Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age‐related muscle dysfunction

McArdle, Anne; H. Dillmann, Wolfgang; Mestril, Ruben; A. Faulkner, John; J. Jackson, Malcolm

doi:10.1096/fj.03-0395fje

Cited by 274Heat shock proteins researchMuscle Physiology and DisordersGenetics, Aging, and Longevity in Model Organisms

Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age‐related muscle dysfunction

McArdle, Anne, H. Dillmann, Wolfgang, Mestril, Ruben, A. Faulkner, John, J. Jackson, Malcolm·2004·The FASEB Journal

DOI 10.1096/fj.03-0395fje

Open this paper in CoChat — free account

Abstract

Ageing is associated with skeletal muscle atrophy, a deficit in force generation, an increased susceptibility to contraction‐induced injury, and a permanent force deficit following severe injury. Muscles of young mice adapt rapidly following exercise by an increase in the production of heat shock proteins (HSPs), whereas muscles of old mice show a severely diminished response. We hypothesized that overexpression of HSP70 in muscle throughout life would reduce age‐related changes in function. The maximum tetanic force of extensor digitorum longus (EDL) muscles of adult and old wild‐type (WT) and HSP70 overexpressor transgenic mice was determined. EDL muscles were subjected to damaging lengthening contractions and the ability to generate force was assessed for up to 28 days following the contractions. Overexpression of HSP70 in muscles of old transgenic mice prevented the specific force deficit observed in muscles of old WT mice. The complete recovery of muscles of old HSP70 transgenic mice by 14 days following the contraction protocol was in contrast to the 44% force deficit, which remained in muscles of old WT mice at 28 days following the protocol. These data indicate that a diminished production of HSP70 in muscles of old mammals has a major effect on age‐related functional deficits.

Integrity signals

Registry

Crossref · 10.1096/fj.03-0395fje

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Overexpression of heat shock protein 70 protects against age- and disease-related tissue degeneration in brain, heart, and skeletal muscle.
“Overexpression of heat shock protein 70 (HSP70), a chaperone protein that recognizes damaged proteins in CMA, also protects against age- and disease-related tissue degeneration in brain, heart and skeletal muscle90–92.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [92]

