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Cited by 213HIV-related health complications and treatmentsHIV/AIDS Research and InterventionsChronic Disease Management Strategies

A cross-sectional, population-based study measuring comorbidity among people living with HIV in Ontario

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Kendall, Claire E, Wong, Jenna, Taljaard, Monica, Glazier, Richard H, Hogg, William, Younger, Jaime, Manuel, Douglas G·2014·BMC Public Health
DOI 10.1186/1471-2458-14-161PMC PMC3933292
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Abstract

BACKGROUND: As people diagnosed with HIV and receiving combination antiretroviral therapy are now living longer, they are likely to acquire chronic conditions related to normal ageing and the effects of HIV and its treatment. Comordidities for people with HIV have not previously been described from a representative population perspective. METHODS: We used linked health administrative data from Ontario, Canada. We applied a validated algorithm to identify people with HIV among all residents aged 18 years or older between April 1, 1992 and March 31, 2009. We randomly selected 5 Ontario adults who were not identified with HIV for each person with HIV for comparison. Previously validated case definitions were used to identify persons with mental health disorders and any of the following physical chronic diseases: diabetes, congestive heart failure, acute myocardial infarction, stroke, hypertension, asthma, chronic obstructive lung disease, peripheral vascular disease and end-stage renal failure. We examined multimorbidity prevalence as the presence of at least two physical chronic conditions, or as combined physical-mental health multimorbidity. Direct age-sex standardized rates were calculated for both cohorts for comparison. RESULTS: 34.4% (95% confidence interval (CI) 33.6% to 35.2%) of people with HIV had at least one other physical condition. Prevalence was especially high for mental health conditions (38.6%), hypertension (14.9%) and asthma (12.7%). After accounting for age and sex differences, people with HIV had significantly higher prevalence of all chronic conditions except myocardial infarction and hypertension, as well as substantially higher multimorbidity (prevalence ratio 1.30, 95% CI 1.18 to 1.44) and combined physical-mental health multimorbidity (1.79, 95% CI 1.65 to 1.94). Prevalence of multimorbidity among people with HIV increased with age. The difference in prevalence of multimorbidity between the two cohorts was more pronounced among women. CONCLUSION: People living with HIV in Ontario, especially women, had higher prevalence of comorbidity and multimorbidity than the general population. Quantifying this morbidity at the population level can help inform healthcare delivery requirements for this complex population.

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  • Mental disorders are the most common comorbidities in HIV infection.

    “Οι ψυχικές διαταραχές, πιο συγκεκριμένα, παραμένουν έως και σήμερα οι συχνότερες συννοσηρότητες στη λοίμωξη HIV, με ποσοστά επίπτωσης που έχουν εκτιμηθεί έως και στο 50%, πολύ υψηλότερα σε σχέση με τον γενικό πληθυσμό και με ομάδες ανθρώπων που πάσχουν από άλλα χρόνια νοσήματα. 7-9”

    From Clinical presentation and requests for support of people with HIV/AIDS seeking counselling and psychotherapy in Greece (2019) · cites this paper as [8]

    Table 2 (Results; page unavailable) shows that mental health conditions were the most prevalent comorbidity measured among people with HIV in Ontario, at 38.6%, and the Discussion reports higher prevalence than in the general population. The cited paper does not report 50% incidence among all people with HIV: its ‘almost 50%’ figure applies only to those with at least one comorbidity. It also does not establish the sentence’s comparison with people who have other chronic diseases. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • In agreement with previous literature, the frequency of anxiety disorders, depression, problematic alcohol and other substance use, and suicidal behavior is particularly high among people living with HIV in the study sample.

    “Σε συμφωνία με την προηγούμενη βιβλιογραφία γύρω από τις ψυχιατρικές εκδηλώσεις στη λοίμωξη HIV, 7-10 στο δείγμα της παρούσας έρευνας βρέθηκε ότι η συχνότητα των αγχωδών διαταραχών, της κατάθλιψης, της προβληματικής χρήσης αλκοόλ και άλλων ψυχοτρόπων ουσιών και της αυτοκτονικής συμπεριφοράς είναι ιδιαίτερα υψηλή μεταξύ των ανθρώπων που ζουν με HIV.”

    From Clinical presentation and requests for support of people with HIV/AIDS seeking counselling and psychotherapy in Greece (2019) · cites this paper as [8]

    The Results report a high prevalence of mental health conditions among people living with HIV in Ontario (38.6%), and the Discussion says these conditions were more prevalent than in the general population. The paper groups mental health conditions together; it does not establish high frequencies for each listed condition—anxiety, depression, problematic alcohol or other substance use, and suicidal behavior. The finding in the citing authors’ own sample is not attributed to this source. (LLM, conf=0.86)

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3 of the 45 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Matheson FI Dunn JR Smith KLW Moineddin R Glazier RH Canadian marginalization index user guide 2012 Toronto, ON: Canadian Journal of Public Health PMC6973681 23618065

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Authors
Kendall, C. E., Wong, J., Taljaard, M., Glazier, R. H., Hogg, W., Younger, J., & Manuel, D. G.
Affiliations
  • Bruyère (CA)
  • McGill University (CA)
  • University of Ottawa (CA)
  • University of Toronto (CA)
  • Ottawa Hospital Research Institute (CA)
Corresponding author
Kendall, Claire E
ORCID
Venue
BMC Public Health
Publisher
Springer Science and Business Media LLC
Published
2014-02-13
Volume
14
Issue
1
Pages
161-161
ISSN
1471-2458 (ISSN-L)
DOI
10.1186/1471-2458-14-161
PMC
PMC3933292
OpenAlex
W2144007968
Cited by
213
References
45
Citations by year
2026: 8 · 2025: 13 · 2024: 11 · 2023: 20 · 2022: 24 · 2021: 27 · 2020: 22 · 2019: 26 · 2018: 16 · 2017: 14 · 2016: 15 · 2015: 10 · 2014: 6 · 2013: 1
FWCI
16.06
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Public Health (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • uO Research (University of Ottawa) (submittedVersion, public-domain)
  • TSpace (University of Toronto) (submittedVersion)
Funders
  • University of Ottawa
  • Ottawa Hospital Research Institute
  • Public Health Agency of Canada
  • Institute for Clinical Evaluative Sciences
  • Ontario Ministry of Health and Long-Term Care
  • University of Toronto
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
Keywords
HIV, multimorbidity, comorbidities, chronic disease, mental illness, hypertension, asthma, diabetes mellitus, women living with HIV, age differences, Ontario
MeSH terms
Adolescent, Adult, Aged, Aging, Chronic Disease, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Heart Failure, Humans, Hypertension, Kidney Failure, Chronic, Male, Middle Aged, Ontario, Retrospective Studies, Sex Factors, Cohort Studies, HIV Infections, Comorbidity, Prevalence

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