Cited by 206Fungal and yeast genetics researchBacterial Genetics and BiotechnologyAntifungal resistance and susceptibility

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Phylogenetic diversity of stress signalling pathways in fungi

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Nikolaou, Elissavet, Agrafioti, Ino, Stumpf, Michael, Quinn, Janet, Stansfield, Ian, Brown, Alistair JP·2009·BMC Evolutionary Biology

DOI 10.1186/1471-2148-9-44PMC PMC2666651

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Abstract

BACKGROUND: Microbes must sense environmental stresses, transduce these signals and mount protective responses to survive in hostile environments. In this study we have tested the hypothesis that fungal stress signalling pathways have evolved rapidly in a niche-specific fashion that is independent of phylogeny. To test this hypothesis we have compared the conservation of stress signalling molecules in diverse fungal species with their stress resistance. These fungi, which include ascomycetes, basidiomycetes and microsporidia, occupy highly divergent niches from saline environments to plant or mammalian hosts. RESULTS: The fungi displayed significant variation in their resistance to osmotic (NaCl and sorbitol), oxidative (H2O2 and menadione) and cell wall stresses (Calcofluor White and Congo Red). There was no strict correlation between fungal phylogeny and stress resistance. Rather, the human pathogens tended to be more resistant to all three types of stress, an exception being the sensitivity of Candida albicans to the cell wall stress, Calcofluor White. In contrast, the plant pathogens were relatively sensitive to oxidative stress. The degree of conservation of osmotic, oxidative and cell wall stress signalling pathways amongst the eighteen fungal species was examined. Putative orthologues of functionally defined signalling components in Saccharomyces cerevisiae were identified by performing reciprocal BLASTP searches, and the percent amino acid identities of these orthologues recorded. This revealed that in general, central components of the osmotic, oxidative and cell wall stress signalling pathways are relatively well conserved, whereas the sensors lying upstream and transcriptional regulators lying downstream of these modules have diverged significantly. There was no obvious correlation between the degree of conservation of stress signalling pathways and the resistance of a particular fungus to the corresponding stress. CONCLUSION: Our data are consistent with the hypothesis that fungal stress signalling components have undergone rapid recent evolution to tune the stress responses in a niche-specific fashion.

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Authors: Nikolaou, E., Agrafioti, I., Stumpf, M., Quinn, J., Stansfield, I., & Brown, A. J.
Affiliations: University of Aberdeen (GB)
Imperial College London (GB)
Newcastle University (GB)
Corresponding author: Brown, Alistair JP
ORCID: Nikolaou, Elissavet
Agrafioti, Ino
Stumpf, Michael
Quinn, Janet
Stansfield, Ian
Brown, Alistair JP
Venue: BMC Evolutionary Biology
Publisher: Springer Science and Business Media LLC
Published: 2009-02-21
Volume: 9
Issue: 1
Pages: 44-44
ISSN: 1471-2148 (ISSN-L)
DOI: 10.1186/1471-2148-9-44
PMC: PMC2666651
OpenAlex: W1985831723
Cited by: 206
References: 159
Citations by year: 2026: 12 · 2025: 13 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 14 · 2019: 13 · 2018: 8 · 2017: 13 · 2016: 15 · 2015: 17 · 2014: 18 · 2013: 16 · 2012: 13
FWCI: 4.69
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: BMC Evolutionary Biology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
Minerva Access (University of Melbourne) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Newcastle University ePrints (Newcastle Univesity)
Funders: Wellcome Trust (080088)
University of Exeter
Imperial College London
University of Aberdeen
Biotechnology and Biological Sciences Research Council (BB/D009308/1, BB/C510391/1, BB/F00513X/1, BB/F013566/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: stress tolerance, osmotic stress, oxidative stress, cell wall stress, phylogenetic conservation, orthologs, human fungal pathogens, plant pathogenic fungi, Candida albicans, Ascomycota, Basidiomycota, microsporidia, signal transduction
MeSH terms: Benzenesulfonates, Candida albicans, Cell Wall, Congo Red, DNA, Fungal, Fungal Proteins, Hydrogen Peroxide, Osmotic Pressure, Phylogeny, Saccharomyces cerevisiae, Sodium Chloride, Sorbitol, Signal Transduction, Gene Expression Regulation, Fungal, Genome, Fungal, Oxidative Stress, Evolution, Molecular, Vitamin K 3

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