The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works
What is the cause of the ageing atrophy?
Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90132-3 · Cited by 2,080 · see citing works
Strength, power and related functional ability of healthy people aged 65-89 years.
SKELTON, D. A., GREIG, C. A., DAVIES, J. M., & YOUNG, A. (1994) · Age and Ageing · doi:10.1093/ageing/23.5.371 · Cited by 934 · see citing works
Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.
Marber, M. S., Mestril, R., H, S., Sayen, M. R., Yellon, D. M., & DILLMANN, W. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117815 · Cited by 843 · see citing works
Self-citation
Contractile properties of skeletal muscles from young, adult and aged mice.
Brooks, S. V., & Faulkner, J. A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017279 · Cited by 777 · cited 4× · see citing works
“Interestingly, the old HSP70 mice were not protected from the age-related muscle atrophy of ~20% that has previously been observed in WT mice (26), rats (28, 29), and humans (35).”
BackgroundMethodResultInfluential
Aging of human muscle: structure, function and adaptability
Porter, M. M., Vandervoort, A. A., & Lexell, J. E. (1995) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.1995.tb00026.x · Cited by 555 · see citing works
Muscle transplantation between young and old rats: age of host determines recovery
Carlson, B. M., & Faulkner, J. A. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.6.c1262 · Cited by 417 · see citing works
Self-citation
Injury to skeletal muscle fibers of mice following lengthening contractions
McCully, K. K., & Faulkner, J. A. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.1.119 · Cited by 408 · see citing works
Nitric oxide release is present from incubated skeletal muscle preparations
Balon, T. W., & Nadler, J. L. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.6.2519 · Cited by 406 · see citing works
HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise
Salo, D. C., Donovan, C. M., & Davies, K. J. A. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90119-n · Cited by 357 · see citing works
Contractile activity-induced oxidative stress: cellular origin and adaptive responses
McArdle, A., Pattwell, D. M., Vasilaki, A., Griffiths, R. D., & Jackson, M. J. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.3.c621 · Cited by 349 · see citing works
Self-citation
Reactive oxygen in skeletal muscle. II. Extracellular release of free radicals
Reid, M. B., Shoji, T., Moody, M. R., & Entman, M. L. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.5.1805 · Cited by 310 · see citing works
Free radical injury to skeletal muscles of young, adult, and old mice
Zerba, E., Komorowski, T. E., & Faulkner, J. A. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.3.c429 · Cited by 279 · see citing works
Superoxide dismutase, aging, and degenerative disease
Warner, H. R. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90080-9 · Cited by 238 · see citing works
Contraction-induced injury: recovery of skeletal muscles in young and old mice
Brooks, S. V., & Faulkner, J. A. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.3.c436 · Cited by 238 · see citing works
Time course of responses of human skeletal muscle to oxidative stress induced by nondamaging exercise
Khassaf, M., Child, R. B., McArdle, A., Brodie, D. A., Esanu, C., & Jackson, M. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.3.1031 · Cited by 219 · see citing works
Self-citation
Production of hydroxyl radicals in contracting skeletal muscle of cats
O’Neill, C., Stebbins, C. L., Bonigut, S., Halliwell, B. B., & Longhurst, J. C. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.3.1197 · Cited by 167 · see citing works
Tissue-specific HSP70 response in animals undergoing heat stress
Flanagan, S. W., Ryan, A. J., GISOLFI, C. V., & Moseley, P. L. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.268.1.r28 · Cited by 159 · see citing works
Heat Shock Proteins and the Inflammatory Response
Moseley, P. L. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08327.x · Cited by 145 · see citing works
Relationship between Antioxidants, Prooxidants, and the Aging Processa
Sohal, R. S., & Orr, W. C. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38651.x · Cited by 125 · see citing works
Skeletal Muscle Regeneration in Very Old Rats
Carlson, B. M., Dedkov, E. I., Borisov, A. B., & Faulkner, J. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.5.b224 · Cited by 119 · see citing works
Mechanical stimulation of osteopontin mRNA expression and synthesis in bone cell cultures
Klein‐Nulend, J., Roelofsen, J., Semeins, C. M., Bronckers, A. L. J. J., & Burger, E. H. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199702)170:2 · Cited by 115 · see citing works
The magnitude of the initial injury induced by stretches of maximally activated muscle fibres of mice and rats increases in old age.
Brooks, S. V., & Faulkner, J. A. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021790 · Cited by 115 · see citing works
Strength and Power in Sport
Komi, P. V. (1994) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199411000-00021 · Cited by 86 · see citing works
Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity
Vasilaki, A., Jackson, M. J., & McArdle, A. (2002) · Muscle & Nerve · doi:10.1002/mus.10094 · Cited by 84 · see citing works
Self-citation
Severity of contraction-induced injury is affected by velocity only during stretches of large strain
Brooks, S. V., & Faulkner, J. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.661 · Cited by 84 · see citing works
Reinnervation of long-term denervated rat muscle freely grafted into an innervated limb
Carlson, B. M., & Faulkner, J. A. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90077-5 · Cited by 83 · see citing works
In mice, the muscle weakness due to age is absent during stretching.
Phillips, S. K., Bruce, S., & WOLEDGE, R. C. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018583 · Cited by 73 · see citing works
Conditioning of Skeletal Muscles in Adult and Old Mice for Protection From Contraction-Induced Injury
Brooks, S. V., Opiteck, J. A., & Faulkner, J. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.4.b163 · Cited by 54 · see citing works
Skeletal muscles of aged male mice fail to adapt following contractile activity
Vasilaki, A., Iwanejko, L. M., McArdle, F., Broome, C. S., Jackson, M. J., & McArdle, A. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310455 · Cited by 34 · see citing works
Self-citation
Functional properties of skeletal muscle from transgenic animals with upregulated heat shock protein 70
Nosek, T. M., Brotto, M. A. P., Essig, D. A., Mestril, R., Conover, R. C., DILLMANN, W. H., & Kolbeck, R. C. (2000) · Physiological Genomics · doi:10.1152/physiolgenomics.2000.4.1.25 · Cited by 30 · see citing works
Self-citation
Motor Unit Properties of Nerve-Intact Extensor Digitorum Longus Muscle Grafts In Young and Old Rats
Cederna, P. S., Asato, H., Gu, X., van der Meulen, J., Kuzon, W. M., Carlson, B. M., & Faulkner, J. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.6.b254 · Cited by 28 · see citing works
Cellular and molecular aspects of adaptation in skeletal muscle
Goldspink, G., & Harridge, S. (2003) · UCL Discovery (University College London) · Cited by 16 · see citing works
Oxidative stress and the pathogenesis of sarcopenia
Lopez, M. E., Zainal, T. A., Chung, S. S., Aiken, J. M., & Weindruch, R. H. (2000) · Elsevier eBooks · doi:10.1016/b978-044482650-3/50029-8 · Cited by 7 · see citing works

