Characterization of murine macrophages from bone marrow, spleen and peritoneum
Open accessAbstract
BACKGROUND: Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared. RESULTS: We found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-α), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-β). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-α) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-β. CONCLUSIONS: Our results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Peritoneal macrophages differentiate within the tissue, allowing them to mold to their environment and experience hormonal changes throughout the animal's lifespan.
“This population was selected over bone-marrow derived macrophages as peritoneal macrophages differentiate within the tissue, which allows them to mold to their environment and experience hormonal changes throughout the animal’s lifespan [29, 31, 32].”
From Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner (2024) · cites this paper as [32]
The Discussion says peritoneal macrophages are obtained directly from the peritoneum, unlike bone-marrow-derived macrophages that can be fully differentiated in vitro. The Background also suggests that conditions in the peritoneal cavity may contribute to their distinct characteristics. Neither section establishes that peritoneal macrophages differentiate within the tissue or experience hormonal changes throughout the animal’s lifespan. (LLM, conf=0.83)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002 · see citing works
Isaacson, P. G., Doǧan, A., Price, S. K., & Spencer, J. (1989) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198912000-00004 · Cited by 1,913 · see citing works
F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Austyn, J. M., & Gordon, S. (1981) · European Journal of Immunology · doi:10.1002/eji.1830111013 · Cited by 1,580 · see citing works
Huang, B., Pan, P.-Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M., & Chen, S.-H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1299 · Cited by 1,435 · see citing works
Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody
Springer, T. A., Galfré, G., Secher, D. S., & Milstein, C. (1979) · European Journal of Immunology · doi:10.1002/eji.1830090410 · Cited by 1,108 · see citing works
Bone Marrow-Derived Macrophages (BMM): Isolation and ApplicationsPreprint
Weischenfeldt, J., & Porse, B. T. (2008) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5080 · Cited by 959 · see citing works
Brown, B. N., Ratner, B. D., Goodman, S. B., Amar, S., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.034 · Cited by 926 · cited 1× · see citing works
“Following great technical improvements in the in vitro generation of macrophages, they are now considered as candidates for cell therapy [17,30-32].”
BackgroundSasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R., & Hume, D. A. (2003) · Blood · doi:10.1182/blood-2002-02-0569 · Cited by 662 · see citing works
Ruffell, D., Mourkioti, F., Gambardella, A., Kirstetter, P., Lopez, R. G., Rosenthal, N., & Nerlov, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908641106 · Cited by 626 · see citing works
The macrophage: Past, present and future
Gordon, S. (2007) · European Journal of Immunology · doi:10.1002/eji.200737638 · Cited by 625 · see citing works
Zhou, X., Nicoletti, A., Elhage, R., & Hansson, G. K. (2000) · Circulation · doi:10.1161/01.cir.102.24.2919 · Cited by 552 · see citing works
The mononuclear phagocyte system revisited
Hume, D. A., Ross, I. L., Himes, S. R., Sasmono, R. T., Wells, C. A., & Ravasi, T. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.4.621 · Cited by 423 · see citing works
Hume, D. A., Robinson, A. P., MacPherson, G. G., & Gordon, S. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.158.5.1522 · Cited by 390 · see citing works
Marim, F. M., Silveira, T. N., Lima-Junior, D. S., & Zamboni, D. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015263 · Cited by 351 · see citing works
A novel phenotype for an activated macrophage: the type 2 activated macrophage
Anderson, C. F., & Mosser, D. M. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.1.101 · Cited by 334 · see citing works
Regulation of human cytolytic lymphocyte responses by interleukin-12
Gately, M. K., Wolitzky, A. G., Quinn, P. M., & Chizzonite, R. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90011-d · Cited by 321 · see citing works
The macrophage capacity for phagocytosis
Cannon, G. J., & Swanson, J. A. (1992) · Journal of Cell Science · doi:10.1242/jcs.101.4.907 · Cited by 289 · see citing works
Wang, Y., & Harris, D. C. H. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010030269 · Cited by 248 · see citing works
Self-citationThe Renal Mononuclear Phagocytic System
Nelson, P. J., Rees, A. J., Griffin, M. D., Hughes, J., Kurts, C., & Duffield, J. S. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011070680 · Cited by 248 · see citing works
The role of the macrophage in immune regulation
Gordon, S. (1998) · Research in Immunology · doi:10.1016/s0923-2494(99)80039-x · Cited by 244 · see citing works
MILLARD, A. L., MERTES, P. M., ITTELET, D., VILLARD, F., JEANNESSON, P., & BERNARD, J. (2002) · Clinical and Experimental Immunology · doi:10.1046/j.0009-9104.2002.01977.x · Cited by 220 · see citing works
Surface Phenotype Analysis of Human Monocyte to Macrophage Maturation
Andreesen, R., Brugger, W., Scheibenbogen, C., Kreutz, M. P., Leser, H.-G., Rehm, A., & Löhr, G. W. (1990) · Journal of Leukocyte Biology · doi:10.1002/jlb.47.6.490 · Cited by 206 · see citing works
Warren, M. K., & Vogel, S. N. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.2.982 · Cited by 179 · see citing works
Kraal, G., Rep, M. I., & Janse, M. (1987) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1987.tb02301.x · Cited by 168 · see citing works
Hume, D., & Gordon, S. (1985) · Springer eBooks · doi:10.1007/978-94-009-5020-7_2 · Cited by 147 · see citing works
The immunogenic capacity of antigen taken up by peritoneal exudate cells.
