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Cited by 217Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsPain Management and Opioid Use

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain

Iskedjian, Michael, Bereza, Basil, Gordon, Allan, Piwko, Charles, Einarson, Thomas R.·2007·Current Medical Research and Opinion
DOI 10.1185/030079906x158066
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Abstract

OBJECTIVE: Debilitating pain, occurring in 50-70% of multiple sclerosis (MS) patients, is poorly understood and infrequently studied. We summarized efficacy and safety data of cannabinoid-based drugs for neuropathic pain. DATA SOURCES: Studies were identified from Medline, Embase, and Cochrane databases; Bayer Healthcare provided additional trials. STUDY SELECTION: Accepted were randomized, double-blinded placebo-controlled trials of cannabinoid-based treatments for MS-related/neuropathic pain in adults > or = 18 years of age. DATA EXTRACTION: Two reviewers identified studies and extracted data; a third adjudicated disagreements. Data included baseline and endpoint pain scores on visual analog or 11-point ordinal scales. DATA SYNTHESIS: Of 18 articles and three randomized controlled trial (RCT) reports identified, 12 articles and two reports were rejected (9 = inappropriate disease or outcome, 1 = duplicate, 1 = review, and 1 = abstract); six accepted articles and one RCT-report involved 298 patients (222 treated, 76 placebo); four examined Sativex (a cannabidiol/delta-9-tetrahydrocannabinol (THC) buccal spray) (observations = 196), five cannabidiol (n = 41), and three dronabinol (n = 91). Homogeneity chi(2) values were non-significant, allowing data combination. Analyses focused on baseline-endpoint score differences. The cannabidiol/THC buccal spray decreased pain 1.7 +/- 0.7 points (p = 0.018), cannabidiol 1.5 +/- 0.7 (p = 0.044), dronabinol 1.5 +/- 0.6 (p = 0.013), and all cannabinoids pooled together 1.6 +/- 0.4 (p < 0.001). Placebo baseline-endpoint scores did not differ (0.8 +/- 0.4 points, p = 0.023). At endpoint, cannabinoids were superior to placebo by 0.8 +/- 0.3 points (p = 0.029). Dizziness was the most commonly observed adverse event in the cannabidiol/THC buccal spray arms (39 +/- 16%), across all cannabinoid treatments (32.5 +/- 16%) as well as in the placebo arms (10 +/- 4%). CONCLUSION: Cannabinoids including the cannabidiol/THC buccal spray are effective in treating neuropathic pain in MS. LIMITATIONS: This review was based on a small number of trials and patients. Pain related to MS was assumed to be similar to neuropathic pain.

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Crossref · 10.1185/030079906x158066

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Show all 38 references

Research works printed but not linked: 6

  1. Bruck G, 2003, Neurol Sci, 24, S265–S267
  2. Burks J, 1992, J Neurol Rehabil, 6, 131
  3. Solaro C, 2003, Pain and MS. Int MS J, 10, 14
  4. Indaco A, 1994, Acta Neurol Scand, 16, 97
  5. Jungmayr P, 2004, Deutsche Apoteker Zeitung, 144, 42
  6. Nurimikko TJ, 2005, Neurology, 64, A374

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Metadata

Authors
Iskedjian, M., Bereza, B., Gordon, A., Piwko, C., & Einarson, T. R.
Affiliations
  • PharmIdeas (Canada) (CA)
  • Mount Sinai Hospital (CA)
  • University of Toronto (CA)
Corresponding author
Einarson, Thomas R.
ORCID
Venue
Current Medical Research and Opinion
Publisher
Informa Healthcare
Published
2006-11-27
Volume
23
Issue
1
Pages
17-24
ISSN
  • 0300-7995 (ISSN-L)
  • 1473-4877
DOI
10.1185/030079906x158066
OpenAlex
W2146626244
Cited by
216
References
38
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 20 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 8 · 2018: 16 · 2017: 11 · 2016: 9 · 2015: 13 · 2014: 9 · 2013: 7 · 2012: 11
FWCI
1.52
Type
journal article
Language
en
Open access
closed
Locations
  • Current Medical Research and Opinion (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bayer HealthCare
  • Bayer Canada
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
neuropathic pain, multiple sclerosis, Sativex, cannabidiol, dronabinol, THC, analgesia, adverse events, dizziness, drug safety, VAS pain score, quality of life
MeSH terms
Cannabinoids, Humans, Multiple Sclerosis, Neuralgia, Pain, Pain Measurement, Chi-Square Distribution, Randomized Controlled Trials as Topic

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