Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
Abstract
OBJECTIVES: To assess the efficacy of a cannabis-based medicine (CBM) in the treatment of pain due to rheumatoid arthritis (RA). METHODS: We compared a CBM (Sativex) with placebo in a randomized, double-blind, parallel group study in 58 patients over 5 weeks of treatment. The CBM was administered by oromucosal spray in the evening and assessments were made the following morning. Efficacy outcomes assessed were pain on movement, pain at rest, morning stiffness and sleep quality measured by a numerical rating scale, the Short-Form McGill Pain Questionnaire (SF-MPQ) and the DAS28 measure of disease activity. RESULTS: Seventy-five patients were screened and 58 met the eligibility criteria. Thirty-one were randomized to the CBM and 27 to placebo. Mean (S.D.) daily dose achieved in the final treatment week was 5.4 (0.84) actuations for the CBM and 5.3 (1.18) for placebo. In comparison with placebo, the CBM produced statistically significant improvements in pain on movement, pain at rest, quality of sleep, DAS28 and the SF-MPQ pain at present component. There was no effect on morning stiffness but baseline scores were low. The large majority of adverse effects were mild or moderate, and there were no adverse effect-related withdrawals or serious adverse effects in the active treatment group. CONCLUSIONS: In the first ever controlled trial of a CBM in RA, a significant analgesic effect was observed and disease activity was significantly suppressed following Sativex treatment. Whilst the differences are small and variable across the population, they represent benefits of clinical relevance and show the need for more detailed investigation in this indication.
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Although the five studies found improvements in nausea with cannabis use, other studies found nausea to be an adverse event associated with cannabis use among some participants.
“Although these five studies found improvements in nausea with cannabis use, other studies found nausea to be an adverse event associated with cannabis use among some participants.”
From Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions (2024) · cites this paper as [48]
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The short-form McGill pain questionnaire
Melzack, R. (1987) · Pain · doi:10.1016/0304-3959(87)91074-8 · Cited by 4,368 · see citing works
Cannabinoid receptors and pain
Pertwee, R. G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00031-9 · Cited by 741 · see citing works
Malfait, A. M., Gallily, R., Sumariwalla, P. F., Malik, A. S., Andreakos, E., Mechoulam, R., & Feldmann, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160105897 · Cited by 669 · see citing works
Wade, D. T., Makela, P., Robson, P., House, H., & Bateman, C. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1082oa · Cited by 589 · see citing works
Self-citationCannabis and Cannabis Extracts: Greater Than the Sum of Their Parts?
McPartland, J. M., & Russo, E. B. (2001) · Journal of Cannabis Therapeutics · doi:10.1300/j175v01n03_08 · Cited by 321 · see citing works
Nicholson, A. N., Turner, C., Stone, B. M., & Robson, P. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000125688.05091.8f · Cited by 291 · see citing works
Self-citationThe medicinal use of cannabis in the UK: results of a nationwide survey
Ware, M. A., Adams, H., & Guy, G. W. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2004.00271.x · Cited by 239 · see citing works
Analgesic and antiinflammatory activity of constituents ofCannabis sativa L.
Formukong, E. A., EVANS, A. T., & Evans, F. J. (1988) · Inflammation · doi:10.1007/bf00915771 · Cited by 130 · see citing works
Human Studies of Cannabinoids and Medicinal Cannabis
Robson, P. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_25 · Cited by 76 · see citing works
Self-citationThe Medicinal Uses of Cannabis and Cannabinoids
Guy, G. W., Whittle, B. A., & Robson, P. (2008) · Le Pharmacien Hospitalier · doi:10.1016/s0768-9179(08)70455-3 · Cited by 47 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Formukong EA, Evans AT, Evans FJ. Analgesic and anti- inflammatory activity of constituents of Cannabis sativa L. Inflammation 1998;12:361-71.
