COL1A2 is a TBX3 target that mediates its impact on fibrosarcoma and chondrosarcoma cell migration

Omar, Rehana; Cooper, Aretha; Maranyane, Hapiloe Mabaruti; Zerbini, Luiz; Prince, Sharon

doi:10.1016/j.canlet.2019.06.004

Cited by 21Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsTGF-β signaling in diseases

COL1A2 is a TBX3 target that mediates its impact on fibrosarcoma and chondrosarcoma cell migration

Omar, Rehana, Cooper, Aretha, Maranyane, Hapiloe Mabaruti, Zerbini, Luiz, Prince, Sharon·2019·Cancer Letters

DOI 10.1016/j.canlet.2019.06.004

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Abstract

The developmentally important T-box transcription factor TBX3, is overexpressed in several cancers and contributes to tumorigenesis as either a tumour promoter or tumour suppressor. For example, TBX3 promotes cell proliferation, migration and invasion of chondrosarcoma cells but inhibits these processes in fibrosarcoma cells. This suggests that the cellular context influences TBX3 oncogenic functions, but the mechanism(s) involved has not been elucidated. COL1A2 encodes type I collagen and, like TBX3, plays important roles during embryogenesis and can act as either oncogene or tumour suppressor. Here we explore the possibility that COL1A2 may be a TBX3 target gene responsible for mediating its opposing oncogenic roles in chondrosarcoma and fibrosarcoma cells. Results from qRT-PCR, western blotting, luciferase reporter and chromatin immunoprecipitation assays show that TBX3 binds and activates the COL1A2 promoter. Furthermore, we show that TBX3 levels are regulated by AKT1 and that pseudo-phosphorylation of TBX3 at an AKT consensus serine site, enhances its ability to activate COL1A2. Importantly, we demonstrate that COL1A2 mediates the pro- and anti-migratory effects of TBX3 in chondrosarcoma and fibrosarcoma cells respectively. Our data reveal that the AKT1/TBX3/COL1A2 axis plays an important role in sarcomagenesis.

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TBX3 behaves as a tumor suppressor or oncoprotein across cancer.
“TBX3 behaves as a tumor suppressor or oncoprotein across cancer.”
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MBoC | ARTICLE The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway
Lia, J., Weinbergb, M. S., Zerbinic, L., & Princea, S. (2013)

Authors: Omar, R., Cooper, A., Maranyane, H. M., Zerbini, L., & Prince, S.
Affiliations: University of Cape Town (ZA)
International Centre for Genetic Engineering and Biotechnology (ZA)
Corresponding author: Prince, Sharon
ORCID: Maranyane, Hapiloe Mabaruti
Zerbini, Luiz
Prince, Sharon
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2019-09
Volume: 459
Pages: 227-239
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2019.06.004
OpenAlex: W2952517832
Cited by: 21
References: 83
Citations by year: 2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 1
FWCI: 1.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Funders: South Africa Medical Research Council
National Research Foundation (NRF)
Cancer Association of South Africa
CANSA
University of Cape Town
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: TBX3, COL1A2, type I collagen, chondrosarcoma, fibrosarcoma, sarcomagenesis, cell migration, AKT1, transcriptional activation, promoter regulation, T-box transcription factor, oncogenic function
MeSH terms: Bone Neoplasms, Cell Line, Cell Movement, Chondrosarcoma, Fibroblasts, Fibrosarcoma, Humans, Phosphorylation, Promoter Regions, Genetic, Signal Transduction, Transcriptional Activation, T-Box Domain Proteins, Collagen Type I, Cell Line, Tumor, Proto-Oncogene Proteins c-akt

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COL1A2 is a TBX3 target that mediates its impact on fibrosarcoma and chondrosarcoma cell migration

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