Cited by 170Pain Management and Opioid UsePain Mechanisms and TreatmentsAnesthesia and Pain Management

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Pharmacological treatment of chronic pain—The need for CHANGE

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Varrassi, G., Müller-Schwefe, G., Pergolizzi, J., Orónska, A., Morlion, B., Mavrocordatos, P., Margarit, C., Mangas, C., Jaksch, W., Huygen, F., Collett, B., Berti, M., Aldington, D., Ahlbeck, K.·2010·Current Medical Research and Opinion

DOI 10.1185/03007991003689175

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Abstract

BACKGROUND: Although chronic pain affects around 20% of adults in Europe and the USA, there is substantial evidence that it is inadequately treated. In June 2009, an international group of pain specialists met in Brussels to identify the reasons for this and to achieve consensus on strategies for improving pain management. SCOPE: Literature on chronic pain management was reviewed, and information presented to and discussed by a panel of experts. FINDINGS: It was agreed that guidelines are not universally accepted by those involved in pain management, and pain treatment seems to be driven mainly by tradition and personal experience. Other factors include poor communication between patients and physicians, the side effects of analgesic drugs, and limited individualisation of therapy. Difficulty in maintaining the balance between adequate pain relief and acceptable tolerability, particularly with strong opioids, can lead to the establishment of a 'vicious circle' that alternates between lack of efficacy and unpleasant side effects, prompting discontinuation of treatment. The medical community's understanding of the physiological differences between nociceptive pain and neuropathic pain, which is often more severe and difficult to treat, could be improved. Increasing physicians' knowledge of the pharmacological options available to manage these different pain mechanisms offers the promise of better treatment decisions and more widespread adoption of a multi-mechanistic approach; this could involve loosely combining two substances from different drug classes, or administering an analgesic with two different mechanisms of action. In some circumstances, a single compound capable of addressing both nociceptive and neuropathic pain is desirable. CONCLUSIONS: To improve patient outcomes, a thorough understanding of pain mechanisms, sensitisation and multi-mechanistic management is required. Universal, user-friendly educational tools are therefore required to familiarise physicians with these topics, and also to improve communication between physicians and their pain patients, so that realistic expectations of treatment can be established.