Cited by
Sorted by citations
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis
Whiting, P. F., Wolff, R. F., Deshpande, S., Di Nisio, M., Duffy, S., Hernandez, A. V., Keurentjes, J. C., Lang, S., Misso, K., Ryder, S., et al. (2015) · JAMA · doi:10.1001/jama.2015.6358 · Cited by 2,169 · see citing works
Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications
Haack, M., Simpson, N. S., Sethna, N. F., Kaur, S., & Mullington, J. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0439-z · Cited by 665 · see citing works
Cannabinoids in medicine: A review of their therapeutic potential
Ben Amar, M. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.02.001 · Cited by 543 · see citing works
Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems
Hill, K. P. (2015) · JAMA · doi:10.1001/jama.2015.6199 · Cited by 508 · see citing works
Stockings, E., Campbell, G., Hall, W. D., Nielsen, S., Zagic, D., Rahman, R., Murnion, B., Farrell, M., Weier, M., & Degenhardt, L. (2018) · Pain · doi:10.1097/j.pain.0000000000001293 · Cited by 460 · see citing works
Smoked cannabis for chronic neuropathic pain: a randomized controlled trial
Ware, M. A., Wang, T., Shapiro, S., Robinson, A., Ducruet, T., Huynh, T., Gamsa, A., Bennett, G. J., & Collet, J.-P. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.091414 · Cited by 450 · see citing works
Borgelt, L. M., Franson, K. L., Nussbaum, A. M., & Wang, G. S. (2013) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1187 · Cited by 423 · see citing works
Cannabinoids for treatment of chronic non‐cancer pain; a systematic review of randomized trials
Lynch, M. E., & Campbell, F. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.03970.x · Cited by 397 · see citing works
Costa, B., Trovato, A. E., Comelli, F., Giagnoni, G., & Colleoni, M. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.11.006 · Cited by 395 · see citing works
Adverse effects of medical cannabinoids: a systematic review
Wang, T., Collet, J.-P., Shapiro, S., & Ware, M. A. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.071178 · Cited by 357 · see citing works
The Therapeutic Potential of Cannabis and Cannabinoids
Grotenhermen, F., & Müller‐Vahl, K. (2012) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2012.0495 · Cited by 309 · see citing works
Aviram, J. (2017) · Pain Physician · doi:10.36076/ppj.20.5.e755 · Cited by 303 · see citing works
Richardson, D., Pearson, R. G., Kurian, N., Latif, M. L., Garle, M. J., Barrett, D. A., Kendall, D. A., Scammell, B. E., Reeve, A. J., & Chapman, V. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2401 · Cited by 303 · see citing works
Wang, L., Hong, P. J., May, C., Rehman, Y., Oparin, Y., Hong, C. J. H., Hong, B. Y., AminiLari, M., Gallo, L., Kaushal, A., et al. (2021) · BMJ · doi:10.1136/bmj.n1034 · Cited by 308 · see citing works
Nugent, S. M., Morasco, B. J., O'Neil, M. E., Freeman, M., Low, A., Kondo, K., Elven, C., Zakher, B., Motu'apuaka, M., Paynter, R., et al. (2017) · Annals of Internal Medicine · doi:10.7326/m17-0155 · Cited by 301 · see citing works
Cannabinoids in the management of difficult to treat pain
Russo, E. B. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s1928 · Cited by 296 · see citing works
Immune Responses Regulated by Cannabidiol
Nichols, J. M., & Kaplan, B. L. F. (2019) · Cannabis and Cannabinoid Research · doi:10.1089/can.2018.0073 · Cited by 297 · see citing works
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action
Mlost, J., Bryk, M., & Starowicz, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228870 · Cited by 300 · see citing works
Fraguas‐Sánchez, A. I., & Torres‐Suárez, A. I. (2018) · Drugs · doi:10.1007/s40265-018-0996-1 · Cited by 271 · see citing works
Positive and Negative Effects of Cannabis and Cannabinoids on Health
Cohen, K., Weizman, A., & Weinstein, A. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1381 · Cited by 255 · see citing works
Baron, E. P. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13345 · Cited by 256 · see citing works
Pharmaceutical and biomedical analysis of cannabinoids: A critical review
Citti, C., Braghiroli, D., Vandelli, M. A., & Cannazza, G. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.06.003 · Cited by 254 · see citing works