Flagged first, then by citations

Sorted by citations

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459 · see citing works
Stem cell aging: mechanisms, regulators and therapeutic opportunities
Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works
Hormesis in aging
Rattan, S. I. S. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.03.002 · Cited by 498 · see citing works
Reactive Oxygen Species: Impact on Skeletal Muscle
Powers, S. K., Ji, L. L., Kavazis, A. N., & Jackson, M. J. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100054 · Cited by 508 · see citing works
Exercise-induced oxidative stress in humans: cause and consequences
Powers, S. K., Nelson, W. B., & Hudson, M. B. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.009 · Cited by 441 · see citing works
Exercise and hormesis: oxidative stress-related adaptation for successful aging
Radak, Z. O., Chung, H. Y., & Goto, S. (2005) · Biogerontology · doi:10.1007/s10522-004-7386-7 · Cited by 413 · see citing works
Chronic low-grade inflammation and age-related sarcopenia
Beyer, I., Mets, T., & Bautmans, I. (2012) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32834dd297 · Cited by 400 · see citing works
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
Zhang, G., Liu, Z., Ding, H., Zhou, Y., Doan, H. A., Sin, K. W. T., Zhu, Z. J., Flores, R., Wen, Y., Gong, X., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00726-x · Cited by 248 · see citing works
The Exercise-Induced Stress Response of Skeletal Muscle, with Specific Emphasis on Humans
Morton, J. P., Kayani, A. C., McArdle, A., & Drust, B. (2009) · Sports Medicine · doi:10.2165/00007256-200939080-00003 · Cited by 245 · see citing works
Self-citation
Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity
Vasilaki, A., Mansouri, A., Remmen, H. V., van der Meulen, J. H., Larkin, L. M., Richardson, A. G., McArdle, A., Faulkner, J. A., & Jackson, M. J. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00198.x · Cited by 215 · see citing works
Self-citation
The production of reactive oxygen and nitrogen species by skeletal muscle
Jackson, M. J., Pye, D., & Palomero, J. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01102.2006 · Cited by 210 · see citing works
Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing
Baumert, P., Lake, M., Stewart, C. E., Drust, B., & Erskine, R. M. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3411-1 · Cited by 194 · see citing works
Amelioration of muscle wasting by glucagon‐like peptide‐1 receptor agonist in muscle atrophy
Hong, Y., Lee, J. H., Jeong, K. W., Choi, C. S., & Jun, H. (2019) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12434 · Cited by 188 · see citing works
Reduced carbohydrate availability does not modulate training-induced heat shock protein adaptations but does upregulate oxidative enzyme activity in human skeletal muscle
Morton, J. P., Croft, L., Bartlett, J. D., MacLaren, D. P. M., Reilly, T., Evans, L., McArdle, A., & Drust, B. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00003.2009 · Cited by 179 · see citing works
Self-citation
Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age
Vasilaki, A., McArdle, F., Iwanejko, L. M., & McArdle, A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.08.004 · Cited by 182 · see citing works
Self-citation
Aging and its effects on inflammation in skeletal muscle at rest and following exercise-induced muscle injury
Peake, J. M., Gatta, P. A. D., & Cameron‐Smith, D. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00467.2009 · Cited by 182 · see citing works
Age‐related changes in skeletal muscle reactive oxygen species generation and adaptive responses to reactive oxygen species
Jackson, M. J., & McArdle, A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.206623 · Cited by 177 · see citing works
Self-citation
Physical Activity and Cancer Prevention: Pathways and Targets for Intervention
Rogers, C. J., Colbert, L. H., Greiner, J. W., Perkins, S. N., & Hursting, S. D. (2008) · Sports Medicine · doi:10.2165/00007256-200838040-00002 · Cited by 170 · see citing works
Maximal eccentric exercise induces a rapid accumulation of small heat shock proteins on myofibrils and a delayed HSP70 response in humans
Paulsen, G., Vissing, K., Kalhovde, J. M., Ugelstad, I., Bayer, M. L., Kadi, F., Schjerling, P., Hallén, J., & Raastad, T. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00677.2006 · Cited by 168 · see citing works
Effect of lifelong overexpression of HSP70 in skeletal muscle on age‐related oxidative stress and adaptation after nondamaging contractile activity
Broome, C. S., Kayani, A. C., Palomero, J., DILLMANN, W. H., Mestril, R., Jackson, M. J., & McArdle, A. (2006) · The FASEB Journal · doi:10.1096/fj.05-4935fje · Cited by 168 · see citing works
Self-citation
Time course and differential responses of the major heat shock protein families in human skeletal muscle following acute nondamaging treadmill exercise
Morton, J. P., MacLaren, D. P. M., Cable, N. T., Bongers, T., Griffiths, R. D., Campbell, I. T., Evans, L., Kayani, A. C., McArdle, A., & Drust, B. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00046.2006 · Cited by 165 · see citing works
Self-citation
Age and natural metabolically-intensive behavior affect oxidative stress and antioxidant mechanisms
Williams, J. B., Roberts, S. P., & Elekonich, M. M. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.02.001 · Cited by 152 · see citing works
Response and function of skeletal muscle heat shock protein 70
Liu, Y. (2006) · Frontiers in bioscience · doi:10.2741/2011 · Cited by 138 · see citing works
The role of hormones, cytokines and heat shock proteins during age-related muscle loss
Lee, C. E., McArdle, A., & Griffiths, R. D. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.05.005 · Cited by 138 · see citing works
Self-citation
Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy
Sakellariou, G. K., Pearson, T., Lightfoot, A. P., Nye, G. A., Wells, N., Giakoumaki, I. I., Vasilaki, A., Griffiths, R. D., Jackson, M. J., & McArdle, A. (2016) · Scientific Reports · doi:10.1038/srep33944 · Cited by 133 · see citing works
Self-citation
The interaction of force and repetition on musculoskeletal and neural tissue responses and sensorimotor behavior in a rat model of work-related musculoskeletal disorders
Barbe, M. F., Gallagher, S., Massicotte, V. S., Tytell, M., Popoff, S. N., & Barr-Gillespie, A. E. (2013) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-14-303 · Cited by 135 · see citing works
