The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Wnt signaling in triple negative breast cancer is associated with metastasis
Open accessAbstract
Background: Triple Negative subset of (TN) Breast Cancers (BC), a close associate of the basal-like subtype (with limited discordance) is an aggressive form of the disease which convey unpredictable, and poor prognosis due to limited treatment options and lack of proven effective targeted therapies. Methods: We conducted an expression study of 240 formalin-fixed, paraffin-embedded (FFPE) primary biopsies from two cohorts, including 130 TN tumors, to identify molecular mechanisms of TN disease. Results: The annotation of differentially expressed genes in TN tumors contained an overrepresentation of canonical Wnt signaling components in our cohort and others. These observations were supported by upregulation of experimentally induced oncogenic Wnt/β-catenin genes in TN tumors, recapitulated using targets induced by Wnt3A. A functional blockade of Wnt/β-catenin pathway by either a pharmacological Wnt-antagonist, WntC59, sulidac sulfide, or β-catenin (functional read out of Wnt/β-catenin pathway) SiRNA mediated genetic manipulation demonstrated that a functional perturbation of the pathway is causal to the metastasis- associated phenotypes including fibronectin-directed migration, F-actin organization, and invasion in TNBC cells. A classifier, trained on microarray data from β-catenin transfected mammary cells, identified a disproportionate number of TNBC breast tumors as compared to other breast cancer subtypes in a meta-analysis of 11 studies and 1,878 breast cancer patients, including the two cohorts published here. Patients identified by the Wnt/β-catenin classifier had a greater risk of lung and brain, but not bone metastases. Conclusion: These data implicate transcriptional Wnt signaling as a hallmark of TNBC disease associated with specific metastatic pathways.
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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
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Genes that mediate breast cancer metastasis to lung
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The clonal and mutational evolution spectrum of primary triple-negative breast cancers
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Regulation of bone mass by Wnt signaling
Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407
Lung metastasis genes couple breast tumor size and metastatic spread
Minn, A. J., Gupta, G. P., Padua, D., Bos, P., Nguyen, D. X., Nuyten, D., Kreike, B., Zhang, Y., Wang, Y., Ishwaran, H., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701138104 · Cited by 400
CREB-binding protein in androgen receptor-mediated signaling
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“, have reported genome and transcriptome sequencing in prospective metastatic triple negative breast cancer [56].”
BackgroundDey, N., De, P. K., Wang, M., Zhang, H., Dobrota, E. A., Robertson, K. A., & Durden, D. L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01352-06 · Cited by 62
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Nedeljković, M., & Damjanović, A. (2019) · Cells · doi:10.3390/cells8090957 · Cited by 870
Jang, G.-B., Kim, J.-Y., Cho, S.-D., Park, K.-S., Jung, J.-Y., Lee, H.-Y., Hong, I.-S., & Nam, J.-S. (2015) · Scientific Reports · doi:10.1038/srep12465 · Cited by 328
Castagnoli, L., Cancila, V., Cordoba-Romero, S. L., Faraci, S., Talarico, G., Belmonte, B., Iorio, M. V., Milani, M., Volpari, T., Chiodoni, C., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0700-2 · Cited by 184
Sun, X., Tang, H., Chen, Y., Chen, Z., Hu, Z., Cui, Z., Tao, Y., Yuan, J., Fu, Y., Zhuang, Z., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00535-w · Cited by 66
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Metadata
- Authors
- Dey, N., Barwick, B. G., Moreno, C. S., Ordanic-Kodani, M., Chen, Z., Oprea-Ilies, G., Tang, W., Catzavelos, C., Kerstann, K. F., Sledge, G. W., Abramovitz, M., Bouzyk, M., De, P., & Leyland-Jones, B. R.
- Venue
- BMC Cancer
- Published
- 2013-11-10
- Volume
- 13
- Issue
- 1
- Pages
- 537-537
- ISSN
- 1471-2407 (ISSN-L)
- OpenAlex
- W2008870230
- Cited by
- 255
- References
- 8
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- gold
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- Dey, N., Barwick, B. G., Moreno, C. S., Ordanic-Kodani, M., Chen, Z., Oprea-Ilies, G., Tang, W., Catzavelos, C., Kerstann, K. F., Sledge, G. W., Abramovitz, M., Bouzyk, M., De, P., & Leyland-Jones, B. R. (2013). Wnt signaling in triple negative breast cancer is associated with metastasis. BMC Cancer. https://doi.org/10.1186/1471-2407-13-537
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