Booz, G. W. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.007 · Cited by 246 · see citing works
Cannabinoids and the immune system: An overview
Tănăsescu, R., & Constantinescu, C. S. (2010) · Immunobiology · doi:10.1016/j.imbio.2009.12.005 · Cited by 243 · see citing works
Karschner, E. L., Darwin, W. D., Goodwin, R. S., Wright, S., & Huestis, M. A. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.152439 · Cited by 231 · see citing works
Russo, E. B., Guy, G. W., & Robson, P. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790150 · Cited by 228 · see citing works
Self-citationSystematic Review and Meta-analysis of Cannabis Treatment for Chronic Pain
Martín-Sánchez, E., Furukawa, T. A., Taylor, J., & Martín, J. L. R. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00703.x · Cited by 227 · see citing works
Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain
Iskedjian, M., Bereza, B., Gordon, A., Piwko, C., & Einarson, T. R. (2007) · Current Medical Research and Opinion · doi:10.1185/030079906x158066 · Cited by 216 · see citing works
Storr, M., Devlin, S. M., Kaplan, G. G., Panaccione, R., & Andrews, C. N. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000440982.79036.d6 · Cited by 207 · see citing works
Baron, E. P. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12570 · Cited by 205 · see citing works
Häuser, W., Finn, D. P., Kalso, E. A., Krcevski‐Škvarč, N., Kress, H. G., Morlion, B. J., Perrot, S., Schäfer, M., Wells, C., & Brill, S. (2018) · European Journal of Pain · doi:10.1002/ejp.1297 · Cited by 201 · see citing works
Marijuana Legalization: Impact on Physicians and Public Health
Wilkinson, S. T., Yarnell, S. C., Radhakrishnan, R., Ball, S. A., & D’Souza, D. C. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-050214-013454 · Cited by 198 · see citing works
Animal models of chronic pain: Advances and challenges for clinical translation
Burma, N. E., Leduc‐Pessah, H., Fan, C. Y., & Trang, T. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23768 · Cited by 198 · see citing works
Romano, B., Borrelli, F., Fasolino, I., Capasso, R., Piscitelli, F., Cascio, M. G., Pertwee, R. G., Coppola, D., Vassallo, L. M., Orlando, P., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12120 · Cited by 181 · see citing works
The Endocannabinoid System, Cannabinoids, and Pain
Fine, P. G., & Rosenfeld, M. J. (2013) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10129 · Cited by 203 · see citing works
Bilbao, A., & Spanagel, R. (2022) · BMC Medicine · doi:10.1186/s12916-022-02459-1 · Cited by 181 · see citing works
Baron, E. P., Lucas, P., Eades, J., & Hogue, O. (2018) · The Journal of Headache and Pain · doi:10.1186/s10194-018-0862-2 · Cited by 182 · see citing works
Mrid, R. B., Bouchmaa, N., Ainani, H., Fatimy, R. E., Malka, G., & Mazini, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113126 · Cited by 183 · see citing works
Cognition enhancers between treating and doping the mind
Lanni, C., Lenzken, S. C., Pascale, A., Vecchio, I. D., Racchi, M., Pistoia, F., & Govoni, S. M. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.02.004 · Cited by 165 · see citing works
Considering Marijuana Legalization: Insights for Vermont and Other Jurisdictions
Caulkins, J. P., Kilmer, B., R.Kleiman, M. A., MacCoun, R. J., Midgette, G., Oglesby, P., Pacula, R. L., & Reuter, P. (2015) · RAND Corporation eBooks · doi:10.7249/rr864 · Cited by 154 · see citing works
Citti, C., Ciccarella, G., Braghiroli, D., Parenti, C., Vandelli, M., & Cannazza, G. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.05.033 · Cited by 139 · see citing works
Cannabis-Based Products for Chronic Pain
McDonagh, M. S., Morasco, B. J., Wagner, J., Ahmed, A. Y., Fu, R. F., Kansagara, D. L., & Chou, R. (2022) · Annals of Internal Medicine · doi:10.7326/m21-4520 · Cited by 150 · see citing works
Fitzcharles, M., Baerwald, C., Ablin, J. N., & Häuser, W. (2016) · Der Schmerz · doi:10.1007/s00482-015-0084-3 · Cited by 150 · see citing works
Macfarlane, G. J., El‐Metwally, A., Silva, V. D., Ernst, E. K., Dowds, G. L., & Moots, R. J. (2011) · Lara D. Veeken · doi:10.1093/rheumatology/ker119 · Cited by 145 · see citing works
The analgesic potential of cannabinoids.
