LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

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Actin stress fibres

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Glucose metabolism and cancer

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Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD

Baas, A. F., Kuipers, J., van der Wel, N. N., Batlle, E., Koerten, H. K., Peters, P. J., & Clevers, H. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00114-x · Cited by 508 · see citing works

Energy-dependent regulation of cell structure by AMP-activated protein kinase

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The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

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Growth suppression by Lkb1 is mediated by a G 1 cell cycle arrest

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A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity

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The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry

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Cell Cycle Arrest

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Roles of p-ERM and Rho–ROCK signaling in lymphocyte polarity and uropod formation

Lee, J., Katakai, T., Hara, T., Gonda, H., Sugai, M., & Shimizu, A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403091 · Cited by 184 · see citing works

Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex

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Activated Ezrin Promotes Cell Migration through Recruitment of the GEF Dbl to Lipid Rafts and Preferential Downstream Activation of Cdc42

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The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity

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Understanding ERM proteins – the awesome power of genetics finally brought to bear

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Regulation of epithelial apical junctional complex by Rho family GTPases

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Autoinhibition Mechanism of Proto-Dbl

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LKB1 regulates polarity remodeling and adherens junction formation in the <i>Drosophila</i> eye

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LKB1 and Lung Cancer: More Than the Usual Suspects

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Gα13 Regulation of Proto-Dbl Signaling

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A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

Mohseni, M., Sun, J., Lau, A., Curtis, S., Goldsmith, J., Fox, V. L., Wei, C., Frazier, M., Samson, O., Wong, K.-K., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2884 · Cited by 294 · see citing works

Competition between human cells by entosis

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A protein interaction landscape of breast cancer

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Cell polarity signaling in the plasticity of cancer cell invasiveness

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Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

Mukhopadhyay, S., Huang, H.-Y., Lin, Z., Ranieri, M., Li, S., Sahu, S., Liu, Y., Ban, Y., Guidry, K., Hu, H., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-2729 · Cited by 105 · see citing works

Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis

Rodriguez-Fraticelli, A., Auzan, M., Alonso, M. A., Bornens, M., & Martín‐Belmonte, F. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201203075 · Cited by 104 · see citing works

The Wnt signaling pathways and cell adhesion

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Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation

Zihni, C., Munro, P., Elbediwy, A., Keep, N. H., Terry, S. J., Harris, J., Balda, M. S., & Matter, K. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201304064 · Cited by 58 · see citing works

Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis

Okon, I. S., Coughlan, K. A., Zhang, C., Moriasi, C., Ding, Y., Song, P., Zhang, W., Li, G., & Zou, M.-H. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75371 · Cited by 52 · see citing works

LKB1 Represses Focal Adhesion Kinase (FAK) Signaling via a FAK-LKB1 Complex to Regulate FAK Site Maturation and Directional Persistence

Kline, E. R., Shupe, J. A., Gilbert‐Ross, M., Zhou, W., & Marcus, A. I. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.444620 · Cited by 50 · see citing works

LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion

Konen, J. M., Wilkinson, S. C., Lee, B., Fu, H., Zhou, W., Jiang, Y., & Marcus, A. I. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-08-0569 · Cited by 47 · see citing works

LKB1 Controls Human Bronchial Epithelial Morphogenesis through p114RhoGEF-Dependent RhoA Activation

Xu, X., Jin, D., Durgan, J., & Hall, A. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00154-13 · Cited by 46 · see citing works

Globular adiponectin induces LKB1/AMPK-dependent glucose uptake via actin cytoskeleton remodeling

Vu, V. P., Bui, P., Eguchi, M., Xu, A., & Sweeney, G. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0059 · Cited by 34 · see citing works

The LKB1 Tumor Suppressor Controls Spindle Orientation and Localization of Activated AMPK in Mitotic Epithelial Cells

Wei, C., Bhattaram, V. K., Igwe, J. C., Fleming, E. S., & Tirnauer, J. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041118 · Cited by 28 · see citing works

Energy management – a critical role in cancer induction?