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Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment
Breivik, H., Collett, B., Ventafridda, V., Cohen, R., & Gallacher, D. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2005.06.009 · Cited by 5,486
Self-citation
Epidemiological features of chronic low-back pain
Andersson, G. B. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01312-4 · Cited by 3,181
pain DETECT : a new screening questionnaire to identify neuropathic components in patients with back pain
Freynhagen, R., Baron, R., Gockel, U., & Tölle, T. R. (2006) · Current Medical Research and Opinion · doi:10.1185/030079906x132488 · Cited by 2,280
Opioid Complications and Side Effects
Benyamin, R. M. (2008) · Pain Physician · doi:10.36076/ppj.2008/11/s105 · Cited by 2,272
Pharmacologic management of neuropathic pain: Evidence-based recommendations
Dworkin, R. H., O’Connor, A. B., Backonja, M., Farrar, J. T., Finnerup, N. B., Jensen, T. S., Kalso, E. A., Loeser, J. D., Miaskowski, C., Nurmikko, T. J., et al. (2007) · Pain · doi:10.1016/j.pain.2007.08.033 · Cited by 2,126
Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage
Costigan, M., Scholz, J., & Woolf, C. J. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135531 · Cited by 2,025
Prevalence of pain in patients with cancer: a systematic review of the past 40 years
van den Beuken-van Everdingen, M. H. J., de Rijke, J. M., Kessels, A. G., Schouten, H. C., van Kleef, M., & Patijn, J. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm056 · Cited by 1,923
The Value of ???Multimodal??? or ???Balanced Analgesia??? in Postoperative Pain Treatment
Kehlet, H., & Dahl, J. R. B. (1993) · Anesthesia & Analgesia · doi:10.1213/00000539-199311000-00030 · Cited by 1,477
Algorithm for neuropathic pain treatment: An evidence based proposal
Finnerup, N. B., Otto, M., McQuay, H. J., Jensen, T. S., & Sindrup, S. H. (2005) · Pain · doi:10.1016/j.pain.2005.08.013 · Cited by 1,337
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
Kalso, E., Edwards, J. E., Moore, A. R., & McQuay, H. J. (2004) · Pain · doi:10.1016/j.pain.2004.09.019 · Cited by 1,216
Advances in Neuropathic Pain
Dworkin, R. H., Bačkonja, M., Rowbotham, M. C., Allen, R. R., Argoff, C., Bennett, G. J., Bushnell, M. C., Farrar, J. T., Galer, B. S., Haythornthwaite, J. A., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.11.1524 · Cited by 1,213
Drug Metabolism and Variability among Patients in Drug Response
Wilkinson, G. R. (2005) · New England Journal of Medicine · doi:10.1056/nejmra032424 · Cited by 1,185
Chronic pain in Australia: a prevalence study.
Blyth, F. M., March, L. M., Brnabic, A. J. M., Jorm, L. R., Williamson, M., & Cousins, M. J. (2001) · Pain · doi:10.1016/s0304-3959(00)00355-9 · Cited by 1,096
EFNS guidelines on pharmacological treatment of neuropathic pain
Attal, N., Cruccu, G., Haanpää, M. L., Hansson, P. T., Jensen, T. S., Nurmikko, T. J., Sampaio, C., Sindrup, S. H., & Wiffen, P. J. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01511.x · Cited by 877
Opioids and the Management of Chronic Severe Pain in the Elderly: Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step III Opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone)
Pergolizzi, J. V., Böger, R. H., Budd, K., Dahan, A., Erdine, S., Hans, G. H., Kress, H. G., Langford, R., Likar, R., Raffa, R. B., et al. (2008) · Pain Practice · doi:10.1111/j.1533-2500.2008.00204.x · Cited by 855
Self-citation
Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications
Whelton, A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00113-8 · Cited by 704
An international survey of cancer pain characteristics and syndromes
Caraceni, A. T., & Portenoy, R. K. (1999) · Pain · doi:10.1016/s0304-3959(99)00073-1 · Cited by 633
Antidepressants in the Treatment of Neuropathic Pain
Sindrup, S. H., Otto, M., Finnerup, N. B., & Jensen, T. S. (2005) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2005.pto_96696601.x · Cited by 625
Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness
Thomas, J., Karver, S. B., Cooney, G. A., Chamberlain, B. H., Watt, C. K., Slatkin, N. E., Stambler, N., Kremer, A. B., & Israel, R. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707377 · Cited by 589
The assessment of chronic health conditions on work performance, absence, and total economic impact for employers
Collins, J. J., Baase, C. M., Sharda, C. E., Ozminkowski, R. J., Nicholson, S., Billotti, G. M., Turpin, R. S., Olson, M., & Berger, M. L. (2005) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000166864.58664.29 · Cited by 566
Pharmacology and mechanism of action of pregabalin: The calcium channel α2–δ (alpha2–delta) subunit as a target for antiepileptic drug discovery