Elikottil, M., Gupta, M., & Gupta, P. (2018) · Journal of Opioid Management · doi:10.5055/jom.2009.0034 · Cited by 141 · see citing works
Cannabinoids and autoimmune diseases: A systematic review
Katchan, V., David, P., & Shoenfeld, Y. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.02.008 · Cited by 143 · see citing works
Medical cannabis or cannabinoids for chronic pain: a clinical practice guideline
Busse, J. W., Vankrunkelsven, P., Zeng, L., Heen, A. F., Merglen, A., Campbell, F. A., Granan, L., Aertgeerts, B., Buchbinder, R., Coen, M., et al. (2021) · BMJ · doi:10.1136/bmj.n2040 · Cited by 142 · see citing works
Cannabinoids, Endocannabinoids and Sleep
Kesner, A. J., & Lovinger, D. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00125 · Cited by 112 · see citing works
Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation
BURSTEIN, S. H., & Zurier, R. B. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9084-5 · Cited by 135 · see citing works
Cannabidiol bioavailability after nasal and transdermal application: effect of permeation enhancers
Paudel, K. S., Hammell, D. C., Agu, R. U., Valiveti, S., & Stinchcomb, A. L. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639041003657295 · Cited by 134 · see citing works
The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease
Barrie, N., & Manolios, N. (2017) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2017.17025 · Cited by 133 · see citing works
Cannabis as an Adjunct to or Substitute for Opiates in the Treatment of Chronic Pain
Lucas, P. (2012) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2012.684624 · Cited by 131 · see citing works
McHugh, D., Tanner, C., Mechoulam, R., Pertwee, R. G., & Ross, R. A. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.041863 · Cited by 131 · see citing works
Kramer, J. L. (2014) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21260 · Cited by 132 · see citing works
Durst, R. Y., Danenberg, H. D., Gallily, R., Mechoulam, R., Meir, K., Grad, E., Beeri, R., Pugatsch, T., Tarsish, E., & Lotan, C. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00098.2007 · Cited by 129 · see citing works
Kraft, B., Frickey, N., Kaufmann, R. M., Reif, M., Frey, R., Gustorff, B., & Kress, H. G. (2008) · Anesthesiology · doi:10.1097/aln.0b013e31817881e1 · Cited by 129 · see citing works
Cannabis, the Endocannabinoid System and Immunity—the Journey from the Bedside to the Bench and Back
Almogi‐Hazan, O., & Or, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124448 · Cited by 132 · see citing works
The effects of cannabinoid administration on sleep: a systematic review of human studies
Gates, P., Albertella, L., & Copeland, J. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.02.005 · Cited by 127 · see citing works
Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors
van Egmond, N., Straub, V. M., & van der Stelt, M. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-030220-112741 · Cited by 129 · see citing works
Therapeutic potential of cannabinoid medicines
Robson, P. (2013) · Drug Testing and Analysis · doi:10.1002/dta.1529 · Cited by 124 · see citing works
Self-citationThe Past, Present and Future of Cannabis sativa Tissue Culture
Monthony, A. S., Page, S. R. G., Hesami, M., & Jones, A. M. P. (2021) · Plants · doi:10.3390/plants10010185 · Cited by 121 · see citing works
Cannabis in Pain Treatment: Clinical and Research Considerations
Savage, S. R., Romero-Sandoval, A. E., Schatman, M. E., Wallace, M. S., Fanciullo, G. J., McCarberg, B. H., & Ware, M. A. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.02.007 · Cited by 120 · see citing works
Subjective and Physiological Effects After Controlled Sativex and Oral THC Administration
Karschner, E. L., Darwin, W. D., McMahon, R. P., Liu, F., Wright, S., Goodwin, R. S., & Huestis, M. A. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.318 · Cited by 117 · see citing works
Cardioprotective effect of cannabidiol in rats exposed to doxorubicin toxicity
Fouad, A. A., Albuali, W. H., Al-Mulhim, A. S., & Jresat, I. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.04.018 · Cited by 116 · see citing works
Pain and Opioids in Cancer Care: Benefits, Risks, and Alternatives
Bennett, M., Paice, J. A., & Wallace, M. S. (2017) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_180469 · Cited by 117 · see citing works
