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Cited by 167Probiotics and Fermented FoodsGut microbiota and healthFood Nutrient Composition and Product Development

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Kefir consumption does not alter plasma lipid levels or cholesterol fractional synthesis rates relative to milk in hyperlipidemic men: a randomized controlled trial [ISRCTN10820810]

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St-Onge, Marie-Pierre, Farnworth, Edward R, Savard, Tony, Chabot, Denise, Mafu, Akier, Jones, Peter JH·2002·BMC Complementary and Alternative Medicine
DOI 10.1186/1472-6882-2-1PMC PMC65674
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Abstract

BACKGROUND: Fermented milk products have been shown to affect serum cholesterol concentrations in humans. Kefir, a fermented milk product, has been traditionally consumed for its potential health benefits but has to date not been studied for its hypocholesterolemic properties. METHODS: Thirteen healthy mildly hypercholesterolemic male subjects consumed a dairy supplement in randomized crossover trial for 2 periods of 4 wk each. Subjects were blinded to the dairy supplement consumed. Blood samples were collected at baseline and after 4 wk of supplementation for measurement of plasma total, low-density lipoprotein, and high-density lipoprotein cholesterol and triglyceride concentrations, as well as fatty acid profile and cholesterol synthesis rate. Fecal samples were collected at baseline and after 2 and 4 wk of supplementation for determination of fecal short chain fatty acid level and bacterial content. RESULTS: Kefir had no effect on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglyceride concentrations nor on cholesterol fractional synthesis rates after 4 wk of supplementation. No significant change on plasma fatty acid levels was observed with diet. However, both kefir and milk increased (p < 0.05) fecal isobutyric, isovaleric and propionic acids as well as the total amount of fecal short chain fatty acids. Kefir supplementation resulted in increased fecal bacterial content in the majority of the subjects. CONCLUSIONS: Since kefir consumption did not result in lowered plasma lipid concentrations, the results of this study do not support consumption of kefir as a cholesterol-lowering agent.

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Metadata

Authors
St-Onge, M.-P., Farnworth, E. R., Savard, T., Chabot, D., Mafu, A., & Jones, P. J.
Affiliations
  • Agriculture and Agri-Food Canada (CA)
  • McGill University (CA)
Corresponding author
Jones, Peter JH
ORCID
Venue
BMC Complementary and Alternative Medicine
Publisher
Springer Science and Business Media LLC
Published
2002-01-22
Volume
2
Issue
1
Pages
1-1
ISSN
1472-6882 (ISSN-L)
DOI
10.1186/1472-6882-2-1
PMC
PMC65674
OpenAlex
W2106353202
Cited by
167
References
29
Citations by year
2026: 1 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 13 · 2020: 8 · 2019: 10 · 2018: 12 · 2017: 5 · 2016: 14 · 2015: 6 · 2014: 5 · 2013: 14 · 2012: 5
FWCI
3.96
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Complementary and Alternative Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food Nutrient Composition and Product Development
Keywords
kefir, fermented milk, hypercholesterolemia, plasma lipids, LDL cholesterol, HDL cholesterol, triglycerides, plasma fatty acid profile, fecal short-chain fatty acids, cholesterol-lowering effect
MeSH terms
Adult, Animals, Cholesterol, Dairy Products, Dietary Fats, Double-Blind Method, Feces, Fermentation, Humans, Hydrogen-Ion Concentration, Hypercholesterolemia, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Milk, Triglycerides, Single-Blind Method, Cross-Over Studies, Dietary Supplements, Probiotics, Cultured Milk Products

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