Mitchison, N. A. (1969) · PubMed Central · Cited by 144 · see citing works
Genetic control of the innate immune response
Wells, C. A., Ravasi, T., Faulkner, G. J., Carninci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M. J., Wainwright, B. J., & Hume, D. A. (2003) · BMC Immunology · doi:10.1186/1471-2172-4-5 · Cited by 138 · see citing works
Baek, Y.-S., Haas, S. A., Hackstein, H., Bein, G., Hernandez-Santana, M., Lehrach, H. R., Sauer, S., & Seitz, H. (2009) · BMC Immunology · doi:10.1186/1471-2172-10-18 · Cited by 125 · see citing works
THE RELATIVE REACTION WITHIN LIVING MAMMALIAN-TISSUES
Rous, P. (1925) · The Journal of Experimental Medicine · doi:10.1084/jem.41.3.399 · Cited by 97 · see citing works
Petroff, M. G., Kharatyan, E., Torry, D. S., & Holets, L. M. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62990-2 · Cited by 86 · see citing works
Xu, W., Schlagwein, N., Roos, A., van den Berg, T. K., Daha, M. R., & van Kooten, C. (2007) · European Journal of Immunology · doi:10.1002/eji.200737042 · Cited by 85 · see citing works
Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus
Zheng, D., Wang, Y., Cao, Q., Lee, V. W., Zheng, G., Sun, Y., Tan, T. K., Wang, Y., Alexander, S. I., & Harris, D. C. H. (2011) · Nephron Experimental Nephrology · doi:10.1159/000321034 · Cited by 82 · see citing works
Self-citationIL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease
Cao, Q., Wang, C., Dong, Z., Wang, Y., Lee, V. W., Wang, Y. M., Zheng, G., Tan, T. K., Yu, D., Alexander, S. I., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010070693 · Cited by 82 · see citing works
Self-citationAntigen presentation and recognition in bacterial infections
Kaufmann, S. H. E., & Schaible, U. E. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.12.004 · Cited by 80 · see citing works
By Homing to the Kidney, Activated Macrophages Potently Exacerbate Renal Injury
Wang, Y., Wang, Y., Cai, Q., Zheng, G., Lee, V. W., Dong, Z., Li, X., Tan, T. K., & Harris, D. C. H. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070825 · Cited by 76 · see citing works
Self-citationLane, T. E., Wu‐Hsieh, B. A., & Howard, D. H. (1993) · Infection and Immunity · doi:10.1128/iai.61.4.1468-1473.1993 · Cited by 65 · see citing works
Liu, G., Xia, X., Gong, S., & Zhao, Y. X. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20732 · Cited by 63 · see citing works
Self-citationAn efficient culture method for generating large quantities of mature mouse splenic macrophages
Alatery, A., & Basta, S. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.07.009 · Cited by 60 · see citing works
A Critical Role of Activin A in Maturation of Mouse Peritoneal Macrophages in vitro and in vivo
Wang, Y., Cui, X., Tai, G., Ge, J., Li, N., Chen, F., Yu, F., & Liu, Z. (2009) · Cellular and Molecular Immunology · doi:10.1038/cmi.2009.50 · Cited by 40 · see citing works
Self-citationFresh mouse peritoneal macrophages have low scavenger receptor activity
Kim, J. G., Keshava, C., Murphy, A. A., Pitas, R. E., & Parthasarathy, S. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34934-8 · Cited by 38 · see citing works
Pathogen recognition or homeostasis? APC receptor functions in innate immunity
Gordon, S. (2004) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2004.04.005 · Cited by 36 · see citing works
THE RELATIVE REACTION WITHIN LIVING MAMMALIAN TISSUES
Rous, P., & Beattie, W. W. (1926) · The Journal of Experimental Medicine · doi:10.1084/jem.44.6.835 · Cited by 33 · see citing works
Are dendritic cells end cells?