Cannabis and Cannabinoids for Chronic Pain
Romero-Sandoval, E. A., Kolano, A. L., & Alvarado-Vazquez, P. A. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0693-1 · Cited by 115 · see citing works
Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence
Jensen, B., Chen, J. L., Furnish, T. J., & Wallace, M. S. (2015) · Current Pain and Headache Reports · doi:10.1007/s11916-015-0524-x · Cited by 111 · see citing works
Review on clinical studies with cannabis and cannabinoids 2005-2009
Hazekamp, A., & Grotenhermen, F. (2010) · Cited by 110 · see citing works
The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence
Boyaji, S., Merkow, J. S., Elman, R. N. M., Kaye, A. D., Yong, R. J., & Urman, R. D. (2020) · Current Pain and Headache Reports · doi:10.1007/s11916-020-0835-4 · Cited by 136 · see citing works
The discovery and development of analgesics: new mechanisms, new modalities
Burgess, G. M., & Williams, D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43195 · Cited by 109 · see citing works
Yakut, Y., Yakut, E., Bayar, K., & Uygur, F. (2006) · Clinical Rheumatology · doi:10.1007/s10067-006-0452-6 · Cited by 108 · see citing works
Cannabinoids, inflammation, and fibrosis
Zurier, R. B., & BURSTEIN, S. H. (2016) · The FASEB Journal · doi:10.1096/fj.201600646r · Cited by 112 · see citing works
Shah, S. A. A., Akhter, N., Auckloo, B. N., Khan, I. L., Lu, Y., Wang, K., Wu, B., & Guo, Y. (2017) · Marine Drugs · doi:10.3390/md15110354 · Cited by 107 · see citing works
Rock, E. M., Limebeer, C. L., & Parker, L. A. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5034-1 · Cited by 107 · see citing works
Cannabis: An Emerging Treatment for Common Symptoms in Older Adults
Yang, K. H., Kaufmann, C. N., Nafsu, R., Lifset, E. T., Nguyen, K., Sexton, M., Han, B. H., Kim, A., & Moore, A. A. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16833 · Cited by 106 · see citing works
Cannabinoids in Chronic Non-Cancer Pain: A Systematic Review and Meta-Analysis
Johal, H. S., Devji, T., Chang, Y., Simone, J. J., Vannabouathong, C., & Bhandari, M. (2020) · Clinical Medicine Insights Arthritis and Musculoskeletal Disorders · doi:10.1177/1179544120906461 · Cited by 105 · see citing works
The role of endocannabinoids in pain modulation
Zogopoulos, P., Vasileiou, I., Patsouris, E., & Theocharis, S. E. (2013) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12008 · Cited by 106 · see citing works
The use of cannabinoids for sleep: A critical review on clinical trials.
Kuhathasan, N., Dufort, A., MacKillop, J. M., Gottschalk, R., Minuzzi, L., & Frey, B. N. (2019) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000285 · Cited by 105 · see citing works
AminiLari, M., Wang, L., Neumark, S., Adli, T., Couban, R., Giangregorio, A., Carney, C. E., & Busse, J. W. (2021) · SLEEP · doi:10.1093/sleep/zsab234 · Cited by 104 · see citing works
Neuromodulators for pain management in rheumatoid arthritis
Richards, B. L., Whittle, S., & Buchbinder, R. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008921.pub2 · Cited by 105 · see citing works
An Update of Current Cannabis-Based Pharmaceuticals in Pain Medicine
Urits, I., Borchart, M. R., Hasegawa, M. E., Kochanski, J. J., Orhurhu, V., & Viswanath, O. (2019) · Pain and Therapy · doi:10.1007/s40122-019-0114-4 · Cited by 105 · see citing works
Jesus, C. H. A., Redivo, D. D. B., Gasparin, A. T., Sotomaior, B. B., de Carvalho, M. C., Genaro, K., Zuardi, A. W., Hallak, J. E. C., Crippa, J. A. S., Zanoveli, J. M., et al. (2019) · Brain Research · doi:10.1016/j.brainres.2019.03.014 · Cited by 102 · see citing works
Ibrahim, E.-S., Wang, M., Radwan, M. M., Wanas, A. S., Majumdar, C. G., Avula, B., Wang, Y., Khan, I. A., Chandra, S., Lata, H., et al. (2019) · Planta Medica · doi:10.1055/a-0828-8387 · Cited by 104 · see citing works
The Effect of Medical Marijuana Laws on Body Weight
Sabia, J. J., Swigert, J. M., & Young, T. C. (2015) · Health Economics · doi:10.1002/hec.3267 · Cited by 100 · see citing works
Effects of cannabis on cognitive function in patients with multiple sclerosis
Honarmand, K., Tierney, M. C., O'Connor, P. W., & Feinstein, A. (2011) · Neurology · doi:10.1212/wnl.0b013e318212ab0c · Cited by 99 · see citing works