Subcellular movement and expression of HSP27, αB-crystallin, and HSP70 after two bouts of eccentric exercise in humans
Paulsen, G., Lauritzen, F., Bayer, M. L., Kalhovde, J. M., Ugelstad, I., Owe, S. G., Hallén, J., Bergersen, L. H., & Raastad, T. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00209.2009 · Cited by 132 · see citing works
Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle
Hafen, P. S., Preece, C. N., Sorensen, J. R., Hancock, C. R., & Hyldahl, R. D. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00383.2018 · Cited by 129 · see citing works
Loss of the Inducible Hsp70 Delays the Inflammatory Response to Skeletal Muscle Injury and Severely Impairs Muscle Regeneration
Judge, S. M., Howard, T. M., Ahn, B., Ferreira, L. F., & Judge, A. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062687 · Cited by 125 · see citing works
Reactive oxygen species and redox-regulation of skeletal muscle adaptations to exercise
Jackson, M. J. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1773 · Cited by 125 · see citing works
Muscle-specific MicroRNA1 (miR1) Targets Heat Shock Protein 70 (HSP70) during Dexamethasone-mediated Atrophy*
Kukreti, H., Amuthavalli, K., Harikumar, A., Sathiyamoorthy, S., Feng, P. Z., Anantharaj, R., Tan, S. L. K., Lokireddy, S., Bonala, S., Sriram, S., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.390369 · Cited by 121 · see citing works
Skeletal muscle heat shock protein 70: diverse functions and therapeutic potential for wasting disorders
Judge, S. M. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00330 · Cited by 110 · see citing works
Aging, Functional Capacity and Eccentric Exercise Training
Gault, M. L. (2013) · Aging and Disease · doi:10.14336/ad.2013.0400351 · Cited by 110 · see citing works
Age-related skeletal muscle dysfunction: causes and mechanisms.
Degens, H. (2007) · PubMed · Cited by 103 · see citing works
Skeletal Muscle Damage with Exercise and Aging
Close, G. L., Kayani, A. C., Vasilaki, A., & McArdle, A. (2005) · Sports Medicine · doi:10.2165/00007256-200535050-00004 · Cited by 104 · see citing works
Self-citation
Resistance training increases heat shock protein levels in skeletal muscle of young and old rats
Murlasits, Z., Cutlip, R. G., Geronilla, K. B., Rao, K. M. K., Wonderlin, W. F., & Alway, S. E. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.005 · Cited by 99 · see citing works
Overexpression of inducible 70-kDa heat shock protein in mouse attenuates skeletal muscle damage induced by cryolesioning
Miyabara, E. H., Martin, J. W., Griffin, T., Moriscot, A. S., & Mestril, R. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00399.2005 · Cited by 95 · see citing works
Self-citation
Aging skeletal muscle shows a drastic increase in the small heat shock proteins αB-crystallin/HspB5 and cvHsp/HspB7
Doran, P., Gannon, J. M., O’Connell, K. M., & Ohlendieck, K. (2007) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2007.07.003 · Cited by 94 · see citing works
Proteomics of muscle chronological ageing in post-menopausal women
Gueugneau, M., Coudy‐Gandilhon, C., Gourbeyre, O., Chambon, C., Combaret, L., Polge, C., Taillandier, D., Attaix, D., Friguet, B., Maier, A. B., et al. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1165 · Cited by 82 · see citing works
Proteomics of skeletal muscle aging
Doran, P., Donoghue, P. M., O’Connell, K. M., Gannon, J. M., & Ohlendieck, K. (2009) · PROTEOMICS · doi:10.1002/pmic.200800365 · Cited by 81 · see citing works
Does Sex Matter in Musculoskeletal Health? The Influence of Sex and Gender on Musculoskeletal Health *
Tosi, L. L. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.e.00218 · Cited by 81 · see citing works
Acute response and subcellular movement of HSP 27, α B‐crystallin and HSP 70 in human skeletal muscle after blood‐flow‐restricted low‐load resistance exercise
Cumming, K. T., Paulsen, G., Wernbom, M., Ugelstad, I., & Raastad, T. (2014) · Acta Physiologica · doi:10.1111/apha.12305 · Cited by 80 · see citing works
Transcriptome response of human skeletal muscle to divergent exercise stimuli
Dickinson, J. M., D’Lugos, A. C., Naymik, M., Siniard, A. L., Wolfe, A. J., Curtis, D. R., Huentelman, M. J., & Carroll, C. C. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00014.2018 · Cited by 76 · see citing works
Intermittent hyperthermia enhances skeletal muscle regrowth and attenuates oxidative damage following reloading
Selsby, J. T., Rother, S., Tsuda, S., Pracash, O., Quindry, J. C., & DODD, S. L. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2006 · Cited by 78 · see citing works
Diet-Induced Obesity Suppresses Expression of Many Proteins at the Blood–Brain Barrier
Ouyang, S., Hsuchou, H., Kastin, A. J., Wang, Y., Yu, C., & Pan, W. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.166 · Cited by 77 · see citing works
Attenuation of muscle damage by preconditioning with muscle hyperthermia 1-day prior to eccentric exercise
Nosaka, K., Muthalib, M., Lavender, A. P., & Laursen, P. B. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0331-5 · Cited by 75 · see citing works
Aging increases the oxidation of dichlorohydrofluorescein in single isolated skeletal muscle fibers at rest, but not during contractions
Palomero, J., Vasilaki, A., Pye, D., McArdle, A., & Jackson, M. J. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00530.2012 · Cited by 71 · see citing works
Self-citation
Hsp70 Inhibits Aminoglycoside-Induced Hair Cell Death and is Necessary for the Protective Effect of Heat Shock
Taleb, M., Brandon, C. S., Lee, F., Lomax, M. I., DILLMANN, W. H., & Cunningham, L. L. (2008) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-008-0122-2 · Cited by 73 · see citing works
Basal and exercise induced label-free quantitative protein profiling of m. vastus lateralis in trained and untrained individuals
Schild, M., Ruhs, A., Beiter, T., Zügel, M., Hudemann, J., Reimer, A., Krumholz-Wagner, I., Wagner, C., Keller, J., Eder, K., et al. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.03.028 · Cited by 71 · see citing works
Controlling chronic low‐grade inflammation to improve follicle development and survival
Yang, Z., Tang, Z.-J., Cao, X., Xie, Q., Hu, C., Zhong, Z., Tan, J., & Zheng, Y. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13265 · Cited by 70 · see citing works
Higher levels of heat shock proteins in longer-lived mammals and birds
