Genetic Risk Factors for Placental Abruption: A HuGE Review and Meta-Analysis
Abstract
BACKGROUND: Although the precise pathophysiology that leads to placental abruption is unknown, there is evidence supporting a genetic etiology. METHODS: We searched PubMed and systematically reviewed all case-control studies that investigated the association between genetic variants and placental abruption. Pooled genetic risks were estimated using fixed and random effects odds ratios. RESULTS: Twenty-two articles, examining a total of 14 gene polymorphisms were identified. Seven polymorphisms (F5 Arg506Gln, F5 Met385Thr, F2 G20210A, MTHFR A1298C, MTHFD1 Arg653Gln, NOS3 Glu298Asp, AGT Met235Thr) show significant association in individual studies. Six of the 7 (all except F5Met385Thr) were studied more than once and we therefore included them in our meta-analyses. A positive association under the dominant model was found for the F5 Arg506Gln and F2 G20210A polymorphisms. The random-effects odds ratio for the F5 Arg506Gln polymorphism was 3.4 (95% confidence interval = 1.4-8.3) and the fixed-effects odds ratio for the F2 G20210A polymorphism was 6.7 (3.2-13). CONCLUSION: Considering the multifactorial etiology of abruption and the relatively small numbers of studies and participants, this review provides only the first clues of possible genetic causes. Larger case-control studies that include gene-gene and gene-environment interactions may help to elucidate the genetics of placental abruption further.
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Iron deficiency anemia, infection and other inflammatory states, folate deficiency, and hyperhomocysteinemia are associated with increased risk of abruption.
“Pregnant people with iron deficiency anemia, infection and other inflammatory states, as well as folate deficiency and hyperhomocysteinemia are also at increased risk (33–36).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [36]
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Abruptio placentae: perinatal outcome in normotensive and hypertensive patients.
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Genome-Wide Scans Meta-Analysis for Pulse Pressure
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Placental Abruption Is More Frequent in Women with the Angiotensinogen Thr235 Mutation
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Abruptio placentae: Perinatal outcome in normotensive and hypertensive patients
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Etiology, clinical manifestations, and prediction of placental abruption
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Novel insights into molecular mechanisms of abruption-induced preterm birth
Buhimschi, C. S., Schatz, F., Krikun, G., Buhimschi, I. A., & Lockwood, C. J. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001675 · Cited by 53 · see citing works
Risk of placental abruption in relation to migraines and headaches
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Ananth, C. V., Skjaerven, R., & Klunssoyr, K. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-007023 · Cited by 17 · see citing works
- Authors
- Zdoukopoulos, N., & Zintzaras, E.
- Affiliations
- University of Thessaly (GR)
- Tufts University (US)
- Corresponding author
- Zdoukopoulos, Nikos
- Zintzaras, Elias
- ORCID
- Zintzaras, Elias
- Venue
- Epidemiology
- Published
- 2008-03
- Volume
- 19
- Issue
- 2
- Pages
- 309-323
- ISSN
- 1044-3983 (ISSN-L)
- OpenAlex
- W2000950416
- Cited by
- 56
- References
- 116
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 6
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- placental abruption, genetic risk factors, genetic polymorphism, MTHFR A1298C, genetic association, case-control study
- MeSH terms
- Abruptio Placentae, Female, Genotype, Humans, Polymorphism, Genetic, Pregnancy, Risk Factors, Odds Ratio, Case-Control Studies, Oxidative Stress, Thrombophilia
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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