Garland, J. M. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.04.001 · Cited by 21 · see citing works

Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex

Ryan, K. E., Kim, P. S., Fleming, J. T., Brignola, E., Cheng, F. Y., Litingtung, Y., & Chiang, C. C. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.09.036 · Cited by 19 · see citing works

Expression and transcriptional profiling of the LKB1 tumor suppressor in cervical cancer cells

Zhang, X., Chen, H., Wang, X., Zhao, W., & Chen, J. J. (2014) · Gynecologic Oncology · doi:10.1016/j.ygyno.2014.04.050 · Cited by 19 · see citing works

Cofilin/Twinstar Phosphorylation Levels Increase in Response to Impaired Coenzyme A Metabolism

Siudeja, K., Grzeschik, N. A., Rana, A., de Jong, J., & Sibon, O. C. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043145 · Cited by 15 · see citing works

LKB1 signaling in cephalic neural crest cells is essential for vertebrate head development

Creuzet, S., Viallet, J. P., Ghawitian, M., Torch, S., Thélu, J., Alrajeh, M., Radu, A. G., Bouvard, D., Costagliola, F., Borgne, M. L., et al. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.08.006 · Cited by 14 · see citing works

Activation of Dbl restores migration in polyamine-depleted intestinal epithelial cells via Rho-GTPases

Ray, R. M., Bavaria, M. N., Bhattacharya, S., & Johnson, L. R. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00409.2010 · Cited by 12 · see citing works

Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers

Okon, I. S., Ye, D., Coughlan, K. A., Wang, Q., Song, P., Benbrook, D. M., & Zou, M. (2015) · Oncotarget · doi:10.18632/oncotarget.6699 · Cited by 12 · see citing works

Coordinated cell motility is regulated by a combination of LKB1 farnesylation and kinase activity

Wilkinson, S. C., Hou, Y., Zoine, J. T., Saltz, J. H., Zhang, C., Chen, Z., Cooper, L., & Marcus, A. I. (2017) · Scientific Reports · doi:10.1038/srep40929 · Cited by 10 · see citing works

Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice

Moon, Y., Kim, J. Y., Choi, S. Y., Cho, H. M., Kim, H., & Sun, W. (2012) · Histochemistry and Cell Biology · doi:10.1007/s00418-012-1048-7 · Cited by 9 · see citing works

Cellular protrusions in 3D: Orchestrating early mouse embryogenesis

Omelchenko, T. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.05.005 · Cited by 6 · see citing works

Bioinformatic search for Ca2+- and calmodulin-dependent protein kinases potentially associated with the regulation of plant cytoskeleton

Novozhylov, D. O., Karpov, P. A., & Blume, Y. B. (2017) · Cytology and Genetics · doi:10.3103/s0095452717040053 · Cited by 4 · see citing works

Genome-wide CRISPR screen identifies STK11 as a critical regulator of sialic acid clusters important for influenza A virus attachment

Sun, H., Zou, J., Tu, S., Luo, D., Xiao, R., Du, Y., Xiong, C., Xie, S., Liu, H., Jin, M., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.09.059 · Cited by 1 · see citing works

Truncated LKB1 nonenzymatically enhances Fas-induced apoptosis by acting as a surrogate of Smac

Yamada, Y., Tsuchida, M., Noguchi, T., Yokosawa, T., Mitsuya, M., Shimada, T., Oikawa, D., Hirata, Y., Tokunaga, F., Schneider, P., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02570-1 · Cited by 1 · see citing works

RAD001 (everolimus) induces antiproliferative effect and abnormal cell morphology in goat fetal fibroblasts under optical microscope

Chen, Y., Fu, H., Liu, B., Cui, X., Wang, X., & Wang, Z. (2011) · International Conference on Human Health and Biomedical Engineering · doi:10.1109/hhbe.2011.6027941

Identification of TGFβ signaling, p53, and actin stress fibers as targets of LKB1 tumor suppressor activity

Vaahtomeri, K. (2011) · Työväentutkimus Vuosikirja

Regulation of Particle Uptake by PP2A/B56 and LKB1 in Dictyostelium Discoideum

Sharief, M. R. (2016) · doi:10.25148/etd.fidc000781

Lkb1 controls expansion and folding of the cerebellar cortex

Ryan, K. E. (2014)

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