Salway, K. D., Gallagher, E. J., Page, M. M., & Stuart, J. A. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.06.002 · Cited by 70 · see citing works
Role of exercise-induced reactive oxygen species in the modulation of heat shock protein response
Fittipaldi, S., Dimauro, I., Mercatelli, N., & Caporossi, D. (2013) · Free Radical Research · doi:10.3109/10715762.2013.835047 · Cited by 70 · see citing works
Muscle fiber type-specific response of Hsp70 expression in human quadriceps following acute isometric exercise
Tupling, A. R., Bombardier, É., Stewart, R. D., Vigna, C., & Aqui, A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00771.2007 · Cited by 69 · see citing works
Trained Men Display Increased Basal Heat Shock Protein Content of Skeletal Muscle
Morton, J. P., MacLaren, D. P. M., Cable, N. T., Campbell, I. T., Evans, L., Kayani, A. C., McArdle, A., & Drust, B. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31816a7171 · Cited by 67 · see citing works
Self-citation
Honey bees as a model for understanding mechanisms of life history transitions
Elekonich, M. M., & Roberts, S. P. (2005) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpb.2005.04.014 · Cited by 67 · see citing works
Eccentric exercise in aging and diseased skeletal muscle: good or bad?
Lovering, R. M., & Brooks, S. V. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00174.2013 · Cited by 65 · see citing works
Role of Heat Shock Proteins in Stem Cell Behavior
Fan, G. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-398459-3.00014-9 · Cited by 63 · see citing works
Role of reactive oxygen species in the defective regeneration seen in aging muscle
Vasilaki, A., & Jackson, M. J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.008 · Cited by 64 · see citing works
Reactive Oxygen Species: Impact on Skeletal Muscle
Powers, S. K., Ji, L. L., Kavazis, A. N., & Jackson, M. J. (2011) · Comprehensive physiology · doi:10.1002/j.2040-4603.2011.tb00348.x · Cited by 63 · see citing works
Acute heat stress prior to downhill running may enhance skeletal muscle remodeling
Touchberry, C. D., Gupte, A. A., Bomhoff, G. L., Graham, Z., Geiger, P. C., & Gallagher, P. M. (2012) · Cell Stress and Chaperones · doi:10.1007/s12192-012-0343-5 · Cited by 61 · see citing works
The age‐related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase
Vasilaki, A., van der Meulen, J. H., Larkin, L. M., Harrison, D. C., Pearson, T., Remmen, H. V., Richardson, A., Brooks, S. V., Jackson, M. J., & McArdle, A. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00635.x · Cited by 60 · see citing works
Self-citation
Effects of heat stress on proliferation, protein turnover, and abundance of heat shock protein messenger ribonucleic acid in cultured porcine muscle satellite cells1
Kamanga‐Sollo, E., Pampusch, M. S., White, M. E., Hathaway, M. R., & Dayton, W. R. (2011) · Journal of Animal Science · doi:10.2527/jas.2011-4123 · Cited by 60 · see citing works
Modulation of Caspase Activity Regulates Skeletal Muscle Regeneration and Function in Response to Vasopressin and Tumor Necrosis Factor
Moresi, V., Garcia-Alvarez, G., Pristerà, A., Rizzuto, E., Albertini, M. C., Rocchi, M., Marazzi, G., Sassoon, D., Adamo, S., & Coletti, D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005570 · Cited by 60 · see citing works
Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death
Taleb, M., Brandon, C. S., Lee, F., Harris, K. C., DILLMANN, W. H., & Cunningham, L. L. (2009) · Cell Stress and Chaperones · doi:10.1007/s12192-008-0097-2 · Cited by 60 · see citing works
Chaperoning heat shock proteins: Proteomic analysis and relevance for normal and dystrophin‐deficient muscle
Brinkmeier, H., & Ohlendieck, K. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400015 · Cited by 59 · see citing works
PGC-1α Transcriptional Response and Mitochondrial Adaptation to Acute Exercise Is Maintained in Skeletal Muscle of Sedentary Elderly Males
Cobley, J. N., Bartlett, J. D., Kayani, A., Murray, S. W., Louhelainen, J., Donovan, T., Waldron, S., Gregson, W., Burniston, J. G., Morton, J. P., et al. (2012) · Biogerontology · doi:10.1007/s10522-012-9408-1 · Cited by 58 · see citing works
Heat stress increases myonuclear number and fiber size via satellite cell activation in rat regenerating soleus fibers
Oishi, Y., Hayashida, M., Tsukiashi, S., Taniguchi, K., Kami, K., Roy, R. R., & Ohira, Y. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91651.2008 · Cited by 56 · see citing works
Drosophila small heat shock protein CryAB ensures structural integrity of developing muscles, and proper muscle and heart performance
Wójtowicz, I., Jabłońska, J., Zmojdzian, M., Taghli-Lamallem, O., Renaud, Y., Junion, G., Daczewska, M., Huelsmann, S., Jagla, K., & Jagla, T. (2015) · Development · doi:10.1242/dev.115352 · Cited by 54 · see citing works
Mitochondria in the middle: exercise preconditioning protection of striated muscle
Lawler, J. M., Rodriguez, D., & Hord, J. M. (2016) · The Journal of Physiology · doi:10.1113/jp270656 · Cited by 53 · see citing works
Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions
Thakur, S. S., Swiderski, K., Ryall, J. G., & Lynch, G. S. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0528 · Cited by 54 · see citing works
Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats
Siu, P. M., Pistilli, E. E., Murlasits, Z., & Alway, S. E. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01012.2005 · Cited by 53 · see citing works
Redox regulation of muscle adaptations to contractile activity and aging
Jackson, M. J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00760.2014 · Cited by 50 · see citing works
The Double Edge of Reactive Oxygen Species as Damaging and Signaling Molecules in HL60 Cell Culture
Ferrer, M. D., Sureda, A., Mestre, A., Tur, J. A., & Pons, A. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000276558 · Cited by 53 · see citing works
Long‐term administration of the mitochondria‐targeted antioxidant mitoquinone mesylate fails to attenuate age‐related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle
Sakellariou, G. K., Pearson, T., Lightfoot, A. P., Nye, G., Wells, N., Giakoumaki, I. I., Griffiths, R. D., McArdle, A., & Jackson, M. J. (2016) · The FASEB Journal · doi:10.1096/fj.201600450r · Cited by 51 · see citing works
Self-citation
Redox regulation of skeletal muscle
Jackson, M. J. (2008) · IUBMB Life · doi:10.1002/iub.72 · Cited by 49 · see citing works
Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon
Shanely, R. A., Nieman, D. C., Zwetsloot, K. A., Knab, A. M., Imagita, H., Luo, B., Davis, B. A., & Zubeldia, J. M. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.09.005 · Cited by 49 · see citing works
Overexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy
Miyabara, E. H., Nascimento, T. L., Rodrigues, D. C., Moriscot, A. S., Davila, W. F., Mou, Y. A., de Tombe, P. P., & Mestril, R. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1087-x · Cited by 48 · see citing works
Self-citation
Combination of peptide OFFGEL fractionation and label‐free quantitation facilitated proteomics profiling of extraocular muscle
Fraterman, S., Zeiger, U., Khurana, T. S., Rubinstein, N. A., & Wilm, M. S. (2007) · PROTEOMICS · doi:10.1002/pmic.200700382 · Cited by 48 · see citing works
Effects of ovarian sex hormones and downhill running on fiber-type-specific HSP70 expression in rat soleus
Bombardier, É., Vigna, C., Iqbal, S., Tiidus, P. M., & Tupling, A. R. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91573.2008 · Cited by 48 · see citing works
Overexpression of HSP10 in skeletal muscle of transgenic mice prevents the age-related fall in maximum tetanic force generation and muscle cross-sectional area
Kayani, A. C., Close, G. L., DILLMANN, W. H., Mestril, R., Jackson, M. J., & McArdle, A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00334.2009 · Cited by 48 · see citing works
Self-citation
Molecular Chaperones and Proteolytic Machineries Regulate Protein Homeostasis in Aging Cells
Margulis, B. A., Сергеевна, Ц. А., Zubova, S. G., & Guzhova, I. V. (2020) · Cells · doi:10.3390/cells9051308 · Cited by 48 · see citing works
The exercise-induced stress response in skeletal muscle: failure during aging
Kayani, A. C., Morton, J. P., & McArdle, A. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h08-089 · Cited by 46 · see citing works
Self-citation
Polyphenols: Well Beyond The Antioxidant Capacity: Polyphenol Supplementation and Exercise-Induced Oxidative Stress and Inflammation
Sureda, A., Tejada, S., Bibiloni, M. D. M., Tur, J. A., & Pons, A. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201015666140813123843 · Cited by 45 · see citing works
Improvements in skeletal muscle fiber size with resistance training are age-dependent in older adults: a systematic review and meta-analysis
Straight, C. R., Fedewa, M. V., Toth, M. J., & Miller, M. S. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00170.2020 · Cited by 46 · see citing works
Heat shock proteins and neuromuscular disease
Nishimura, R. N., & Sharp, F. R. (2005) · Muscle & Nerve · doi:10.1002/mus.20373 · Cited by 45 · see citing works
Differential cell death regulation between adult-unloaded and aged rat soleus muscle
Ogata, T., Machida, S., Oishi, Y., Higuchi, M., & Muraoka, I. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.02.001 · Cited by 44 · see citing works
A proteomic study of plasma protein changes under extreme physical stress
Balfoussia, E., Skenderi, K., Tsironi, M., Anagnostopoulos, A. K., Parthimos, N., Vougas, K. N., Papassotiriou, I., Tsangaris, G. T., & Chrousos, G. P. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.12.004 · Cited by 43 · see citing works
Role of nerve–muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing
Vasilaki, A., Richardson, A. G., Remmen, H. V., Brooks, S. V., Larkin, L. M., McArdle, A., & Jackson, M. J. (2017) · The Journal of Physiology · doi:10.1113/jp274336 · Cited by 44 · see citing works
Self-citation
Recovery from contraction-induced injury is impaired in weight-bearing muscles of old male mice
Rader, E. P., & Faulkner, J. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00663.2005 · Cited by 44 · see citing works
Neuromuscular recovery after a strength training session in elderly people
Ferri, A., Narici, M. V., Grassi, B., & Pousson, M. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0168-y · Cited by 44 · see citing works
Estrogen administration attenuates immobilization-induced skeletal muscle atrophy in male rats.
Sugiura, T., Ito, N., Goto, K., Naito, H., Yoshioka, T., & Powers, S. (2006) · Journal of Physiological Sciences · doi:10.2170/physiolsci.rp006906 · Cited by 45 · see citing works
Exercise training–induced gender‐specific heat shock protein adaptations in human skeletal muscle
Morton, J. P., Holloway, K., Woods, P., Cable, N. T., Burniston, J. G., Evans, L., Kayani, A. C., & McArdle, A. (2008) · Muscle & Nerve · doi:10.1002/mus.21182 · Cited by 43 · see citing works
Self-citation
Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration
Fan, W., Gao, X. K., Rao, X. S., Shi, Y. P., Liu, X. C., Wang, F. Y., Liu, Y. F., Cong, X. X., He, M. Y., Xu, S. B., et al. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00211-18 · Cited by 41 · see citing works
Effect of aging on the recovery following contraction-induced injury in muscles of female mice
Rader, E. P., & Faulkner, J. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00380.2006 · Cited by 41 · see citing works
Prolonged exercise training induces long-term enhancement of HSP70 expression in rat plantaris muscle
Ogata, T., Oishi, Y., Higashida, K., Higuchi, M., & Muraoka, I. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90911.2008 · Cited by 41 · see citing works
Skeletal muscle aging: Role of reactive oxygen species
Jackson, M. J. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b6f97f · Cited by 38 · see citing works
Interaction between Hsp70 and the SR Ca2+pump: a potential mechanism for cytoprotection in heart and skeletal muscle
Tupling, A. R., Bombardier, É., Vigna, C., Quadrilatero, J., & Fu, M. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h08-067 · Cited by 38 · see citing works
Microwave hyperthermia treatment increases heat shock proteins in human skeletal muscle
Ogura, Y., Naıto, H., Tsurukawa, T., Ichinoseki‐Sekine, N., Saga, N., Sugiura, T., & Katamoto, S. (2007) · British Journal of Sports Medicine · doi:10.1136/bjsm.2006.032938 · Cited by 38 · see citing works
Aberrant redox signalling and stress response in age-related muscle decline: Role in inter- and intra-cellular signalling
McArdle, A., Pollock, N., Staunton, C. A., & Jackson, M. J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.11.038 · Cited by 35 · see citing works
Self-citation
Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits
Kayani, A. C., Close, G. L., Jackson, M. J., & McArdle, A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00575.2007 · Cited by 35 · see citing works
Self-citation

