The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion
Open accessAbstract
The T-box transcription factor, TBX3, is overexpressed in several cancers and has been proposed as a chemotherapeutic target. Several lines of evidence suggest that TBX3 may be a key contributor to malignant melanoma, a highly aggressive and intractable disease. Using in vitro and in vivo assays we demonstrate here for the first time that overexpressing TBX3 in non-tumourigenic early stage melanoma cells is sufficient to promote tumour formation and invasion. Furthermore, we show that TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion.
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TBX3 has been confirmed to be highly pro-tumorigenic in melanoma.
“where TBX3 has been confirmed to be highly pro-tumorigenic46.”
From Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis (2024) · cites this paper as [46]
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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predispositionPreprint
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Ontogeny of the enteric nervous system
Boismoreau, F. (2020) · doi:10.70675/b24ef52fz17c8z48e3za3afz5cc386550b86
- Authors
- Peres, J., & Prince, S.
- Affiliations
- University of Cape Town (ZA)
- Corresponding author
- Prince, Sharon
- Venue
- Molecular Cancer
- Published
- 2013
- Volume
- 12
- Issue
- 1
- Pages
- 117
- ISSN
- 1476-4598 (ISSN-L)
- PMC
- PMC3851469
- OpenAlex
- W2164694940
- Semantic Scholar
- 08cc6b953845f4828e2ae1a989b31ce5108a96ce
- Cited by
- 50
- References
- 12
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 8 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 1
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Cancer (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open University of Cape Town (University of Cape Town) (submittedVersion, cc-by)
- Funders
- National Research Foundation
- Cancer Association of South Africa
- University of Cape Town
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
- Keywords
- TBX3, T-box transcription factor, melanoma, tumor invasion, tumor formation, cell proliferation
- MeSH terms
- Animals, Cell Adhesion, Cell Movement, Humans, Melanoma, Mice, Nude, Neoplasm Invasiveness, Neoplasm Transplantation, T-Box Domain Proteins, Cell Line, Tumor, Cell Proliferation, Mice, Carcinogenesis
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