Taylor, C. P., Angelotti, T. P., & Fauman, E. B. (2006) · Epilepsy Research · doi:10.1016/j.eplepsyres.2006.09.008 · Cited by 566
Prediction of Pharmacokinetic Alterations Caused by Drug-Drug Interactions: Metabolic Interaction in the Liver
Ito, K., Iwatsubo, T., Kanamitsu, S.-I., Ueda, K., Suzuki, H., & Sugiyama, Y. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01372-3 · Cited by 511
The Prevalence, Severity, and Impact of Opioid-Induced Bowel Dysfunction: Results of a US and European Patient Survey (PROBE 1)
BELL, T. J., Panchal, S. J., Miaskowski, C. A., Bolge, S. C., Milanova, T. F., & Williamson, R. (2008) · Pain Medicine · doi:10.1111/j.1526-4637.2008.00495.x · Cited by 500
Prevalence of Disabilities and Associated Health Conditions Among Adults—United States, 1999
(2001) · JAMA · doi:10.1001/jama.285.12.1571-jwr0328-3-1 · Cited by 495
Costs of back pain in Germany
Wenig, C. M., Schmidt, C. O., Kohlmann, T., & Schweikert, B. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.04.005 · Cited by 431
Pain epidemiology and health related quality of life in chronic non-malignant pain patients referred to a Danish multidisciplinary pain center
Becker, N., Thomsen, A. B., Olsen, A. K., Sjøgren, P., Bech, P., & Eriksen, J. (1997) · Pain · doi:10.1016/s0304-3959(97)00126-7 · Cited by 425
(–)-(1 R,2 R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol Hydrochloride (Tapentadol HCl): a Novel μ-Opioid Receptor Agonist/Norepinephrine Reuptake Inhibitor with Broad-Spectrum Analgesic Properties
Tzschentke, T., Christoph, T., Kögel, B. Y., Schiene, K., Hennies, H. ‐., Englberger, W., Haurand, M., Jahnel, U., Cremers, T. I. F. H., Friderichs, E., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.126052 · Cited by 395
The burden of neuropathic pain: results from a cross‐sectional survey
McDermott, A. M., Toelle, T. R., Rowbotham, D. J., Schaefer, C. P., & Dukes, E. M. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2005.01.014 · Cited by 378
Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids
Moore, R. A., & McQuay, H. J. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1782 · Cited by 377
Efficacy of Opioids for Chronic Pain: A Review of the Evidence
Ballantyne, J., & Shin, N. S. (2008) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e31816b2f26 · Cited by 361
A Randomized Study of the Effects of Single-dose Gabapentin versus Placebo on Postoperative Pain and Morphine Consumption after Mastectomy
Dirks, J., Fredensborg, B. B., Christensen, D., Fomsgaard, J. S., Flyger, H., & Dahl, J. B. (2002) · Anesthesiology · doi:10.1097/00000542-200209000-00007 · Cited by 360
Persistent Pain as a Disease Entity: Implications for Clinical Management
Siddall, P. J., & Cousins, M. J. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000133383.17666.3a · Cited by 350
Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden
Panchal, S. J., Müller-Schwefe, P. C. G., & Wurzelmann, J. I. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01415.x · Cited by 330
Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers
Eckhardt, K., Ammon, S., Hofmann, U., Riebe, A., Gugeler, N., & Mikus, G. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200007000-00035 · Cited by 287
The symptoms of advanced cancer.
Donnelly, S. M., & Walsh, D. (1995) · PubMed · Cited by 283
Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents
Nguyen, J. K., Fouts, M. M., Kotabe, S. E., & Lo, E. (2006) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2006.03.002 · Cited by 265
Prevalence and characteristics of chronic pain in the general Norwegian population
Rustøen, T., Wahl, A. K., Hanestad, B. R., Lerdal, A., Paul, S. M., & Miaskowski, C. A. (2004) · European Journal of Pain · doi:10.1016/j.ejpain.2004.02.002 · Cited by 263
A randomised controlled trial with prolonged‐release oral oxycodone and naloxone to prevent and reverse opioid‐induced constipation
Meißner, W., Leyendecker, P., Mueller‐Lissner, S., Nadstawek, J., Hopp, M., Ruckes, C., Wirz, S., Fleischer, W., & Reimer, K. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.06.012 · Cited by 257
Burden of Illness in Painful Diabetic Peripheral Neuropathy: The Patients’ Perspectives
Gore, M. R., Brandenburg, N. A., Hoffman, D. L., Tai, K.-S., & Stacey, B. R. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.04.013 · Cited by 244
Prolonged‐release oxycodone enhances the effects of existing gabapentin therapy in painful diabetic neuropathy patients
Hanna, M., O’Brien, C., & Wilson, M. C. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2007.12.010 · Cited by 225
Chronic pain: treatment barriers and strategies for clinical practice.
Glajchen, M. (2001) · PubMed · Cited by 224
Nausea and Vomiting Side Effects with Opioid Analgesics during Treatment of Chronic Pain: Mechanisms, Implications, and Management Options