Effect of lifelong overexpression of HSP70 in skeletal muscle on age‐related oxidative stress and adaptation after nondamaging contractile activity
Broome, C. S., Kayani, A. C., Palomero, J., DILLMANN, W. H., Mestril, R., Jackson, M. J., & McArdle, A. (2006) · The FASEB Journal · doi:10.1096/fj.05-4935fje · Cited by 168 · see citing works
Self-citation
Overexpression of HSP10 in skeletal muscle of transgenic mice prevents the age-related fall in maximum tetanic force generation and muscle cross-sectional area
Kayani, A. C., Close, G. L., DILLMANN, W. H., Mestril, R., Jackson, M. J., & McArdle, A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00334.2009 · Cited by 48 · see citing works
Self-citation
Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity
Vasilaki, A., Jackson, M. J., & McArdle, A. (2002) · Muscle & Nerve · doi:10.1002/mus.10094 · Cited by 84 · see citing works
Self-citation
Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits
Kayani, A. C., Close, G. L., Jackson, M. J., & McArdle, A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00575.2007 · Cited by 35 · see citing works
Self-citation
Enhanced Recovery from Contraction-Induced Damage in Skeletal Muscles of Old Mice Following Treatment with the Heat Shock Protein Inducer 17-(Allylamino)-17-Demethoxygeldanamycin
Kayani, A. C., Close, G. L., Broome, C. S., Jackson, M. J., & McArdle, A. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0795 · Cited by 34 · see citing works
Self-citation