Shortman, K., & Wu, L. (2004) · Nature Immunology · doi:10.1038/ni1104-1105 · Cited by 22 · see citing works
Complement Component C3 Secretion by Mouse Macrophage-Like Cell Lines
Goodrum, K. J. (1987) · Journal of Leukocyte Biology · doi:10.1002/jlb.41.4.295 · Cited by 20 · see citing works
Zhu, Y., Yang, Y., Ono, S., Zhong, X., Feng, Y., Ren, Y., Ni, J., Fu, Y., Tang, W., & Zuo, J. (2006) · International Immunology · doi:10.1093/intimm/dxl034 · Cited by 15 · see citing works
Pathways of T Cell Activation and Terminal Differentiation in Chronic Inflammation
Isomäki, P., Clark, J., Panesar, M., & Cope, A. P. (2005) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010054022042 · Cited by 15 · see citing works
Regulation of Bone-Marrow Macrophage Proliferation
Hume, D. A., & Gordon, S. (1982) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-4394-3_26 · Cited by 7 · see citing works
Yang, X., Ye, R. G., Kong, Q. Y., Yang, Q., Gao, Y., Zhong, J., & Wang, T. (2000) · PubMed · Cited by 7 · see citing works
Galligioni, E., Favaro, D., Santarosa, M., Quaia, M., Spada, A., Freschi, A., & Alberti, D. (1995) · PubMed · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis
Chen, P., Zuo, H., Xiong, H., Kolar, M. J., Chu, Q., Saghatelian, A., Siegwart, D. J., & Wan, Y. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614035114 · Cited by 523 · see citing works
Qian, Y., Qiao, S., Dai, Y., Xu, G., Dai, B., Lu, L., Yu, X. M., Luo, Q., & Zhang, Z. (2017) · ACS Nano · doi:10.1021/acsnano.7b05465 · Cited by 338 · see citing works
Self-citationRevisiting Mouse Peritoneal Macrophages: Heterogeneity, Development, and Function
Cassado, A. D. A., D’Império Lima, M. R., & Bortoluci, K. R. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00225 · Cited by 315 · see citing works
The origin, fate, and contribution of macrophages to spinal cord injury pathology
Milich, L. M., Ryan, C. B., & Lee, J. K. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01992-3 · Cited by 283 · see citing works
Parayath, N. N., Parikh, A. B., & Amiji, M. M. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00689 · Cited by 263 · see citing works
Natrajan, M. S., de la Fuente, A. G., Crawford, A. H., Linehan, E., Núñez, V., Johnson, K. R., Wu, T., Fitzgerald, D. C., Ricote, M., Bielekova, B., et al. (2015) · Brain · doi:10.1093/brain/awv289 · Cited by 217 · see citing works
Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis
Jing, C., Castro‐Dopico, T., Richoz, N., Tuong, Z. K., Ferdinand, J. R., Lok, L. S. C., Loudon, K. W., Banham, G. D., Mathews, R. J., Cader, M. Z., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000943117 · Cited by 215 · see citing works
Macrophages: sentinels and regulators of the immune system
Franken, L., Schiwon, M., & Kurts, C. (2016) · Cellular Microbiology · doi:10.1111/cmi.12580 · Cited by 211 · see citing works
Undernutrition and Tuberculosis: Public Health Implications
Sinha, P., Davis, J., Peetluk, L. S., WANKE, C. A., Salgame, P. R., Mesick, J., Horsburgh, C. R., & Hochberg, N. S. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy675 · Cited by 204 · see citing works
Local effects of human PCSK9 on the atherosclerotic lesion
Giunzioni, I., Tavori, H., Covarrubias, R., Major, A. S., Ding, L., Zhang, Y., DeVay, R. M., Hong, L., Fan, D., Predazzi, I. M., et al. (2015) · The Journal of Pathology · doi:10.1002/path.4630 · Cited by 179 · see citing works
Isolation, Culture, and Polarization of Murine Bone Marrow-Derived and Peritoneal Macrophages
Pineda‐Torra, I., Gage, M., de Juan, A., & Pello, Ó. M. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2929-0_6 · Cited by 173 · see citing works
Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity
Trim, W. V., Turner, J. E., & Thompson, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00169 · Cited by 167 · see citing works
Trained immunity modulates inflammation-induced fibrosis
Jeljeli, M. M., Riccio, L. G. C., Doridot, L., Chêne, C., Nicco, C., Chouzenoux, S., Deletang, Q., Allanore, Y., Kavian, N., & Batteux, F. (2019) · Nature Communications · doi:10.1038/s41467-019-13636-x · Cited by 157 · see citing works
STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
Balic, J. J., Albargy, H. A., Luu, K., Kirby, F. J., Jayasekara, W. S. N., Mansell, F., Garama, D. J., Nardo, D. D., Baschuk, N., Louis, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17669-5 · Cited by 156 · see citing works
Tariq, M., Zhang, J., Liang, G., He, Q., Ding, L., & Yang, B. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.124 · Cited by 127 · see citing works
Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab
Kurdi, A. T., Glavey, S. V., Bezman, N., Jhatakia, A., Guerriero, J. L., Manier, S., Moschetta, M., Mishima, Y., Roccaro, A. M., Detappe, A., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0998 · Cited by 98 · see citing works
NAMPT: A pleiotropic modulator of monocytes and macrophages
Travelli, C., Colombo, G., Mola, S., Genazzani, A. A., & Porta, C. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.06.022 · Cited by 91 · see citing works
Macrophage Immune Memory Controls Endometriosis in Mice and Humans
Jeljeli, M. M., Riccio, L. G. C., Chouzenoux, S., Moresi, F., Toullec, L., Doridot, L., Nicco, C., Bourdon, M., Marcellin, L., Santulli, P., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108325 · Cited by 93 · see citing works
Cellular and physiological functions of C9ORF72 and implications for ALS/FTD
Pang, W., & Hu, F. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15255 · Cited by 87 · see citing works
Nguyen, V. D., Min, H.-K., Kim, H. Y., Han, J., Choi, Y. H., Kim, C., Park, J.-O., & Choi, E. (2021) · ACS Nano · doi:10.1021/acsnano.1c00114 · Cited by 89 · see citing works
Yang, Y. J., Pham, T. X., Wegner, C., Kim, B., Ku, C. S., Park, Y., & Lee, J. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514002554 · Cited by 87 · see citing works
Layoun, A., Samba-Mondonga, M., & Santos, M. M. (2015) · Journal of Visualized Experiments · doi:10.3791/52749 · Cited by 81 · see citing works
CD14 is critical for TLR2-mediated M1 macrophage activation triggered by N-glycan recognition
da Silva, T. A., Zorzetto-Fernandes, A. L., Cecílio, N. T., Sardinha-Silva, A., Fernandes, F. F., & Roque‐Barreira, M. C. (2017) · Scientific Reports · doi:10.1038/s41598-017-07397-0 · Cited by 76 · see citing works
Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators
Elisia, I., Pae, H. B., Lam, V., Cederberg, R. A., Hofs, E., & Krystal, G. (2017) · Journal of Immunological Methods · doi:10.1016/j.jim.2017.10.004 · Cited by 76 · see citing works
Yang, M., Song, L., Wang, L., Yukht, A., Ruther, H., Li, F., Qin, M., Ghiasi, H., Sharifi, B. G., & Shah, P. K. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.061 · Cited by 73 · see citing works
Chen, K.-H. E., Lainez, N. M., & Coss, D. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000490 · Cited by 73 · see citing works
Källenius, G., Correia‐Neves, M., Buteme, H. K., Hamasur, B., & Svenson, S. B. (2015) · Tuberculosis · doi:10.1016/j.tube.2015.09.005 · Cited by 72 · see citing works
Macrophage based drug delivery: Key challenges and strategies
Guo, Q., & Qian, Z. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.04.004 · Cited by 74 · see citing works
Park, E., Оскарович, Х. Т., Shurin, M. R., Kisin, E. R., Yanamala, N. V. K., Fadeel, B., Chang, J., & Shvedova, A. A. (2017) · Journal of Immunotoxicology · doi:10.1080/1547691x.2017.1414339 · Cited by 69 · see citing works
Meindl, C., Öhlinger, K., Ober, J., Roblegg, E., & Eleonore, F. (2017) · Toxicology · doi:10.1016/j.tox.2017.01.001 · Cited by 67 · see citing works
Thermoresponsive hyaluronic acid nanogels as hydrophobic drug carrier to macrophages
Stefanello, T. F., Szarpak, A., Appaix, F., Louage, B., Hamard, L., Geest, B. G. D., van der Sanden, B. P. J., Nakamura, C. V., & Auzély‐Velty, R. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.07.033 · Cited by 64 · see citing works
Macrophage variants in laboratory research: most are well done, but some are RAW
Herb, M., Schatz, V., Hadrian, K., Hos, D., Holoborodko, B., Jantsch, J., & Brigo, N. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1457323 · Cited by 63 · see citing works
Mao, R., Wang, C., Zhang, F., Zhao, M., Liu, S., Liao, G., Li, L., Chen, Y., Cheng, J., Liu, J., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15005 · Cited by 60 · see citing works
Self-citationKim, S., Cho, W., Kim, I., Lee, S., Oh, G. T., & Park, Y. M. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01923-w · Cited by 59 · see citing works
Kim, H., Park, H., Chang, H., Back, J. H., Lee, S.-J., Park, Y., Kim, E. H., Hong, Y., Kwak, G., Kwon, I., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.07.021 · Cited by 69 · see citing works
Shao, Q., Yang, M., Chen, L., Ma, L., Zhang, W., Jiang, Z., Luo, J., Lee, J., Liang, C., & Chen, J. (2019) · Autophagy · doi:10.1080/15548627.2019.1703353 · Cited by 58 · see citing works
Macrophage heterogeneity, phenotypes, and roles in renal fibrosis
Cao, Q., Wang, Y., & Harris, D. C. H. (2014) · Kidney International Supplements · doi:10.1038/kisup.2014.4 · Cited by 57 · see citing works
Self-citationRegulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response
Mingomataj, E., & Bakiri, A. H. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8514-7 · Cited by 54 · see citing works
Duong, L., Radley‐Crabb, H. G., Gardner, J. K., Tomay, F., Dye, D. E., Grounds, M. D., Pixley, F. J., Nelson, D. J., & Jackaman, C. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00526 · Cited by 54 · see citing works
Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages
Sun, Y., Reid, B., Ferreira, F., Luxardi, G., Ma, L., Lokken, K. L., Zhu, K., Xu, G., Sun, Y., Ryzhuk, V., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000044 · Cited by 52 · see citing works
Jantan, I., Ahmad, W., Kumolosasi, E., & Bukhari, S. N. A. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s85405 · Cited by 50 · see citing works
The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms
Pourcet, B., Gage, M., León, T. E., Waddington, K. E., Pello, Ó. M., Steffensen, K. R., Castrillo, A., Valledor, A. F., & Pineda‐Torra, I. (2016) · Scientific Reports · doi:10.1038/srep25481 · Cited by 50 · see citing works
Mesenchymal stem cells promote macrophage polarization toward M2b-like cells
Kudlik, G., Hegyi, B., Czibula, Á., Monostori, É., Buday, L., & Uher, F. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.08.022 · Cited by 48 · see citing works
Distinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives
Nagpal, R., Indugu, N., & Singh, P. R. (2021) · Microorganisms · doi:10.3390/microorganisms9112311 · Cited by 51 · see citing works
Yuan, P., & Taché, Y. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00121.2017 · Cited by 50 · see citing works
Zajd, C. M., Ziemba, A. M., Miralles, G. M., Nguyen, T., Feustel, P. J., Dunn, S. M., Gilbert, R. J., & Lennartz, M. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00269 · Cited by 48 · see citing works
ROCK inhibition impedes macrophage polarity and functions
Liu, Y., Tejpal, N., You, J., Li, X. C., Ghobrial, R. M., & Kloc, M. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.12.005 · Cited by 46 · see citing works
Peng, Z., Ehrmann, M. A., Waldhuber, A., Niemeyer, C., Miethke, T., Frick, J.-S., Xiong, T., & Vogel, R. F. (2017) · Research in Microbiology · doi:10.1016/j.resmic.2017.03.003 · Cited by 44 · see citing works
Macrophages in aseptic loosening: Characteristics, functions, and mechanisms
Cong, Y., Wang, Y., Yuan, T., Zhang, Z., Ge, J., Meng, Q., Li, Z., & Sun, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1122057 · Cited by 45 · see citing works
Self-citationModel Systems for Pulmonary Infectious Diseases: Paradigms of Anthrax and Tuberculosis
Arora, G., Misra, R., & Sajid, A. (2017) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026617666170130111324 · Cited by 43 · see citing works
Influenza Virus Infection Induces ZBP1 Expression and Necroptosis in Mouse Lungs