Porreca, F., & Ossipov, M. H. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00583.x · Cited by 220
Epidemiology of chronic pain in Denmark: An update
Sjøgren, P., Ekholm, O., Peuckmann, V., & Grønbæk, M. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2008.04.007 · Cited by 203
Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers
Eckhardt, K., Ammon, S., Hofmann, U., et al. (2000) · Anesthesia & Analgesia · doi:10.1213/00000539-200007000-00035 · Cited by 198
Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma
Kim, Y., Giuliano, A. R., Hatch, K. D., Schneider, A., Nour, M., Dallal, G. E., Selhub, J., & Mason, J. B. (1994) · Cancer · doi:10.1002/1097-0142(19940801)74:3 · Cited by 195
Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain
Simpson, K. H., Leyendecker, P., Hopp, M., Müller-Lissner, S. A., Löwenstein, O., Andrés, J. A. D., Ferrarons, J. T., Bosse, B., Krain, B., Nichols, T., et al. (2008) · Current Medical Research and Opinion · doi:10.1185/03007990802584454 · Cited by 177
Survey of select practice behaviors by primary care physicians on the use of opioids for chronic pain
Bhamb, B., Brown, D. C., Hariharan, J., Anderson, J. E., Balousek, S. L., & Fleming, M. F. (2006) · Current Medical Research and Opinion · doi:10.1185/030079906x132398 · Cited by 172
Alvimopan: An oral, peripherally acting, μ-opioid receptor antagonist for the treatment of opioid-induced bowel dysfunction—A 21-day treatment-randomized clinical trial
Paulson, D. M., Kennedy, D. T., Donovick, R. A., Carpenter, R. L., Cherubini, M., Techner, L. M., Du, W., Ma, Y., Schmidt, W. K., Wallin, B., et al. (2005) · Journal of Pain · doi:10.1016/j.jpain.2004.12.001 · Cited by 157
Pain, opioid use, and survival in hospitalized patients with advanced cancer.
Brescia, F. J., Portenoy, R. K., Ryan, M. A., Krasnoff, L., & Gray, G. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.1.149 · Cited by 153
Epidemiology and natural history of low back pain.
Dunn, K. M., & Croft, P. (2004) · PubMed · Cited by 147
Mechanisms of the analgesic actions of opiates and opioids
Dickenson, A. H. (1991) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072501 · Cited by 147
Opioid Metabolites
Lötsch, J. (2005) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2005.01.004 · Cited by 145
Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain
Webster, L. R., Jansen, J. P., Peppin, J. F., Lasko, B., Irving, G. A., Morlion, B. J., Snidow, J. W., Pierce, A., Mortensen, E. R., Kleoudis, C. S., et al. (2008) · Pain · doi:10.1016/j.pain.2007.11.008 · Cited by 144
Self-citation
Adverse Effects of Opioids on the Central Nervous Systems of Palliative Care Patients
Vella-Brincat, J., & Macleod, A. D. (2007) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/j354v21n01_05 · Cited by 138
Tolerability of tapentadol immediate release in patients with lower back pain or osteoarthritis of the hip or knee over 90 days: a randomized, double-blind study
Hale, M. E., Upmalis, D. H., Okamoto, A., Lange, C., & Rauschkolb, C. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990902816970 · Cited by 133
Circuitry Underlying Antiopioid Actions of Cholecystokinin Within the Rostral Ventromedial Medulla
Heinricher, M. M., McGaraughty, S., & Tortorici, V. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.1.280 · Cited by 125
Role of active metabolites in the use of opioids
Coller, J. K., Christrup, L. L., & Somogyi, A. A. (2008) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-008-0570-y · Cited by 113
Management of Expected and Unexpected Opioid-related Side Effects
Harris, J.-D. (2008) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31816b58eb · Cited by 101
Modelling the prevalence and cost of back pain with neuropathic components in the general population
Schmidt, C. O., Schweikert, B., Wenig, C. M., Schmidt, U., Gockel, U., Freynhagen, R., Tölle, T. R., Baron, R., & Kohlmann, T. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2008.12.003 · Cited by 101
Assessing and Managing Opiate-Induced Constipation in Adults with Cancer
McMillan, S. C. (2004) · Cancer Control · doi:10.1177/10732748040110s302 · Cited by 95
Opioid Metabolism and Effects of Cytochrome P450
Holmquist, G. L. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00596.x · Cited by 94
Physician-related barriers to cancer pain management with opioid analgesics: A systematic review
Jacobsen, R., Per Sjøgren, M., Møldrup, C., & Christrup, L. L. (2007) · Journal of Opioid Management · doi:10.5055/jom.2007.0006 · Cited by 92
Cellular Actions Of Opioids And Other Analgesics: Implications For Synergism In Pain Relief
Christie, M. J., Connor, M. A., Vaughan, C. W., Ingram, S., & Bagley, E. E. (2000) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2000.03291.x · Cited by 90
Gabapentin may inhibit synaptic transmission in the mouse spinal cord dorsal horn through a preferential block of P/Q-type Ca2+ channels
Bayer, K., Ahmadi, S., & Zeilhofer, H. U. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.11.010 · Cited by 90
Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes
Kneip, C., Terlinden, R., Beier, H., & Chen, G. (2008) · Drug Metabolism Letters · doi:10.2174/187231208783478434 · Cited by 87
What is new in neuropathic pain?
Davis, M. P. (2006) · Supportive Care in Cancer · doi:10.1007/s00520-006-0156-0 · Cited by 67
SNRIs: mechanism of action and clinical features
Lambert, O., & Bourin, M. (2002) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2.6.849 · Cited by 63
How do opiates inhibit neurotransmitter release?
NORTH, R. A., & Williams, J. T. (1983) · Trends in Neurosciences · doi:10.1016/0166-2236(83)90151-0 · Cited by 57
Enhancement of opioid inhibition of GABAergic synaptic transmission by cyclo‐oxygenase inhibitors in rat periaqueductal grey neurones
Vaughan, C. W. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701818 · Cited by 56
Management of cancer pain: ESMO Clinical Recommendations
Jost, L., & Roila, F. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp164 · Cited by 56
Pain: Causes and Management
Davis, B. (1999) · Journal of Psychiatric and Mental Health Nursing · doi:10.1046/j.1365-2850.1999.00227-8.x · Cited by 52
Differences in the Prevalence and Severity of Side Effects Based on Type of Analgesic Prescription in Patients with Chronic Cancer Pain
Villars, P., Dodd, M. J., West, C. M., Koetters, T., Paul, S. M., Schumacher, K. L., Tripathy, D., Koo, P., & Miaskowski, C. A. (2006) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2006.07.011 · Cited by 47
Der Chronische Schmerz
Zimmermann, M. (2004) · Der Orthop�de · doi:10.1007/s00132-003-0609-9 · Cited by 46
Pain as an Early Symptom in Cancer
Vuorinen, E. (1993) · Clinical Journal of Pain · doi:10.1097/00002508-199312000-00009 · Cited by 41
Referral practices in patients suffering from non‐malignant chronic pain
Schulte, E., Hermann, K., Berghöfer, A., Hagmeister, H., Schuh‐Hofer, S., Schenk, M., Köpf, A., Vilain, M., Martus, P., Willich, S. N., et al. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2009.05.015 · Cited by 38
Opioid Prescribing Practices in Chronic Pain Management: Guidelines Do Not Sufficiently Influence Clinical Practice
Victor, T. W., Álvarez, N. A., & Gould, E. M. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.03.019 · Cited by 37
Amantadine, a N-Methyl-d-Aspartate Receptor Antagonist, Does Not Enhance Postoperative Analgesia in Women Undergoing Abdominal Hysterectomy
Gottschalk, A., Schroeder, F., Ufer, M., Oncü, A., Buerkle, H., & Standl, T. G. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200107000-00038 · Cited by 33
Significant anticonvulsant side-effects in children and adolescents
Harbord, M. G. (2000) · Journal of Clinical Neuroscience · doi:10.1054/jocn.1999.0190 · Cited by 33
Effect of nonsteroidal anti-inflammatory drugs on the gastrointestinal tract: diagnosis by wireless capsule endoscopy
Chutkan, R. K., & Toubia, N. A. (2004) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2003.10.009 · Cited by 30
Management of cancer pain: ESMO Clinical Recommendations
Jost, L., & Roila, F. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn108 · Cited by 22
New Pain Guideline for Older Patients
Kuehn, B. M. (2009) · JAMA · doi:10.1001/jama.2009.887 · Cited by 18
Opioid Side-effects
SHERRY, K. M., & Fallon, M. (2000) · Cited by 17
(224) Tapentadol immediate release compared with oxycodone immediate release for the relief of moderate-to-severe pain in patients with end stage joint disease
Afilalo, M., Oh, C., Okamoto, A., Hove, I. V., Stegmann, J., & Upmalis, D. H. (2008) · Journal of Pain · doi:10.1016/j.jpain.2008.01.145 · Cited by 8
Multimodal Analgesic Therapy
Pergolizzi, J. V., & WILLS, L. M. (2005) · Elsevier eBooks · doi:10.1016/b978-1-4160-2454-5.50024-2 · Cited by 7
Self-citation
NA and 5‐HT Reuptake Inhibitors and α 2 Agonists
Tzschentke, T. (2002) · doi:10.1002/3527605614.ch4 · Cited by 6
New classes of antidepressant drugs
Scott, A. I. F. (1999) · Advances in Psychiatric Treatment · doi:10.1192/apt.5.2.104 · Cited by 2
705 INDIVIUDAL TREATMENT TARGETS IN CHRONIC PAIN MANAGEMENT
Ueberall, M. A., & Mueller-Schwefe, G. H. H. (2006) · European Journal of Pain · doi:10.1016/s1090-3801(06)60708-8 · Cited by 1
188 PROSPECTIVE STUDY OF THE PHARMACOLOGIC MANAGEMENT OF CHRONIC NEUROPATHIC NON‐CANCER PAIN
Moulin, D. E., Morley-Forster, P. K., Connolly, B. S., Guerin, J., & Clark, A. J. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2007.03.203 · Cited by 1