Authors: McArdle, A., H. Dillmann, W., Mestril, R., A. Faulkner, J., & J. Jackson, M.
Affiliations: University of Liverpool (GB)
Department of Medicine University of California San Diego CA
Loyola University Chicago (US)
Institute of Gerontology University of Michigan Ann Arbor MI
Department of Medicine University of Liverpool Liverpool L69 3GA UK
ORCID: McArdle, Anne
Mestril, Ruben
Venue: The FASEB Journal
Publisher: Wiley
Published: 2003-12-19
Volume: 18
Issue: 2
Pages: 1-12
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.03-0395fje
OpenAlex: W2148331882
Cited by: 274
References: 34
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 7 · 2022: 4 · 2021: 8 · 2020: 13 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 15 · 2015: 15 · 2014: 14 · 2013: 21 · 2012: 11
FWCI: 4.71
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (acceptedVersion)
Funders: Wellcome Trust (043364/Z/95/Z)
National Institutes of Health (R37HL 049434)
Joe Andruzzi Foundation
National Institute on Aging (Ag20591)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: HSP70, heat shock proteins, skeletal muscle aging, muscle atrophy, muscle damage, contraction-induced injury, transgenic overexpression, extensor digitorum longus, tetanic force, muscle force recovery, exercise adaptation
MeSH terms: Aging, Animals, Female, Male, Mice, Transgenic, Muscle Contraction, Muscular Diseases, Muscle, Skeletal, HSP70 Heat-Shock Proteins, Transgenes, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age‐related muscle dysfunction

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks