Chondroitin sulfate proteoglycans regulate the growth, differentiation and migration of multipotent neural precursor cells through the integrin signaling pathway
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Background: Neural precursor cells (NPCs) are defined by their ability to proliferate, self-renew, and retain the potential to differentiate into neurons and glia. Deciphering the factors that regulate their behaviors will greatly aid in their use as potential therapeutic agents or targets. Chondroitin sulfate proteoglycans (CSPGs) are prominent components of the extracellular matrix (ECM) in the central nervous system (CNS) and are assumed to play important roles in controlling neuronal differentiation and development. Results: In the present study, we demonstrated that CSPGs were constitutively expressed on the NPCs isolated from the E16 rat embryonic brain. When chondroitinase ABC was used to abolish the function of endogenous CSPGs on NPCs, it induced a series of biological responses including the proliferation, differentiation and migration of NPCs, indicating that CSPGs may play a critical role in NPC development and differentiation. Finally, we provided evidence suggesting that integrin signaling pathway may be involved in the effects of CSPGs on NPCs. Conclusion: The present study investigating the influence and mechanisms of CSPGs on the differentiation and migration of NPCs should help us to understand the basic biology of NPCs during CNS development and provide new insights into developing new strategies for the treatment of the neurological disorders in the CNS.
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Aggrecan and CS-6 expression in glial cells are involved in regulation of astrocyte maturation, which has a key role in PNN formation and maintenance.
“Furthermore, aggrecan and CS-6 expression in glial cells are involved in the regulation of astrocyte maturation, which, in turn, has a key role in PNN formation and maintenance.35, 49”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [49]
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Self-citation
- Authors
- Gu, W.-L., Fu, S.-L., Wang, Y.-X., Li, Y., Lü, H.-Z., Xu, X.-M., & Lu, P.-H.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Xu, Xiao-Ming
- Lu, Pei-Hua
- Venue
- BMC Neuroscience
- Published
- 2009-10-21
- Volume
- 10
- Issue
- 1
- Pages
- 128-128
- ISSN
- 1471-2202 (ISSN-L)
- PMC
- PMC2773784
- OpenAlex
- W1965593502
- Cited by
- 80
- References
- 57
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 9 · 2016: 5 · 2015: 8 · 2014: 11 · 2013: 2 · 2012: 6
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by)
- Purdue University Indianapolis (Indiana University) (submittedVersion, cc-by)
- Publisher
- Funders
- Shanghai Jiao Tong University
- Major State Basic Research Development Program of China (2003CB515302)
- National Institutes of Health
- School of Medicine, Shanghai Jiao Tong University
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- chondroitin sulfate proteoglycans, neural progenitor cells, integrin signaling, cell proliferation, neuronal differentiation, cell migration, chondroitinase ABC, extracellular matrix, embryonic brain, central nervous system development, neurological disorders
- MeSH terms
- Animals, Astrocytes, Cell Differentiation, Cell Movement, Cells, Cultured, Flow Cytometry, Fluorescent Antibody Technique, Neurons, Oligodendroglia, Peptides, Platelet Aggregation Inhibitors, Chondroitin Sulfate Proteoglycans, Blotting, Western, Integrins, Rats, Sprague-Dawley, Chondroitin ABC Lyase, Intercellular Signaling Peptides and Proteins, Multipotent Stem Cells, Cell Shape, Cell Proliferation, Rats
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