9 · Cited by 18
van de Donk, T., van Cosburgh, J., van Dasselaar, T., van Velzen, M., Drewes, A. M., Dahan, A., & Niesters, M. (2020) · PAIN Reports · doi:10.1097/pr9.0000000000000877 · Cited by 18
Wakaizumi, K., Vigotsky, A. D., Jabakhanji, R., Abdallah, M. O., Barroso, J., Schnitzer, T. J., Apkarian, A. V., & Baliki, M. N. (2021) · Pain and Therapy · doi:10.1007/s40122-021-00257-w · Cited by 20
“PainDETECT A seven-item screening questionnaire for neuropathic pain [29].”
MethodChilkoti, G. T., Gaur, D., Saxena, A., Gupta, A., Agarwal, R., & Jain, S. (2022) · Indian Journal of Anaesthesia · doi:10.4103/ija.ija_173_22 · Cited by 18
Etiología y manejo de la neuropatía diabética dolorosa
Bernal, D. S., Tabasco, M. D. M. M., Riera, M. H., & Pedrola, M. S. (2010) · Revista de la Sociedad Española del Dolor · doi:10.1016/j.resed.2010.06.002 · Cited by 18
Characterizing neuropathic pain profiles: enriching interpretation of painDETECT
Sadosky, A., Koduru, V., Bienen, E. J., & Cappelleri, J. C. (2016) · Patient Related Outcome Measures · doi:10.2147/prom.s101892 · Cited by 18
“18 painDETECT has a score range from –1 to 38 that is used for classifying pain as NeP (score ≥ 19), nociceptive (score ≤ 12), or unclear (scores 13–18).”
Zgierska, A. E., Burzinski, C. A., Garland, E. L., Lennon, R. P., Jamison, R., Nakamura, Y., Barrett, B., Sehgal, N., Mirgain, S. A., Singles, J. M., et al. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106548 · Cited by 18
Amyotrophic Lateral Sclerosis and Pain: A Narrative Review from Pain Assessment to Therapy
Pota, V., Sansone, P., Sarno, S. D., Aurilio, C., Coppolino, F., Barbarisi, M., Barbato, F., Fiore, M., Cosenza, G., Passavanti, M. B., et al. (2024) · Behavioural Neurology · doi:10.1155/2024/1228194 · Cited by 19
Sensorimotor Integration in Chronic Low Back Pain
Massé‐Alarie, H., Shraim, M. A., & Hodges, P. W. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.06.008 · Cited by 17
“…questionnaire [35]], fracture, tumor, inflammatory disease), areas of numbness in the lower back, history of spinal or lumbar surgery, major neurological disorders, major medical diseases (e.g. cardiovascular disease), psychiatric illness, insufficient knowledge of the English language to…”
BackgroundKawi, J., Yeh, C. H., Lukkahatai, N., Wu, H., Morone, N. E., Glick, R. M., Schlenk, E. A., Campbell, C. M., Thrul, J., Huang, X., et al. (2025) · Pain Medicine · doi:10.1093/pm/pnaf035 · Cited by 19
“50 All measures had a Cronbach’s α ≥ 0.84 for the current study (Table S2).”
InfluentialSpinal pain: current understanding, trends, and the future of care
Parkin-Smith, G. F., Amorin-Woods, L., Davies, S., Losco, B. E., & Adams, J. (2015) · Journal of Pain Research · doi:10.2147/jpr.s55600 · Cited by 17
“In addition, buprenorphine has both an analgesic and antihyperalgesic effect(82) which is relevant in neuropathic pain, which can be a contributor in spinal pain.(86) Strong opioid drugs (S8) and benzodiazepines are associated with much higher risks and complications related to tolerance, addiction, and abuse, particu…”
Ramaswamy, S., Wodehouse, T., Langford, R., Thomson, S., Taylor, R. S., & Mehta, V. (2018) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12862 · Cited by 17
“Questionnaires such as painDetect grades different pain characteristics from none to severe, which gives us some understanding about the somatosensory profile of the patients (23,24).”
BackgroundHasani, F., Haines, T. P., Munteanu, S. E., Vicenzino, B., & Malliaras, P. (2020) · Pilot and Feasibility Studies · doi:10.1186/s40814-020-00639-5 · Cited by 19
“This is a validated patient-reported measure that identifies the presence of neuropathic pain with high sensitivity, specificity, and positive predictive value [22].”
BackgroundDevelopment of a Screening Tool for Pediatric Neuropathic Pain and Complex Regional Pain Syndrome
Mesaroli, G., Campbell, F. A., Hundert, A. S., Birnie, K. A., Sun, N., Davidge, K. M., Lalloo, C., Davies-Chalmers, C., Harris, L. S., & Stinson, J. (2021) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000993 · Cited by 18
“South Asian 2 (8) South East Asian 1 (4) White 15 (60) Multiracial 3 (12) Pain duration* Resolved 5 (20)”
BackgroundChalermkitpanit, P., Limthongkul, W., Yingsakmongkol, W., Thepsoparn, M., Pannangpetch, P., Tangchitcharoen, N., Tanasansomboon, T., & Singhatanadgige, W. (2022) · Asian Spine Journal · doi:10.31616/asj.2021.0337 · Cited by 17
“After obtaining informed consent, the patients were asked to complete the painDETECT Questionnaire (PDQ) to assess preoperative neuropathic pain [9].”
MethodUse of IMMPACT Recommendations to Explore Pain Phenotypes in People with Knee Osteoarthritis
Carlesso, L. C., Feldman, D. E., Vendittoli, P., Lavoie, F., Choinière, M., Bolduc, M.-È., Fernandes, J., Newman, N. M., & Sabouret, P. (2022) · Pain Medicine · doi:10.1093/pm/pnac044 · Cited by 17
Chronic pain domains and their relationship to personality, abilities, and brain networks
Pinto, C. B., Bielefeld, J., Barroso, J., Yip, B. K., Huang, L. Q., Schnitzer, T. J., & Apkarian, A. V. (2022) · Pain · doi:10.1097/j.pain.0000000000002657 · Cited by 18
Cole, S., Sanchez-Santos, M. T., Kolovos, S., Javaid, M. K., & Pinedo‐Villanueva, R. (2023) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-023-02620-w · Cited by 17
“PainDETECT measures neuropathic pain [19] as well.”
Stephens‐Shields, A. J., Lai, H. H., Landis, J. R., Kreder, K. J., Rodríguez, L. V., Naliboff, B. D., Afari, N., Sutcliffe, S., Moldwin, R., Griffith, J. W., et al. (2023) · The Journal of Urology · doi:10.1097/ju.0000000000003394 · Cited by 18
Mackenzie, S. C., Stephen, J., Williams, L. J., DANIELS, J. P., Norrie, J. D., Becker, C. M., Byrne, D. L., Cheong, Y. C., Clark, T. J., Cooper, K. G., et al. (2023) · Trials · doi:10.1186/s13063-023-07386-x · Cited by 17
Brandl, A., Wilke, J., Egner, C., Schmidt, T., Schilder, A., & Schleip, R. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02896-8 · Cited by 17
“Multiple descriptors have been used to distinguish, for example, between primary and secondary chronic pain syndromes [60], trigeminal neuralgia and atypical facial pain [37], nociceptive and neuropathic pain [20], and A-delta-mediated and C-fiber-mediated pain [28].”
BackgroundCory, L. A., Harvie, H. S., Northington, G. M., Malykhina, A. P., WHITMORE, K. E., & Arya, L. A. (2011) · The Journal of Urology · doi:10.1016/j.juro.2011.10.036 · Cited by 17
Martin, M. L., Blum, S. I., Liedgens, H., Bushnell, D. M., McCarrier, K. P., Hatley, N. V., Ramasamy, A., Freynhagen, R., Wallace, M. S., Argoff, C. E., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001187 · Cited by 17
“The painDETECT is a 9-item screening tool that was originally developed to distinguish neuropathic LBP (score of 19-38) from nonneuropathic LBP (score of 0-12).(13) It was given at the enrollment visit to categorize patients based on neuropathic/nonneuropathic pain.”
MethodSelf-citationNeuropathic Pain Prevalence of Older Adults in an Urban Area of Iran: A Population-Based Study
Roghani, R. S., Delbari, A., Asadi‐Lari, M., Rashedi, V., & Lökk, J. (2019) · Pain Research and Treatment · doi:10.1155/2019/9015695 · Cited by 19
Salehpour, F., Aghazadeh, J., Mirzaei, F., Ziaeii, E., & Alavi, S. A. N. (2019) · The International Journal of Spine Surgery · doi:10.14444/6019 · Cited by 17
“Low back pain (LBP) is the most common social, economic, clinical, and public health problem affecting the human population worldwide.(1) About 70% of adults suffer from LBP with various degrees of severity at some time during their lives.”
BackgroundMemory of pain in adults: a protocol for systematic review and meta-analysis
Adamczyk, W. M., Farley, D., Wiercioch‐Kuzianik, K., Bajcar, E. A., Buglewicz, E., Nastaj, J., Gruszka, A., & Bąbel, P. (2019) · Systematic Reviews · doi:10.1186/s13643-019-1115-4 · Cited by 19
Central pain modulatory mechanisms of attentional analgesia are preserved in fibromyalgia
Oliva, V. N. L. D. S., Gregory, R. J., Brooks, J. C. W., & Pickering, A. E. (2021) · Pain · doi:10.1097/j.pain.0000000000002319 · Cited by 17
de Heer, E. W., Dekker, J., van der Sluijs, J. F. V. E., Beekman, A. T. F., van Marwijk, H., Holwerda, T. J., Bet, P. M., Roth, J., Roijen, L. H., Ringoir, L., et al. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-147 · Cited by 17
“quences in the treatment of (sub)chronic pain [74], we address both these issues in this RCT.”
