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Cited by 135Ergonomics and Musculoskeletal DisordersTendon Structure and TreatmentEffects of Vibration on Health

The interaction of force and repetition on musculoskeletal and neural tissue responses and sensorimotor behavior in a rat model of work-related musculoskeletal disorders

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Barbe, Mary F, Gallagher, Sean, Massicotte, Vicky S, Tytell, Michael, Popoff, Steven N, Barr-Gillespie, Ann E·2013·BMC Musculoskeletal Disorders
DOI 10.1186/1471-2474-14-303PMC PMC3924406
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Abstract

BACKGROUND: We examined the relationship of musculoskeletal risk factors underlying force and repetition on tissue responses in an operant rat model of repetitive reaching and pulling, and if force x repetition interactions were present, indicative of a fatigue failure process. We examined exposure-dependent changes in biochemical, morphological and sensorimotor responses occurring with repeated performance of a handle-pulling task for 12 weeks at one of four repetition and force levels: 1) low repetition with low force, 2) high repetition with low force, 3) low repetition with high force, and 4) high repetition with high force (HRHF). METHODS: Rats underwent initial training for 4-6 weeks, and then performed one of the tasks for 12 weeks, 2 hours/day, 3 days/week. Reflexive grip strength and sensitivity to touch were assayed as functional outcomes. Flexor digitorum muscles and tendons, forelimb bones, and serum were assayed using ELISA for indicators of inflammation, tissue stress and repair, and bone turnover. Histomorphometry was used to assay macrophage infiltration of tissues, spinal cord substance P changes, and tissue adaptative or degradative changes. MicroCT was used to assay bones for changes in bone quality. RESULTS: Several force x repetition interactions were observed for: muscle IL-1alpha and bone IL-1beta; serum TNFalpha, IL-1alpha, and IL-1beta; muscle HSP72, a tissue stress and repair protein; histomorphological evidence of tendon and cartilage degradation; serum biomarkers of bone degradation (CTXI) and bone formation (osteocalcin); and morphological evidence of bone adaptation versus resorption. In most cases, performance of the HRHF task induced the greatest tissue degenerative changes, while performance of moderate level tasks induced bone adaptation and a suggestion of muscle adaptation. Both high force tasks induced median nerve macrophage infiltration, spinal cord sensitization (increased substance P), grip strength declines and forepaw mechanical allodynia by task week 12. CONCLUSIONS: Although not consistent in all tissues, we found several significant interactions between the critical musculoskeletal risk factors of force and repetition, consistent with a fatigue failure process in musculoskeletal tissues. Prolonged performance of HRHF tasks exhibited significantly increased risk for musculoskeletal disorders, while performance of moderate level tasks exhibited adaptation to task demands.

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  • Chronic inflammation with macrophage infiltration and fibrosis of deep fasciae and perineural tissues has been well documented in an animal model of repetitive motion injury.

    “Chronic inflammation with macrophage infiltration and fibrosis of deep fasciae and perineural tissues has been well documented in an animal model of repetitive motion injury [42].”

    From Fascia Mobility, Proprioception, and Myofascial Pain. (2021) · cites this paper as [42]

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Cited by

Sorted by citations

Authors
Barbe, M. F., Gallagher, S., Massicotte, V. S., Tytell, M., Popoff, S. N., & Barr-Gillespie, A. E.
Affiliations
  • Temple University (US)
  • Auburn University (US)
  • Wake Forest University Health Sciences (US)
  • Pacific University Oregon (US)
Corresponding author
Barbe, Mary F
ORCID
Venue
BMC Musculoskeletal Disorders
Publisher
Springer Science and Business Media LLC
Published
2013-10-25
Volume
14
Issue
1
Pages
303-303
ISSN
1471-2474 (ISSN-L)
DOI
10.1186/1471-2474-14-303
PMC
PMC3924406
OpenAlex
W2090795576
Cited by
135
References
4
Citations by year
2026: 3 · 2025: 11 · 2024: 3 · 2023: 8 · 2022: 18 · 2021: 17 · 2020: 12 · 2019: 14 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 15 · 2014: 8
FWCI
15.01
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Musculoskeletal Disorders (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • CommonKnowledge Research Repository (Pacific University Oregon) (submittedVersion, public-domain)
Funders
  • University of New England
  • National Institutes of Health (AR056019)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR056019, R01AR056019)
  • National Center for Research Resources (S10RR026727)
  • National Institute for Occupational Safety and Health (OH03970)
Topics
  • Social Sciences › Psychology › Social Psychology › Ergonomics and Musculoskeletal Disorders
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Effects of Vibration on Health
Keywords
work-related musculoskeletal disorders, fatigue failure, muscle degeneration, bone adaptation, bone resorption, bone turnover markers, macrophage infiltration, median nerve, mechanical allodynia, grip strength, tactile sensitivity, inflammatory cytokines, HSP72, histomorphometry, rat model
MeSH terms
Animals, Bone and Bones, Cartilage, Conditioning, Operant, Disease Models, Animal, Female, Musculoskeletal Diseases, Musculoskeletal System, Nerve Tissue, Peptides, Platelet-Derived Growth Factor, Random Allocation, Cumulative Trauma Disorders, Stress, Physiological, Osteocalcin, Cytokines, Bone Remodeling, Rats, Sprague-Dawley, Matrix Metalloproteinase 2, Collagen Type I, HSP72 Heat-Shock Proteins, Rats, Muscle Strength, X-Ray Microtomography

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