The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Role of TNFα in pulmonary pathophysiology
Open accessAbstract
Tumor necrosis factor alpha (TNFα) is the most widely studied pleiotropic cytokine of the TNF superfamily. In pathophysiological conditions, generation of TNFα at high levels leads to the development of inflammatory responses that are hallmarks of many diseases. Of the various pulmonary diseases, TNFα is implicated in asthma, chronic bronchitis (CB), chronic obstructive pulmonary disease (COPD), acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In addition to its underlying role in the inflammatory events, there is increasing evidence for involvement of TNFα in the cytotoxicity. Thus, pharmacological agents that can either suppress the production of TNFα or block its biological actions may have potential therapeutic value against a wide variety of diseases. Despite some immunological side effects, anti-TNFα therapeutic strategies represent an important breakthrough in the treatment of inflammatory diseases and may have a role in pulmonary diseases characterized by inflammation and cell death.
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Cites
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“A high level of TNFα is also observed in human subjects administered bacterial endotoxin [10].”
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Cited by
TNF-mediated inflammatory disease
Bradley, Jr. (2008) · The Journal of Pathology · doi:10.1002/path.2287 · Cited by 2,094
Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections
Debarbieux, L., Leduc, D., Maura, D., Morello, E., Criscuolo, A., Grossi, O., Balloy, V., & Touqui, L. (2010) · The Journal of Infectious Diseases · doi:10.1086/651135 · Cited by 304
TNFα inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation
Borges, V. M., Vandivier, R. W., McPhillips, K. A., Kench, J. A., Morimoto, K., Groshong, S. D., Richens, T. R., Graham, B. B., Muldrow, A. M., Heule, L. V., et al. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90569.2008 · Cited by 56
Investigating NF-κB signaling in lung fibroblasts in 2D and 3D culture systems
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Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its Activity
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Metadata
- Authors
- Mukhopadhyay, S., Hoidal, J. R., & Mukherjee, T. K.
- Venue
- Respiratory Research
- Published
- 2006-10-11
- Volume
- 7
- Issue
- 1
- Pages
- 125-125
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- OpenAlex
- W2102996167
- Cited by
- 576
- References
- 4
- FWCI
- 16.08
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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