Wang, Y., Hao, Q., Florence, J., Jung, B., Kurdowska, A., Samten, B., Idell, S., & Tang, H. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00286 · Cited by 42 · see citing works
Self-citationWithholding of M-CSF Supplement Reprograms Macrophages to M2-Like via Endogenous CSF-1 Activation
Chen, Y., Lai, Y., Hsuuw, Y.-D., & Chang, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073532 · Cited by 42 · see citing works
Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic Caspase 3
Liu, Y., Minze, L. J., Mumma, L., Li, X. C., Ghobrial, R. M., & Kloc, M. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.02.004 · Cited by 39 · see citing works
Yonezawa, Y., Miyashita, T., Nejishima, H., Takeda, Y., Imai, K., & Ogawa, H. K. (2018) · Journal of Veterinary Medical Science · doi:10.1292/jvms.18-0250 · Cited by 40 · see citing works
Role for Mechanotransduction in Macrophage and Dendritic Cell Immunobiology
Mennens, S. F. B., van den Dries, K., & Cambi, A. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-54090-0_9 · Cited by 39 · see citing works
Aoki, J. I., Muxel, S. M., Zampieri, R. A., Müller, K. E., Nerland, A. H., & Floeter‐Winter, L. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-56305-1 · Cited by 39 · see citing works
Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference
Liu, Y., Chen, W., Minze, L. J., Kubiak, J. Z., Li, X. C., Ghobrial, R. M., & Kloc, M. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2491-x · Cited by 39 · see citing works
Huang, Q., Yang, Y., Luo, C., Wen, Y., Liu, R., Li, S., Chen, T., Sun, H., & Tang, L. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1405-8 · Cited by 38 · see citing works
Cytomegalovirus immune evasion of myeloid lineage cells
Brinkmann, M. M., Dağ, F., Hengel, H., Messerle, M., Kalinke, U., & Čičin‐Šain, L. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0403-4 · Cited by 36 · see citing works
Sojoodi, M., Erstad, D. J., Barrett, S. C., Salloum, S., Zhu, S., Qian, T., Colon, S., Gale, E. M., Jordan, V. C., Wang, Y., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.01.015 · Cited by 35 · see citing works
Self-citationJantan, I., Ilangkovan, M., Mesaik, M. A., & Bhukari, S. N. A. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s88189 · Cited by 34 · see citing works
Serpa, G. L., Renton, N., Lee, N., Crane, M. J., & Jamieson, A. M. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0200oc · Cited by 34 · see citing works
Comprehensive review of macrophage models: primary cells and immortalized lines across species
Ding, T., Du, Y., Yang, B., Tian, W., Li, J., & Xie, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1640935 · Cited by 32 · see citing works
Tanaka, A., To, J., O’Brien, B. A., Donnelly, S., & Lund, M. E. (2017) · BMC Immunology · doi:10.1186/s12865-017-0223-y · Cited by 33 · see citing works
A Rapid Induction Mechanism for Lin28a in Trophic Responses
Amen, A. M., Ruiz, C. R., Shi, J., Subramanian, M. P., Pham, D. L., & Meffert, M. K. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.12.025 · Cited by 32 · see citing works
Feng, M., Dai, M., Cao, W., Tan, Y., Li, Z., Shi, M., & Zhang, X. (2016) · Poultry Science · doi:10.3382/ps/pew229 · Cited by 32 · see citing works
Pelletier, M. G. H., Szymczak, K., Barbeau, A. M., Prata, G. N., O’Fallon, K. S., & Gaines, P. C. W. (2016) · Methods · doi:10.1016/j.ymeth.2016.09.005 · Cited by 32 · see citing works
Protein energy malnutrition increases arginase activity in monocytes and macrophages
Corware, K., Yardley, V., Mack, C., Schuster, S., Al-Hassi, H. O., Herath, S., Bergin, P. J., Modolell, M., Munder, M., Müller, I., et al. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-51 · Cited by 31 · see citing works
Cruz, F. F., Borg, Z. D., Goodwin, M., Coffey, A. L., Wagner, D. E., Rocco, P. R. M., & Weiss, D. J. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0141 · Cited by 31 · see citing works
Shen, T., Lin, R., Hu, C., Yu, D., Ren, C., Li, T., Zhu, M., Wan, Z., Su, T., Wu, Y. X., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02998-1 · Cited by 32 · see citing works
