Risk of placental abruption in relation to migraines and headaches
Open accessAbstract
BACKGROUND: Migraine, a common chronic-intermittent disorder of idiopathic origin characterized by severe debilitating headaches and autonomic nervous system dysfunction, and placental abruption, the premature separation of the placenta, share many common pathophysiological characteristics. Moreover, endothelial dysfunction, platelet activation, hypercoagulation, and inflammation are common to both disorders. We assessed risk of placental abruption in relation to maternal history of migraine before and during pregnancy in Peruvian women. METHODS: Cases were 375 women with pregnancies complicated by placental abruption, and controls were 368 women without an abruption. During in-person interviews conducted following delivery, women were asked if they had physician-diagnosed migraine, and they were asked questions that allowed headaches and migraine to be classified according to criteria established by the International Headache Society. Logistic regression procedures were used to calculate odds ratios (aOR) and 95% confidence intervals (CI) adjusted for confounders. RESULTS: Overall, a lifetime history of any headaches or migraine was associated with an increased odds of placental abruption (aOR = 1.60; 95% CI 1.16-2.20). A lifetime history of migraine was associated with a 2.14-fold increased odds of placental abruption (aOR = 2.14; 95% CI 1.22-3.75). The odds of placental abruption was 2.11 (95% CI 1.00-4.45) for migraineurs without aura; and 1.59 (95% 0.70-3.62) for migraineurs with aura. A lifetime history of tension-type headache was also increased with placental abruption (aOR = 1.61; 95% CI 1.01-2.57). CONCLUSIONS: This study adds placental abruption to a growing list of pregnancy complications associated with maternal headache/migraine disorders. Nevertheless, prospective cohort studies are needed to more rigorously evaluate the extent to which migraines and/or its treatments are associated with the occurrence of placental abruption.
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People who suffer from mental stress or depression, especially in the latter half of pregnancy, have an increased risk of abruption.
“People who suffer from mental stress or depression, especially in the latter half of pregnancy, also have an increased risk of abruption (45, 46).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [46]
The Background identifies maternal psychiatric disorders, including depression, as putative risk factors for placental abruption. The Results report increased odds among women with both depression and migraine or headache disorders, but do not establish an independent risk from depression or mental stress. The paper does not support the claim that risk is especially increased in the latter half of pregnancy. (LLM, conf=0.86)
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Self-citation
- Authors
- Sanchez, S. E., Williams, M. A., Pacora, P. N., Ananth, C. V., Qiu, C., Aurora, S. K., & Sorensen, T. K.
- Affiliations
- University of Washington (US)
- National University of San Marcos (PE)
- Rutgers, The State University of New Jersey (US)
- Swedish Medical Center (US)
- Corresponding author
- Williams, Michelle A
- Venue
- BMC Women s Health
- Published
- 2010-10-26
- Volume
- 10
- Issue
- 1
- Pages
- 30-30
- ISSN
- 1472-6874 (ISSN-L)
- PMC
- PMC2984417
- OpenAlex
- W2074610458
- Cited by
- 28
- References
- 50
- Citations by year
- 2025: 2 · 2023: 4 · 2022: 1 · 2021: 2 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 2
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Women s Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Greater South Information System
- Funders
- National Institutes of Health
- Fogarty International Center (R03TW007426)
- National Institute of Child Health and Human Development
- National Center on Minority Health and Health Disparities (T37-MD001449)
- National Institute on Minority Health and Health Disparities (T37MD001449)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD055566)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- placental abruption, migraine, headache, tension-type headache, pregnancy complications, migraine with aura, migraine without aura, endothelial dysfunction, hypercoagulability, Peruvian women
- MeSH terms
- Abruptio Placentae, Adult, Female, Headache, Humans, Interviews as Topic, Migraine Disorders, Peru, Pregnancy, Pregnancy Complications, Risk Factors, Prevalence, Logistic Models, Case-Control Studies, Young Adult
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