Symptoms of depression impact the course of lung function in adolescents and adults with cystic fibrosis
Open accessAbstract
BACKGROUND: Epidemiological studies report high rates of depression among patients with cystic fibrosis (CF). Assuming a causal relationship between depression and the progression of CF, our hypothesis is that elevated symptoms of depression would be a predictor of worse lung function after two years. METHODS: In the context of the TIDES study, 473 German patients with CF (age 12-53 years, FEV1% predicted M = 66.2, range 13-137) completed the Hospital Anxiety and Depression Scale (HADS). Lung function (FEV1% predicted) was assessed at baseline and followed up two years later. Repeated measures analysis was performed involving the level of FEV1% and the level of depressive symptoms at baseline as independent factors and FEV1% at the 2-year follow-up as the dependent variable. RESULTS: Interaction between lung function and depression at baseline significantly affected the change in lung function at the 2-years observation interval. The largest decline in FEV1% occurred in depressed patients with good lung function at baseline. In contrast, patients without any clinically relevant depressive symptoms and with poor lung function at baseline showed a slight increase two years later. CONCLUSION: The findings emphasise the need to screen patients with CF for symptoms of depression and to treat co-morbid depression.
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Comorbid depressive and anxiety symptoms can negatively impact the long-term outcomes of the disease.
“Comorbid depressive and anxiety symptoms can additionally impact AYA's quality of life, treatment adherence, and outcomes (Havermans et al., 2008) as well as negatively impact the long-term outcomes of the disease (Fidika et al., 2014).”
From Involving patients' perspective in the development of an internet- and mobile-based CBT intervention for adolescents with chronic medical conditions: Findings from a qualitative study (2021) · cites this paper as Fidika et al., 2014
The Results (‘Depression and course of FEV1%’; page not provided) report that patients with depressive symptoms and moderate or good baseline lung function had the greatest decline in lung function over two years. The Methods (‘Statistical analyses’; page not provided) show that the longitudinal analysis tested depressive symptoms, not anxiety symptoms. The paper therefore supports the claim for depression and a two-year lung-function outcome, but not for anxiety or disease outcomes more broadly. (LLM, conf=0.88)
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- Authors
- Fidika, A., Herle, M., & Goldbeck, L.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Fidika, Astrid
- ORCID
- Herle, Marion
- Venue
- BMC Pulmonary Medicine
- Published
- 2014-12
- Volume
- 14
- Issue
- 1
- Pages
- 205-205
- ISSN
- 1471-2466 (ISSN-L)
- PMC
- PMC4277836
- OpenAlex
- W2150851088
- Cited by
- 46
- References
- 38
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 9 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 4
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Pulmonary Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- cystic fibrosis, depression, depressive symptoms, lung function decline, FEV1, disease progression, adolescents, adults, Hospital Anxiety and Depression Scale, depression screening, comorbidities
- MeSH terms
- Adolescent, Adult, Child, Cystic Fibrosis, Depression, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Disease Progression, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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