Wu, K.-Y., Li, Y., Lin, Y., Xu, B., Yang, J., Li, M., Huang, R., & Zhang, X. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.12.127 · Cited by 29 · see citing works
Enhanced RIPK3 kinase activity-dependent lytic cell death in M1 but not M2 macrophages
Hao, Q., Kundu, S., Kleam, J. K., Zhao, Z. J., Idell, S., & Tang, H. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.11.001 · Cited by 28 · see citing works
Khatua, S., & Acharya, K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00985 · Cited by 28 · see citing works
Felizardo, A. A., Caldas, I. S., Mendonça, A. A. S., Gonçalves, R. V., Tana, F. L., de Almeida, L. A., & Novaes, R. D. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.031 · Cited by 28 · see citing works
Fereig, R. M., Kuroda, Y., Terkawi, M. A., Mahmoud, M. E., & Nishikawa, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176324 · Cited by 27 · see citing works
Husain, K., Villalobos-Ayala, K., Laverde, V., Vazquez, O. A., Miller, B., Kazim, S., Blanck, G., Hibbs, M. L., Krystal, G., Elhussin, I., et al. (2022) · Cancers · doi:10.3390/cancers14153613 · Cited by 26 · see citing works
Döring, M., Lessin, I., Frenz, T., Spanier, J., Keßler, A., Tegtmeyer, P.-K., Dağ, F., Thiel, N., Trilling, M., Lienenklaus, S., et al. (2014) · Journal of Virology · doi:10.1128/jvi.00216-14 · Cited by 25 · see citing works
Exopolysaccharides from Aspergillus terreus: Production, chemical elucidation and immunoactivity
Costa, C. R. L. D. M., Menolli, R. A., Osaku, É. F., Tramontina, R., de Melo, R. H., do Amaral, A. E., Duarte, P. A. D., de Carvalho, M. M., Smiderle, F. R., Silva, J. L. D. C., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.08.039 · Cited by 25 · see citing works
Choi, D., Jung, S. Y., Kang, J., Nam, Y., Lim, S., Kim, K. T., & Shin, H. S. (2018) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1709.09024 · Cited by 25 · see citing works
Heller, R. A., Seelig, J., Crowell, H. L., Pilz, M., Haubruck, P., Sun, Q., Schomburg, L., Daniel, V., Moghaddam, A., & Biglari, B. (2021) · Brain · doi:10.1093/brain/awab203 · Cited by 23 · see citing works
Denisenko, E., Guler, R., Mhlanga, M. M., Suzuki, H., Brombacher, F., & Schmeier, S. (2019) · BMC Genomics · doi:10.1186/s12864-019-5450-6 · Cited by 22 · see citing works
Menarim, B. C., Gillis, K. H., Oliver, A., Mason, C., Ngo, Y., Werre, S. R., Barrett, S. H., Luo, X., Byron, C. R., & Dahlgren, L. A. (2019) · The FASEB Journal · doi:10.1096/fj.201901684rr · Cited by 23 · see citing works
Silva, A. H., Lima, E., Mansilla, M. V., Zysler, R. D., Mojica‐Pisciotti, M. L., Locatelli, C., Rajoli, R. K. R., Owen, A., Creczynski‐Pasa, T. B., & Siccardi, M. (2017) · European Journal of Nanomedicine · doi:10.1515/ejnm-2017-0001 · Cited by 22 · see citing works
Gasco, S., Zaragoza, P., García‐Redondo, A., Calvo, A. C., & Osta, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184626 · Cited by 21 · see citing works
Plasma-treated medium tunes the inflammatory profile in murine bone marrow-derived macrophages
Bekeschus, S., Scherwietes, L., Freund, E., Liedtke, K. R., Hackbarth, C., von Woedtke, T., & Partecke, L.-I. (2018) · Clinical Plasma Medicine · doi:10.1016/j.cpme.2018.06.001 · Cited by 21 · see citing works
Mulder, R., Banete, A., Seaver, K., & Basta, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01629 · Cited by 21 · see citing works
Micallef, P., Vujičić, M., Wu, Y., Peris, E., Wang, Y., Chanclón, B., Ståhlberg, A., Cardell, S., & Asterholm, I. W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.914956 · Cited by 20 · see citing works
Self-citationCyclophilin A protects mice against infection by influenza A virus
Li, J., Chen, C., Wong, G., Dong, W., Zheng, W., Li, Y., Sun, L., Zhang, L., Gao, G. F., Bi, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep28978 · Cited by 20 · see citing works
Khan, Y. A., Maurya, S. K., Kulkarni, C., Tiwari, M. C., Nagar, G. K., & Chattopadhyay, N. (2019) · The FASEB Journal · doi:10.1096/fj.201901480rr · Cited by 22 · see citing works