MethodInfluentialChetty, S., Baalbergen, E., Bhigjee, A. I., Kamerman, P. R., Ouma, J., Raath, R., Raff, M., & Salduker, S. (2013) · South African Family Practice · doi:10.1080/20786204.2013.10874323 · Cited by 17
Interdisciplinary Management of Complex Regional Pain Syndrome of the Face
Parkitny, L., Wand, B. M., Graham, C., Quintner, J. L., & Moseley, G. L. (2016) · Physical Therapy · doi:10.2522/ptj.20150183 · Cited by 17
Turner, K. V., Moreton, B. J., Walsh, D. A., & Lincoln, N. B. (2016) · Disability and Rehabilitation · doi:10.3109/09638288.2016.1161840 · Cited by 17
“The painDETECT questionnaire [10] was designed to assess the neuropathic elements of pain, and classifies people into groups based on a summative score from nine-items: a neuropathic component is unlikely ( 12), result is ambiguous (13–18) and neuropathic component is likely ( 19).”
BackgroundMethodTapentadol for Cancer Pain Management: A Narrative Review
Carmona‐Bayonas, A., Fonseca, P. J., & Echaburu, J. V. (2017) · Pain Practice · doi:10.1111/papr.12556 · Cited by 17
Treatment of painful radiculopathies with capsaicin 8% cutaneous patch
Baron, R., Treede, R., Birklein, F., Cegla, T. H., Freynhagen, R., Heskamp, M. ‐. S., Kern, K., Maier, C., Rolke, R., Seddigh, S., et al. (2017) · Current Medical Research and Opinion · doi:10.1080/03007995.2017.1322569 · Cited by 18
Self-citationThe effect of numbness on outcome from total knee replacement
Blackburn, J., Wylde, V., Greenwood, R., Blom, A. W., & Levy, A. (2017) · Annals of The Royal College of Surgeons of England · doi:10.1308/rcsann.2017.0026 · Cited by 17
Peripheral Interventions for Painful Stump Neuromas of the Lower Limb
Poyntz, S. A., Hacking, N. M., Dalal, M. D., & Fowler, S. J. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000533 · Cited by 17
Matsuki, Y., Sukenaga, N., Miyagi, K., Tsunetoh, T., Mizogami, M., Shigemi, K., Maeda, L., & Hirose, M. (2018) · Journal of Anesthesia · doi:10.1007/s00540-018-2495-7 · Cited by 16
Musculoskeletal Pain in Individuals With Inflammatory Bowel Disease Reflects Three Distinct Profiles
Falling, C., Stebbings, S. M., Baxter, D. G., Gearry, R. B., & Mani, R. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000698 · Cited by 17
“Interpretation of PainDETECT scores identify neuropathic components as likely (≥ 19), unlikely (≤ 12), and unclear (13-18) [43].”
BackgroundMethod
Metadata
- Authors
- Freynhagen, R., Baron, R., Gockel, U., & Tölle, T. R.
- Affiliations
- Düsseldorf University Hospital (DE)
- University Hospital Schleswig-Holstein (DE)
- Pfizer (Germany) (DE)
- Technical University of Munich (DE)
- Corresponding author
- Freynhagen, Rainer
- Venue
- Current Medical Research and Opinion
- Publisher
- Informa UK Limited
- Published
- 2006-08-29
- Volume
- 22
- Issue
- 10
- Pages
- 1911-1920
- ISSN
- 0300-7995 (ISSN-L)
- 1473-4877
- OpenAlex
- W2154693681
- Cited by
- 2,280
- References
- 25
- Citations by year
- 2026: 158 · 2025: 182 · 2024: 187 · 2023: 177 · 2022: 172 · 2021: 179 · 2020: 149 · 2019: 121 · 2018: 161 · 2017: 128 · 2016: 130 · 2015: 99 · 2014: 99 · 2013: 102 · 2012: 68
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Medical Research and Opinion (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- neuropathic pain, low back pain, chronic pain, painDETECT questionnaire, screening questionnaire, prevalence, comorbidities, depression, anxiety, sleep disorders, pain intensity, quality of life, health care utilization, pain diagnosis
- MeSH terms
- Adult, Aged, Chronic Disease, Female, Humans, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Sensitivity and Specificity, Comorbidity, Low Back Pain
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