Cannabinoid derivatives and the pharmacological management of pain
Lessa, M. A., Cavalcanti, I. L., & Figueiredo, N. V. (2016) · Revista Dor · doi:10.5935/1806-0013.20160012 · Cited by 101 · see citing works
Role of Cannabinoids in the Treatment of Pain and (Painful) Spasticity
Karst, M., Wippermann, S., & Ahrens, J. (2010) · Drugs · doi:10.2165/11585260-000000000-00000 · Cited by 91 · see citing works
Abraham, T. T., Lowe, R. H., Pirnay, S., Darwin, W. D., & Huestis, M. A. (2007) · Journal of Analytical Toxicology · doi:10.1093/jat/31.8.477 · Cited by 89 · see citing works
Fitzcharles, M., Ste‐Marie, P. A., Häuser, W., Clauw, D. J., Jamal, S., Karsh, J., Landry, T., LECLERCQ, S. A., McDougall, J. J., Shir, Y., et al. (2015) · Arthritis Care & Research · doi:10.1002/acr.22727 · Cited by 85 · see citing works
Cannabidiol-Δ 9 -tetrahydrocannabinol interactions on acute pain and locomotor activity
Britch, S. C., Wiley, J. L., Yu, Z., Clowers, B. H., & Craft, R. M. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.01.046 · Cited by 83 · see citing works
Khurana, L., Mackie, K., Piomelli, D., & Kendall, D. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.05.018 · Cited by 79 · see citing works
Linciano, P., Citti, C., Luongo, L., Belardo, C., Maione, S., Vandelli, M. A., Forni, F., Gigli, G., Laganà, A., Montone, C. M., et al. (2019) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b00876 · Cited by 80 · see citing works
Ueberall, M. A. (2020) · Journal of Pain Research · doi:10.2147/jpr.s240011 · Cited by 79 · see citing works
McCarberg, B. H., & Barkin, R. L. (2007) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3180a5e581 · Cited by 76 · see citing works
Bell, A. D., MacCallum, C., Margolese, S., Walsh, Z., Wright, P., Daeninck, P. J., Mandarino, E., Lacasse, G., Kaur Deol, J., de Freitas, L., et al. (2024) · Cannabis & Cannabinoid Research · doi:10.1089/can.2021.0156 · Cited by 78 · see citing works
Medicinal Uses of Marijuana and Cannabinoids
Grotenhermen, F., & Müller‐Vahl, K. (2016) · Critical Reviews in Plant Sciences · doi:10.1080/07352689.2016.1265360 · Cited by 72 · see citing works
Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations
Arout, C. A., Edens, E., Petrakis, I. L., & Sofuoglu, M. (2015) · CNS Drugs · doi:10.1007/s40263-015-0255-x · Cited by 80 · see citing works
Lowe, R. H., Karschner, E. L., Schwilke, E. W., Barnes, A. J., & Huestis, M. A. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.06.069 · Cited by 73 · see citing works
Schröder, S., Beckmann, K. H., Franconi, G., Meyer‐Hamme, G., Friedemann, T., Greten, H. J., Rostock, M., & Efferth, T. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/423713 · Cited by 72 · see citing works
Current application of cannabidiol (CBD) in the management and treatment of neurological disorders
Fiani, B., Sarhadi, K. J., Soula, M., Zafar, A., & Quadri, S. A. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04514-2 · Cited by 70 · see citing works
- Authors
- Blake, D. R., Robson, P., Ho, M., Jubb, R. W., & McCabe, C. S.
- Affiliations
- Royal National Hospital for Rheumatic Diseases (GB)
- University of Oxford (GB)
- Northampton General Hospital (GB)
- Selly Oak Hospital (GB)
- Corresponding author
- Blake, D. R.
- ORCID
- McCabe, C. S.
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-11-09
- Volume
- 45
- Issue
- 1
- Pages
- 50-52
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2155565260
- Cited by
- 433
- References
- 10
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 25 · 2023: 19 · 2022: 45 · 2021: 34 · 2020: 37 · 2019: 35 · 2018: 31 · 2017: 19 · 2016: 22 · 2015: 14 · 2014: 18 · 2013: 11 · 2012: 16
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lara D. Veeken (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GW Pharmaceuticals
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- Sativex, cannabis-based medicines, rheumatoid arthritis, pain, oromucosal spray, analgesia, disease activity, sleep quality, morning stiffness, tolerability, adverse effects
- MeSH terms
- Administration, Oral, Analgesics, Arthritis, Rheumatoid, Cannabidiol, Double-Blind Method, Drug Combinations, Female, Humans, Male, Middle Aged, Pain, Pain Measurement, Plant Extracts, Dronabinol, Treatment Outcome
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