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Cited by 146Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisHIV, TB, and STIs Epidemiology

Treatment outcome of smear-positive pulmonary tuberculosis patients in Tigray Region, Northern Ethiopia

Open access
Berhe, Gebretsadik, Enquselassie, Fikre, Aseffa, Abraham·2012·BMC Public Health
DOI 10.1186/1471-2458-12-537PMC PMC3414747
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Abstract

BACKGROUND: Monitoring the outcome of tuberculosis treatment and understanding the specific reasons for unsuccessful treatment outcome are important in evaluating the effectiveness of tuberculosis control program. This study investigated tuberculosis treatment outcomes and predictors for unsuccessful treatment outcome in the Tigray region of Ethiopia. METHODS: Medical records of smear-positive pulmonary tuberculosis (PTB) patients registered from September 2009 to June 2011 in 15 districts of Tigray region, Northern Ethiopia, were reviewed. Additional data were collected using a structured questionnaire administered through house-to-house visits by trained nurses. Tuberculosis treatment outcomes were assessed according to WHO guidelines. The association of unsuccessful treatment outcome with socio-demographic and clinical factors was analyzed using logistic regression model. RESULTS: Out of the 407 PTB patients (221 males and 186 females) aged 15 years and above, 89.2% had successful and 10.8% had unsuccessful treatment outcome. In the final multivariate logistic model, the odds of unsuccessful treatment outcome was higher among patients older than 40 years of age (adj. OR=2.50, 95% CI: 1.12-5.59), family size greater than 5 persons (adj. OR=3.26, 95% CI: 1.43-7.44), unemployed (adj. OR=3.10, 95% CI: 1.33-7.24) and among retreatment cases (adj. OR=2.00, 95% CI: 1.37-2.92) as compared to their respective comparison groups. CONCLUSIONS: Treatment outcome among smear-positive PTB patients was satisfactory in the Tigray region of Ethiopia. Nonetheless, those patients at high risk of an unfavorable treatment outcome should be identified early and given additional follow-up and social support.

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  • Only a few studies have been conducted to assess treatment outcome of TB patients in northern Ethiopia.

    “However, only a few studies have been conducted to assess the treatment outcome of TB patients in northern Ethiopia [7,9].”

    From Treatment success rate of tuberculosis patients in Dabat, northwest Ethiopia (2014) · cites this paper as [7]

  • The implementation of DOTS as a treatment strategy in Ethiopia has shown a marked success in improving patient adherence to treatment and consequently increasing the chance of patient cure.

    “The implementation of DOTS as a treatment strategy in Ethiopia has shown a marked success in improving patient adherence to treatment and consequently increasing the chance of patient cure [7].”

    From Treatment success rate of tuberculosis patients in Dabat, northwest Ethiopia (2014) · cites this paper as [7]

  • Studies in other parts of Ethiopia and Tanzania reported higher successful treatment outcomes by using community health extension workers to follow-up patients.

    “Studies conducted in other parts of Ethiopia [7,14] and Tanzania [15] reported higher successful treatment outcomes by using community health extension workers to follow-up patients.”

    From Treatment success rate of tuberculosis patients in Dabat, northwest Ethiopia (2014) · cites this paper as [7]

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1 of the 42 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Federal Ministry of Health Overview of National TB Control Implementation status 2011 Gondar, Ethiopia: Sixth National TB Research Workshop, Gondar University, 6–8 June 2011
  2. Tigray Health Bureau nnual TB performance report in Tigray region 2011 Gondar, Ethiopia: Sixth National TB Research Workshop, Gondar University, 6–8 June 2011
  3. Veen J Raviglione M Rieder HL Migliori GB Graf P Grzemska M Zalesky R Standardized tuberculosis treatment outcome monitoring in Europe. Recommendations of a Working Group of the World Health Organization (WHO) and the European Region of the International Union Against Tuberculosis and Lung Disease (IUATLD) for uniform reporting by cohort analysis of treatment outcome in tuberculosis patients Eur Respir J 1998 12 505 510 http://erj.ersjournals.com/content/12/2/505.long 9727811

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Authors
Berhe, G., Enquselassie, F., & Aseffa, A.
Affiliations
  • Mekelle University (ET)
  • Addis Ababa University (ET)
  • Armauer Hansen Research Institute (ET)
Corresponding author
Berhe, Gebretsadik
ORCID
Venue
BMC Public Health
Publisher
Springer Science and Business Media LLC
Published
2012-07-23
Volume
12
Issue
1
Pages
537-537
ISSN
1471-2458 (ISSN-L)
DOI
10.1186/1471-2458-12-537
PMC
PMC3414747
OpenAlex
W2027862365
Cited by
146
References
42
Citations by year
2025: 4 · 2024: 8 · 2023: 3 · 2022: 6 · 2021: 21 · 2020: 14 · 2019: 14 · 2018: 18 · 2017: 14 · 2016: 14 · 2015: 9 · 2014: 14 · 2013: 6 · 2012: 1
FWCI
6.58
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Public Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Greater South Information System
Funders
  • Armauer Hansen Research Institute
  • Addis Ababa University
  • Mekelle University
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
  • Social Sciences › General Social Sciences › HIV, TB, and STIs Epidemiology
Keywords
smear-positive tuberculosis, tuberculosis treatment outcomes, treatment failure, predictors of treatment failure, retreatment tuberculosis, household size, unemployment, old age, Tigray
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Ethiopia, Female, Humans, Male, Middle Aged, Retrospective Studies, Sputum, Tuberculosis, Pulmonary, Treatment Outcome, Young Adult

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