Unique Pro-Inflammatory Response of Macrophages during Apoptotic Cancer Cell Clearance
Mendoza‐Reinoso, V., Baek, D. Y., Kurutz, A., Rubin, J. R., Koh, A. J., McCauley, L. K., & Roca, H. (2020) · Cells · doi:10.3390/cells9020429 · Cited by 20 · see citing works
Isolation of functional mature peritoneal macrophages from healthy humans
Ruiz‐Alcaraz, A. J., Martínez‐Banaclocha, H., Marín‐Sánchez, P., Carmona‐Martínez, V., Iniesta‐Albadalejo, M. A., Tristán‐Manzano, M., Tapia‐Abellán, A., García–Peñarrubia, P., Machado‐Linde, F., Pelegrı́n, P., et al. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12305 · Cited by 20 · see citing works
Maehara, T., & Fujimori, K. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158654 · Cited by 19 · see citing works
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4
Mendes, A. V., Gigan, J. P., Rodrígues, C. R., Choteau, S. A., Sanséau, D., Barros, D., Almeida, C. R., Camosseto, V., Chasson, L., Chasson, L., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.202000865 · Cited by 18 · see citing works
Vanoni, S., Tsai, Y.-T., Waddell, A., Waggoner, L., Klarquist, J. S., Divanovic, S., Hoebe, K. H. N., Steinbrecher, K. A., & Hogan, S. P. (2016) · Innate Immunity · doi:10.1177/1753425916681444 · Cited by 17 · see citing works
FUN14 domain‐containing 1-mediated mitophagy suppresses interleukin-1β production in macrophages
Huang, J., Zhu, T., Rong, R., You, M., Ji, D., & Li, H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106964 · Cited by 17 · see citing works
Kim, H.-Y., Nam, S.-Y., Yang, S.-Y., Kim, H.-M., & Jeong, H. (2016) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2016.1202960 · Cited by 17 · see citing works
Basso, E. K. G., Ju, J., Soliman, E., de Jager, C., Wei, X., Pridham, K. J., Olsen, M. L., & Theus, M. H. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03032-8 · Cited by 16 · see citing works
Role of bone marrow-derived macrophages (BMDMs) in neurovascular interactions during stroke
Srivastava, A., Srivastava, P., & Verma, R. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104480 · Cited by 16 · see citing works
Choi, J., Nam, J. H., Rod–in, W., Monmai, C., Jang, A.-Y., You, S., & Park, W. J. (2023) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2211.11056 · Cited by 15 · see citing works
A new model and precious tool to study molecular mechanisms of macrophage aging
Smith, R., Bassand, K., Dussol, A., Piesse, C., Duplus, E., & Hadri, K. E. (2024) · Aging · doi:10.18632/aging.206124 · Cited by 18 · see citing works
- Authors
- Wang, C., Yu, X., Cao, Q., Wang, Y., Zheng, G., Tan, T. K., Zhao, H., Zhao, Y., Wang, Y., & Harris, D. C.
- Affiliations
- Westmead Hospital (AU)
- Shanxi Medical University (CN)
- Corresponding author
- Wang, Changqi
- Venue
- BMC Immunology
- Published
- 2013-02-05
- Volume
- 14
- Issue
- 1
- Pages
- 6-6
- ISSN
- 1471-2172 (ISSN-L)
- PMC
- PMC3574850
- OpenAlex
- W2171040124
- Cited by
- 225
- References
- 50
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 18 · 2023: 16 · 2022: 12 · 2021: 13 · 2020: 32 · 2019: 22 · 2018: 25 · 2017: 27 · 2016: 17 · 2015: 17 · 2014: 7
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Medical Research Council
- National Health and Medical Research Council (457345)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- macrophage heterogeneity, peritoneal macrophages, bone marrow-derived macrophages, splenic macrophages, macrophage maturation, phagocytosis, macrophage proliferation, inflammatory cytokines, IL-10, TGF-beta, lipopolysaccharide stimulation, murine macrophages
- MeSH terms
- Animals, Bone Marrow Cells, Cell Membrane, Cells, Cultured, Dextrans, Flow Cytometry, Gene Expression Regulation, Lymphocyte Activation, Macrophages, Male, Mice, Inbred BALB C, Phagocytosis, Phenotype, RNA, Messenger, Spleen, CD4-Positive T-Lymphocytes, Cytokines, Fluorescein-5-isothiocyanate, Macrophages, Peritoneal, Antigen Presentation, Cell Shape, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