Flagged first, then by citations

Research works printed but not linked: 3

Coda BA Bonica JJ. General considerations of acute pain. In: Loeser JD Butler SH Chapman CR Turk DC eds. Bonica’s Management of Pain 3rd edn. Philadelphia PA: Lippincott Williams & Wilkins 2001:222-40
Rodriguez MJ. Survey of therapeutic attitudes towards patients with chronic pain in Spanish Pain Units. Rev Soc Esp Dolor 2006;13:525-32
Workers’ Compensation Report. Kew Victoria: Journal of Risk and Insurance 1 November 2004

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Austin, P. J., & Moalem-Taylor, G. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.08.013 · Cited by 607
Dorsal Horn Circuits for Persistent Mechanical Pain
Peirs, C., Williams, S.-P. G., Zhao, X., Walsh, C. E., Gedeon, J. Y., Cagle, N. E., Goldring, A. C., Hioki, H., Liu, Z., Marell, P. S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.029 · Cited by 327
Management of Persistent Pain in the Older Patient
Makris, U. E., Abrams, R. C., Gurland, B. J., & Reid, M. C. (2014) · JAMA · doi:10.1001/jama.2014.9405 · Cited by 337
Effects of yoga interventions on pain and pain-associated disability: a meta-analysis.
Büssing, A., Ostermann, T., Lüdtke, R., & Michalsen, A. (2012) · Journal of Pain · doi:10.1016/j.jpain.2011.10.001 · Cited by 293
Trends in analgesic consumption in France over the last 10 years and comparison of patterns across Europe
Hider‐Mlynarz, K., Cavalié, P., & Maison, P. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13564 · Cited by 166

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Authors: Varrassi, G., Müller-Schwefe, G., Pergolizzi, J., Orónska, A., Morlion, B., Mavrocordatos, P., Margarit, C., Mangas, C., Jaksch, W., Huygen, F., Collett, B., Berti, M., Aldington, D., & Ahlbeck, K.
Affiliations: University of L'Aquila (IT)
Schmerz- und Palliativzentrum, Göppingen, Germany
Naples Anesthesia & Physician Associates (US)
Hospicjum Domowe, Wrocław, Poland
Universitair Ziekenhuis Leuven (BE)
Hirslanden Clinique Cecil (CH)
Hospital General Universitario de Alicante Doctor Balmis (ES)
Hospital de Santo André (PT)
Wilhelminen Hospital (AT)
Erasmus MC (NL)
Leicester Royal Infirmary (GB)
Ospedale di Parma (IT)
Churchill Hospital (GB)
Karolinska University Hospital (SE)
Corresponding author: Pergolizzi, J.
ORCID: Varrassi, G.
Pergolizzi, J.
Morlion, B.
Margarit, C.
Jaksch, W.
Huygen, F.
Berti, M.
Aldington, D.
Venue: Current Medical Research and Opinion
Publisher: Informa UK Limited
Published: 2010-03-25
Volume: 26
Issue: 5
Pages: 1231-1245
ISSN: 0300-7995 (ISSN-L)
1473-4877
DOI: 10.1185/03007991003689175
OpenAlex: W2003872067
Cited by: 167
References: 88
Citations by year: 2026: 5 · 2025: 8 · 2024: 7 · 2023: 14 · 2022: 3 · 2021: 15 · 2020: 12 · 2019: 13 · 2018: 10 · 2017: 6 · 2016: 2 · 2015: 12 · 2014: 8 · 2013: 12 · 2012: 12
FWCI: 3.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Current Medical Research and Opinion (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics: Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
Keywords: chronic pain, pharmacotherapy, pain management, analgesic side effects, strong opioids, opioid tolerability, neuropathic pain, nociceptive pain, analgesic combination therapy, pain mechanisms, sensitization, physician-patient communication, treatment guidelines, physician training
MeSH terms: Analgesics, Chronic Disease, Humans, Pain, Practice Guidelines as Topic

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Pharmacological treatment of chronic pain—The need for CHANGE

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